Mutagenetix > Incidental Mutations

Incidental Mutation 'R7166:Olfr1098'

557916

Institutional Source

Beutler Lab

Gene Symbol

Olfr1098

Ensembl Gene

ENSMUSG00000075169

Gene Name

olfactory receptor 1098

Synonyms

MOR206-1, GA_x6K02T2Q125-48410458-48409511

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R7166 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

86920949-86924545 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 86922748 bp

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 261 (K261N)

Ref Sequence

ENSEMBL: ENSMUSP00000107200 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099872] [ENSMUST00000111574]

Predicted Effect

probably damaging
Transcript: ENSMUST00000099872
AA Change: K261N

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000097457
Gene: ENSMUSG00000075169
AA Change: K261N

Domain	Start	End	E-Value	Type
Pfam:7tm_1	41	290	7e-29	PFAM
Pfam:7tm_4	140	283	3.3e-41	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000111574
AA Change: K261N

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000107200
Gene: ENSMUSG00000075169
AA Change: K261N

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.8e-52	PFAM
Pfam:7tm_1	41	309	8.1e-20	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

98% (52/53)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ambn	T	C	5: 88,467,528	L272P	possibly damaging	Het
Ash2l	C	A	8: 25,827,320	G335V	probably damaging	Het
Atp13a1	T	A	8: 69,799,316		probably null	Het
Atp13a2	G	A	4: 141,006,984	R1139Q	possibly damaging	Het
Atxn2	T	A	5: 121,796,397	N886K	possibly damaging	Het
Celsr3	G	T	9: 108,842,951	C2512F	probably damaging	Het
Cfap221	A	G	1: 119,948,113	V449A	probably benign	Het
Cfhr2	A	T	1: 139,831,101	C70*	probably null	Het
Chfr	C	A	5: 110,158,805	P472Q	probably benign	Het
Crybg2	G	A	4: 134,060,882	R22Q	probably damaging	Het
Eef2k	T	C	7: 120,884,772	F244L	probably damaging	Het
Efcab11	A	T	12: 99,883,355	M23K		Het
Ercc8	T	A	13: 108,169,433	M114K	possibly damaging	Het
Fam217a	T	C	13: 34,910,315	Y487C	probably benign	Het
Farsb	T	C	1: 78,471,184	N205S	probably benign	Het
Glra1	A	G	11: 55,515,078	F370S	probably benign	Het
Gm12258	T	A	11: 58,858,473	M158K		Het
Gm14305	T	A	2: 176,720,943	H209Q	probably damaging	Het
Gm4924	A	T	10: 82,378,201	Q611L	unknown	Het
Gm5580	A	G	6: 116,551,368	I69V	probably benign	Het
Haus6	T	C	4: 86,583,687	E649G	possibly damaging	Het
Hist1h4j	A	G	13: 21,735,151	H19R	unknown	Het
Hlcs	C	T	16: 94,262,726	D345N	possibly damaging	Het
Htt	C	A	5: 34,852,894	Q1564K	probably benign	Het
Itpr1	G	A	6: 108,378,190	V481I	probably benign	Het
Jak3	T	C	8: 71,682,316	I531T	probably damaging	Het
Kng1	T	A	16: 23,079,678	H609Q	probably benign	Het
Mdn1	T	A	4: 32,746,446	S4131T	probably damaging	Het
Npnt	A	G	3: 132,948,128	S31P	probably damaging	Het
Olfr1186	A	T	2: 88,525,646	Q21L	possibly damaging	Het
Olfr398	A	T	11: 73,984,295	F104L	possibly damaging	Het
Paxx	A	T	2: 25,460,226	L123Q	probably damaging	Het
Prdm13	C	T	4: 21,683,528	R144Q	unknown	Het
Rab2b	C	A	14: 52,279,345		probably benign	Het
Rnf207	A	G	4: 152,311,780	I509T	probably damaging	Het
Ropn1l	T	C	15: 31,453,509	Q12R		Het
Ryr3	T	G	2: 112,875,028	Y847S	probably damaging	Het
Slc1a6	A	T	10: 78,812,812	T456S	possibly damaging	Het
Slc26a2	A	T	18: 61,198,829	M510K	possibly damaging	Het
Slc5a9	T	C	4: 111,883,839	T537A	probably benign	Het
Slc9b2	T	C	3: 135,326,178	Y132H	unknown	Het
Sltm	T	C	9: 70,584,850	L725S	probably damaging	Het
Spz1	A	G	13: 92,575,927	C14R	probably benign	Het
Srrm4	T	A	5: 116,471,242	Q172L	unknown	Het
Synj2bp	T	C	12: 81,504,515	D92G	probably benign	Het
Tmem169	A	C	1: 72,301,070	T220P	probably benign	Het
Ttn	T	A	2: 76,888,028	I7270F	unknown	Het
Txndc16	T	G	14: 45,183,154	N137H	probably benign	Het
Ubr5	A	G	15: 37,976,145	Y2499H		Het
Ugt2b38	T	C	5: 87,410,446	D452G	probably damaging	Het
Zfp12	T	A	5: 143,245,502	I560N	possibly damaging	Het
Zfp60	A	G	7: 27,749,512	K535R	possibly damaging	Het
Zfp960	T	A	17: 17,088,499	C492S	probably damaging	Het

Other mutations in Olfr1098

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01318:Olfr1098	APN	2	86922949	missense	probably benign
IGL02547:Olfr1098	APN	2	86923028	missense	probably damaging	1.00
IGL02881:Olfr1098	APN	2	86922713	missense	possibly damaging	0.94
IGL03073:Olfr1098	APN	2	86923353	missense	probably damaging	1.00
R0117:Olfr1098	UTSW	2	86922870	missense	probably damaging	1.00
R0808:Olfr1098	UTSW	2	86923451	missense	probably damaging	1.00
R1061:Olfr1098	UTSW	2	86922782	missense	possibly damaging	0.93
R1471:Olfr1098	UTSW	2	86922578	splice site	probably null
R1571:Olfr1098	UTSW	2	86923445	missense	probably benign	0.01
R1680:Olfr1098	UTSW	2	86923161	missense	probably benign	0.10
R2341:Olfr1098	UTSW	2	86922638	missense	possibly damaging	0.63
R2368:Olfr1098	UTSW	2	86923107	missense	probably benign
R3158:Olfr1098	UTSW	2	86922606	missense	probably benign
R3425:Olfr1098	UTSW	2	86922606	missense	probably benign
R3499:Olfr1098	UTSW	2	86923029	missense	possibly damaging	0.94
R4156:Olfr1098	UTSW	2	86922878	missense	probably damaging	1.00
R4526:Olfr1098	UTSW	2	86922995	missense	possibly damaging	0.90
R5743:Olfr1098	UTSW	2	86923205	missense	probably benign	0.01
R5942:Olfr1098	UTSW	2	86923406	missense	probably damaging	1.00
R6372:Olfr1098	UTSW	2	86923155	missense	probably damaging	1.00
R6409:Olfr1098	UTSW	2	86923171	nonsense	probably null
R6517:Olfr1098	UTSW	2	86923097	missense	probably benign	0.05
R6661:Olfr1098	UTSW	2	86923148	missense	probably benign	0.02
R7075:Olfr1098	UTSW	2	86922646	missense	possibly damaging	0.88
R8058:Olfr1098	UTSW	2	86922807	missense	probably benign	0.32
R8234:Olfr1098	UTSW	2	86922969	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTCTTCAGTTTTGTGCCAAGAGC -3'
(R):5'- AGCTGGTTCCACTCTATTGCTG -3'

Sequencing Primer
(F):5'- CCAAGAGCAAAGCTGAAGAAC -3'
(R):5'- GCTGTCGCTAATCACGATATCCG -3'

Posted On

2019-06-26