Incidental Mutation 'R7166:Slc5a9'
ID 557924
Institutional Source Beutler Lab
Gene Symbol Slc5a9
Ensembl Gene ENSMUSG00000028544
Gene Name solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms SGLT4
MMRRC Submission 045227-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R7166 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 111732571-111759993 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 111741036 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 537 (T537A)
Ref Sequence ENSEMBL: ENSMUSP00000099780 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102719] [ENSMUST00000102720] [ENSMUST00000102721]
AlphaFold Q8VDT1
Predicted Effect probably benign
Transcript: ENSMUST00000102719
AA Change: T537A

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000099780
Gene: ENSMUSG00000028544
AA Change: T537A

DomainStartEndE-ValueType
low complexity region 34 44 N/A INTRINSIC
Pfam:SSF 63 492 2.3e-152 PFAM
transmembrane domain 526 548 N/A INTRINSIC
transmembrane domain 665 684 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000102720
AA Change: T537A

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000099781
Gene: ENSMUSG00000028544
AA Change: T537A

DomainStartEndE-ValueType
low complexity region 34 44 N/A INTRINSIC
Pfam:SSF 63 492 2.3e-152 PFAM
transmembrane domain 526 548 N/A INTRINSIC
transmembrane domain 665 684 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000102721
AA Change: T537A

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000099782
Gene: ENSMUSG00000028544
AA Change: T537A

DomainStartEndE-ValueType
low complexity region 34 44 N/A INTRINSIC
Pfam:SSF 63 492 2.3e-152 PFAM
transmembrane domain 526 548 N/A INTRINSIC
transmembrane domain 665 684 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ambn T C 5: 88,615,387 (GRCm39) L272P possibly damaging Het
Ash2l C A 8: 26,317,348 (GRCm39) G335V probably damaging Het
Atp13a1 T A 8: 70,251,966 (GRCm39) probably null Het
Atp13a2 G A 4: 140,734,295 (GRCm39) R1139Q possibly damaging Het
Atxn2 T A 5: 121,934,460 (GRCm39) N886K possibly damaging Het
Celsr3 G T 9: 108,720,150 (GRCm39) C2512F probably damaging Het
Cfap221 A G 1: 119,875,843 (GRCm39) V449A probably benign Het
Cfhr2 A T 1: 139,758,839 (GRCm39) C70* probably null Het
Chfr C A 5: 110,306,671 (GRCm39) P472Q probably benign Het
Crybg2 G A 4: 133,788,193 (GRCm39) R22Q probably damaging Het
Eef2k T C 7: 120,483,995 (GRCm39) F244L probably damaging Het
Efcab11 A T 12: 99,849,614 (GRCm39) M23K Het
Eif4a3l2 A G 6: 116,528,329 (GRCm39) I69V probably benign Het
Ercc8 T A 13: 108,305,967 (GRCm39) M114K possibly damaging Het
Fam217a T C 13: 35,094,298 (GRCm39) Y487C probably benign Het
Farsb T C 1: 78,447,821 (GRCm39) N205S probably benign Het
Glra1 A G 11: 55,405,904 (GRCm39) F370S probably benign Het
Gm12258 T A 11: 58,749,299 (GRCm39) M158K Het
Gm14305 T A 2: 176,412,736 (GRCm39) H209Q probably damaging Het
Gm4924 A T 10: 82,214,035 (GRCm39) Q611L unknown Het
H4c11 A G 13: 21,919,321 (GRCm39) H19R unknown Het
Haus6 T C 4: 86,501,924 (GRCm39) E649G possibly damaging Het
Hlcs C T 16: 94,063,585 (GRCm39) D345N possibly damaging Het
Htt C A 5: 35,010,238 (GRCm39) Q1564K probably benign Het
Itpr1 G A 6: 108,355,151 (GRCm39) V481I probably benign Het
Jak3 T C 8: 72,134,960 (GRCm39) I531T probably damaging Het
Kng1 T A 16: 22,898,428 (GRCm39) H609Q probably benign Het
Mdn1 T A 4: 32,746,446 (GRCm39) S4131T probably damaging Het
Npnt A G 3: 132,653,889 (GRCm39) S31P probably damaging Het
Or1r1 A T 11: 73,875,121 (GRCm39) F104L possibly damaging Het
Or4c100 A T 2: 88,355,990 (GRCm39) Q21L possibly damaging Het
Or8h8 T A 2: 86,753,092 (GRCm39) K261N probably damaging Het
Paxx A T 2: 25,350,238 (GRCm39) L123Q probably damaging Het
Prdm13 C T 4: 21,683,528 (GRCm39) R144Q unknown Het
Rab2b C A 14: 52,516,802 (GRCm39) probably benign Het
Rnf207 A G 4: 152,396,237 (GRCm39) I509T probably damaging Het
Ropn1l T C 15: 31,453,655 (GRCm39) Q12R Het
Ryr3 T G 2: 112,705,373 (GRCm39) Y847S probably damaging Het
Slc1a6 A T 10: 78,648,646 (GRCm39) T456S possibly damaging Het
Slc26a2 A T 18: 61,331,901 (GRCm39) M510K possibly damaging Het
Slc9b2 T C 3: 135,031,939 (GRCm39) Y132H unknown Het
Sltm T C 9: 70,492,132 (GRCm39) L725S probably damaging Het
Spz1 A G 13: 92,712,435 (GRCm39) C14R probably benign Het
Srrm4 T A 5: 116,609,301 (GRCm39) Q172L unknown Het
Synj2bp T C 12: 81,551,289 (GRCm39) D92G probably benign Het
Tmem169 A C 1: 72,340,229 (GRCm39) T220P probably benign Het
Ttn T A 2: 76,718,372 (GRCm39) I7270F unknown Het
Txndc16 T G 14: 45,420,611 (GRCm39) N137H probably benign Het
Ubr5 A G 15: 37,976,389 (GRCm39) Y2499H Het
Ugt2b38 T C 5: 87,558,305 (GRCm39) D452G probably damaging Het
Zfp12 T A 5: 143,231,257 (GRCm39) I560N possibly damaging Het
Zfp60 A G 7: 27,448,937 (GRCm39) K535R possibly damaging Het
Zfp960 T A 17: 17,308,761 (GRCm39) C492S probably damaging Het
Other mutations in Slc5a9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00326:Slc5a9 APN 4 111,755,766 (GRCm39) missense probably damaging 0.99
IGL00837:Slc5a9 APN 4 111,750,887 (GRCm39) intron probably benign
IGL01556:Slc5a9 APN 4 111,755,833 (GRCm39) missense probably benign 0.00
IGL01807:Slc5a9 APN 4 111,734,737 (GRCm39) makesense probably null
IGL01816:Slc5a9 APN 4 111,755,811 (GRCm39) missense probably damaging 1.00
IGL02066:Slc5a9 APN 4 111,744,719 (GRCm39) missense probably damaging 1.00
IGL02370:Slc5a9 APN 4 111,734,826 (GRCm39) missense probably benign 0.01
IGL02491:Slc5a9 APN 4 111,753,549 (GRCm39) missense probably damaging 0.99
IGL02971:Slc5a9 APN 4 111,747,497 (GRCm39) missense possibly damaging 0.58
IGL03008:Slc5a9 APN 4 111,748,138 (GRCm39) missense probably benign 0.14
R0365:Slc5a9 UTSW 4 111,749,033 (GRCm39) nonsense probably null
R0559:Slc5a9 UTSW 4 111,742,779 (GRCm39) missense probably benign 0.02
R0659:Slc5a9 UTSW 4 111,741,068 (GRCm39) missense possibly damaging 0.82
R1454:Slc5a9 UTSW 4 111,741,161 (GRCm39) missense probably benign 0.04
R2006:Slc5a9 UTSW 4 111,737,423 (GRCm39) missense probably benign
R2014:Slc5a9 UTSW 4 111,753,546 (GRCm39) missense possibly damaging 0.76
R2024:Slc5a9 UTSW 4 111,747,728 (GRCm39) missense probably damaging 1.00
R2076:Slc5a9 UTSW 4 111,742,770 (GRCm39) missense possibly damaging 0.76
R2152:Slc5a9 UTSW 4 111,750,420 (GRCm39) missense possibly damaging 0.76
R3156:Slc5a9 UTSW 4 111,747,421 (GRCm39) missense possibly damaging 0.80
R4566:Slc5a9 UTSW 4 111,748,941 (GRCm39) splice site probably null
R4568:Slc5a9 UTSW 4 111,748,941 (GRCm39) splice site probably null
R4579:Slc5a9 UTSW 4 111,750,384 (GRCm39) missense probably damaging 1.00
R4656:Slc5a9 UTSW 4 111,748,941 (GRCm39) splice site probably null
R4657:Slc5a9 UTSW 4 111,748,941 (GRCm39) splice site probably null
R4700:Slc5a9 UTSW 4 111,748,134 (GRCm39) missense possibly damaging 0.64
R4889:Slc5a9 UTSW 4 111,748,941 (GRCm39) splice site probably null
R4891:Slc5a9 UTSW 4 111,748,941 (GRCm39) splice site probably null
R4911:Slc5a9 UTSW 4 111,748,941 (GRCm39) splice site probably null
R4948:Slc5a9 UTSW 4 111,748,941 (GRCm39) splice site probably null
R4953:Slc5a9 UTSW 4 111,748,941 (GRCm39) splice site probably null
R5222:Slc5a9 UTSW 4 111,755,808 (GRCm39) missense possibly damaging 0.55
R5376:Slc5a9 UTSW 4 111,750,414 (GRCm39) missense possibly damaging 0.80
R5502:Slc5a9 UTSW 4 111,750,366 (GRCm39) nonsense probably null
R5851:Slc5a9 UTSW 4 111,742,797 (GRCm39) missense probably benign
R6030:Slc5a9 UTSW 4 111,742,725 (GRCm39) missense possibly damaging 0.64
R6030:Slc5a9 UTSW 4 111,742,725 (GRCm39) missense possibly damaging 0.64
R6125:Slc5a9 UTSW 4 111,741,002 (GRCm39) missense probably damaging 1.00
R6326:Slc5a9 UTSW 4 111,737,450 (GRCm39) missense probably benign
R6438:Slc5a9 UTSW 4 111,749,022 (GRCm39) missense probably benign 0.00
R7105:Slc5a9 UTSW 4 111,755,892 (GRCm39) missense probably benign
R7489:Slc5a9 UTSW 4 111,741,113 (GRCm39) missense probably damaging 1.00
R7599:Slc5a9 UTSW 4 111,734,937 (GRCm39) missense probably benign
R7662:Slc5a9 UTSW 4 111,734,737 (GRCm39) makesense probably null
R7762:Slc5a9 UTSW 4 111,747,371 (GRCm39) missense probably damaging 0.99
R7992:Slc5a9 UTSW 4 111,747,729 (GRCm39) missense probably benign 0.37
R8851:Slc5a9 UTSW 4 111,755,790 (GRCm39) missense probably damaging 0.97
R8918:Slc5a9 UTSW 4 111,741,147 (GRCm39) missense probably benign 0.00
R9387:Slc5a9 UTSW 4 111,750,864 (GRCm39) missense probably damaging 1.00
R9425:Slc5a9 UTSW 4 111,734,803 (GRCm39) missense probably damaging 0.96
R9483:Slc5a9 UTSW 4 111,747,418 (GRCm39) missense probably damaging 1.00
R9506:Slc5a9 UTSW 4 111,750,439 (GRCm39) nonsense probably null
X0012:Slc5a9 UTSW 4 111,750,511 (GRCm39) missense probably damaging 0.99
Z1177:Slc5a9 UTSW 4 111,749,013 (GRCm39) missense probably null 1.00
Predicted Primers PCR Primer
(F):5'- TGAGCACGTCCTCCAAAAGC -3'
(R):5'- ATGTTAGAGCATGGTGTCTCAC -3'

Sequencing Primer
(F):5'- GCACGTCCTCCAAAAGCTATCTG -3'
(R):5'- TAGGATCTCCCCCAACTCATC -3'
Posted On 2019-06-26