|Institutional Source||Beutler Lab|
|Gene Name||histone cluster 1, H4j|
|Is this an essential gene?||Not available|
|Stock #||R7166 (G1)|
|Chromosomal Location||21735064-21735837 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 21735151 bp|
|Amino Acid Change||Histidine to Arginine at position 19 (H19R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000085006 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000087714]|
2.6 A CRYSTAL STRUCTURE OF A NUCLEOSOME CORE PARTICLE CONTAINING THE VARIANT HISTONE H2A.Z [X-RAY DIFFRACTION]
Crystal structure of the nucleosome core particle containing the histone domain of macroH2A [X-RAY DIFFRACTION]
Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide. [X-RAY DIFFRACTION]
The structure of the Suv4-20h2 ternary complex with histone H4 [X-RAY DIFFRACTION]
Structure of mouse ORC1 BAH domain bound to H4K20me2 [X-RAY DIFFRACTION]
AA Change: H19R
AA Change: H19R
|Coding Region Coverage||
|Validation Efficiency||98% (52/53)|
|MGI Phenotype||FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Hist1h4j||
(F):5'- GTGCGCTCGATTCTCCAAAC -3'
(R):5'- ATGTGGTGGTCCTGAAAAGG -3'
(F):5'- TCTCCAAACTCTTAAAAGGGCGTG -3'
(R):5'- CCTTTAGGGAAATATAGTGTAAGCG -3'