Incidental Mutation 'R7167:Trap1'
ID 558016
Institutional Source Beutler Lab
Gene Symbol Trap1
Ensembl Gene ENSMUSG00000005981
Gene Name TNF receptor-associated protein 1
Synonyms HSP75, 2410002K23Rik
MMRRC Submission 045228-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7167 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 3857835-3895691 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 3870792 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 393 (V393G)
Ref Sequence ENSEMBL: ENSMUSP00000006137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006137]
AlphaFold Q9CQN1
Predicted Effect probably damaging
Transcript: ENSMUST00000006137
AA Change: V393G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000006137
Gene: ENSMUSG00000005981
AA Change: V393G

DomainStartEndE-ValueType
HATPase_c 110 263 3.68e-3 SMART
Pfam:HSP90 290 706 2.6e-98 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000150354
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 94% (65/69)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit reduced body weight; liver and spleen hyperplasia; decreased chronic inflammation and tumor incidents; deregulated mitochondrial respiration; and increased oxidative stress. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,624,930 (GRCm39) V436A probably benign Het
Abcc5 T C 16: 20,224,251 (GRCm39) T111A possibly damaging Het
Acsbg2 T A 17: 57,164,000 (GRCm39) D203V probably benign Het
Alpk2 G T 18: 65,440,049 (GRCm39) T448K probably benign Het
Arhgef2 A G 3: 88,551,179 (GRCm39) N780S possibly damaging Het
Atxn2l T C 7: 126,098,394 (GRCm39) N252S possibly damaging Het
Bmpr1b A T 3: 141,568,841 (GRCm39) L163Q probably benign Het
Clca3a2 T C 3: 144,803,545 (GRCm39) R100G probably benign Het
Col2a1 A G 15: 97,898,337 (GRCm39) I79T unknown Het
Csmd1 A G 8: 15,976,524 (GRCm39) V2898A probably benign Het
Cux1 G A 5: 136,338,895 (GRCm39) probably null Het
Cyp2u1 A G 3: 131,096,773 (GRCm39) S2P probably benign Het
Daam1 C A 12: 72,035,678 (GRCm39) H958N probably damaging Het
Dnah7a C T 1: 53,542,935 (GRCm39) V2412I probably benign Het
Ergic2 T C 6: 148,108,133 (GRCm39) R2G probably damaging Het
Fat2 T C 11: 55,175,827 (GRCm39) T1629A possibly damaging Het
Ftl1 T A 7: 45,109,202 (GRCm39) probably benign Het
Fut8 T C 12: 77,495,406 (GRCm39) V332A possibly damaging Het
Gm28363 T C 1: 117,655,119 (GRCm39) S113P probably damaging Het
Hfe A T 13: 23,892,052 (GRCm39) V104E probably damaging Het
Ifih1 A T 2: 62,429,240 (GRCm39) N899K probably benign Het
Krt75 A G 15: 101,476,750 (GRCm39) S380P possibly damaging Het
Meiob T G 17: 25,055,419 (GRCm39) F409V probably damaging Het
Mkrn2os A T 6: 115,562,474 (GRCm39) I163N probably damaging Het
Nanos1 G T 19: 60,745,046 (GRCm39) G115W probably damaging Het
Naprt C T 15: 75,764,461 (GRCm39) A276T probably damaging Het
Oas1e G T 5: 120,933,487 (GRCm39) T26N probably benign Het
Oog2 T G 4: 143,921,745 (GRCm39) D218E probably benign Het
Optn T C 2: 5,047,294 (GRCm39) N207S probably benign Het
Or13a20 T A 7: 140,232,466 (GRCm39) C191* probably null Het
Or1l8 T C 2: 36,817,533 (GRCm39) I198V probably benign Het
Or4g16 T C 2: 111,136,793 (GRCm39) M81T probably benign Het
Or4p18 A G 2: 88,232,552 (GRCm39) V242A possibly damaging Het
Or6c63-ps1 T G 10: 128,899,141 (GRCm39) Q245P probably damaging Het
Or6c66b T C 10: 129,376,607 (GRCm39) L67P possibly damaging Het
Or8g4 T C 9: 39,661,865 (GRCm39) F61S probably damaging Het
Oxnad1 G T 14: 31,822,976 (GRCm39) E236* probably null Het
Pcdha3 G A 18: 37,080,046 (GRCm39) A263T probably damaging Het
Pex13 A T 11: 23,605,472 (GRCm39) W253R possibly damaging Het
Pip5k1b T A 19: 24,374,433 (GRCm39) E49D probably benign Het
Plau C A 14: 20,889,518 (GRCm39) F194L possibly damaging Het
Ppm1n A G 7: 19,013,666 (GRCm39) L95S probably damaging Het
Pramel40 G A 5: 94,464,984 (GRCm39) A457T possibly damaging Het
Radil G T 5: 142,471,260 (GRCm39) probably null Het
Ralgapa2 C T 2: 146,190,374 (GRCm39) M1266I probably benign Het
Reln A T 5: 22,147,618 (GRCm39) L2444Q probably damaging Het
Rims2 T C 15: 39,300,473 (GRCm39) V260A probably benign Het
Rnase2b T A 14: 51,400,222 (GRCm39) V101E probably damaging Het
Rtp3 T A 9: 110,815,772 (GRCm39) T198S probably benign Het
Shisal2b A G 13: 105,000,166 (GRCm39) V19A probably damaging Het
Smad3 T A 9: 63,573,435 (GRCm39) D201V probably benign Het
Son AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,457,222 (GRCm39) probably benign Het
Spata7 T G 12: 98,630,555 (GRCm39) F371C probably damaging Het
Stag1 T G 9: 100,827,942 (GRCm39) N990K probably benign Het
Tbx18 C T 9: 87,589,883 (GRCm39) A352T probably damaging Het
Thada C T 17: 84,538,391 (GRCm39) R1539Q probably benign Het
Thrap3 A C 4: 126,078,920 (GRCm39) probably benign Het
Tnks G A 8: 35,316,458 (GRCm39) T887M probably damaging Het
Trpm4 A G 7: 44,977,143 (GRCm39) probably null Het
Trrap G T 5: 144,776,424 (GRCm39) G3007C probably benign Het
U2surp A T 9: 95,363,726 (GRCm39) N611K probably damaging Het
Usp12 A G 5: 146,705,745 (GRCm39) probably null Het
Vmn1r200 A G 13: 22,579,487 (GRCm39) T97A possibly damaging Het
Vmn2r110 C T 17: 20,794,441 (GRCm39) V743I probably benign Het
Vps50 C T 6: 3,600,256 (GRCm39) T905M probably damaging Het
Wdr48 T A 9: 119,736,855 (GRCm39) probably null Het
Zfp446 C T 7: 12,712,049 (GRCm39) probably benign Het
Zfr T C 15: 12,181,015 (GRCm39) S1012P probably benign Het
Other mutations in Trap1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01155:Trap1 APN 16 3,861,842 (GRCm39) nonsense probably null
IGL03087:Trap1 APN 16 3,862,565 (GRCm39) splice site probably null
gloria UTSW 16 3,863,903 (GRCm39) nonsense probably null
mundi UTSW 16 3,883,131 (GRCm39) missense probably benign 0.00
E0354:Trap1 UTSW 16 3,883,152 (GRCm39) missense probably benign 0.01
R0034:Trap1 UTSW 16 3,886,894 (GRCm39) splice site probably benign
R0034:Trap1 UTSW 16 3,886,894 (GRCm39) splice site probably benign
R0316:Trap1 UTSW 16 3,863,424 (GRCm39) missense probably benign
R0336:Trap1 UTSW 16 3,862,490 (GRCm39) missense probably damaging 0.99
R0614:Trap1 UTSW 16 3,878,615 (GRCm39) splice site probably benign
R2069:Trap1 UTSW 16 3,886,200 (GRCm39) missense probably benign
R2089:Trap1 UTSW 16 3,863,903 (GRCm39) nonsense probably null
R2091:Trap1 UTSW 16 3,863,903 (GRCm39) nonsense probably null
R2091:Trap1 UTSW 16 3,863,903 (GRCm39) nonsense probably null
R2148:Trap1 UTSW 16 3,878,624 (GRCm39) missense probably damaging 0.97
R2419:Trap1 UTSW 16 3,886,194 (GRCm39) missense probably benign 0.23
R3853:Trap1 UTSW 16 3,872,686 (GRCm39) missense possibly damaging 0.69
R4926:Trap1 UTSW 16 3,863,352 (GRCm39) missense probably benign 0.27
R5120:Trap1 UTSW 16 3,861,952 (GRCm39) missense probably damaging 1.00
R5261:Trap1 UTSW 16 3,874,286 (GRCm39) missense probably damaging 1.00
R5434:Trap1 UTSW 16 3,862,529 (GRCm39) missense probably benign 0.00
R6194:Trap1 UTSW 16 3,872,664 (GRCm39) missense possibly damaging 0.94
R6284:Trap1 UTSW 16 3,878,673 (GRCm39) missense probably benign 0.07
R6415:Trap1 UTSW 16 3,861,856 (GRCm39) missense possibly damaging 0.92
R7132:Trap1 UTSW 16 3,873,693 (GRCm39) missense probably benign 0.17
R8968:Trap1 UTSW 16 3,862,490 (GRCm39) missense possibly damaging 0.65
R9438:Trap1 UTSW 16 3,883,131 (GRCm39) missense probably benign 0.00
R9596:Trap1 UTSW 16 3,871,374 (GRCm39) missense probably damaging 1.00
R9620:Trap1 UTSW 16 3,858,083 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGCTCACTAGGTCAGAACACC -3'
(R):5'- AGGTCTTCTACACAGCCCAG -3'

Sequencing Primer
(F):5'- CCTAGAAGGTCAGGGAGGGATCC -3'
(R):5'- CTCCGAGATCTGGGATTACATAG -3'
Posted On 2019-06-26