Incidental Mutation 'R7169:Vmn2r73'
| ID |
558122 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r73
|
| Ensembl Gene |
ENSMUSG00000070458 |
| Gene Name |
vomeronasal 2, receptor 73 |
| Synonyms |
EG620928 |
| MMRRC Submission |
045229-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R7169 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85506755-85525146 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 85507663 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 550
(Q550*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076687
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077478]
|
| AlphaFold |
D3Z7M3 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000077478
AA Change: Q550*
|
| SMART Domains |
Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: Q550*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
508 |
560 |
5.9e-21 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
4.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts14 |
A |
G |
10: 61,040,707 (GRCm39) |
V870A |
probably damaging |
Het |
| Ahi1 |
T |
G |
10: 20,930,918 (GRCm39) |
D919E |
probably damaging |
Het |
| Angptl6 |
T |
A |
9: 20,786,475 (GRCm39) |
R390S |
probably damaging |
Het |
| Arhgef11 |
A |
G |
3: 87,634,755 (GRCm39) |
I873V |
possibly damaging |
Het |
| BC024063 |
T |
C |
10: 81,946,293 (GRCm39) |
Y638H |
possibly damaging |
Het |
| Brsk1 |
T |
C |
7: 4,718,403 (GRCm39) |
S751P |
probably benign |
Het |
| Calhm5 |
T |
A |
10: 33,968,160 (GRCm39) |
T298S |
probably damaging |
Het |
| Cdh20 |
G |
A |
1: 104,875,078 (GRCm39) |
A287T |
possibly damaging |
Het |
| Clic3 |
G |
A |
2: 25,348,731 (GRCm39) |
R237H |
probably benign |
Het |
| Cog6 |
G |
T |
3: 52,897,387 (GRCm39) |
P562H |
possibly damaging |
Het |
| Csnk2a2 |
A |
G |
8: 96,215,006 (GRCm39) |
Y24H |
|
Het |
| Ctif |
T |
C |
18: 75,605,087 (GRCm39) |
D484G |
probably damaging |
Het |
| Cyria |
A |
G |
12: 12,409,233 (GRCm39) |
D71G |
possibly damaging |
Het |
| Dennd6b |
A |
T |
15: 89,073,055 (GRCm39) |
F161I |
possibly damaging |
Het |
| Dnah14 |
G |
T |
1: 181,529,930 (GRCm39) |
V2235L |
probably benign |
Het |
| Dnah6 |
A |
T |
6: 73,015,729 (GRCm39) |
V3636D |
probably damaging |
Het |
| Dpm1 |
A |
T |
2: 168,053,343 (GRCm39) |
Y207* |
probably null |
Het |
| Eml3 |
A |
G |
19: 8,910,828 (GRCm39) |
T227A |
probably damaging |
Het |
| Enpp5 |
G |
A |
17: 44,396,155 (GRCm39) |
G356S |
probably damaging |
Het |
| Eppk1 |
C |
A |
15: 75,990,114 (GRCm39) |
A2256S |
probably benign |
Het |
| Etnppl |
A |
T |
3: 130,414,345 (GRCm39) |
N80I |
probably damaging |
Het |
| Eya4 |
A |
T |
10: 23,031,845 (GRCm39) |
N236K |
probably benign |
Het |
| Gm12886 |
T |
G |
4: 121,273,948 (GRCm39) |
Q89H |
probably damaging |
Het |
| Gsdme |
T |
C |
6: 50,204,358 (GRCm39) |
T200A |
probably benign |
Het |
| Hipk1 |
C |
T |
3: 103,651,533 (GRCm39) |
A1122T |
probably benign |
Het |
| Icos |
A |
G |
1: 61,034,705 (GRCm39) |
D176G |
probably damaging |
Het |
| Igkv5-43 |
T |
A |
6: 69,800,519 (GRCm39) |
Y56F |
probably damaging |
Het |
| Il1r1 |
T |
C |
1: 40,332,519 (GRCm39) |
|
probably null |
Het |
| Ildr2 |
G |
A |
1: 166,135,503 (GRCm39) |
|
probably null |
Het |
| Ilf3 |
T |
A |
9: 21,306,722 (GRCm39) |
H305Q |
probably damaging |
Het |
| Insrr |
A |
G |
3: 87,715,901 (GRCm39) |
H532R |
probably benign |
Het |
| Lmbr1l |
CACTACATACTACATACTACATACTACATACTACATACTACATAC |
CACTACATACTACATACTACATACTACATACTACATACTACATACTACATAC |
15: 98,807,039 (GRCm39) |
|
probably null |
Het |
| Lmbr1l |
ACTACAT |
ACTACATGCTACAT |
15: 98,807,075 (GRCm39) |
|
probably benign |
Het |
| Lratd1 |
A |
G |
12: 14,200,619 (GRCm39) |
F36S |
probably damaging |
Het |
| Lrrc25 |
T |
G |
8: 71,070,437 (GRCm39) |
S73A |
probably benign |
Het |
| Lrrn1 |
T |
C |
6: 107,544,565 (GRCm39) |
L121P |
probably damaging |
Het |
| Ly6c1 |
C |
A |
15: 74,916,495 (GRCm39) |
V116L |
probably benign |
Het |
| Meltf |
A |
G |
16: 31,698,980 (GRCm39) |
D30G |
probably benign |
Het |
| Mroh7 |
T |
A |
4: 106,548,836 (GRCm39) |
D1009V |
probably damaging |
Het |
| Mybpc3 |
T |
C |
2: 90,948,524 (GRCm39) |
V4A |
possibly damaging |
Het |
| Mycbp2 |
A |
G |
14: 103,497,636 (GRCm39) |
S979P |
possibly damaging |
Het |
| Ntn5 |
C |
T |
7: 45,336,198 (GRCm39) |
R210* |
probably null |
Het |
| Nuak1 |
T |
C |
10: 84,210,609 (GRCm39) |
D493G |
probably damaging |
Het |
| Oprk1 |
T |
A |
1: 5,659,304 (GRCm39) |
D11E |
probably benign |
Het |
| Or13a1 |
G |
T |
6: 116,471,025 (GRCm39) |
A152S |
probably benign |
Het |
| Or4f14 |
A |
G |
2: 111,742,939 (GRCm39) |
M112T |
possibly damaging |
Het |
| Or4k37 |
T |
A |
2: 111,158,943 (GRCm39) |
Y60N |
probably damaging |
Het |
| Or56a41 |
T |
C |
7: 104,740,397 (GRCm39) |
I150V |
possibly damaging |
Het |
| Pkd1l2 |
T |
A |
8: 117,767,574 (GRCm39) |
T1239S |
possibly damaging |
Het |
| Pkm |
A |
G |
9: 59,578,908 (GRCm39) |
D296G |
possibly damaging |
Het |
| Pof1b |
A |
G |
X: 111,554,042 (GRCm39) |
I544T |
probably benign |
Het |
| Pop5 |
T |
A |
5: 115,378,287 (GRCm39) |
V77E |
possibly damaging |
Het |
| Ppp1r10 |
T |
C |
17: 36,240,365 (GRCm39) |
S552P |
probably damaging |
Het |
| Rabggta |
C |
G |
14: 55,958,358 (GRCm39) |
R101P |
probably damaging |
Het |
| Rorc |
A |
T |
3: 94,296,487 (GRCm39) |
E243V |
probably benign |
Het |
| Setmar |
C |
A |
6: 108,042,049 (GRCm39) |
A3E |
possibly damaging |
Het |
| Skor2 |
T |
A |
18: 76,948,681 (GRCm39) |
V801E |
probably benign |
Het |
| Slc12a7 |
G |
A |
13: 73,932,679 (GRCm39) |
V56M |
probably benign |
Het |
| Snph |
T |
A |
2: 151,436,307 (GRCm39) |
N207I |
probably damaging |
Het |
| Snx14 |
A |
G |
9: 88,280,362 (GRCm39) |
V531A |
probably damaging |
Het |
| Thap1 |
CAGCATCTGCTCGGAGCA |
CAGCA |
8: 26,650,884 (GRCm39) |
|
probably null |
Het |
| Tlr3 |
A |
T |
8: 45,850,056 (GRCm39) |
M871K |
probably damaging |
Het |
| Tnfrsf11a |
A |
T |
1: 105,772,421 (GRCm39) |
R569S |
possibly damaging |
Het |
| Trim66 |
A |
G |
7: 109,054,328 (GRCm39) |
V1294A |
probably benign |
Het |
| Vldlr |
G |
A |
19: 27,221,728 (GRCm39) |
V698I |
probably benign |
Het |
| Zdhhc5 |
A |
T |
2: 84,532,675 (GRCm39) |
|
probably null |
Het |
| Zfhx3 |
T |
A |
8: 109,678,030 (GRCm39) |
Y3027N |
possibly damaging |
Het |
| Zfp663 |
C |
T |
2: 165,194,359 (GRCm39) |
S620N |
probably benign |
Het |
|
| Other mutations in Vmn2r73 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r73
|
APN |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
IGL01151:Vmn2r73
|
APN |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01408:Vmn2r73
|
APN |
7 |
85,521,455 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL01505:Vmn2r73
|
APN |
7 |
85,507,267 (GRCm39) |
nonsense |
probably null |
|
|
IGL01731:Vmn2r73
|
APN |
7 |
85,506,757 (GRCm39) |
makesense |
probably null |
|
|
IGL01818:Vmn2r73
|
APN |
7 |
85,519,109 (GRCm39) |
splice site |
probably benign |
|
|
IGL02236:Vmn2r73
|
APN |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02265:Vmn2r73
|
APN |
7 |
85,520,847 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02266:Vmn2r73
|
APN |
7 |
85,525,007 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02276:Vmn2r73
|
APN |
7 |
85,518,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02284:Vmn2r73
|
APN |
7 |
85,507,123 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02380:Vmn2r73
|
APN |
7 |
85,507,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02466:Vmn2r73
|
APN |
7 |
85,522,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Vmn2r73
|
APN |
7 |
85,507,495 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03179:Vmn2r73
|
APN |
7 |
85,519,468 (GRCm39) |
missense |
probably benign |
0.04 |
|
G1Funyon:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0077:Vmn2r73
|
UTSW |
7 |
85,525,075 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0311:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R0413:Vmn2r73
|
UTSW |
7 |
85,521,087 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0494:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R1523:Vmn2r73
|
UTSW |
7 |
85,519,486 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1618:Vmn2r73
|
UTSW |
7 |
85,525,120 (GRCm39) |
nonsense |
probably null |
|
|
R1667:Vmn2r73
|
UTSW |
7 |
85,506,889 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1728:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1729:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Vmn2r73
|
UTSW |
7 |
85,507,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2152:Vmn2r73
|
UTSW |
7 |
85,506,936 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2395:Vmn2r73
|
UTSW |
7 |
85,506,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2415:Vmn2r73
|
UTSW |
7 |
85,521,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Vmn2r73
|
UTSW |
7 |
85,520,871 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3719:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3766:Vmn2r73
|
UTSW |
7 |
85,521,198 (GRCm39) |
missense |
probably benign |
|
|
R3838:Vmn2r73
|
UTSW |
7 |
85,507,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3890:Vmn2r73
|
UTSW |
7 |
85,507,144 (GRCm39) |
missense |
probably benign |
|
|
R4030:Vmn2r73
|
UTSW |
7 |
85,521,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4247:Vmn2r73
|
UTSW |
7 |
85,521,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4409:Vmn2r73
|
UTSW |
7 |
85,520,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4427:Vmn2r73
|
UTSW |
7 |
85,506,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4430:Vmn2r73
|
UTSW |
7 |
85,519,449 (GRCm39) |
missense |
probably benign |
|
|
R4552:Vmn2r73
|
UTSW |
7 |
85,525,055 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4779:Vmn2r73
|
UTSW |
7 |
85,520,923 (GRCm39) |
nonsense |
probably null |
|
|
R4906:Vmn2r73
|
UTSW |
7 |
85,506,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4942:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r73
|
UTSW |
7 |
85,507,155 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5344:Vmn2r73
|
UTSW |
7 |
85,525,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5478:Vmn2r73
|
UTSW |
7 |
85,518,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5527:Vmn2r73
|
UTSW |
7 |
85,507,575 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5691:Vmn2r73
|
UTSW |
7 |
85,507,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5826:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6018:Vmn2r73
|
UTSW |
7 |
85,521,875 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6082:Vmn2r73
|
UTSW |
7 |
85,507,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6111:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R6233:Vmn2r73
|
UTSW |
7 |
85,519,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6278:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R6283:Vmn2r73
|
UTSW |
7 |
85,521,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r73
|
UTSW |
7 |
85,506,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6413:Vmn2r73
|
UTSW |
7 |
85,519,544 (GRCm39) |
nonsense |
probably null |
|
|
R6782:Vmn2r73
|
UTSW |
7 |
85,519,563 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6884:Vmn2r73
|
UTSW |
7 |
85,507,213 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6921:Vmn2r73
|
UTSW |
7 |
85,507,446 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7206:Vmn2r73
|
UTSW |
7 |
85,522,075 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7311:Vmn2r73
|
UTSW |
7 |
85,521,192 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7650:Vmn2r73
|
UTSW |
7 |
85,521,147 (GRCm39) |
missense |
probably benign |
|
|
R7811:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8263:Vmn2r73
|
UTSW |
7 |
85,507,619 (GRCm39) |
missense |
probably benign |
|
|
R8301:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8341:Vmn2r73
|
UTSW |
7 |
85,507,128 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8500:Vmn2r73
|
UTSW |
7 |
85,519,638 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8673:Vmn2r73
|
UTSW |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8719:Vmn2r73
|
UTSW |
7 |
85,521,095 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8783:Vmn2r73
|
UTSW |
7 |
85,507,668 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8828:Vmn2r73
|
UTSW |
7 |
85,521,179 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8860:Vmn2r73
|
UTSW |
7 |
85,522,149 (GRCm39) |
splice site |
probably benign |
|
|
R9002:Vmn2r73
|
UTSW |
7 |
85,507,284 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9008:Vmn2r73
|
UTSW |
7 |
85,521,904 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9159:Vmn2r73
|
UTSW |
7 |
85,521,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9180:Vmn2r73
|
UTSW |
7 |
85,507,123 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9198:Vmn2r73
|
UTSW |
7 |
85,518,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9329:Vmn2r73
|
UTSW |
7 |
85,519,073 (GRCm39) |
missense |
probably benign |
|
|
R9448:Vmn2r73
|
UTSW |
7 |
85,522,027 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9463:Vmn2r73
|
UTSW |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
R9589:Vmn2r73
|
UTSW |
7 |
85,519,659 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0023:Vmn2r73
|
UTSW |
7 |
85,507,664 (GRCm39) |
missense |
probably benign |
0.31 |
|
Z1176:Vmn2r73
|
UTSW |
7 |
85,521,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r73
|
UTSW |
7 |
85,521,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGTTTCAGGAAGATGCAAAG -3'
(R):5'- GCTAAGATATGTGACTGTGGAAAC -3'
Sequencing Primer
(F):5'- TGTTTCAGGAAGATGCAAAGAACACC -3'
(R):5'- ATGCTATGGAGCTTGCAC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation