Incidental Mutation 'R7174:Or5g9'
ID 558468
Institutional Source Beutler Lab
Gene Symbol Or5g9
Ensembl Gene ENSMUSG00000043226
Gene Name olfactory receptor family 5 subfamily G member 9
Synonyms Olfr1009, MOR175-3, GA_x6K02T2Q125-47195323-47196267
MMRRC Submission 045266-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R7174 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85551751-85552695 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 85552297 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 183 (P183S)
Ref Sequence ENSEMBL: ENSMUSP00000150450 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055517] [ENSMUST00000216443]
AlphaFold Q8VFK1
Predicted Effect possibly damaging
Transcript: ENSMUST00000055517
AA Change: P183S

PolyPhen 2 Score 0.812 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000061475
Gene: ENSMUSG00000043226
AA Change: P183S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.4e-55 PFAM
Pfam:7tm_1 41 290 4.3e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216443
AA Change: P183S

PolyPhen 2 Score 0.812 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 97% (61/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik C A 5: 144,981,627 (GRCm39) A154E probably benign Het
Adamts1 C A 16: 85,596,060 (GRCm39) A419S probably benign Het
Arap2 C G 5: 62,761,621 (GRCm39) V1702L probably benign Het
Arpc1a C T 5: 145,034,087 (GRCm39) P152S probably benign Het
Bbs10 T A 10: 111,136,628 (GRCm39) C580* probably null Het
Bcam A G 7: 19,499,376 (GRCm39) Y216H probably damaging Het
C2cd3 T C 7: 100,081,405 (GRCm39) S1016P Het
Card6 TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG 15: 5,128,173 (GRCm39) probably benign Het
Cd86 CA CAA 16: 36,426,917 (GRCm39) probably null Het
Ceacam5 T A 7: 17,491,839 (GRCm39) probably null Het
Cfap57 A G 4: 118,446,264 (GRCm39) V666A probably benign Het
Cntn3 A G 6: 102,142,305 (GRCm39) F1021L probably benign Het
Cr1l C T 1: 194,811,497 (GRCm39) G119D probably benign Het
Fgf10 A T 13: 118,851,942 (GRCm39) H8L probably benign Het
Fras1 T A 5: 96,903,436 (GRCm39) probably null Het
Frem1 G T 4: 82,840,493 (GRCm39) T1811N probably benign Het
Fsd1 A T 17: 56,298,356 (GRCm39) Q227L probably benign Het
Galk2 A G 2: 125,738,621 (GRCm39) I138M probably damaging Het
Igkv8-30 A G 6: 70,094,582 (GRCm39) V7A possibly damaging Het
Katnb1 G A 8: 95,824,069 (GRCm39) A450T probably benign Het
Kif14 A T 1: 136,448,995 (GRCm39) E1465V possibly damaging Het
Klra3 A T 6: 130,312,941 (GRCm39) probably null Het
Krt9 TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC 11: 100,079,903 (GRCm39) probably benign Het
Lepr A G 4: 101,607,535 (GRCm39) N251S probably benign Het
Lrp2 T C 2: 69,263,416 (GRCm39) M4379V probably benign Het
Lrriq1 T C 10: 103,060,826 (GRCm39) N92S probably benign Het
Map3k13 A G 16: 21,745,006 (GRCm39) N855S probably damaging Het
Marf1 T A 16: 13,954,817 (GRCm39) D900V probably damaging Het
Nckap5l A T 15: 99,321,884 (GRCm39) M1087K probably benign Het
Nlrp9c T C 7: 26,084,722 (GRCm39) N286D probably benign Het
Or12j4 T C 7: 140,047,076 (GRCm39) *321Q probably null Het
Or13c7d C T 4: 43,770,691 (GRCm39) A107T not run Het
Or4k2 T C 14: 50,424,153 (GRCm39) I175V probably benign Het
Or51ah3 A T 7: 103,210,598 (GRCm39) R305* probably null Het
Or5p72 T A 7: 108,022,367 (GRCm39) S196R probably benign Het
Pcdhga3 A G 18: 37,808,980 (GRCm39) T478A probably benign Het
Pdgfrb T C 18: 61,199,587 (GRCm39) I385T probably benign Het
Poteg C T 8: 27,943,305 (GRCm39) R192W probably benign Het
Prmt2 G T 10: 76,061,173 (GRCm39) D104E probably benign Het
Rgl2 T C 17: 34,153,964 (GRCm39) F457L possibly damaging Het
Rlbp1 T C 7: 79,027,090 (GRCm39) N190S possibly damaging Het
Ryr2 T C 13: 11,816,063 (GRCm39) D641G possibly damaging Het
Sh3gl1 A T 17: 56,324,846 (GRCm39) M303K probably benign Het
Slc26a5 A G 5: 22,018,892 (GRCm39) V649A probably damaging Het
Slco4c1 T C 1: 96,765,323 (GRCm39) N376D possibly damaging Het
Socs3 A T 11: 117,858,553 (GRCm39) Y168* probably null Het
Spata31d1d A T 13: 59,876,394 (GRCm39) N380K possibly damaging Het
Speer1c T C 5: 10,295,237 (GRCm39) K56E probably damaging Het
Ssbp3 A G 4: 106,894,843 (GRCm39) N254S probably benign Het
Stard10 C T 7: 100,995,226 (GRCm39) S326L probably damaging Het
Taf2 T C 15: 54,912,135 (GRCm39) D524G possibly damaging Het
Taf7 A T 18: 37,776,053 (GRCm39) S171R probably damaging Het
Tchh C T 3: 93,353,478 (GRCm39) R973C unknown Het
Tmem67 T C 4: 12,077,337 (GRCm39) R172G possibly damaging Het
Top2a C A 11: 98,914,922 (GRCm39) probably benign Het
Ttc8 T A 12: 98,940,960 (GRCm39) N323K possibly damaging Het
Txnl1 T C 18: 63,804,667 (GRCm39) N276D probably benign Het
Usp24 T G 4: 106,219,878 (GRCm39) probably null Het
Vmn1r18 A C 6: 57,366,609 (GRCm39) probably null Het
Vmn2r53 A T 7: 12,315,628 (GRCm39) H730Q probably benign Het
Wnk1 A C 6: 119,947,939 (GRCm39) I500M probably damaging Het
Zfp335 A T 2: 164,744,423 (GRCm39) Y451N probably damaging Het
Zfp683 T A 4: 133,783,064 (GRCm39) I176N probably damaging Het
Other mutations in Or5g9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00920:Or5g9 APN 2 85,552,583 (GRCm39) missense probably damaging 1.00
IGL01862:Or5g9 APN 2 85,552,472 (GRCm39) missense probably damaging 0.99
IGL02868:Or5g9 APN 2 85,551,919 (GRCm39) missense probably benign 0.19
IGL02904:Or5g9 APN 2 85,552,099 (GRCm39) missense probably damaging 0.99
IGL03240:Or5g9 APN 2 85,552,675 (GRCm39) nonsense probably null
IGL03347:Or5g9 APN 2 85,552,151 (GRCm39) missense probably benign 0.01
R1148:Or5g9 UTSW 2 85,552,620 (GRCm39) nonsense probably null
R1148:Or5g9 UTSW 2 85,552,620 (GRCm39) nonsense probably null
R1446:Or5g9 UTSW 2 85,551,917 (GRCm39) missense probably damaging 0.99
R3782:Or5g9 UTSW 2 85,552,040 (GRCm39) missense probably damaging 1.00
R4343:Or5g9 UTSW 2 85,552,592 (GRCm39) missense probably damaging 1.00
R4836:Or5g9 UTSW 2 85,551,793 (GRCm39) missense probably benign
R4845:Or5g9 UTSW 2 85,551,836 (GRCm39) nonsense probably null
R5490:Or5g9 UTSW 2 85,552,666 (GRCm39) missense probably benign 0.01
R5534:Or5g9 UTSW 2 85,552,331 (GRCm39) missense probably benign 0.35
R5679:Or5g9 UTSW 2 85,552,390 (GRCm39) missense probably damaging 1.00
R6476:Or5g9 UTSW 2 85,551,928 (GRCm39) missense probably damaging 1.00
R6701:Or5g9 UTSW 2 85,552,675 (GRCm39) missense probably benign 0.28
R7024:Or5g9 UTSW 2 85,551,952 (GRCm39) missense probably damaging 1.00
R7140:Or5g9 UTSW 2 85,551,818 (GRCm39) missense probably damaging 0.97
R8079:Or5g9 UTSW 2 85,552,387 (GRCm39) missense probably benign 0.07
R8082:Or5g9 UTSW 2 85,551,824 (GRCm39) missense probably benign 0.01
R8213:Or5g9 UTSW 2 85,551,845 (GRCm39) missense probably null 1.00
R9103:Or5g9 UTSW 2 85,552,527 (GRCm39) nonsense probably null
R9387:Or5g9 UTSW 2 85,551,806 (GRCm39) missense probably benign 0.00
R9508:Or5g9 UTSW 2 85,552,165 (GRCm39) missense possibly damaging 0.82
R9679:Or5g9 UTSW 2 85,552,482 (GRCm39) missense probably damaging 0.99
R9776:Or5g9 UTSW 2 85,552,145 (GRCm39) missense probably damaging 1.00
X0020:Or5g9 UTSW 2 85,552,322 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGCCATTGAGTGTCTTCTC -3'
(R):5'- CAGGTAGAGAAGGCTTTCCTCC -3'

Sequencing Primer
(F):5'- GGCCTATGACAGATATGTAGCCATC -3'
(R):5'- CTACCTTCAGCTGAGCGGATTC -3'
Posted On 2019-06-26