Incidental Mutation 'R0589:Tex44'
ID 55854
Institutional Source Beutler Lab
Gene Symbol Tex44
Ensembl Gene ENSMUSG00000036574
Gene Name testis expressed 44
Synonyms 1700019O17Rik
MMRRC Submission 038779-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0589 (G1)
Quality Score 177
Status Validated
Chromosome 1
Chromosomal Location 86354051-86355771 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86355453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 454 (D454G)
Ref Sequence ENSEMBL: ENSMUSP00000136430 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046004] [ENSMUST00000212541]
AlphaFold Q9DA60
Predicted Effect probably damaging
Transcript: ENSMUST00000046004
AA Change: D454G

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000136430
Gene: ENSMUSG00000036574
AA Change: D454G

DomainStartEndE-ValueType
internal_repeat_1 60 129 5.56e-9 PROSPERO
Pfam:DUF4678 147 529 4.3e-99 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212541
Meta Mutation Damage Score 0.2855 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.1%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b G T 11: 109,833,094 (GRCm39) A1202E probably damaging Het
Abcc12 A T 8: 87,287,101 (GRCm39) I155N possibly damaging Het
Atf4 T A 15: 80,140,640 (GRCm39) H47Q probably damaging Het
Atm T A 9: 53,401,492 (GRCm39) D1459V possibly damaging Het
Bicral A G 17: 47,112,522 (GRCm39) S893P probably benign Het
Camk2a G A 18: 61,097,036 (GRCm39) probably null Het
Cebpz G A 17: 79,244,308 (GRCm39) T51I probably damaging Het
Cers5 A T 15: 99,638,837 (GRCm39) D208E probably damaging Het
Cimip2b T C 4: 43,427,355 (GRCm39) probably benign Het
Cyp1a2 T C 9: 57,586,345 (GRCm39) D391G possibly damaging Het
Dct G T 14: 118,280,682 (GRCm39) F111L probably benign Het
Ddb1 T G 19: 10,599,080 (GRCm39) I529S probably benign Het
Dhx9 G T 1: 153,348,037 (GRCm39) Q361K probably damaging Het
Dnai3 A G 3: 145,768,086 (GRCm39) S592P probably benign Het
Erbin G T 13: 104,022,795 (GRCm39) R15S probably damaging Het
F13b T C 1: 139,434,671 (GRCm39) S146P possibly damaging Het
Ggnbp2 A T 11: 84,727,277 (GRCm39) C520S probably damaging Het
Gpx3 A G 11: 54,800,329 (GRCm39) I208V probably benign Het
Grk3 A G 5: 113,076,629 (GRCm39) probably benign Het
Heatr9 T C 11: 83,405,516 (GRCm39) probably benign Het
Heg1 T G 16: 33,552,077 (GRCm39) I762R probably damaging Het
Ints11 A T 4: 155,971,343 (GRCm39) T264S probably damaging Het
Ints14 T C 9: 64,887,113 (GRCm39) L348P probably damaging Het
Maco1 C A 4: 134,555,528 (GRCm39) C315F probably benign Het
Marf1 C A 16: 13,959,919 (GRCm39) probably benign Het
Med13 A G 11: 86,174,075 (GRCm39) Y1808H probably damaging Het
Mef2a G T 7: 66,884,896 (GRCm39) S406* probably null Het
Mrpl45 A T 11: 97,214,714 (GRCm39) T134S probably benign Het
Myh8 A G 11: 67,189,453 (GRCm39) I1210V probably benign Het
Nsd3 T C 8: 26,131,303 (GRCm39) S223P probably damaging Het
Or2j6 T G 7: 139,980,813 (GRCm39) S49R possibly damaging Het
Or4c115 A G 2: 88,927,606 (GRCm39) F222L probably benign Het
Or5be3 A T 2: 86,864,459 (GRCm39) Y35* probably null Het
P3h3 T A 6: 124,818,644 (GRCm39) E731D probably damaging Het
Pcdhac2 A G 18: 37,279,527 (GRCm39) R836G probably benign Het
Pdzd2 A G 15: 12,376,385 (GRCm39) V1250A probably benign Het
Pgbd1 G A 13: 21,618,600 (GRCm39) T19I possibly damaging Het
Phtf2 T A 5: 21,018,249 (GRCm39) R31* probably null Het
Plod2 T A 9: 92,475,799 (GRCm39) V294D probably benign Het
Rassf5 C T 1: 131,172,720 (GRCm39) G50R probably damaging Het
Rexo5 A G 7: 119,444,606 (GRCm39) T694A probably benign Het
Rtcb A C 10: 85,787,315 (GRCm39) S82A probably damaging Het
Rufy4 T C 1: 74,172,042 (GRCm39) L255P probably damaging Het
Slc35c1 A G 2: 92,284,859 (GRCm39) F252L probably damaging Het
Slco6d1 A T 1: 98,427,472 (GRCm39) probably benign Het
Sox10 T G 15: 79,047,485 (GRCm39) probably benign Het
Stard9 A G 2: 120,529,028 (GRCm39) M1762V probably benign Het
Stat3 A T 11: 100,798,909 (GRCm39) Y94N probably damaging Het
Tasor T C 14: 27,183,107 (GRCm39) I522T probably benign Het
Tecta T A 9: 42,256,930 (GRCm39) Y1582F probably benign Het
Tle6 A G 10: 81,431,253 (GRCm39) probably benign Het
Tmod2 T C 9: 75,484,041 (GRCm39) E303G probably damaging Het
Trem1 A G 17: 48,544,245 (GRCm39) D90G possibly damaging Het
Trhde A T 10: 114,284,229 (GRCm39) D751E probably benign Het
Ttn A T 2: 76,795,589 (GRCm39) probably null Het
Vars2 T C 17: 35,970,068 (GRCm39) T774A probably benign Het
Other mutations in Tex44
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02579:Tex44 APN 1 86,354,169 (GRCm39) missense probably benign 0.00
IGL02683:Tex44 APN 1 86,355,465 (GRCm39) missense probably benign 0.01
R1077:Tex44 UTSW 1 86,354,777 (GRCm39) missense probably benign 0.00
R1468:Tex44 UTSW 1 86,354,834 (GRCm39) missense probably benign 0.16
R1468:Tex44 UTSW 1 86,354,834 (GRCm39) missense probably benign 0.16
R1483:Tex44 UTSW 1 86,354,908 (GRCm39) missense probably damaging 0.99
R1485:Tex44 UTSW 1 86,355,640 (GRCm39) missense possibly damaging 0.72
R1527:Tex44 UTSW 1 86,355,368 (GRCm39) missense probably benign 0.01
R2058:Tex44 UTSW 1 86,354,728 (GRCm39) missense probably damaging 1.00
R2126:Tex44 UTSW 1 86,354,811 (GRCm39) missense probably benign 0.04
R4394:Tex44 UTSW 1 86,355,489 (GRCm39) missense probably benign 0.16
R4524:Tex44 UTSW 1 86,355,298 (GRCm39) missense probably benign 0.03
R6191:Tex44 UTSW 1 86,354,306 (GRCm39) unclassified probably benign
R6658:Tex44 UTSW 1 86,354,751 (GRCm39) missense probably benign 0.01
R6731:Tex44 UTSW 1 86,354,207 (GRCm39) missense probably benign 0.04
R7526:Tex44 UTSW 1 86,354,237 (GRCm39) missense probably benign 0.33
R7625:Tex44 UTSW 1 86,354,459 (GRCm39) nonsense probably null
R8251:Tex44 UTSW 1 86,354,936 (GRCm39) missense probably benign 0.05
R8446:Tex44 UTSW 1 86,354,696 (GRCm39) missense possibly damaging 0.92
R9369:Tex44 UTSW 1 86,355,383 (GRCm39) missense probably damaging 1.00
R9625:Tex44 UTSW 1 86,354,253 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACGACTACATGCGCTCCATGAC -3'
(R):5'- AGCAACAGGCAGGTACATGTCCTC -3'

Sequencing Primer
(F):5'- GCTCCATGACCAGCCTG -3'
(R):5'- TGTCCCACTGCATGGATAAG -3'
Posted On 2013-07-11