Incidental Mutation 'R0589:Olfr1105'
ID55859
Institutional Source Beutler Lab
Gene Symbol Olfr1105
Ensembl Gene ENSMUSG00000075165
Gene Nameolfactory receptor 1105
SynonymsMOR172-7, MOR0-6P, GA_x6K02T2Q125-48521031-48520093
MMRRC Submission 038779-MU
Accession Numbers

Genbank: NM_001011825; MGI: 3030939

Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #R0589 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location87031260-87036531 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 87034115 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 35 (Y35*)
Ref Sequence ENSEMBL: ENSMUSP00000149148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099868] [ENSMUST00000215978]
Predicted Effect probably null
Transcript: ENSMUST00000099868
AA Change: Y35*
SMART Domains Protein: ENSMUSP00000097453
Gene: ENSMUSG00000075165
AA Change: Y35*

DomainStartEndE-ValueType
Pfam:7tm_4 30 308 5.2e-47 PFAM
Pfam:7TM_GPCR_Srsx 35 305 5.5e-6 PFAM
Pfam:7tm_1 41 308 5.2e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215978
AA Change: Y35*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.1%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b G T 11: 109,942,268 A1202E probably damaging Het
Abcc12 A T 8: 86,560,472 I155N possibly damaging Het
Atf4 T A 15: 80,256,439 H47Q probably damaging Het
Atm T A 9: 53,490,192 D1459V possibly damaging Het
Bicral A G 17: 46,801,596 S893P probably benign Het
Camk2a G A 18: 60,963,964 probably null Het
Cebpz G A 17: 78,936,879 T51I probably damaging Het
Cers5 A T 15: 99,740,956 D208E probably damaging Het
Cyp1a2 T C 9: 57,679,062 D391G possibly damaging Het
Dct G T 14: 118,043,270 F111L probably benign Het
Ddb1 T G 19: 10,621,716 I529S probably benign Het
Dhx9 G T 1: 153,472,291 Q361K probably damaging Het
Erbin G T 13: 103,886,287 R15S probably damaging Het
F13b T C 1: 139,506,933 S146P possibly damaging Het
Fam166b T C 4: 43,427,355 probably benign Het
Fam208a T C 14: 27,461,150 I522T probably benign Het
Ggnbp2 A T 11: 84,836,451 C520S probably damaging Het
Gpx3 A G 11: 54,909,503 I208V probably benign Het
Grk3 A G 5: 112,928,763 probably benign Het
Heatr9 T C 11: 83,514,690 probably benign Het
Heg1 T G 16: 33,731,707 I762R probably damaging Het
Ints11 A T 4: 155,886,886 T264S probably damaging Het
Ints14 T C 9: 64,979,831 L348P probably damaging Het
Marf1 C A 16: 14,142,055 probably benign Het
Med13 A G 11: 86,283,249 Y1808H probably damaging Het
Mef2a G T 7: 67,235,148 S406* probably null Het
Mrpl45 A T 11: 97,323,888 T134S probably benign Het
Myh8 A G 11: 67,298,627 I1210V probably benign Het
Nsd3 T C 8: 25,641,287 S223P probably damaging Het
Olfr1220 A G 2: 89,097,262 F222L probably benign Het
Olfr531 T G 7: 140,400,900 S49R possibly damaging Het
P3h3 T A 6: 124,841,681 E731D probably damaging Het
Pcdhac2 A G 18: 37,146,474 R836G probably benign Het
Pdzd2 A G 15: 12,376,299 V1250A probably benign Het
Pgbd1 G A 13: 21,434,430 T19I possibly damaging Het
Phtf2 T A 5: 20,813,251 R31* probably null Het
Plod2 T A 9: 92,593,746 V294D probably benign Het
Rassf5 C T 1: 131,244,983 G50R probably damaging Het
Rexo5 A G 7: 119,845,383 T694A probably benign Het
Rtcb A C 10: 85,951,451 S82A probably damaging Het
Rufy4 T C 1: 74,132,883 L255P probably damaging Het
Slc35c1 A G 2: 92,454,514 F252L probably damaging Het
Slco6d1 A T 1: 98,499,747 probably benign Het
Sox10 T G 15: 79,163,285 probably benign Het
Stard9 A G 2: 120,698,547 M1762V probably benign Het
Stat3 A T 11: 100,908,083 Y94N probably damaging Het
Tecta T A 9: 42,345,634 Y1582F probably benign Het
Tex44 A G 1: 86,427,731 D454G probably damaging Het
Tle6 A G 10: 81,595,419 probably benign Het
Tmem57 C A 4: 134,828,217 C315F probably benign Het
Tmod2 T C 9: 75,576,759 E303G probably damaging Het
Trem1 A G 17: 48,237,217 D90G possibly damaging Het
Trhde A T 10: 114,448,324 D751E probably benign Het
Ttn A T 2: 76,965,245 probably null Het
Vars2 T C 17: 35,659,176 T774A probably benign Het
Wdr63 A G 3: 146,062,331 S592P probably benign Het
Other mutations in Olfr1105
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01673:Olfr1105 APN 2 87033387 missense probably damaging 1.00
IGL02029:Olfr1105 APN 2 87033901 missense probably benign 0.00
IGL02332:Olfr1105 APN 2 87034212 missense probably benign 0.32
3-1:Olfr1105 UTSW 2 87033684 missense probably damaging 1.00
R0060:Olfr1105 UTSW 2 87033774 missense probably damaging 1.00
R0060:Olfr1105 UTSW 2 87033774 missense probably damaging 1.00
R0100:Olfr1105 UTSW 2 87033595 missense probably benign 0.01
R0100:Olfr1105 UTSW 2 87033595 missense probably benign 0.01
R0417:Olfr1105 UTSW 2 87033445 missense probably damaging 0.99
R0573:Olfr1105 UTSW 2 87033468 missense probably damaging 1.00
R0630:Olfr1105 UTSW 2 87033309 missense probably benign 0.05
R0690:Olfr1105 UTSW 2 87033882 missense probably damaging 1.00
R3929:Olfr1105 UTSW 2 87034084 missense possibly damaging 0.88
R4563:Olfr1105 UTSW 2 87033684 missense probably damaging 1.00
R4718:Olfr1105 UTSW 2 87033895 missense probably damaging 0.99
R6362:Olfr1105 UTSW 2 87033289 missense probably benign 0.11
RF011:Olfr1105 UTSW 2 87034041 missense probably damaging 0.96
Z1176:Olfr1105 UTSW 2 87033487 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGGTACGAGATGCTGTTTTGTCCTAC -3'
(R):5'- ACCCCTCCGAAATTGGTAAATGTCAAG -3'

Sequencing Primer
(F):5'- ACTAAGTAGTTTATCAGCATTTTGGG -3'
(R):5'- GGAGTCACATCAATGGCTGA -3'
Posted On2013-07-11