Incidental Mutation 'R0589:Dnai3'
ID 55863
Institutional Source Beutler Lab
Gene Symbol Dnai3
Ensembl Gene ENSMUSG00000043020
Gene Name dynein axonemal intermediate chain 3
Synonyms 4931433A13Rik, Wdr63, Ida7, IC140
MMRRC Submission 038779-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R0589 (G1)
Quality Score 186
Status Validated
Chromosome 3
Chromosomal Location 145746281-145813855 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 145768086 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 592 (S592P)
Ref Sequence ENSEMBL: ENSMUSP00000124475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160285]
AlphaFold B2RY71
Predicted Effect probably benign
Transcript: ENSMUST00000160285
AA Change: S592P

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000124475
Gene: ENSMUSG00000043020
AA Change: S592P

DomainStartEndE-ValueType
low complexity region 3 22 N/A INTRINSIC
low complexity region 26 35 N/A INTRINSIC
low complexity region 133 150 N/A INTRINSIC
low complexity region 165 180 N/A INTRINSIC
Blast:WD40 321 367 6e-19 BLAST
low complexity region 375 383 N/A INTRINSIC
WD40 390 429 6.34e-2 SMART
WD40 470 527 1.15e-4 SMART
low complexity region 536 553 N/A INTRINSIC
WD40 693 732 1.07e1 SMART
WD40 737 776 1.1e2 SMART
coiled coil region 867 902 N/A INTRINSIC
Meta Mutation Damage Score 0.0675 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.1%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b G T 11: 109,833,094 (GRCm39) A1202E probably damaging Het
Abcc12 A T 8: 87,287,101 (GRCm39) I155N possibly damaging Het
Atf4 T A 15: 80,140,640 (GRCm39) H47Q probably damaging Het
Atm T A 9: 53,401,492 (GRCm39) D1459V possibly damaging Het
Bicral A G 17: 47,112,522 (GRCm39) S893P probably benign Het
Camk2a G A 18: 61,097,036 (GRCm39) probably null Het
Cebpz G A 17: 79,244,308 (GRCm39) T51I probably damaging Het
Cers5 A T 15: 99,638,837 (GRCm39) D208E probably damaging Het
Cimip2b T C 4: 43,427,355 (GRCm39) probably benign Het
Cyp1a2 T C 9: 57,586,345 (GRCm39) D391G possibly damaging Het
Dct G T 14: 118,280,682 (GRCm39) F111L probably benign Het
Ddb1 T G 19: 10,599,080 (GRCm39) I529S probably benign Het
Dhx9 G T 1: 153,348,037 (GRCm39) Q361K probably damaging Het
Erbin G T 13: 104,022,795 (GRCm39) R15S probably damaging Het
F13b T C 1: 139,434,671 (GRCm39) S146P possibly damaging Het
Ggnbp2 A T 11: 84,727,277 (GRCm39) C520S probably damaging Het
Gpx3 A G 11: 54,800,329 (GRCm39) I208V probably benign Het
Grk3 A G 5: 113,076,629 (GRCm39) probably benign Het
Heatr9 T C 11: 83,405,516 (GRCm39) probably benign Het
Heg1 T G 16: 33,552,077 (GRCm39) I762R probably damaging Het
Ints11 A T 4: 155,971,343 (GRCm39) T264S probably damaging Het
Ints14 T C 9: 64,887,113 (GRCm39) L348P probably damaging Het
Maco1 C A 4: 134,555,528 (GRCm39) C315F probably benign Het
Marf1 C A 16: 13,959,919 (GRCm39) probably benign Het
Med13 A G 11: 86,174,075 (GRCm39) Y1808H probably damaging Het
Mef2a G T 7: 66,884,896 (GRCm39) S406* probably null Het
Mrpl45 A T 11: 97,214,714 (GRCm39) T134S probably benign Het
Myh8 A G 11: 67,189,453 (GRCm39) I1210V probably benign Het
Nsd3 T C 8: 26,131,303 (GRCm39) S223P probably damaging Het
Or2j6 T G 7: 139,980,813 (GRCm39) S49R possibly damaging Het
Or4c115 A G 2: 88,927,606 (GRCm39) F222L probably benign Het
Or5be3 A T 2: 86,864,459 (GRCm39) Y35* probably null Het
P3h3 T A 6: 124,818,644 (GRCm39) E731D probably damaging Het
Pcdhac2 A G 18: 37,279,527 (GRCm39) R836G probably benign Het
Pdzd2 A G 15: 12,376,385 (GRCm39) V1250A probably benign Het
Pgbd1 G A 13: 21,618,600 (GRCm39) T19I possibly damaging Het
Phtf2 T A 5: 21,018,249 (GRCm39) R31* probably null Het
Plod2 T A 9: 92,475,799 (GRCm39) V294D probably benign Het
Rassf5 C T 1: 131,172,720 (GRCm39) G50R probably damaging Het
Rexo5 A G 7: 119,444,606 (GRCm39) T694A probably benign Het
Rtcb A C 10: 85,787,315 (GRCm39) S82A probably damaging Het
Rufy4 T C 1: 74,172,042 (GRCm39) L255P probably damaging Het
Slc35c1 A G 2: 92,284,859 (GRCm39) F252L probably damaging Het
Slco6d1 A T 1: 98,427,472 (GRCm39) probably benign Het
Sox10 T G 15: 79,047,485 (GRCm39) probably benign Het
Stard9 A G 2: 120,529,028 (GRCm39) M1762V probably benign Het
Stat3 A T 11: 100,798,909 (GRCm39) Y94N probably damaging Het
Tasor T C 14: 27,183,107 (GRCm39) I522T probably benign Het
Tecta T A 9: 42,256,930 (GRCm39) Y1582F probably benign Het
Tex44 A G 1: 86,355,453 (GRCm39) D454G probably damaging Het
Tle6 A G 10: 81,431,253 (GRCm39) probably benign Het
Tmod2 T C 9: 75,484,041 (GRCm39) E303G probably damaging Het
Trem1 A G 17: 48,544,245 (GRCm39) D90G possibly damaging Het
Trhde A T 10: 114,284,229 (GRCm39) D751E probably benign Het
Ttn A T 2: 76,795,589 (GRCm39) probably null Het
Vars2 T C 17: 35,970,068 (GRCm39) T774A probably benign Het
Other mutations in Dnai3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Dnai3 APN 3 145,788,759 (GRCm39) missense probably benign
IGL00565:Dnai3 APN 3 145,750,674 (GRCm39) splice site probably benign
IGL01339:Dnai3 APN 3 145,748,591 (GRCm39) missense probably benign 0.14
IGL01952:Dnai3 APN 3 145,802,918 (GRCm39) missense probably damaging 0.96
IGL02663:Dnai3 APN 3 145,760,312 (GRCm39) missense possibly damaging 0.53
IGL02710:Dnai3 APN 3 145,753,903 (GRCm39) missense possibly damaging 0.96
P0041:Dnai3 UTSW 3 145,786,997 (GRCm39) missense possibly damaging 0.96
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0498:Dnai3 UTSW 3 145,787,119 (GRCm39) missense possibly damaging 0.54
R1484:Dnai3 UTSW 3 145,802,996 (GRCm39) missense probably benign 0.02
R1537:Dnai3 UTSW 3 145,748,504 (GRCm39) missense probably damaging 0.98
R1611:Dnai3 UTSW 3 145,801,113 (GRCm39) missense probably damaging 1.00
R1743:Dnai3 UTSW 3 145,803,017 (GRCm39) missense possibly damaging 0.81
R1861:Dnai3 UTSW 3 145,788,801 (GRCm39) missense probably damaging 1.00
R1991:Dnai3 UTSW 3 145,769,235 (GRCm39) missense possibly damaging 0.82
R2185:Dnai3 UTSW 3 145,772,619 (GRCm39) missense possibly damaging 0.76
R4299:Dnai3 UTSW 3 145,774,561 (GRCm39) missense probably damaging 1.00
R4620:Dnai3 UTSW 3 145,748,564 (GRCm39) missense probably damaging 1.00
R4649:Dnai3 UTSW 3 145,753,922 (GRCm39) missense probably damaging 1.00
R4914:Dnai3 UTSW 3 145,772,582 (GRCm39) missense probably damaging 0.98
R4948:Dnai3 UTSW 3 145,788,820 (GRCm39) nonsense probably null
R5578:Dnai3 UTSW 3 145,802,983 (GRCm39) nonsense probably null
R6130:Dnai3 UTSW 3 145,748,559 (GRCm39) missense probably benign 0.25
R6162:Dnai3 UTSW 3 145,750,617 (GRCm39) missense probably damaging 1.00
R6291:Dnai3 UTSW 3 145,772,648 (GRCm39) missense probably benign 0.00
R6390:Dnai3 UTSW 3 145,801,143 (GRCm39) missense probably damaging 1.00
R6560:Dnai3 UTSW 3 145,801,161 (GRCm39) missense possibly damaging 0.79
R6893:Dnai3 UTSW 3 145,786,184 (GRCm39) missense probably damaging 1.00
R7090:Dnai3 UTSW 3 145,746,582 (GRCm39) missense possibly damaging 0.80
R7102:Dnai3 UTSW 3 145,761,459 (GRCm39) missense possibly damaging 0.49
R7111:Dnai3 UTSW 3 145,803,028 (GRCm39) missense probably damaging 0.99
R7260:Dnai3 UTSW 3 145,752,295 (GRCm39) missense probably benign 0.01
R7288:Dnai3 UTSW 3 145,787,007 (GRCm39) missense probably damaging 0.97
R7411:Dnai3 UTSW 3 145,802,900 (GRCm39) missense probably damaging 0.98
R7417:Dnai3 UTSW 3 145,798,835 (GRCm39) splice site probably null
R7466:Dnai3 UTSW 3 145,761,373 (GRCm39) missense probably benign 0.01
R7860:Dnai3 UTSW 3 145,772,675 (GRCm39) missense probably damaging 0.99
R7964:Dnai3 UTSW 3 145,774,531 (GRCm39) missense probably benign 0.09
R8013:Dnai3 UTSW 3 145,787,040 (GRCm39) missense probably damaging 1.00
R8059:Dnai3 UTSW 3 145,752,428 (GRCm39) missense possibly damaging 0.75
R8191:Dnai3 UTSW 3 145,800,066 (GRCm39) missense probably damaging 1.00
R8354:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8454:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8770:Dnai3 UTSW 3 145,752,298 (GRCm39) missense probably benign 0.01
R8967:Dnai3 UTSW 3 145,761,395 (GRCm39) missense possibly damaging 0.95
R9135:Dnai3 UTSW 3 145,772,589 (GRCm39) missense probably benign 0.39
R9310:Dnai3 UTSW 3 145,802,895 (GRCm39) critical splice donor site probably null
R9664:Dnai3 UTSW 3 145,748,594 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GCACAAGCTGCCTCTCTCGTAAAG -3'
(R):5'- GCCATCCAGTTAAAAGCAAGGTCCC -3'

Sequencing Primer
(F):5'- GCGTGCTCTTACGAATCAG -3'
(R):5'- GGGGTAGTGATACAAGGTGAGTTTC -3'
Posted On 2013-07-11