Incidental Mutation 'R0589:Rexo5'
ID55871
Institutional Source Beutler Lab
Gene Symbol Rexo5
Ensembl Gene ENSMUSG00000030924
Gene NameRNA exonuclease 5
Synonyms2610020H08Rik
MMRRC Submission 038779-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.145) question?
Stock #R0589 (G1)
Quality Score168
Status Validated
Chromosome7
Chromosomal Location119794006-119848943 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 119845383 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 694 (T694A)
Ref Sequence ENSEMBL: ENSMUSP00000102130 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033218] [ENSMUST00000084644] [ENSMUST00000106520] [ENSMUST00000133758]
Predicted Effect probably benign
Transcript: ENSMUST00000033218
SMART Domains Protein: ENSMUSP00000033218
Gene: ENSMUSG00000030924

DomainStartEndE-ValueType
low complexity region 105 116 N/A INTRINSIC
low complexity region 123 134 N/A INTRINSIC
Pfam:RNase_T 225 330 1.4e-12 PFAM
Blast:RRM 424 463 5e-17 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000084644
SMART Domains Protein: ENSMUSP00000081694
Gene: ENSMUSG00000030924

DomainStartEndE-ValueType
EXOIII 31 189 2.72e-29 SMART
RRM 298 367 3.23e-9 SMART
Blast:RRM 393 437 2e-22 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000106520
AA Change: T694A

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000102130
Gene: ENSMUSG00000030924
AA Change: T694A

DomainStartEndE-ValueType
low complexity region 105 116 N/A INTRINSIC
low complexity region 123 134 N/A INTRINSIC
EXOIII 223 381 2.72e-29 SMART
RRM 491 560 3.23e-9 SMART
RRM 586 661 3.28e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000133758
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138689
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151248
Predicted Effect probably benign
Transcript: ENSMUST00000207042
Predicted Effect unknown
Transcript: ENSMUST00000208789
AA Change: N67S
Meta Mutation Damage Score 0.0601 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.1%
Validation Efficiency 98% (62/63)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b G T 11: 109,942,268 A1202E probably damaging Het
Abcc12 A T 8: 86,560,472 I155N possibly damaging Het
Atf4 T A 15: 80,256,439 H47Q probably damaging Het
Atm T A 9: 53,490,192 D1459V possibly damaging Het
Bicral A G 17: 46,801,596 S893P probably benign Het
Camk2a G A 18: 60,963,964 probably null Het
Cebpz G A 17: 78,936,879 T51I probably damaging Het
Cers5 A T 15: 99,740,956 D208E probably damaging Het
Cyp1a2 T C 9: 57,679,062 D391G possibly damaging Het
Dct G T 14: 118,043,270 F111L probably benign Het
Ddb1 T G 19: 10,621,716 I529S probably benign Het
Dhx9 G T 1: 153,472,291 Q361K probably damaging Het
Erbin G T 13: 103,886,287 R15S probably damaging Het
F13b T C 1: 139,506,933 S146P possibly damaging Het
Fam166b T C 4: 43,427,355 probably benign Het
Fam208a T C 14: 27,461,150 I522T probably benign Het
Ggnbp2 A T 11: 84,836,451 C520S probably damaging Het
Gpx3 A G 11: 54,909,503 I208V probably benign Het
Grk3 A G 5: 112,928,763 probably benign Het
Heatr9 T C 11: 83,514,690 probably benign Het
Heg1 T G 16: 33,731,707 I762R probably damaging Het
Ints11 A T 4: 155,886,886 T264S probably damaging Het
Ints14 T C 9: 64,979,831 L348P probably damaging Het
Marf1 C A 16: 14,142,055 probably benign Het
Med13 A G 11: 86,283,249 Y1808H probably damaging Het
Mef2a G T 7: 67,235,148 S406* probably null Het
Mrpl45 A T 11: 97,323,888 T134S probably benign Het
Myh8 A G 11: 67,298,627 I1210V probably benign Het
Nsd3 T C 8: 25,641,287 S223P probably damaging Het
Olfr1105 A T 2: 87,034,115 Y35* probably null Het
Olfr1220 A G 2: 89,097,262 F222L probably benign Het
Olfr531 T G 7: 140,400,900 S49R possibly damaging Het
P3h3 T A 6: 124,841,681 E731D probably damaging Het
Pcdhac2 A G 18: 37,146,474 R836G probably benign Het
Pdzd2 A G 15: 12,376,299 V1250A probably benign Het
Pgbd1 G A 13: 21,434,430 T19I possibly damaging Het
Phtf2 T A 5: 20,813,251 R31* probably null Het
Plod2 T A 9: 92,593,746 V294D probably benign Het
Rassf5 C T 1: 131,244,983 G50R probably damaging Het
Rtcb A C 10: 85,951,451 S82A probably damaging Het
Rufy4 T C 1: 74,132,883 L255P probably damaging Het
Slc35c1 A G 2: 92,454,514 F252L probably damaging Het
Slco6d1 A T 1: 98,499,747 probably benign Het
Sox10 T G 15: 79,163,285 probably benign Het
Stard9 A G 2: 120,698,547 M1762V probably benign Het
Stat3 A T 11: 100,908,083 Y94N probably damaging Het
Tecta T A 9: 42,345,634 Y1582F probably benign Het
Tex44 A G 1: 86,427,731 D454G probably damaging Het
Tle6 A G 10: 81,595,419 probably benign Het
Tmem57 C A 4: 134,828,217 C315F probably benign Het
Tmod2 T C 9: 75,576,759 E303G probably damaging Het
Trem1 A G 17: 48,237,217 D90G possibly damaging Het
Trhde A T 10: 114,448,324 D751E probably benign Het
Ttn A T 2: 76,965,245 probably null Het
Vars2 T C 17: 35,659,176 T774A probably benign Het
Wdr63 A G 3: 146,062,331 S592P probably benign Het
Other mutations in Rexo5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01308:Rexo5 APN 7 119834276 missense probably damaging 1.00
R0347:Rexo5 UTSW 7 119823896 critical splice donor site probably null
R0442:Rexo5 UTSW 7 119843285 missense probably damaging 1.00
R0980:Rexo5 UTSW 7 119823812 missense probably damaging 1.00
R1465:Rexo5 UTSW 7 119801358 critical splice donor site probably null
R1465:Rexo5 UTSW 7 119801358 critical splice donor site probably null
R1505:Rexo5 UTSW 7 119799603 nonsense probably null
R1775:Rexo5 UTSW 7 119845411 missense probably benign 0.00
R1911:Rexo5 UTSW 7 119799644 missense probably damaging 1.00
R1996:Rexo5 UTSW 7 119823857 missense probably damaging 1.00
R4168:Rexo5 UTSW 7 119827398 intron probably benign
R4169:Rexo5 UTSW 7 119827398 intron probably benign
R4402:Rexo5 UTSW 7 119834376 missense possibly damaging 0.82
R4486:Rexo5 UTSW 7 119825577 missense probably benign 0.00
R4620:Rexo5 UTSW 7 119827303 missense probably benign 0.37
R4621:Rexo5 UTSW 7 119819499 missense probably benign 0.19
R4865:Rexo5 UTSW 7 119801330 nonsense probably null
R4884:Rexo5 UTSW 7 119825551 nonsense probably null
R5171:Rexo5 UTSW 7 119823779 missense probably damaging 1.00
R5209:Rexo5 UTSW 7 119834299 nonsense probably null
R5266:Rexo5 UTSW 7 119844437 missense probably benign 0.00
R5463:Rexo5 UTSW 7 119834303 missense probably damaging 1.00
R5579:Rexo5 UTSW 7 119834403 critical splice donor site probably null
R6163:Rexo5 UTSW 7 119805247 missense probably damaging 1.00
R6305:Rexo5 UTSW 7 119828125 missense probably damaging 1.00
R7144:Rexo5 UTSW 7 119805191 missense probably damaging 1.00
R7282:Rexo5 UTSW 7 119818413 missense probably damaging 0.97
R8143:Rexo5 UTSW 7 119834261 splice site probably null
R8379:Rexo5 UTSW 7 119834285 missense probably benign 0.03
R8550:Rexo5 UTSW 7 119801345 missense probably benign 0.01
R8841:Rexo5 UTSW 7 119848788 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGCAGGGAGCCTCATCAATGTATG -3'
(R):5'- GGGACAGCTAAATTCCAAGGGTCAG -3'

Sequencing Primer
(F):5'- AATGTATGGCTCCCTAGCTTAG -3'
(R):5'- TTCCAAGGGTCAGAATCATGAG -3'
Posted On2013-07-11