Incidental Mutation 'R7181:Rmdn3'
ID 558961
Institutional Source Beutler Lab
Gene Symbol Rmdn3
Ensembl Gene ENSMUSG00000070730
Gene Name regulator of microtubule dynamics 3
Synonyms Fam82a2, 1200015F23Rik
MMRRC Submission 045270-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7181 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 118967482-118987515 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 118969849 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 404 (L404Q)
Ref Sequence ENSEMBL: ENSMUSP00000092283 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028795] [ENSMUST00000094695] [ENSMUST00000152327]
AlphaFold Q3UJU9
Predicted Effect probably benign
Transcript: ENSMUST00000028795
SMART Domains Protein: ENSMUSP00000028795
Gene: ENSMUSG00000027323

DomainStartEndE-ValueType
HhH1 58 77 1.08e0 SMART
AAA 119 306 8.27e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000094695
AA Change: L404Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092283
Gene: ENSMUSG00000070730
AA Change: L404Q

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
coiled coil region 91 122 N/A INTRINSIC
low complexity region 135 148 N/A INTRINSIC
low complexity region 216 234 N/A INTRINSIC
SCOP:d1hxia_ 354 445 1e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000151406
SMART Domains Protein: ENSMUSP00000117939
Gene: ENSMUSG00000027323

DomainStartEndE-ValueType
Pfam:Rad51 1 196 5.4e-103 PFAM
Pfam:AAA_25 2 152 1.9e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000152327
SMART Domains Protein: ENSMUSP00000119101
Gene: ENSMUSG00000027323

DomainStartEndE-ValueType
HhH1 58 77 1.08e0 SMART
Pfam:Rad51 83 218 2.6e-71 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 98% (62/63)
MGI Phenotype PHENOTYPE: Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 A G 17: 57,188,037 (GRCm39) N182D probably benign Het
Adgrl1 A G 8: 84,652,878 (GRCm39) probably null Het
Adm T C 7: 110,228,236 (GRCm39) I139T probably damaging Het
Ahnak A T 19: 8,990,852 (GRCm39) K4045N probably damaging Het
Axin1 T A 17: 26,392,752 (GRCm39) S344R probably damaging Het
Cacna1g T C 11: 94,306,691 (GRCm39) S1896G probably benign Het
Cd209c A G 8: 3,995,712 (GRCm39) V30A probably benign Het
Cd86 CA CAA 16: 36,426,917 (GRCm39) probably null Het
Cdh8 A T 8: 99,825,557 (GRCm39) M520K probably benign Het
Cyp2b23 G A 7: 26,373,828 (GRCm39) T306I probably damaging Het
Dnajc10 T G 2: 80,149,587 (GRCm39) Y96* probably null Het
Eif1ad14 G A 12: 87,886,492 (GRCm39) R46W possibly damaging Het
Elmod1 A C 9: 53,841,382 (GRCm39) probably null Het
Eva1b A G 4: 126,043,446 (GRCm39) H162R possibly damaging Het
Fam222b A T 11: 78,045,804 (GRCm39) N455I probably damaging Het
Fer1l6 G A 15: 58,447,146 (GRCm39) A626T probably benign Het
Fgd6 A G 10: 93,879,373 (GRCm39) T76A probably benign Het
Fndc7 A G 3: 108,788,640 (GRCm39) probably null Het
Gabrg2 T A 11: 41,811,261 (GRCm39) I295F probably damaging Het
Gm10406 A T 14: 7,027,359 (GRCm38) probably null Het
Gm47189 T C 14: 41,492,059 (GRCm39) M73V probably benign Het
Gm9758 A T 5: 14,963,667 (GRCm39) S54T probably damaging Het
Gm9857 A G 3: 108,847,554 (GRCm39) S70P unknown Het
Gsap A T 5: 21,458,427 (GRCm39) E470D probably damaging Het
Hesx1 T A 14: 26,722,678 (GRCm39) M1K probably null Het
Hirip3 A G 7: 126,463,235 (GRCm39) D397G probably damaging Het
Kalrn T A 16: 33,983,447 (GRCm39) N13I probably benign Het
Mettl8 A T 2: 70,803,706 (GRCm39) S194T possibly damaging Het
Mrps35 T G 6: 146,957,491 (GRCm39) probably null Het
Myrfl G T 10: 116,697,448 (GRCm39) N25K probably damaging Het
Or51b6b C A 7: 103,310,020 (GRCm39) G146C probably damaging Het
Or7a41 A G 10: 78,871,287 (GRCm39) Y219C probably damaging Het
Or9k2b A T 10: 130,016,626 (GRCm39) I41N possibly damaging Het
Phf14 A T 6: 11,933,340 (GRCm39) E67D unknown Het
Prdm16 C T 4: 154,613,094 (GRCm39) G111D probably damaging Het
Prex1 G A 2: 166,412,291 (GRCm39) A1568V probably damaging Het
Ptpn23 G A 9: 110,214,325 (GRCm39) T1692I unknown Het
Ptprb C T 10: 116,204,671 (GRCm39) S1835L probably damaging Het
Rbm19 G A 5: 120,254,532 (GRCm39) probably benign Het
Rgs7bp T A 13: 105,119,382 (GRCm39) H152L possibly damaging Het
Rock2 T A 12: 17,023,144 (GRCm39) F1148I probably benign Het
Runx2 G A 17: 45,125,079 (GRCm39) P80L probably damaging Het
Sec24c C A 14: 20,739,401 (GRCm39) H559N probably damaging Het
Sephs2 T C 7: 126,872,992 (GRCm39) S34G probably benign Het
Serpina6 A T 12: 103,613,203 (GRCm39) S366T probably benign Het
Serpinb7 A T 1: 107,378,052 (GRCm39) E248D probably benign Het
Sesn1 G T 10: 41,779,724 (GRCm39) R386L possibly damaging Het
Skida1 T C 2: 18,051,602 (GRCm39) S430G unknown Het
Slc28a2 A T 2: 122,282,462 (GRCm39) probably null Het
Slc39a8 T C 3: 135,563,299 (GRCm39) F203S possibly damaging Het
Svip A G 7: 51,653,177 (GRCm39) S46P possibly damaging Het
Tbx21 T A 11: 96,989,923 (GRCm39) D423V probably benign Het
Tcirg1 G A 19: 3,953,576 (GRCm39) A117V probably null Het
Tmem63b T A 17: 45,984,094 (GRCm39) K258N probably benign Het
Tmem94 A G 11: 115,685,600 (GRCm39) N951S probably damaging Het
Uba2 G T 7: 33,840,854 (GRCm39) D591E probably benign Het
Unc13b C T 4: 43,258,893 (GRCm39) R1356W probably damaging Het
Wasf3 A G 5: 146,403,615 (GRCm39) T242A probably benign Het
Wscd1 T C 11: 71,650,709 (GRCm39) L12P probably damaging Het
Zfp770 T C 2: 114,027,872 (GRCm39) K66E probably damaging Het
Zfyve26 A T 12: 79,315,182 (GRCm39) D1431E probably benign Het
Zhx2 G A 15: 57,686,746 (GRCm39) R705H probably benign Het
Other mutations in Rmdn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01374:Rmdn3 APN 2 118,984,428 (GRCm39) missense probably damaging 1.00
IGL01684:Rmdn3 APN 2 118,978,055 (GRCm39) missense probably damaging 1.00
IGL02892:Rmdn3 APN 2 118,984,561 (GRCm39) missense probably benign 0.00
R0534:Rmdn3 UTSW 2 118,976,851 (GRCm39) missense probably benign 0.00
R1126:Rmdn3 UTSW 2 118,984,476 (GRCm39) missense probably benign 0.01
R2332:Rmdn3 UTSW 2 118,984,008 (GRCm39) unclassified probably benign
R3850:Rmdn3 UTSW 2 118,986,903 (GRCm39) missense possibly damaging 0.65
R5034:Rmdn3 UTSW 2 118,978,058 (GRCm39) missense probably damaging 1.00
R5221:Rmdn3 UTSW 2 118,986,935 (GRCm39) missense probably damaging 1.00
R5942:Rmdn3 UTSW 2 118,978,058 (GRCm39) missense probably damaging 1.00
R6049:Rmdn3 UTSW 2 118,983,906 (GRCm39) missense probably damaging 1.00
R6188:Rmdn3 UTSW 2 118,969,831 (GRCm39) critical splice donor site probably null
R7011:Rmdn3 UTSW 2 118,968,904 (GRCm39) missense probably damaging 1.00
R8277:Rmdn3 UTSW 2 118,976,905 (GRCm39) missense probably damaging 1.00
R8721:Rmdn3 UTSW 2 118,969,846 (GRCm39) missense possibly damaging 0.87
R9144:Rmdn3 UTSW 2 118,969,847 (GRCm39) missense probably benign 0.21
R9172:Rmdn3 UTSW 2 118,968,863 (GRCm39) missense probably benign 0.00
R9317:Rmdn3 UTSW 2 118,986,991 (GRCm39) missense unknown
R9727:Rmdn3 UTSW 2 118,968,827 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TAGTTCCTCAGCCTGGAAGAAG -3'
(R):5'- CCTTATTCTACCTATGAACTGATAGCG -3'

Sequencing Primer
(F):5'- GCTGAAATACACGTATTAGAAAGCTC -3'
(R):5'- ACCTATGAACTGATAGCGTCTTC -3'
Posted On 2019-06-26