|Institutional Source||Beutler Lab|
|Gene Name||triggering receptor expressed on myeloid cells 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0589 (G1)|
|Chromosomal Location||48232768-48246924 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 48237217 bp|
|Amino Acid Change||Aspartic acid to Glycine at position 90 (D90G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000038636 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000048782] [ENSMUST00000113251]|
|Predicted Effect||possibly damaging
AA Change: D90G
PolyPhen 2 Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
AA Change: D90G
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.1795|
|Coding Region Coverage||
|Validation Efficiency||98% (62/63)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Mice homozygous for a reporter allele exhibit decreased susceptibility to DEN induced tumors and liver damage. Mice homozygous for a knock-out allele of Trem1 and Trem3 exhibit increased susceptibility to P. aeruginosa infection with reduced neutrophil transepithelial migration. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Trem1||
(F):5'- CGTCATTCCCTACAGAGCCTGATTC -3'
(R):5'- CAATAGCTCCATTCATGTCTGGCCC -3'
(F):5'- GAAGTCAAAGCTGCCATTGTTC -3'
(R):5'- cattcatgtctGGCCCTCTCTG -3'