Incidental Mutation 'R7184:Cdon'
ID 559189
Institutional Source Beutler Lab
Gene Symbol Cdon
Ensembl Gene ENSMUSG00000038119
Gene Name cell adhesion molecule-related/down-regulated by oncogenes
Synonyms CAM-related/down-regulated by oncogenes, CDO
MMRRC Submission 045236-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.351) question?
Stock # R7184 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 35332836-35418948 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 35375191 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 406 (I406V)
Ref Sequence ENSEMBL: ENSMUSP00000045547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042842] [ENSMUST00000119129] [ENSMUST00000154652]
AlphaFold Q32MD9
Predicted Effect probably benign
Transcript: ENSMUST00000042842
AA Change: I406V

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000045547
Gene: ENSMUSG00000038119
AA Change: I406V

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000119129
AA Change: I406V

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000113977
Gene: ENSMUSG00000038119
AA Change: I406V

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127264
AA Change: I70V

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000115216
Gene: ENSMUSG00000038119
AA Change: I70V

DomainStartEndE-ValueType
IGc2 1 51 6.26e-5 SMART
IG_like 18 62 1.06e2 SMART
IGc2 81 134 6.45e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000154652
AA Change: I406V

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000117499
Gene: ENSMUSG00000038119
AA Change: I406V

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
Meta Mutation Damage Score 0.1596 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (63/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass A G 6: 23,094,219 (GRCm39) S500P possibly damaging Het
Aldh9a1 T A 1: 167,184,965 (GRCm39) N292K probably benign Het
Art2b A T 7: 101,229,658 (GRCm39) S80R probably benign Het
Atp6v1b2 G T 8: 69,555,219 (GRCm39) A194S possibly damaging Het
Bsnd T C 4: 106,349,109 (GRCm39) M44V probably damaging Het
Cadps2 A T 6: 23,583,428 (GRCm39) V383E probably benign Het
Cd93 T C 2: 148,284,459 (GRCm39) T296A possibly damaging Het
Cdk15 G T 1: 59,304,814 (GRCm39) E138D probably benign Het
Cfhr4 A G 1: 139,660,822 (GRCm39) V622A possibly damaging Het
Cyp3a41a A G 5: 145,642,663 (GRCm39) V232A probably benign Het
Dbndd1 T A 8: 124,235,860 (GRCm39) D130V probably damaging Het
Dnah14 C T 1: 181,532,094 (GRCm39) R2294* probably null Het
Eddm3b A G 14: 51,354,387 (GRCm39) Y125C probably damaging Het
Eif1ad14 G A 12: 87,886,492 (GRCm39) R46W possibly damaging Het
Enah A T 1: 181,749,957 (GRCm39) V294E probably damaging Het
Farp2 A G 1: 93,531,137 (GRCm39) E545G probably damaging Het
Farsb T C 1: 78,458,994 (GRCm39) E22G possibly damaging Het
Fcsk G A 8: 111,613,788 (GRCm39) P758S probably damaging Het
Fezf1 A G 6: 23,247,835 (GRCm39) V80A probably benign Het
Fpr2 T C 17: 18,113,533 (GRCm39) Y39H unknown Het
Fsd1l C A 4: 53,694,054 (GRCm39) R344S probably damaging Het
Fxyd1 G T 7: 30,751,401 (GRCm39) R90S unknown Het
Galnt4 T A 10: 98,944,466 (GRCm39) Y64N probably damaging Het
Gatb C T 3: 85,544,258 (GRCm39) Q409* probably null Het
Glipr2 A C 4: 43,968,667 (GRCm39) D73A possibly damaging Het
Gm40460 ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,450 (GRCm39) probably benign Het
Gpr88 C T 3: 116,045,643 (GRCm39) V223I possibly damaging Het
Gtf2h3 A G 5: 124,722,067 (GRCm39) N55S probably benign Het
Htr4 T A 18: 62,570,498 (GRCm39) C184* probably null Het
Ighv6-3 T A 12: 114,355,475 (GRCm39) R71S probably benign Het
Itpr2 G C 6: 146,212,585 (GRCm39) I1510M possibly damaging Het
Keap1 T C 9: 21,145,134 (GRCm39) Q292R probably benign Het
Mab21l4 T C 1: 93,082,237 (GRCm39) N294S probably benign Het
Malt1 A C 18: 65,580,764 (GRCm39) E219D probably benign Het
Manba T C 3: 135,228,915 (GRCm39) V279A possibly damaging Het
Map4k5 T A 12: 69,921,095 (GRCm39) H41L probably benign Het
Mcm2 T G 6: 88,868,776 (GRCm39) Y327S probably damaging Het
Nectin3 A G 16: 46,215,484 (GRCm39) I503T possibly damaging Het
Nqo1 T C 8: 108,119,279 (GRCm39) I99M probably damaging Het
Nrxn2 A G 19: 6,540,582 (GRCm39) H845R probably damaging Het
Otogl C T 10: 107,599,061 (GRCm39) C2254Y probably damaging Het
Pmm1 T C 15: 81,840,415 (GRCm39) N110S probably damaging Het
Poc1b G T 10: 98,970,199 (GRCm39) C68F probably benign Het
Polr1b A G 2: 128,965,842 (GRCm39) Y828C possibly damaging Het
Prl3d1 A G 13: 27,282,619 (GRCm39) H119R probably damaging Het
Pum3 A G 19: 27,403,412 (GRCm39) S30P probably benign Het
Rgl2 T C 17: 34,153,964 (GRCm39) F457L possibly damaging Het
Rusc1 T C 3: 88,999,194 (GRCm39) E196G possibly damaging Het
Sf3a3 A G 4: 124,608,772 (GRCm39) K29E probably benign Het
Slc13a1 A T 6: 24,092,311 (GRCm39) I475K probably damaging Het
Slc26a5 G T 5: 22,042,244 (GRCm39) Y237* probably null Het
Slc7a14 C T 3: 31,281,212 (GRCm39) G366D probably damaging Het
Tbc1d5 A G 17: 51,107,110 (GRCm39) V482A probably benign Het
Tdrd5 G T 1: 156,087,505 (GRCm39) Q883K probably benign Het
Tet2 T C 3: 133,179,391 (GRCm39) Y1258C probably damaging Het
Upf2 A G 2: 6,028,131 (GRCm39) D739G unknown Het
Vmn1r122 A T 7: 20,867,820 (GRCm39) F78L probably benign Het
Vmn1r75 A T 7: 11,614,915 (GRCm39) K216* probably null Het
Vmn2r11 A T 5: 109,201,281 (GRCm39) Y408N probably damaging Het
Wscd1 T A 11: 71,679,543 (GRCm39) V472D probably damaging Het
Zdbf2 G T 1: 63,345,664 (GRCm39) V1348F possibly damaging Het
Zfp442 G T 2: 150,250,056 (GRCm39) H615Q possibly damaging Het
Zfp457 C A 13: 67,442,065 (GRCm39) C170F possibly damaging Het
Zscan10 A G 17: 23,826,003 (GRCm39) probably null Het
Other mutations in Cdon
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Cdon APN 9 35,389,412 (GRCm39) missense probably damaging 1.00
IGL01307:Cdon APN 9 35,368,860 (GRCm39) missense probably benign 0.01
IGL01528:Cdon APN 9 35,381,403 (GRCm39) missense possibly damaging 0.95
IGL01663:Cdon APN 9 35,394,510 (GRCm39) missense possibly damaging 0.57
IGL01723:Cdon APN 9 35,414,634 (GRCm39) missense probably benign 0.05
IGL02200:Cdon APN 9 35,394,405 (GRCm39) missense probably benign 0.28
IGL02444:Cdon APN 9 35,384,744 (GRCm39) missense probably benign 0.09
IGL02547:Cdon APN 9 35,389,950 (GRCm39) missense probably damaging 1.00
IGL02620:Cdon APN 9 35,364,095 (GRCm39) missense probably benign 0.00
IGL02861:Cdon APN 9 35,398,253 (GRCm39) missense probably damaging 0.96
IGL02894:Cdon APN 9 35,366,722 (GRCm39) missense probably benign 0.01
IGL03153:Cdon APN 9 35,389,255 (GRCm39) missense probably damaging 1.00
IGL03206:Cdon APN 9 35,414,602 (GRCm39) missense probably benign
IGL03374:Cdon APN 9 35,389,299 (GRCm39) missense possibly damaging 0.46
corleone UTSW 9 35,398,252 (GRCm39) nonsense probably null
indentured UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
Molar UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
Servitude UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
PIT4280001:Cdon UTSW 9 35,398,231 (GRCm39) missense probably damaging 1.00
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0064:Cdon UTSW 9 35,400,523 (GRCm39) missense probably benign 0.03
R0396:Cdon UTSW 9 35,381,426 (GRCm39) missense probably damaging 1.00
R0403:Cdon UTSW 9 35,384,796 (GRCm39) missense probably benign 0.00
R0490:Cdon UTSW 9 35,363,978 (GRCm39) missense probably damaging 1.00
R0547:Cdon UTSW 9 35,368,794 (GRCm39) missense possibly damaging 0.88
R0609:Cdon UTSW 9 35,389,907 (GRCm39) missense probably damaging 1.00
R0645:Cdon UTSW 9 35,388,379 (GRCm39) splice site probably null
R0781:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1110:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1391:Cdon UTSW 9 35,415,485 (GRCm39) missense possibly damaging 0.51
R1574:Cdon UTSW 9 35,364,233 (GRCm39) splice site probably benign
R1851:Cdon UTSW 9 35,394,454 (GRCm39) missense probably damaging 1.00
R2031:Cdon UTSW 9 35,415,370 (GRCm39) missense probably damaging 0.96
R2230:Cdon UTSW 9 35,403,222 (GRCm39) critical splice donor site probably null
R3683:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3684:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3685:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3941:Cdon UTSW 9 35,375,467 (GRCm39) missense probably benign 0.09
R4030:Cdon UTSW 9 35,403,202 (GRCm39) missense probably damaging 1.00
R4084:Cdon UTSW 9 35,389,427 (GRCm39) missense probably damaging 0.98
R4462:Cdon UTSW 9 35,368,876 (GRCm39) missense probably damaging 0.97
R4569:Cdon UTSW 9 35,388,265 (GRCm39) missense probably damaging 1.00
R4677:Cdon UTSW 9 35,389,901 (GRCm39) missense probably damaging 1.00
R4869:Cdon UTSW 9 35,364,200 (GRCm39) missense possibly damaging 0.71
R5032:Cdon UTSW 9 35,400,330 (GRCm39) missense probably damaging 1.00
R5047:Cdon UTSW 9 35,389,935 (GRCm39) missense probably damaging 1.00
R5214:Cdon UTSW 9 35,394,504 (GRCm39) missense probably damaging 1.00
R5341:Cdon UTSW 9 35,381,431 (GRCm39) missense probably damaging 1.00
R5410:Cdon UTSW 9 35,381,331 (GRCm39) missense probably damaging 0.99
R5581:Cdon UTSW 9 35,415,377 (GRCm39) missense probably benign 0.01
R5696:Cdon UTSW 9 35,403,162 (GRCm39) missense possibly damaging 0.69
R5757:Cdon UTSW 9 35,364,068 (GRCm39) missense probably damaging 0.98
R5802:Cdon UTSW 9 35,365,716 (GRCm39) missense probably damaging 0.99
R5845:Cdon UTSW 9 35,368,762 (GRCm39) missense probably damaging 1.00
R5949:Cdon UTSW 9 35,398,247 (GRCm39) missense probably benign 0.32
R6106:Cdon UTSW 9 35,366,704 (GRCm39) nonsense probably null
R6245:Cdon UTSW 9 35,388,235 (GRCm39) missense probably damaging 1.00
R6845:Cdon UTSW 9 35,398,252 (GRCm39) nonsense probably null
R6896:Cdon UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
R7060:Cdon UTSW 9 35,398,205 (GRCm39) missense probably damaging 1.00
R7076:Cdon UTSW 9 35,415,446 (GRCm39) missense probably benign 0.00
R7382:Cdon UTSW 9 35,389,944 (GRCm39) missense probably damaging 1.00
R7763:Cdon UTSW 9 35,365,711 (GRCm39) nonsense probably null
R7857:Cdon UTSW 9 35,367,908 (GRCm39) missense possibly damaging 0.79
R7885:Cdon UTSW 9 35,367,818 (GRCm39) missense probably benign 0.01
R7894:Cdon UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
R7984:Cdon UTSW 9 35,414,598 (GRCm39) missense probably benign 0.00
R8287:Cdon UTSW 9 35,375,225 (GRCm39) missense probably benign
R8428:Cdon UTSW 9 35,403,163 (GRCm39) missense probably benign 0.21
R8519:Cdon UTSW 9 35,389,950 (GRCm39) missense probably damaging 1.00
R8698:Cdon UTSW 9 35,398,269 (GRCm39) critical splice donor site probably null
R8797:Cdon UTSW 9 35,389,931 (GRCm39) missense probably damaging 1.00
R8995:Cdon UTSW 9 35,398,093 (GRCm39) missense probably damaging 1.00
R9090:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9177:Cdon UTSW 9 35,381,230 (GRCm39) missense probably benign 0.00
R9200:Cdon UTSW 9 35,414,617 (GRCm39) missense probably benign 0.00
R9271:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9330:Cdon UTSW 9 35,400,275 (GRCm39) nonsense probably null
R9477:Cdon UTSW 9 35,403,201 (GRCm39) missense probably damaging 1.00
R9612:Cdon UTSW 9 35,398,201 (GRCm39) missense probably damaging 1.00
R9730:Cdon UTSW 9 35,398,263 (GRCm39) missense probably benign 0.00
Z1177:Cdon UTSW 9 35,403,196 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTCTGAAACATTCTGCTTCCAG -3'
(R):5'- ATGAGGTAGACAGGCTCCAG -3'

Sequencing Primer
(F):5'- GAAACATTCTGCTTCCAGTTGTCAG -3'
(R):5'- TAGACAGGCTCCAGGTCCAG -3'
Posted On 2019-06-26