Mutagenetix > Incidental Mutation

Incidental Mutation 'R0590:Vmn1r23'

55925

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r23

Ensembl Gene

ENSMUSG00000093376

Gene Name

vomeronasal 1 receptor 23

Synonyms

V1rc24

MMRRC Submission

038780-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.303) question?

Stock #

R0590 (G1)

Quality Score

211

Status

Validated

Chromosome

Chromosomal Location

57925842-57926838 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 57926364 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 143 (V143A)

Ref Sequence

ENSEMBL: ENSMUSP00000135676 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000175817]

AlphaFold

Q8R2D0

Predicted Effect

probably benign
Transcript: ENSMUST00000175817
AA Change: V143A

PolyPhen 2 Score 0.429 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000135676
Gene: ENSMUSG00000093376
AA Change: V143A

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	3.1e-57	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 99.0%
10x: 97.7%
20x: 95.7%

Validation Efficiency

100% (47/47)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acnat2	C	T	4: 49,383,273	M93I	probably benign	Het
Adamts16	T	C	13: 70,800,954	D196G	probably benign	Het
Adhfe1	T	A	1: 9,548,153		probably null	Het
AI661453	A	G	17: 47,467,074		probably benign	Het
Apc	G	T	18: 34,316,230	E2026*	probably null	Het
Atg2a	GCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC	GCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC	19: 6,245,007		probably benign	Het
BC017158	A	G	7: 128,297,470	L134P	probably damaging	Het
Cad	T	C	5: 31,062,231	S688P	probably damaging	Het
Ccdc191	C	T	16: 43,931,341	R345*	probably null	Het
Dcaf13	T	A	15: 39,145,085		probably benign	Het
Drc1	A	G	5: 30,363,136	D607G	probably benign	Het
Fam160a1	T	C	3: 85,672,376	R841G	probably benign	Het
Gli1	G	T	10: 127,331,563	A607E	possibly damaging	Het
Gls	G	A	1: 52,212,375		probably benign	Het
Gria1	A	T	11: 57,289,409	Q728H	probably damaging	Het
Hcrtr1	A	G	4: 130,135,694	L198P	probably damaging	Het
Ifngr1	T	A	10: 19,603,942		probably benign	Het
Ipo5	T	C	14: 120,944,357	V954A	possibly damaging	Het
Kcnh5	G	T	12: 74,965,261	A628D	probably damaging	Het
Kif14	T	C	1: 136,482,472	S646P	probably damaging	Het
Ksr1	A	G	11: 79,045,140	S133P	probably damaging	Het
Neb	T	C	2: 52,137,290	M7143V	probably damaging	Het
Nelfa	G	A	5: 33,901,825	P229S	probably damaging	Het
Nfatc2	T	C	2: 168,571,199	T169A	probably damaging	Het
Nr1h4	A	G	10: 89,456,567	Y398H	probably damaging	Het
Nrcam	A	G	12: 44,564,032	E511G	probably damaging	Het
Ocstamp	T	A	2: 165,397,751	R172W	probably damaging	Het
Olfr1130	A	G	2: 87,607,994	E202G	probably damaging	Het
Olfr26	T	A	9: 38,855,470	M136K	probably damaging	Het
Olfr27	T	C	9: 39,144,721	V207A	probably benign	Het
Phf14	G	A	6: 11,961,578	V405I	possibly damaging	Het
Plk5	G	A	10: 80,360,223	R238H	probably damaging	Het
Pole	A	G	5: 110,317,926	E1240G	probably benign	Het
Prdm15	A	G	16: 97,797,761	I899T	possibly damaging	Het
Psip1	T	C	4: 83,458,144	N486S	probably benign	Het
Rlf	A	G	4: 121,170,833		probably benign	Het
Rttn	T	C	18: 88,979,635	S255P	probably damaging	Het
Sema6c	A	G	3: 95,172,623	K711E	probably damaging	Het
Slc4a10	A	T	2: 62,190,893		probably benign	Het
Trim36	T	G	18: 46,172,576	S435R	probably benign	Het
Ucp1	A	G	8: 83,291,603		probably benign	Het
Vmn1r17	T	C	6: 57,361,014	Y122C	probably benign	Het
Wdfy4	T	A	14: 33,041,174	Q2166L	probably benign	Het
Zc3h7b	C	T	15: 81,776,998	T346M	possibly damaging	Het
Zfhx4	T	A	3: 5,402,633	V2617D	probably damaging	Het

Other mutations in Vmn1r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01563:Vmn1r23	APN	6	57926076	missense	possibly damaging	0.89
IGL01980:Vmn1r23	APN	6	57926490	missense	probably damaging	1.00
IGL02934:Vmn1r23	APN	6	57925929	missense	probably benign	0.26
IGL03153:Vmn1r23	APN	6	57925932	missense	probably damaging	0.98
R0410:Vmn1r23	UTSW	6	57926190	missense	probably benign	0.11
R0452:Vmn1r23	UTSW	6	57926484	missense	possibly damaging	0.90
R0647:Vmn1r23	UTSW	6	57926184	missense	probably benign
R0692:Vmn1r23	UTSW	6	57926125	nonsense	probably null
R1674:Vmn1r23	UTSW	6	57926061	missense	possibly damaging	0.75
R1744:Vmn1r23	UTSW	6	57925925	missense	possibly damaging	0.81
R1774:Vmn1r23	UTSW	6	57926690	missense	probably damaging	0.97
R2101:Vmn1r23	UTSW	6	57926452	missense	possibly damaging	0.90
R2202:Vmn1r23	UTSW	6	57926619	missense	probably benign	0.01
R2204:Vmn1r23	UTSW	6	57926619	missense	probably benign	0.01
R2205:Vmn1r23	UTSW	6	57926619	missense	probably benign	0.01
R4282:Vmn1r23	UTSW	6	57926467	missense	probably benign	0.27
R4408:Vmn1r23	UTSW	6	57926368	missense	probably benign	0.01
R4532:Vmn1r23	UTSW	6	57925929	missense	probably benign	0.21
R4690:Vmn1r23	UTSW	6	57926025	missense	probably benign
R4700:Vmn1r23	UTSW	6	57926205	missense	probably benign	0.17
R4894:Vmn1r23	UTSW	6	57926325	missense	probably benign	0.00
R6164:Vmn1r23	UTSW	6	57926055	missense	possibly damaging	0.90
R6930:Vmn1r23	UTSW	6	57926145	missense	probably benign
R7129:Vmn1r23	UTSW	6	57926076	missense	possibly damaging	0.89
R7731:Vmn1r23	UTSW	6	57926334	missense	probably benign	0.03
R7877:Vmn1r23	UTSW	6	57926556	missense	probably benign
R8751:Vmn1r23	UTSW	6	57926467	missense	probably benign	0.27
R8809:Vmn1r23	UTSW	6	57926367	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- TGAGGTCTACCCAGTACATGACCAC -3'
(R):5'- TGAGAGGACTCTCTATGGGCATCAC -3'

Sequencing Primer
(F):5'- GCCTGATGCTATGAAGATGC -3'
(R):5'- ATGGGCATCACATGCCTC -3'

Posted On

2013-07-11