Mutagenetix > Incidental Mutation

Incidental Mutation 'R7187:Or5p61'

559362

Institutional Source

Beutler Lab

Gene Symbol

Or5p61

Ensembl Gene

ENSMUSG00000108995

Gene Name

olfactory receptor family 5 subfamily P member 61

Synonyms

MOR204-30P, GA_x6K02T2PBJ9-10489044-10488091, Olfr485, MOR204-40_p

MMRRC Submission

045377-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R7187 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

107758125-107759078 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 107758585 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 165 (V165E)

Ref Sequence

ENSEMBL: ENSMUSP00000147194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000208296]

AlphaFold

A0A140LJF5

Predicted Effect

probably benign
Transcript: ENSMUST00000208296
AA Change: V165E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

100% (59/59)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca2	A	G	2: 25,327,733 (GRCm39)	Y716C	probably damaging	Het
Abcc1	A	G	16: 14,284,861 (GRCm39)	I1237V	probably benign	Het
Adam34	C	T	8: 44,105,565 (GRCm39)	A27T	probably benign	Het
Aff3	T	C	1: 38,257,478 (GRCm39)	S415G	probably damaging	Het
Ak7	T	C	12: 105,711,532 (GRCm39)	Y390H	probably benign	Het
Arap2	A	C	5: 62,826,396 (GRCm39)	M1056R	probably damaging	Het
Brf1	T	C	12: 112,923,945 (GRCm39)	Y676C	unknown	Het
Cachd1	T	A	4: 100,833,552 (GRCm39)	H776Q	possibly damaging	Het
Cacng7	T	C	7: 3,385,183 (GRCm39)	V28A	probably damaging	Het
Camk2g	A	T	14: 20,792,780 (GRCm39)	D359E	probably benign	Het
Cd209b	T	C	8: 3,976,638 (GRCm39)	D16G	probably benign	Het
Ceacam5	A	G	7: 17,493,410 (GRCm39)	E811G	possibly damaging	Het
Cecr2	T	A	6: 120,733,647 (GRCm39)	S545T	probably benign	Het
Cep55	T	C	19: 38,048,806 (GRCm39)		probably null	Het
Ctif	C	A	18: 75,770,290 (GRCm39)	V32L	probably damaging	Het
Cwc27	G	A	13: 104,797,900 (GRCm39)	A353V	probably benign	Het
Dclk3	T	A	9: 111,314,064 (GRCm39)	S713R	probably damaging	Het
Dlec1	C	T	9: 118,941,214 (GRCm39)	H255Y	probably benign	Het
Dlgap1	A	G	17: 70,823,093 (GRCm39)	H26R	possibly damaging	Het
Dydc1	C	T	14: 40,800,051 (GRCm39)	T19I	possibly damaging	Het
Efcab12	G	A	6: 115,800,474 (GRCm39)	P183L	not run	Het
Eif1ad19	T	C	12: 87,740,708 (GRCm39)		probably benign	Het
Eri3	C	A	4: 117,446,343 (GRCm39)	Q219K	probably benign	Het
Fam135a	A	G	1: 24,083,295 (GRCm39)	L310P	probably damaging	Het
Fgd5	T	A	6: 91,965,272 (GRCm39)	S502T	possibly damaging	Het
Fgf8	A	G	19: 45,730,106 (GRCm39)	S57P	probably benign	Het
Gls	T	C	1: 52,259,139 (GRCm39)	E154G	probably damaging	Het
Gm28042	T	C	2: 119,870,176 (GRCm39)	L705P	probably damaging	Het
Golgb1	C	A	16: 36,736,512 (GRCm39)	Q1961K	probably benign	Het
Herc3	C	A	6: 58,833,616 (GRCm39)	Q168K	probably benign	Het
Il31ra	C	A	13: 112,682,845 (GRCm39)	C168F	probably benign	Het
Ino80	A	T	2: 119,257,072 (GRCm39)	D860E	probably benign	Het
Iqcm	T	G	8: 76,480,044 (GRCm39)	L334R	probably benign	Het
Lrrk2	A	G	15: 91,641,204 (GRCm39)	D1587G	possibly damaging	Het
Map4	T	A	9: 109,882,201 (GRCm39)	V355E	probably benign	Het
Mapk13	T	A	17: 28,995,361 (GRCm39)	I194N	probably damaging	Het
Mtus2	A	G	5: 148,013,515 (GRCm39)	T103A	probably benign	Het
Naglu	G	T	11: 100,961,158 (GRCm39)	G70W	probably benign	Het
Nlrp4f	A	T	13: 65,343,201 (GRCm39)	M126K	possibly damaging	Het
Or4c120	T	C	2: 89,001,714 (GRCm39)		probably benign	Het
Pdia4	T	C	6: 47,790,193 (GRCm39)	T16A	unknown	Het
Pou6f2	G	A	13: 18,414,298 (GRCm39)	A159V		Het
Ripor1	A	G	8: 106,344,506 (GRCm39)	T547A	probably benign	Het
Rundc3b	A	G	5: 8,542,506 (GRCm39)	S389P	probably damaging	Het
Sorbs1	G	C	19: 40,365,244 (GRCm39)	R180G	probably benign	Het
Spats2	T	C	15: 99,110,054 (GRCm39)	S484P	probably benign	Het
Supv3l1	G	A	10: 62,271,328 (GRCm39)	T403I	probably damaging	Het
Tacstd2	G	A	6: 67,512,180 (GRCm39)	R171W	probably damaging	Het
Taok2	A	T	7: 126,471,552 (GRCm39)	F542L	probably damaging	Het
Tbc1d31	T	A	15: 57,801,459 (GRCm39)	N331K	possibly damaging	Het
Tff2	A	T	17: 31,361,200 (GRCm39)	C118S	probably damaging	Het
Tmprss7	G	A	16: 45,498,317 (GRCm39)	T354I	possibly damaging	Het
Tmtc3	A	T	10: 100,313,774 (GRCm39)	F33I	probably damaging	Het
Tpbpa	G	A	13: 61,088,399 (GRCm39)		probably benign	Het
Ube3a	G	T	7: 58,925,653 (GRCm39)	V165F	probably benign	Het
Vmn2r4	T	G	3: 64,322,681 (GRCm39)	T13P	probably benign	Het
Wnt8b	A	G	19: 44,500,121 (GRCm39)	D236G	probably benign	Het
Ythdf3	C	A	3: 16,258,451 (GRCm39)	D210E	probably benign	Het
Zfp110	T	A	7: 12,583,753 (GRCm39)	Y800*	probably null	Het

Other mutations in Or5p61

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R3115:Or5p61	UTSW	7	107,759,029 (GRCm39)	missense	probably benign	0.00
R3116:Or5p61	UTSW	7	107,759,029 (GRCm39)	missense	probably benign	0.00
R3978:Or5p61	UTSW	7	107,758,819 (GRCm39)	missense	possibly damaging	0.52
R4722:Or5p61	UTSW	7	107,758,445 (GRCm39)	missense	probably benign	0.04
R5337:Or5p61	UTSW	7	107,758,480 (GRCm39)	missense	probably benign	0.01
R5553:Or5p61	UTSW	7	107,758,478 (GRCm39)	missense	probably benign	0.02
R6258:Or5p61	UTSW	7	107,758,181 (GRCm39)	missense	probably damaging	1.00
R6386:Or5p61	UTSW	7	107,758,409 (GRCm39)	missense	probably damaging	1.00
R6498:Or5p61	UTSW	7	107,758,639 (GRCm39)	missense	probably benign	0.20
R7096:Or5p61	UTSW	7	107,758,848 (GRCm39)	missense	probably benign
R7134:Or5p61	UTSW	7	107,758,883 (GRCm39)	missense	probably damaging	1.00
R7226:Or5p61	UTSW	7	107,758,164 (GRCm39)	missense	probably benign	0.00
R7799:Or5p61	UTSW	7	107,758,637 (GRCm39)	missense	probably benign	0.00
R8371:Or5p61	UTSW	7	107,758,435 (GRCm39)	missense	probably benign
R8704:Or5p61	UTSW	7	107,758,711 (GRCm39)	missense	possibly damaging	0.66
R8814:Or5p61	UTSW	7	107,758,272 (GRCm39)	missense	probably benign	0.03
R9451:Or5p61	UTSW	7	107,758,468 (GRCm39)	missense	probably benign	0.06
R9536:Or5p61	UTSW	7	107,759,075 (GRCm39)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- CTCAGTGGAGTGCATCTTTAGG -3'
(R):5'- TGTGGCATACAGCTCAGCTC -3'

Sequencing Primer
(F):5'- GAGATCGAACCAGCAGTA -3'
(R):5'- AGCTCAGCTGCTTTCTTTGG -3'

Posted On

2019-06-26