Incidental Mutation 'R7190:Gpr6'
ID 559555
Institutional Source Beutler Lab
Gene Symbol Gpr6
Ensembl Gene ENSMUSG00000046922
Gene Name G protein-coupled receptor 6
Synonyms
MMRRC Submission 045273-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7190 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 40945973-40948281 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 40946956 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 209 (N209D)
Ref Sequence ENSEMBL: ENSMUSP00000057323 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061796]
AlphaFold Q6YNI2
Predicted Effect probably damaging
Transcript: ENSMUST00000061796
AA Change: N209D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000057323
Gene: ENSMUSG00000046922
AA Change: N209D

DomainStartEndE-ValueType
low complexity region 13 30 N/A INTRINSIC
low complexity region 37 59 N/A INTRINSIC
Pfam:7tm_1 90 330 2.5e-32 PFAM
Meta Mutation Damage Score 0.2695 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 100% (50/50)
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actmap G A 7: 26,900,548 (GRCm39) A176T probably damaging Het
Add3 C T 19: 53,205,330 (GRCm39) R27* probably null Het
Armc3 T A 2: 19,297,947 (GRCm39) Y573N probably damaging Het
Bod1l A C 5: 41,977,281 (GRCm39) N1344K probably benign Het
Camta1 T G 4: 151,232,980 (GRCm39) N231T possibly damaging Het
Capza2 T A 6: 17,654,120 (GRCm39) Y57* probably null Het
Ccdc168 A C 1: 44,100,775 (GRCm39) S108A probably benign Het
Ccdc186 T A 19: 56,780,432 (GRCm39) I871F probably damaging Het
Cntnap5b A G 1: 100,359,574 (GRCm39) probably null Het
Dnah2 G T 11: 69,439,923 (GRCm39) probably null Het
Fhod3 T C 18: 25,223,812 (GRCm39) F1053L probably damaging Het
Foxj1 A G 11: 116,223,201 (GRCm39) Y201H possibly damaging Het
Gatad2b T A 3: 90,257,722 (GRCm39) I210N probably benign Het
Gba1 T A 3: 89,111,669 (GRCm39) I112N probably damaging Het
Gbp2 T C 3: 142,339,208 (GRCm39) V420A probably benign Het
Golga3 T A 5: 110,357,721 (GRCm39) H1072Q probably damaging Het
Gpr150 C T 13: 76,203,992 (GRCm39) A318T probably benign Het
Grin2b T C 6: 135,709,946 (GRCm39) N1200S possibly damaging Het
Ifi207 G A 1: 173,557,818 (GRCm39) H307Y unknown Het
Il20ra A T 10: 19,618,689 (GRCm39) I46F probably damaging Het
Lvrn A G 18: 47,033,570 (GRCm39) D927G probably benign Het
Nlrc4 G T 17: 74,752,198 (GRCm39) D728E probably damaging Het
Nup107 T C 10: 117,598,040 (GRCm39) D630G probably benign Het
Or1e19 A T 11: 73,315,990 (GRCm39) I273N probably benign Het
Or6c5c T C 10: 129,298,626 (GRCm39) I27T probably benign Het
Pclo C A 5: 14,729,743 (GRCm39) A2867D unknown Het
Perm1 A G 4: 156,304,272 (GRCm39) T754A possibly damaging Het
Plpbp G T 8: 27,541,325 (GRCm39) V162L probably benign Het
Plscr4 A T 9: 92,370,694 (GRCm39) E220D probably benign Het
Ppp2r3d A T 9: 101,089,726 (GRCm39) M199K probably benign Het
Pramel38 T G 5: 94,366,096 (GRCm39) N71K probably benign Het
Rassf6 T C 5: 90,754,666 (GRCm39) E204G probably damaging Het
Reln A C 5: 22,252,945 (GRCm39) D667E probably damaging Het
Rere A G 4: 150,695,410 (GRCm39) I462V unknown Het
Rpain A G 11: 70,862,735 (GRCm39) E76G possibly damaging Het
Strc T G 2: 121,199,507 (GRCm39) I1311L probably benign Het
Svil A G 18: 5,092,937 (GRCm39) M1385V probably benign Het
Syne2 T A 12: 76,113,361 (GRCm39) D1083E probably benign Het
Szt2 T A 4: 118,246,203 (GRCm39) H986L probably damaging Het
Tcl1b2 G T 12: 105,113,493 (GRCm39) probably null Het
Thy1 T A 9: 43,958,222 (GRCm39) S117T possibly damaging Het
Tmem183a A T 1: 134,282,496 (GRCm39) I203N probably damaging Het
Tmprss11g T C 5: 86,644,491 (GRCm39) I118V probably benign Het
Tsen34 T C 7: 3,697,806 (GRCm39) V69A possibly damaging Het
Ttn T C 2: 76,717,143 (GRCm39) Q7506R unknown Het
Vmn1r184 T C 7: 25,967,105 (GRCm39) S284P probably damaging Het
Wdr19 A G 5: 65,398,205 (GRCm39) D810G probably benign Het
Zer1 T C 2: 29,993,444 (GRCm39) D554G probably damaging Het
Zfp626 A T 7: 27,517,768 (GRCm39) T250S probably benign Het
Other mutations in Gpr6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Gpr6 APN 10 40,946,812 (GRCm39) missense probably damaging 0.99
IGL01010:Gpr6 APN 10 40,947,147 (GRCm39) missense probably benign
IGL01098:Gpr6 APN 10 40,946,739 (GRCm39) missense probably damaging 1.00
IGL01323:Gpr6 APN 10 40,947,555 (GRCm39) missense possibly damaging 0.96
R1153:Gpr6 UTSW 10 40,946,833 (GRCm39) missense probably damaging 1.00
R1154:Gpr6 UTSW 10 40,946,833 (GRCm39) missense probably damaging 1.00
R1622:Gpr6 UTSW 10 40,947,288 (GRCm39) missense probably damaging 1.00
R1628:Gpr6 UTSW 10 40,947,544 (GRCm39) missense possibly damaging 0.96
R1638:Gpr6 UTSW 10 40,946,530 (GRCm39) missense probably benign 0.02
R1935:Gpr6 UTSW 10 40,947,477 (GRCm39) missense probably benign 0.02
R1936:Gpr6 UTSW 10 40,947,477 (GRCm39) missense probably benign 0.02
R2108:Gpr6 UTSW 10 40,946,649 (GRCm39) missense possibly damaging 0.79
R2129:Gpr6 UTSW 10 40,947,168 (GRCm39) missense possibly damaging 0.50
R4024:Gpr6 UTSW 10 40,947,264 (GRCm39) missense probably damaging 1.00
R4237:Gpr6 UTSW 10 40,946,604 (GRCm39) missense probably damaging 1.00
R4418:Gpr6 UTSW 10 40,946,604 (GRCm39) missense probably damaging 1.00
R4703:Gpr6 UTSW 10 40,947,037 (GRCm39) missense probably damaging 1.00
R4814:Gpr6 UTSW 10 40,947,258 (GRCm39) missense possibly damaging 0.94
R6821:Gpr6 UTSW 10 40,947,004 (GRCm39) missense probably benign 0.04
R7573:Gpr6 UTSW 10 40,946,868 (GRCm39) missense probably damaging 0.99
R7574:Gpr6 UTSW 10 40,946,652 (GRCm39) missense possibly damaging 0.47
R7611:Gpr6 UTSW 10 40,946,875 (GRCm39) missense probably benign 0.02
R8011:Gpr6 UTSW 10 40,946,911 (GRCm39) missense probably benign 0.01
R9416:Gpr6 UTSW 10 40,946,944 (GRCm39) missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- GTTGCAAAGCGATCTGGTG -3'
(R):5'- TACACTTCGTGTTCCAGTACGTG -3'

Sequencing Primer
(F):5'- AAGCGATCTGGTGGGCGTG -3'
(R):5'- TCGGAGACTGTGAGCCTG -3'
Posted On 2019-06-26