Mutagenetix > Incidental Mutation

Incidental Mutation 'R7193:Ccng2'

559713

Institutional Source

Beutler Lab

Gene Symbol

Ccng2

Ensembl Gene

ENSMUSG00000029385

Gene Name

cyclin G2

Synonyms

MMRRC Submission

045334-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7193 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

93267257-93276231 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to G at 93273343 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 237 (S237R)

Ref Sequence

ENSEMBL: ENSMUSP00000113278 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031331] [ENSMUST00000121127]

AlphaFold

O08918

Predicted Effect

probably benign
Transcript: ENSMUST00000031331
AA Change: S237R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000031331
Gene: ENSMUSG00000029385
AA Change: S237R

Domain	Start	End	E-Value	Type
CYCLIN	61	147	3.06e-15	SMART
low complexity region	218	237	N/A	INTRINSIC
low complexity region	295	317	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000121127
AA Change: S237R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000113278
Gene: ENSMUSG00000029385
AA Change: S237R

Domain	Start	End	E-Value	Type
CYCLIN	61	147	3.06e-15	SMART
low complexity region	218	237	N/A	INTRINSIC
low complexity region	295	317	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130183

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149329

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152097

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153260

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

100% (60/60)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	A	G	12: 71,219,189		probably null	Het
4930402H24Rik	C	A	2: 130,806,788	R258L	unknown	Het
Abca16	T	C	7: 120,427,186	S124P	probably damaging	Het
Acan	A	T	7: 79,086,342	S179C	probably damaging	Het
Atg2b	A	C	12: 105,664,708	H319Q	probably damaging	Het
Bptf	G	A	11: 107,054,809	Q2535*	probably null	Het
Brpf3	T	C	17: 28,836,691	*1205R	probably null	Het
Cabyr	C	A	18: 12,751,758	P434Q	probably damaging	Het
Cacna1g	C	A	11: 94,409,231	D2268Y	possibly damaging	Het
Cct4	A	G	11: 22,997,111	T201A	probably benign	Het
Cdyl2	A	C	8: 116,623,994	S133A	probably benign	Het
Cep76	A	G	18: 67,641,134	L14P	possibly damaging	Het
Col4a3bp	T	A	13: 96,630,833		probably null	Het
Crybg3	A	T	16: 59,559,593	S433T	possibly damaging	Het
Cul9	T	C	17: 46,538,497	K574R	probably damaging	Het
Cyp2u1	T	C	3: 131,291,143	I527V	probably benign	Het
E130309D02Rik	A	G	5: 143,307,843	V293A	probably benign	Het
F5	A	G	1: 164,219,397	N2142S	probably damaging	Het
Fam50b	G	A	13: 34,747,101	E187K	possibly damaging	Het
Flnc	A	G	6: 29,450,871	Y1506C	probably damaging	Het
Foxred2	T	A	15: 77,952,030	S376C	probably damaging	Het
Gbe1	T	C	16: 70,495,370	L530P	probably damaging	Het
Gm8994	A	T	6: 136,329,215	I225F	probably damaging	Het
Hmcn1	T	C	1: 150,649,580	R3398G	probably null	Het
Igf1r	T	C	7: 68,187,157	L587P	probably damaging	Het
Kcna3	T	C	3: 107,036,537	Y39H	probably benign	Het
Krtap5-2	GCCACAGCCTCCCTTGCAACCCCCACAGGAGCCACAGCCCCCACAGGAACTACAGCCTCCCTTGCA	GCTACAGCCTCCCTTGCA	7: 142,175,243		probably benign	Het
Mbl1	T	C	14: 41,158,712	F186L	probably damaging	Het
Ncam2	A	T	16: 81,589,795	K687N	probably damaging	Het
Nedd4l	T	C	18: 64,997,370	V24A	probably damaging	Het
Nek1	A	G	8: 61,073,578	E661G	probably damaging	Het
Nudt14	G	T	12: 112,939,320	D28E	probably benign	Het
Olfr1297	A	T	2: 111,621,255	V273E	probably damaging	Het
Olfr134	T	A	17: 38,175,096	I4N	probably benign	Het
Olfr344	T	A	2: 36,569,236	C213S	probably benign	Het
Olfr702	T	C	7: 106,824,591		probably benign	Het
Pdk4	A	T	6: 5,487,089	M319K	probably benign	Het
Pfkp	T	C	13: 6,593,216	N522S	probably benign	Het
Pias2	T	C	18: 77,120,121	V234A	possibly damaging	Het
Pik3c2b	C	A	1: 133,079,774	H625Q	probably benign	Het
Pnpla7	T	C	2: 25,051,615	S1117P	probably damaging	Het
Prdm2	A	T	4: 143,180,894	V36D	probably damaging	Het
Prep	C	T	10: 45,092,699	R98C	probably benign	Het
Rae1	T	C	2: 173,008,317		probably null	Het
Rgs3	T	A	4: 62,615,336	V138E	probably damaging	Het
Rnf185	T	C	11: 3,425,329	T142A	possibly damaging	Het
Rsph6a	C	A	7: 19,065,647	P401Q	probably damaging	Het
Runx3	A	T	4: 135,121,145	T14S	probably benign	Het
Scaf11	A	G	15: 96,419,161	S841P	probably damaging	Het
Spta1	T	A	1: 174,184,612	L328Q	probably damaging	Het
Sqor	G	A	2: 122,804,009	V318M	probably damaging	Het
Stox2	T	C	8: 47,186,454	T902A	probably benign	Het
Susd3	T	C	13: 49,231,203	H248R	probably damaging	Het
Syne1	T	C	10: 5,233,406	Y4133C	probably damaging	Het
Tbc1d20	C	T	2: 152,311,417	T289M	probably benign	Het
Unc80	T	A	1: 66,549,784	F1036Y	possibly damaging	Het
Zbtb7c	T	C	18: 76,137,938	C366R	probably damaging	Het
Zeb1	A	T	18: 5,772,756	D1015V	probably damaging	Het
Zfp606	T	G	7: 12,494,039	S696A	probably benign	Het

Other mutations in Ccng2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01148:Ccng2	APN	5	93270887	missense	probably damaging	0.99
IGL01289:Ccng2	APN	5	93273417	missense	probably null	0.88
R0133:Ccng2	UTSW	5	93273381	missense	probably benign	0.15
R0266:Ccng2	UTSW	5	93271289	splice site	probably benign
R0346:Ccng2	UTSW	5	93270894	missense	probably damaging	1.00
R0401:Ccng2	UTSW	5	93273413	missense	possibly damaging	0.52
R1087:Ccng2	UTSW	5	93273444	missense	probably benign	0.17
R1373:Ccng2	UTSW	5	93271055	splice site	probably benign
R1696:Ccng2	UTSW	5	93273382	missense	possibly damaging	0.90
R3727:Ccng2	UTSW	5	93274951	missense	probably damaging	1.00
R5395:Ccng2	UTSW	5	93269398	missense	possibly damaging	0.84
R6337:Ccng2	UTSW	5	93270921	missense	probably benign
R6611:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7077:Ccng2	UTSW	5	93269340	missense	possibly damaging	0.91
R7140:Ccng2	UTSW	5	93268755	missense	probably benign	0.00
R7161:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7233:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7235:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7269:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7270:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7271:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7449:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7451:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7567:Ccng2	UTSW	5	93270872	missense	probably benign	0.01
R7614:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7657:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7658:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7743:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7744:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7745:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7874:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7875:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7876:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7877:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R7884:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R8053:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R8279:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R8282:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R8492:Ccng2	UTSW	5	93271454	missense	probably damaging	1.00
R8503:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R8504:Ccng2	UTSW	5	93273343	missense	probably benign	0.00
R8528:Ccng2	UTSW	5	93269305	missense	possibly damaging	0.60
R9010:Ccng2	UTSW	5	93268757	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TCCTGTGTAAGTAATACTTGGAGTG -3'
(R):5'- TTTCACTTCCGTCAAAGCAACC -3'

Sequencing Primer
(F):5'- GGAGTGTTATTTCAACCAGCAGTTCC -3'
(R):5'- GAACACTGTAGTAGCTGC -3'

Posted On

2019-06-26