Incidental Mutation 'R7195:Map4k4'
| ID |
559826 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Map4k4
|
| Ensembl Gene |
ENSMUSG00000026074 |
| Gene Name |
mitogen-activated protein kinase kinase kinase kinase 4 |
| Synonyms |
9430080K19Rik, Nik |
| MMRRC Submission |
045336-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7195 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
39900913-40026310 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 40019669 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 1008
(Y1008H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141862
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163854]
[ENSMUST00000168431]
[ENSMUST00000192509]
[ENSMUST00000193682]
[ENSMUST00000195259]
[ENSMUST00000195636]
[ENSMUST00000195860]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163854
AA Change: Y1075H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126961
Gene: ENSMUSG00000026074
AA Change: Y1075H
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000129796
Gene: ENSMUSG00000026074
AA Change: Y1025H
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000192509
AA Change: Y1021H
|
| SMART Domains |
Protein: ENSMUSP00000141665
Gene: ENSMUSG00000026074
AA Change: Y1021H
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
783 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
850 |
N/A |
INTRINSIC |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
CNH
|
916 |
1214 |
2.76e-127 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000193682
AA Change: Y1008H
PolyPhen 2
Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000141862
Gene: ENSMUSG00000026074
AA Change: Y1008H
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
556 |
567 |
N/A |
INTRINSIC |
|
low complexity region
|
590 |
616 |
N/A |
INTRINSIC |
|
low complexity region
|
623 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
680 |
706 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
814 |
N/A |
INTRINSIC |
|
low complexity region
|
824 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
862 |
N/A |
INTRINSIC |
|
CNH
|
903 |
1201 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000195259
AA Change: Y995H
|
| SMART Domains |
Protein: ENSMUSP00000142056
Gene: ENSMUSG00000026074
AA Change: Y995H
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
824 |
N/A |
INTRINSIC |
|
low complexity region
|
839 |
849 |
N/A |
INTRINSIC |
|
CNH
|
890 |
1188 |
2.76e-127 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000195636
AA Change: Y1059H
|
| SMART Domains |
Protein: ENSMUSP00000141613
Gene: ENSMUSG00000026074
AA Change: Y1059H
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
3.4e-97 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
836 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
875 |
888 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
913 |
N/A |
INTRINSIC |
|
CNH
|
954 |
1252 |
1.4e-129 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000195860
AA Change: Y1075H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000141400
Gene: ENSMUSG00000026074
AA Change: Y1075H
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
6.87e-95 |
SMART |
|
low complexity region
|
318 |
342 |
N/A |
INTRINSIC |
|
coiled coil region
|
357 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
503 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
747 |
N/A |
INTRINSIC |
|
low complexity region
|
754 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
891 |
904 |
N/A |
INTRINSIC |
|
low complexity region
|
919 |
929 |
N/A |
INTRINSIC |
|
CNH
|
970 |
1268 |
2.76e-127 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos around day E9.5-10.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930438A08Rik |
T |
C |
11: 58,288,416 |
|
probably null |
Het |
| 4930563D23Rik |
C |
T |
16: 92,321,149 |
V84M |
probably damaging |
Het |
| Abca2 |
A |
G |
2: 25,442,076 |
D1400G |
probably benign |
Het |
| Actl11 |
A |
T |
9: 107,928,870 |
K131* |
probably null |
Het |
| Adam39 |
A |
T |
8: 40,824,775 |
R68* |
probably null |
Het |
| Akap7 |
A |
T |
10: 25,271,507 |
N108K |
probably damaging |
Het |
| Arhgef10l |
C |
A |
4: 140,611,410 |
A14S |
probably benign |
Het |
| BC067074 |
A |
T |
13: 113,367,929 |
D1864V |
|
Het |
| Ccdc141 |
T |
G |
2: 77,049,583 |
N632T |
probably benign |
Het |
| Ccm2 |
T |
C |
11: 6,596,302 |
S435P |
probably damaging |
Het |
| Cd36 |
A |
G |
5: 17,814,189 |
L178P |
probably damaging |
Het |
| Cd7 |
T |
C |
11: 121,038,249 |
I59V |
probably benign |
Het |
| Cds2 |
T |
A |
2: 132,293,284 |
S32T |
probably benign |
Het |
| Cep19 |
A |
G |
16: 32,107,086 |
D104G |
probably damaging |
Het |
| Col1a2 |
C |
T |
6: 4,510,753 |
P68S |
unknown |
Het |
| Col20a1 |
A |
G |
2: 181,007,231 |
H1011R |
probably damaging |
Het |
| D7Ertd443e |
A |
G |
7: 134,295,122 |
V513A |
probably damaging |
Het |
| Egfr |
C |
T |
11: 16,868,162 |
P228L |
probably damaging |
Het |
| Fam78b |
A |
G |
1: 167,078,562 |
R97G |
probably damaging |
Het |
| Flt1 |
C |
T |
5: 147,603,576 |
V768M |
probably damaging |
Het |
| Gdap1l1 |
A |
T |
2: 163,446,130 |
N96Y |
probably damaging |
Het |
| Gm7168 |
T |
A |
17: 13,949,360 |
Y330N |
probably benign |
Het |
| Hnrnpul1 |
T |
C |
7: 25,724,778 |
N683S |
unknown |
Het |
| Ice2 |
C |
T |
9: 69,428,500 |
P922S |
possibly damaging |
Het |
| Iglv2 |
A |
G |
16: 19,260,510 |
V81A |
not run |
Het |
| Irs1 |
A |
G |
1: 82,287,456 |
I1013T |
probably benign |
Het |
| Itih4 |
T |
C |
14: 30,899,475 |
S832P |
probably damaging |
Het |
| Klhl1 |
A |
T |
14: 96,280,077 |
Y388N |
probably benign |
Het |
| Lrrc37a |
G |
A |
11: 103,457,775 |
S2698L |
unknown |
Het |
| Mdn1 |
G |
T |
4: 32,701,823 |
G1519W |
probably damaging |
Het |
| Mga |
T |
A |
2: 119,917,328 |
D653E |
probably damaging |
Het |
| Npas1 |
T |
C |
7: 16,474,808 |
E48G |
probably damaging |
Het |
| Nup188 |
G |
A |
2: 30,341,830 |
|
probably null |
Het |
| Olfr1215 |
G |
A |
2: 89,001,731 |
L186F |
|
Het |
| Olfr33 |
A |
G |
7: 102,713,666 |
V249A |
possibly damaging |
Het |
| Olfr399 |
T |
A |
11: 74,054,397 |
M121L |
probably damaging |
Het |
| Olfr404-ps1 |
G |
T |
11: 74,239,568 |
M1I |
probably null |
Het |
| Olfr544 |
A |
T |
7: 102,484,367 |
V251D |
probably damaging |
Het |
| Olfr871 |
A |
G |
9: 20,212,544 |
N65S |
probably damaging |
Het |
| Oxct1 |
T |
C |
15: 4,128,901 |
V439A |
probably damaging |
Het |
| Pcdhb22 |
G |
T |
18: 37,519,288 |
G13W |
probably damaging |
Het |
| Pex11g |
A |
G |
8: 3,459,237 |
V230A |
probably benign |
Het |
| Pop1 |
C |
T |
15: 34,510,379 |
S439L |
probably damaging |
Het |
| Ptpn9 |
T |
A |
9: 57,022,249 |
H83Q |
probably benign |
Het |
| Qrfp |
C |
T |
2: 31,808,692 |
R76H |
probably benign |
Het |
| Slc30a3 |
A |
G |
5: 31,088,795 |
V197A |
probably benign |
Het |
| Slc8a3 |
T |
C |
12: 81,314,273 |
N591D |
possibly damaging |
Het |
| Sp4 |
G |
T |
12: 118,300,072 |
Q80K |
possibly damaging |
Het |
| Spock1 |
C |
T |
13: 57,907,502 |
G29D |
possibly damaging |
Het |
| Sprr1a |
G |
T |
3: 92,484,367 |
P109Q |
probably damaging |
Het |
| Suz12 |
T |
A |
11: 80,013,483 |
F239L |
probably damaging |
Het |
| Tbx3 |
A |
G |
5: 119,675,583 |
Y248C |
probably damaging |
Het |
| Trabd2b |
T |
C |
4: 114,409,440 |
L217P |
probably damaging |
Het |
| Ubxn11 |
A |
C |
4: 134,126,415 |
I398L |
possibly damaging |
Het |
| Vmn1r173 |
T |
A |
7: 23,702,459 |
S40T |
probably damaging |
Het |
| Vmn2r2 |
T |
C |
3: 64,116,479 |
S894G |
probably benign |
Het |
| Vmn2r65 |
A |
G |
7: 84,943,139 |
|
probably null |
Het |
| Vps13c |
G |
A |
9: 67,945,825 |
G2400D |
possibly damaging |
Het |
| Vps8 |
T |
C |
16: 21,456,282 |
Y197H |
probably damaging |
Het |
| Wdr91 |
T |
C |
6: 34,889,274 |
N486D |
possibly damaging |
Het |
| Wwp1 |
A |
G |
4: 19,627,908 |
I695T |
possibly damaging |
Het |
| Zc3hc1 |
T |
C |
6: 30,382,548 |
D133G |
probably benign |
Het |
| Zcchc14 |
T |
C |
8: 121,608,461 |
I307V |
unknown |
Het |
| Zfp933 |
G |
A |
4: 147,826,179 |
T320I |
probably benign |
Het |
|
| Other mutations in Map4k4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00328:Map4k4
|
APN |
1 |
40,004,816 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL00417:Map4k4
|
APN |
1 |
40,014,532 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL00516:Map4k4
|
APN |
1 |
40,014,602 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01545:Map4k4
|
APN |
1 |
40,014,229 (GRCm38) |
splice site |
probably benign |
|
|
IGL02092:Map4k4
|
APN |
1 |
40,024,348 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02092:Map4k4
|
APN |
1 |
39,986,783 (GRCm38) |
missense |
probably benign |
0.12 |
|
IGL02570:Map4k4
|
APN |
1 |
39,980,579 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL02626:Map4k4
|
APN |
1 |
40,014,097 (GRCm38) |
splice site |
probably benign |
|
|
IGL02993:Map4k4
|
APN |
1 |
40,014,188 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03178:Map4k4
|
APN |
1 |
39,986,693 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
tank
|
UTSW |
1 |
40,004,864 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL02835:Map4k4
|
UTSW |
1 |
40,010,600 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0496:Map4k4
|
UTSW |
1 |
40,006,822 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0498:Map4k4
|
UTSW |
1 |
39,990,178 (GRCm38) |
missense |
probably benign |
0.22 |
|
R0588:Map4k4
|
UTSW |
1 |
40,004,864 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R0674:Map4k4
|
UTSW |
1 |
40,003,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1205:Map4k4
|
UTSW |
1 |
40,003,844 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1349:Map4k4
|
UTSW |
1 |
40,021,159 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1615:Map4k4
|
UTSW |
1 |
40,006,830 (GRCm38) |
splice site |
probably benign |
|
|
R1763:Map4k4
|
UTSW |
1 |
40,000,757 (GRCm38) |
splice site |
probably benign |
|
|
R1800:Map4k4
|
UTSW |
1 |
40,023,460 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1893:Map4k4
|
UTSW |
1 |
40,001,557 (GRCm38) |
missense |
probably benign |
0.08 |
|
R2411:Map4k4
|
UTSW |
1 |
40,007,496 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2851:Map4k4
|
UTSW |
1 |
40,000,755 (GRCm38) |
splice site |
probably benign |
|
|
R2852:Map4k4
|
UTSW |
1 |
40,000,755 (GRCm38) |
splice site |
probably benign |
|
|
R2987:Map4k4
|
UTSW |
1 |
39,986,765 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3087:Map4k4
|
UTSW |
1 |
40,021,082 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R3688:Map4k4
|
UTSW |
1 |
39,985,171 (GRCm38) |
splice site |
probably null |
|
|
R4075:Map4k4
|
UTSW |
1 |
40,023,462 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4304:Map4k4
|
UTSW |
1 |
39,973,972 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R4564:Map4k4
|
UTSW |
1 |
39,988,975 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4569:Map4k4
|
UTSW |
1 |
40,000,538 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4613:Map4k4
|
UTSW |
1 |
40,017,191 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4715:Map4k4
|
UTSW |
1 |
40,019,564 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4788:Map4k4
|
UTSW |
1 |
40,003,916 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4926:Map4k4
|
UTSW |
1 |
40,017,225 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4943:Map4k4
|
UTSW |
1 |
40,019,594 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5033:Map4k4
|
UTSW |
1 |
40,007,502 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5177:Map4k4
|
UTSW |
1 |
39,986,762 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5297:Map4k4
|
UTSW |
1 |
39,962,217 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5844:Map4k4
|
UTSW |
1 |
39,999,876 (GRCm38) |
splice site |
probably benign |
|
|
R5952:Map4k4
|
UTSW |
1 |
39,999,922 (GRCm38) |
unclassified |
probably benign |
|
|
R6111:Map4k4
|
UTSW |
1 |
40,011,662 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6125:Map4k4
|
UTSW |
1 |
40,003,965 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R6838:Map4k4
|
UTSW |
1 |
39,976,722 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6927:Map4k4
|
UTSW |
1 |
40,011,682 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7008:Map4k4
|
UTSW |
1 |
39,988,971 (GRCm38) |
missense |
probably benign |
0.44 |
|
R7164:Map4k4
|
UTSW |
1 |
39,973,972 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R7352:Map4k4
|
UTSW |
1 |
39,962,227 (GRCm38) |
missense |
unknown |
|
|
R7589:Map4k4
|
UTSW |
1 |
40,021,091 (GRCm38) |
nonsense |
probably null |
|
|
R7816:Map4k4
|
UTSW |
1 |
40,014,208 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R7869:Map4k4
|
UTSW |
1 |
39,974,044 (GRCm38) |
missense |
unknown |
|
|
R8013:Map4k4
|
UTSW |
1 |
39,962,212 (GRCm38) |
missense |
unknown |
|
|
R8145:Map4k4
|
UTSW |
1 |
40,000,534 (GRCm38) |
missense |
|
|
|
R8154:Map4k4
|
UTSW |
1 |
40,021,142 (GRCm38) |
nonsense |
probably null |
|
|
R8254:Map4k4
|
UTSW |
1 |
40,006,675 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8266:Map4k4
|
UTSW |
1 |
40,011,653 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R8375:Map4k4
|
UTSW |
1 |
40,024,641 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R8487:Map4k4
|
UTSW |
1 |
39,988,976 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8699:Map4k4
|
UTSW |
1 |
39,976,750 (GRCm38) |
missense |
unknown |
|
|
R8726:Map4k4
|
UTSW |
1 |
40,003,982 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8907:Map4k4
|
UTSW |
1 |
40,019,610 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8956:Map4k4
|
UTSW |
1 |
40,000,680 (GRCm38) |
missense |
probably benign |
0.11 |
|
R8963:Map4k4
|
UTSW |
1 |
40,000,580 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9091:Map4k4
|
UTSW |
1 |
40,003,763 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9234:Map4k4
|
UTSW |
1 |
39,990,101 (GRCm38) |
missense |
unknown |
|
|
R9270:Map4k4
|
UTSW |
1 |
40,003,763 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9438:Map4k4
|
UTSW |
1 |
40,006,792 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9689:Map4k4
|
UTSW |
1 |
40,019,562 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R9771:Map4k4
|
UTSW |
1 |
39,986,717 (GRCm38) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCTCAGAGGAAATGTGTCTAC -3'
(R):5'- TGAAGGACCTCCCAGCATAC -3'
Sequencing Primer
(F):5'- CAGAGGAAATGTGTCTACTGTTTTTG -3'
(R):5'- TACAATATCTACAAGCTGGAAAGGTG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation