Incidental Mutation 'R7196:Robo4'
| ID |
559941 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo4
|
| Ensembl Gene |
ENSMUSG00000032125 |
| Gene Name |
roundabout guidance receptor 4 |
| Synonyms |
Magic roundabout, 1200012D01Rik |
| MMRRC Submission |
045275-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.224)
|
| Stock # |
R7196 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
37313198-37325319 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 37314001 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 84
(M84K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150722
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102895]
[ENSMUST00000115046]
[ENSMUST00000115048]
[ENSMUST00000156972]
[ENSMUST00000214185]
|
| AlphaFold |
Q8C310 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102895
AA Change: M84K
PolyPhen 2
Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000099959
Gene: ENSMUSG00000032125
AA Change: M84K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
748 |
762 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
871 |
880 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000115046
AA Change: M84K
PolyPhen 2
Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000110698
Gene: ENSMUSG00000032125
AA Change: M84K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
484 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
540 |
546 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
756 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
834 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
925 |
N/A |
INTRINSIC |
|
low complexity region
|
930 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115048
|
| SMART Domains |
Protein: ENSMUSP00000110700
Gene: ENSMUSG00000032125
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
695 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
769 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
806 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
887 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000156972
AA Change: M84K
PolyPhen 2
Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000214185
AA Change: M84K
PolyPhen 2
Score 0.917 (Sensitivity: 0.81; Specificity: 0.94)
|
| Meta Mutation Damage Score |
0.1278 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.5%
|
| Validation Efficiency |
99% (94/95) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a reporter/null allele display enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and show increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
AGCTTCCCTGCTT |
AGCTT |
9: 57,165,505 (GRCm39) |
|
probably null |
Het |
| 4921504E06Rik |
A |
C |
2: 19,498,806 (GRCm39) |
S396A |
probably benign |
Het |
| Actr6 |
C |
A |
10: 89,550,784 (GRCm39) |
V337F |
possibly damaging |
Het |
| Agtpbp1 |
T |
C |
13: 59,680,994 (GRCm39) |
T73A |
possibly damaging |
Het |
| AI182371 |
A |
T |
2: 34,976,441 (GRCm39) |
|
probably null |
Het |
| Apob |
A |
G |
12: 8,033,893 (GRCm39) |
E202G |
possibly damaging |
Het |
| Asb4 |
A |
T |
6: 5,423,356 (GRCm39) |
M168L |
probably benign |
Het |
| AU018091 |
T |
C |
7: 3,213,788 (GRCm39) |
Y152C |
probably damaging |
Het |
| Casp3 |
G |
A |
8: 47,088,498 (GRCm39) |
G132R |
possibly damaging |
Het |
| Cbfa2t3 |
C |
A |
8: 123,365,729 (GRCm39) |
A229S |
probably benign |
Het |
| Cdh23 |
A |
T |
10: 60,143,759 (GRCm39) |
Y2949N |
probably damaging |
Het |
| Ceacam3 |
T |
C |
7: 16,888,881 (GRCm39) |
Y217H |
|
Het |
| Cldn5 |
A |
T |
16: 18,595,630 (GRCm39) |
|
probably benign |
Het |
| Cltc |
T |
C |
11: 86,597,657 (GRCm39) |
D1093G |
probably damaging |
Het |
| Cnn3 |
G |
A |
3: 121,248,437 (GRCm39) |
|
probably null |
Het |
| Col4a2 |
A |
G |
8: 11,448,693 (GRCm39) |
Y71C |
probably damaging |
Het |
| Csf1 |
T |
C |
3: 107,661,214 (GRCm39) |
D77G |
possibly damaging |
Het |
| Cyp2j7 |
T |
A |
4: 96,103,651 (GRCm39) |
T295S |
probably benign |
Het |
| Dnah7a |
A |
T |
1: 53,724,000 (GRCm39) |
M133K |
probably benign |
Het |
| Dock5 |
G |
A |
14: 67,993,919 (GRCm39) |
P1852L |
probably damaging |
Het |
| Dpysl3 |
T |
A |
18: 43,462,910 (GRCm39) |
D489V |
probably damaging |
Het |
| Dsg4 |
T |
C |
18: 20,599,537 (GRCm39) |
Y718H |
probably damaging |
Het |
| Dync2h1 |
G |
A |
9: 7,147,715 (GRCm39) |
Q972* |
probably null |
Het |
| Epn1 |
G |
A |
7: 5,096,380 (GRCm39) |
D225N |
possibly damaging |
Het |
| Esp4 |
A |
G |
17: 40,913,256 (GRCm39) |
E41G |
probably benign |
Het |
| Fam171a2 |
T |
C |
11: 102,329,172 (GRCm39) |
D529G |
probably benign |
Het |
| Fbxl13 |
A |
T |
5: 21,691,301 (GRCm39) |
I694N |
probably damaging |
Het |
| Fshr |
C |
T |
17: 89,292,897 (GRCm39) |
A594T |
probably damaging |
Het |
| Galnt3 |
A |
G |
2: 65,921,268 (GRCm39) |
Y533H |
probably damaging |
Het |
| Gja5 |
C |
A |
3: 96,958,422 (GRCm39) |
R160S |
probably damaging |
Het |
| Gm12353 |
A |
T |
4: 19,608,938 (GRCm39) |
D7V |
unknown |
Het |
| Gm17669 |
T |
C |
18: 67,695,572 (GRCm39) |
F39S |
probably damaging |
Het |
| Gm7145 |
T |
A |
1: 117,913,791 (GRCm39) |
N224K |
possibly damaging |
Het |
| Gpd1 |
G |
T |
15: 99,619,936 (GRCm39) |
G245C |
probably benign |
Het |
| Gpr4 |
G |
A |
7: 18,957,089 (GRCm39) |
G337D |
probably benign |
Het |
| Hgd |
G |
A |
16: 37,409,078 (GRCm39) |
C14Y |
probably benign |
Het |
| Ibtk |
A |
T |
9: 85,625,709 (GRCm39) |
S14T |
probably damaging |
Het |
| Ifi205 |
G |
T |
1: 173,854,109 (GRCm39) |
N181K |
probably damaging |
Het |
| Inppl1 |
G |
A |
7: 101,477,993 (GRCm39) |
A673V |
probably benign |
Het |
| Itgb3 |
C |
A |
11: 104,524,438 (GRCm39) |
Y191* |
probably null |
Het |
| Jrkl |
G |
T |
9: 13,244,162 (GRCm39) |
P500T |
probably benign |
Het |
| Kcnq1 |
G |
A |
7: 142,912,478 (GRCm39) |
V515I |
possibly damaging |
Het |
| Kifc3 |
A |
G |
8: 95,833,239 (GRCm39) |
V453A |
probably benign |
Het |
| Krt10 |
C |
T |
11: 99,278,371 (GRCm39) |
E263K |
probably damaging |
Het |
| Lingo1 |
A |
T |
9: 56,527,903 (GRCm39) |
F235I |
probably damaging |
Het |
| Lmo7 |
T |
A |
14: 102,133,936 (GRCm39) |
D660E |
possibly damaging |
Het |
| Magi3 |
A |
C |
3: 103,956,484 (GRCm39) |
C661W |
probably benign |
Het |
| Mmp1a |
C |
T |
9: 7,476,018 (GRCm39) |
Q428* |
probably null |
Het |
| Msrb1 |
A |
T |
17: 24,958,556 (GRCm39) |
T47S |
probably benign |
Het |
| Naip6 |
A |
T |
13: 100,436,666 (GRCm39) |
I619K |
probably benign |
Het |
| Ndfip2 |
T |
C |
14: 105,535,472 (GRCm39) |
S253P |
probably damaging |
Het |
| Nebl |
A |
T |
2: 17,457,329 (GRCm39) |
V77E |
probably damaging |
Het |
| Nit1 |
T |
C |
1: 171,172,003 (GRCm39) |
E65G |
probably benign |
Het |
| Ntn4 |
C |
T |
10: 93,569,576 (GRCm39) |
H430Y |
probably benign |
Het |
| Nxpe5 |
A |
T |
5: 138,237,586 (GRCm39) |
I49F |
probably benign |
Het |
| Or10a2 |
A |
G |
7: 106,673,935 (GRCm39) |
N300S |
probably benign |
Het |
| Or10c1 |
A |
G |
17: 37,522,084 (GRCm39) |
I220T |
probably damaging |
Het |
| Or14c46 |
A |
T |
7: 85,918,649 (GRCm39) |
M116K |
probably damaging |
Het |
| Or1e23 |
A |
G |
11: 73,407,957 (GRCm39) |
Y23H |
probably benign |
Het |
| Or1m1 |
A |
T |
9: 18,666,886 (GRCm39) |
L15* |
probably null |
Het |
| Or4k49 |
T |
G |
2: 111,495,042 (GRCm39) |
L157W |
probably damaging |
Het |
| Or52s6 |
A |
T |
7: 103,092,204 (GRCm39) |
M42K |
probably benign |
Het |
| Or7e178 |
A |
G |
9: 20,225,494 (GRCm39) |
Y241H |
probably benign |
Het |
| Oxct2a |
T |
A |
4: 123,217,165 (GRCm39) |
N72I |
probably damaging |
Het |
| Pappa |
G |
A |
4: 65,242,128 (GRCm39) |
|
probably null |
Het |
| Pcnx1 |
G |
A |
12: 82,042,312 (GRCm39) |
R34H |
possibly damaging |
Het |
| Plekha5 |
G |
T |
6: 140,489,648 (GRCm39) |
V236L |
possibly damaging |
Het |
| Prdm1 |
A |
G |
10: 44,332,988 (GRCm39) |
S44P |
probably benign |
Het |
| Prss46 |
T |
A |
9: 110,680,533 (GRCm39) |
L226Q |
probably benign |
Het |
| Prss47 |
C |
A |
13: 65,192,640 (GRCm39) |
W380C |
probably benign |
Het |
| Ptch2 |
T |
G |
4: 116,971,946 (GRCm39) |
V1156G |
probably benign |
Het |
| Rab3gap2 |
T |
C |
1: 185,013,864 (GRCm39) |
F1190S |
probably damaging |
Het |
| Raver2 |
T |
G |
4: 100,960,056 (GRCm39) |
Y179D |
probably damaging |
Het |
| Rgl2 |
C |
T |
17: 34,152,403 (GRCm39) |
R367W |
probably damaging |
Het |
| Ripor2 |
T |
G |
13: 24,888,808 (GRCm39) |
I629S |
possibly damaging |
Het |
| Rps6ka5 |
A |
T |
12: 100,562,123 (GRCm39) |
S252T |
possibly damaging |
Het |
| Rtl1 |
C |
T |
12: 109,559,221 (GRCm39) |
V873M |
possibly damaging |
Het |
| Sla |
T |
A |
15: 66,703,420 (GRCm39) |
R4W |
probably benign |
Het |
| Smco1 |
A |
G |
16: 32,092,620 (GRCm39) |
D97G |
probably damaging |
Het |
| Srgap1 |
T |
C |
10: 121,676,753 (GRCm39) |
T414A |
probably benign |
Het |
| Syt14 |
A |
G |
1: 192,717,936 (GRCm39) |
I3T |
probably benign |
Het |
| Tnpo2 |
G |
A |
8: 85,773,766 (GRCm39) |
V303M |
possibly damaging |
Het |
| Tstd2 |
A |
C |
4: 46,119,955 (GRCm39) |
S332R |
probably damaging |
Het |
| Ttn |
C |
A |
2: 76,582,386 (GRCm39) |
A22836S |
possibly damaging |
Het |
| Ufl1 |
A |
G |
4: 25,250,669 (GRCm39) |
V728A |
probably benign |
Het |
| Usp33 |
A |
T |
3: 152,089,828 (GRCm39) |
K789N |
possibly damaging |
Het |
| Usp54 |
T |
A |
14: 20,638,438 (GRCm39) |
Q214L |
probably damaging |
Het |
| Vmn2r7 |
T |
G |
3: 64,623,198 (GRCm39) |
N374T |
probably benign |
Het |
| Zbtb7a |
T |
A |
10: 80,980,434 (GRCm39) |
N209K |
probably damaging |
Het |
| Zc3hav1 |
A |
G |
6: 38,306,207 (GRCm39) |
V615A |
probably benign |
Het |
| Zdhhc20 |
A |
G |
14: 58,111,348 (GRCm39) |
|
probably null |
Het |
| Zfp90 |
G |
T |
8: 107,151,780 (GRCm39) |
V498L |
probably damaging |
Het |
|
| Other mutations in Robo4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Robo4
|
APN |
9 |
37,322,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Robo4
|
APN |
9 |
37,319,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00491:Robo4
|
APN |
9 |
37,317,231 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL00792:Robo4
|
APN |
9 |
37,319,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Robo4
|
APN |
9 |
37,317,296 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01287:Robo4
|
APN |
9 |
37,324,336 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02289:Robo4
|
APN |
9 |
37,319,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02486:Robo4
|
APN |
9 |
37,319,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02851:Robo4
|
APN |
9 |
37,324,678 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02898:Robo4
|
APN |
9 |
37,319,472 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02965:Robo4
|
APN |
9 |
37,321,765 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03071:Robo4
|
APN |
9 |
37,315,580 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Robo4
|
APN |
9 |
37,315,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Robo4
|
UTSW |
9 |
37,317,106 (GRCm39) |
intron |
probably benign |
|
|
PIT4305001:Robo4
|
UTSW |
9 |
37,322,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0068:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0416:Robo4
|
UTSW |
9 |
37,316,062 (GRCm39) |
splice site |
probably benign |
|
|
R1005:Robo4
|
UTSW |
9 |
37,319,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Robo4
|
UTSW |
9 |
37,324,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1183:Robo4
|
UTSW |
9 |
37,319,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1254:Robo4
|
UTSW |
9 |
37,322,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1398:Robo4
|
UTSW |
9 |
37,319,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1505:Robo4
|
UTSW |
9 |
37,314,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Robo4
|
UTSW |
9 |
37,314,739 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1834:Robo4
|
UTSW |
9 |
37,324,355 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1899:Robo4
|
UTSW |
9 |
37,315,366 (GRCm39) |
splice site |
probably benign |
|
|
R2203:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2204:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2351:Robo4
|
UTSW |
9 |
37,322,956 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2448:Robo4
|
UTSW |
9 |
37,313,958 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2847:Robo4
|
UTSW |
9 |
37,315,772 (GRCm39) |
nonsense |
probably null |
|
|
R2851:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2852:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2877:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3123:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3124:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3125:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3805:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3806:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3892:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3905:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R3938:Robo4
|
UTSW |
9 |
37,313,313 (GRCm39) |
start gained |
probably benign |
|
|
R4261:Robo4
|
UTSW |
9 |
37,316,877 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4434:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4435:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4561:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4562:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4568:Robo4
|
UTSW |
9 |
37,316,118 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4695:Robo4
|
UTSW |
9 |
37,314,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Robo4
|
UTSW |
9 |
37,313,856 (GRCm39) |
missense |
probably benign |
|
|
R5000:Robo4
|
UTSW |
9 |
37,319,664 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5056:Robo4
|
UTSW |
9 |
37,316,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5125:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5279:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5285:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5347:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5348:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5361:Robo4
|
UTSW |
9 |
37,324,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5403:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5404:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5488:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5489:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5490:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5494:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5629:Robo4
|
UTSW |
9 |
37,319,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5736:Robo4
|
UTSW |
9 |
37,316,093 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5796:Robo4
|
UTSW |
9 |
37,322,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5987:Robo4
|
UTSW |
9 |
37,322,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6178:Robo4
|
UTSW |
9 |
37,316,926 (GRCm39) |
nonsense |
probably null |
|
|
R6189:Robo4
|
UTSW |
9 |
37,314,829 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6365:Robo4
|
UTSW |
9 |
37,322,008 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6528:Robo4
|
UTSW |
9 |
37,315,664 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6887:Robo4
|
UTSW |
9 |
37,313,363 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7408:Robo4
|
UTSW |
9 |
37,322,277 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7419:Robo4
|
UTSW |
9 |
37,314,105 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7486:Robo4
|
UTSW |
9 |
37,316,870 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7707:Robo4
|
UTSW |
9 |
37,324,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7839:Robo4
|
UTSW |
9 |
37,322,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8079:Robo4
|
UTSW |
9 |
37,313,931 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8081:Robo4
|
UTSW |
9 |
37,316,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8280:Robo4
|
UTSW |
9 |
37,315,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R8547:Robo4
|
UTSW |
9 |
37,315,674 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8735:Robo4
|
UTSW |
9 |
37,319,577 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8836:Robo4
|
UTSW |
9 |
37,317,130 (GRCm39) |
missense |
unknown |
|
|
R8889:Robo4
|
UTSW |
9 |
37,314,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Robo4
|
UTSW |
9 |
37,315,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Robo4
|
UTSW |
9 |
37,313,206 (GRCm39) |
start gained |
probably benign |
|
|
R9375:Robo4
|
UTSW |
9 |
37,316,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9621:Robo4
|
UTSW |
9 |
37,317,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGTACAGGAGTCTCTCTTTCC -3'
(R):5'- AGCATCTCAGCCTAACTCTGC -3'
Sequencing Primer
(F):5'- AGGAGTCTCTCTTTCCCTCTTAGGAG -3'
(R):5'- AACTCTGCTTCCCCCTGGG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation