Incidental Mutation 'R7197:Vmn2r67'
ID |
560017 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r67
|
Ensembl Gene |
ENSMUSG00000095664 |
Gene Name |
vomeronasal 2, receptor 67 |
Synonyms |
EG620672 |
MMRRC Submission |
045276-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.114)
|
Stock # |
R7197 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
84785448-84805110 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 84785774 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Isoleucine
at position 744
(V744I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126007
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168730]
|
AlphaFold |
K7N6T2 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168730
AA Change: V744I
PolyPhen 2
Score 0.775 (Sensitivity: 0.85; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000126007 Gene: ENSMUSG00000095664 AA Change: V744I
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
464 |
2.1e-31 |
PFAM |
Pfam:NCD3G
|
507 |
559 |
4.8e-19 |
PFAM |
Pfam:7tm_3
|
590 |
827 |
1.4e-53 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
Validation Efficiency |
97% (77/79) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 77 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700017B05Rik |
AGCTTCCCTGCTT |
AGCTT |
9: 57,165,505 (GRCm39) |
|
probably null |
Het |
Aars2 |
T |
C |
17: 45,819,885 (GRCm39) |
Y221H |
probably damaging |
Het |
Abca8b |
G |
A |
11: 109,836,648 (GRCm39) |
R1216* |
probably null |
Het |
Acad8 |
A |
T |
9: 26,888,967 (GRCm39) |
|
probably null |
Het |
Acer2 |
A |
G |
4: 86,805,287 (GRCm39) |
T84A |
probably null |
Het |
Adgrb2 |
A |
G |
4: 129,903,315 (GRCm39) |
N613S |
probably damaging |
Het |
Arap2 |
T |
C |
5: 62,798,729 (GRCm39) |
D1300G |
possibly damaging |
Het |
Castor1 |
T |
C |
11: 4,168,949 (GRCm39) |
C39R |
probably damaging |
Het |
Ccl11 |
A |
T |
11: 81,948,665 (GRCm39) |
|
probably benign |
Het |
Cfh |
A |
T |
1: 140,016,505 (GRCm39) |
Y1151* |
probably null |
Het |
Cobll1 |
A |
G |
2: 64,928,882 (GRCm39) |
S815P |
probably benign |
Het |
Cryz |
T |
C |
3: 154,327,205 (GRCm39) |
S240P |
probably damaging |
Het |
Csmd2 |
A |
G |
4: 128,404,826 (GRCm39) |
Y2404C |
|
Het |
F13a1 |
T |
C |
13: 37,100,860 (GRCm39) |
D428G |
probably damaging |
Het |
Fbxo42 |
A |
G |
4: 140,927,396 (GRCm39) |
S559G |
probably benign |
Het |
Fry |
A |
G |
5: 150,393,232 (GRCm39) |
S263G |
|
Het |
Fshr |
C |
T |
17: 89,292,897 (GRCm39) |
A594T |
probably damaging |
Het |
Gm1527 |
A |
G |
3: 28,980,690 (GRCm39) |
M597V |
probably null |
Het |
Gpr158 |
A |
T |
2: 21,815,412 (GRCm39) |
T602S |
probably damaging |
Het |
Hmgxb4 |
C |
A |
8: 75,756,624 (GRCm39) |
T583K |
probably damaging |
Het |
Igkv8-30 |
C |
T |
6: 70,094,069 (GRCm39) |
C114Y |
probably damaging |
Het |
Igsf5 |
T |
A |
16: 96,204,546 (GRCm39) |
N366K |
probably damaging |
Het |
Kif15 |
T |
C |
9: 122,838,991 (GRCm39) |
|
probably null |
Het |
Klk1b26 |
T |
A |
7: 43,665,821 (GRCm39) |
|
probably null |
Het |
Lama1 |
G |
T |
17: 68,044,700 (GRCm39) |
E200* |
probably null |
Het |
Lpar5 |
C |
T |
6: 125,059,347 (GRCm39) |
T356I |
probably benign |
Het |
Lrch3 |
A |
T |
16: 32,810,665 (GRCm39) |
T538S |
probably damaging |
Het |
Mansc4 |
A |
G |
6: 146,977,203 (GRCm39) |
S138P |
probably damaging |
Het |
Mief1 |
T |
C |
15: 80,134,061 (GRCm39) |
S373P |
possibly damaging |
Het |
Nbas |
G |
T |
12: 13,570,751 (GRCm39) |
V2053F |
possibly damaging |
Het |
Nek11 |
T |
C |
9: 105,121,614 (GRCm39) |
E435G |
probably damaging |
Het |
Nynrin |
A |
T |
14: 56,109,380 (GRCm39) |
I1496F |
probably benign |
Het |
Odf1 |
A |
T |
15: 38,219,794 (GRCm39) |
M41L |
probably benign |
Het |
Or10a5 |
A |
G |
7: 106,635,364 (GRCm39) |
M8V |
probably benign |
Het |
Or4c115 |
A |
G |
2: 88,927,626 (GRCm39) |
V215A |
probably benign |
Het |
Or4c29 |
A |
T |
2: 88,740,708 (GRCm39) |
F10I |
probably benign |
Het |
Or7h8 |
T |
G |
9: 20,123,851 (GRCm39) |
S69A |
probably benign |
Het |
Oxnad1 |
T |
C |
14: 31,818,473 (GRCm39) |
V106A |
possibly damaging |
Het |
Padi4 |
C |
A |
4: 140,488,969 (GRCm39) |
E157* |
probably null |
Het |
Parp10 |
A |
T |
15: 76,126,616 (GRCm39) |
F217L |
probably damaging |
Het |
Pcdhb18 |
T |
A |
18: 37,623,436 (GRCm39) |
S255R |
probably benign |
Het |
Pde4c |
G |
T |
8: 71,197,978 (GRCm39) |
G102W |
probably damaging |
Het |
Pde6a |
T |
C |
18: 61,391,295 (GRCm39) |
Y547H |
probably damaging |
Het |
Phf11b |
A |
T |
14: 59,563,507 (GRCm39) |
L137I |
probably benign |
Het |
Pigh |
A |
C |
12: 79,130,463 (GRCm39) |
I134S |
probably damaging |
Het |
Pigt |
G |
A |
2: 164,344,436 (GRCm39) |
V362M |
probably damaging |
Het |
Pld1 |
A |
G |
3: 28,078,401 (GRCm39) |
D20G |
probably damaging |
Het |
Pou3f2 |
T |
C |
4: 22,487,288 (GRCm39) |
R282G |
probably damaging |
Het |
Ppp2r5d |
A |
G |
17: 46,996,527 (GRCm39) |
V382A |
probably damaging |
Het |
Prdm16 |
T |
C |
4: 154,425,967 (GRCm39) |
E606G |
probably damaging |
Het |
Psg28 |
A |
G |
7: 18,164,509 (GRCm39) |
Y68H |
probably damaging |
Het |
Qpctl |
C |
A |
7: 18,882,944 (GRCm39) |
W56L |
probably damaging |
Het |
Rab11fip5 |
G |
A |
6: 85,319,137 (GRCm39) |
P584L |
probably damaging |
Het |
Sde2 |
C |
T |
1: 180,678,843 (GRCm39) |
H36Y |
probably benign |
Het |
Sema4d |
T |
C |
13: 51,856,872 (GRCm39) |
S787G |
probably benign |
Het |
Sgca |
C |
T |
11: 94,864,014 (GRCm39) |
|
probably null |
Het |
Shroom3 |
A |
G |
5: 93,090,463 (GRCm39) |
E1071G |
probably damaging |
Het |
Skint5 |
A |
G |
4: 113,437,679 (GRCm39) |
|
probably null |
Het |
Slc44a3 |
T |
A |
3: 121,319,411 (GRCm39) |
D110V |
probably benign |
Het |
Slc4a4 |
A |
C |
5: 89,082,433 (GRCm39) |
|
probably benign |
Het |
Slc4a8 |
A |
G |
15: 100,688,857 (GRCm39) |
D389G |
probably damaging |
Het |
Sp3 |
C |
G |
2: 72,809,953 (GRCm39) |
E11Q |
probably benign |
Het |
Srrm2 |
A |
G |
17: 24,037,198 (GRCm39) |
S1281G |
unknown |
Het |
Tat |
A |
T |
8: 110,723,459 (GRCm39) |
I316F |
probably benign |
Het |
Thoc5 |
A |
G |
11: 4,865,563 (GRCm39) |
T381A |
probably benign |
Het |
Tiam1 |
T |
C |
16: 89,681,826 (GRCm39) |
Y384C |
probably damaging |
Het |
Tmem45a |
A |
T |
16: 56,632,026 (GRCm39) |
F197L |
probably damaging |
Het |
Trav8d-1 |
A |
G |
14: 53,016,435 (GRCm39) |
Y107C |
probably damaging |
Het |
Trim10 |
T |
A |
17: 37,187,846 (GRCm39) |
V354D |
probably damaging |
Het |
Unc45b |
A |
T |
11: 82,831,013 (GRCm39) |
|
probably null |
Het |
Unc79 |
A |
G |
12: 103,078,765 (GRCm39) |
I1643M |
probably benign |
Het |
Unc80 |
G |
T |
1: 66,560,725 (GRCm39) |
G818* |
probably null |
Het |
Usp15 |
A |
T |
10: 122,966,910 (GRCm39) |
M470K |
possibly damaging |
Het |
Vldlr |
T |
C |
19: 27,212,241 (GRCm39) |
V85A |
probably benign |
Het |
Vma21-ps |
A |
G |
4: 52,496,994 (GRCm39) |
V84A |
probably benign |
Het |
Wdr73 |
A |
G |
7: 80,542,946 (GRCm39) |
C221R |
probably benign |
Het |
Zxdc |
C |
T |
6: 90,355,819 (GRCm39) |
H443Y |
probably damaging |
Het |
|
Other mutations in Vmn2r67 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00096:Vmn2r67
|
APN |
7 |
84,801,138 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01346:Vmn2r67
|
APN |
7 |
84,786,127 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01373:Vmn2r67
|
APN |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
IGL01674:Vmn2r67
|
APN |
7 |
84,785,651 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01978:Vmn2r67
|
APN |
7 |
84,800,649 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02013:Vmn2r67
|
APN |
7 |
84,800,863 (GRCm39) |
missense |
probably benign |
0.09 |
IGL02115:Vmn2r67
|
APN |
7 |
84,800,787 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02250:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
IGL02252:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
IGL02328:Vmn2r67
|
APN |
7 |
84,799,898 (GRCm39) |
missense |
probably benign |
0.41 |
IGL02740:Vmn2r67
|
APN |
7 |
84,785,818 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02940:Vmn2r67
|
APN |
7 |
84,785,951 (GRCm39) |
missense |
probably benign |
0.07 |
IGL03237:Vmn2r67
|
APN |
7 |
84,799,118 (GRCm39) |
missense |
probably damaging |
1.00 |
R0512:Vmn2r67
|
UTSW |
7 |
84,799,900 (GRCm39) |
missense |
probably damaging |
1.00 |
R1029:Vmn2r67
|
UTSW |
7 |
84,785,974 (GRCm39) |
missense |
probably damaging |
1.00 |
R1193:Vmn2r67
|
UTSW |
7 |
84,800,653 (GRCm39) |
missense |
probably damaging |
0.98 |
R1282:Vmn2r67
|
UTSW |
7 |
84,785,932 (GRCm39) |
missense |
probably benign |
|
R1416:Vmn2r67
|
UTSW |
7 |
84,800,824 (GRCm39) |
missense |
probably benign |
0.06 |
R1429:Vmn2r67
|
UTSW |
7 |
84,802,031 (GRCm39) |
missense |
possibly damaging |
0.65 |
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
R1970:Vmn2r67
|
UTSW |
7 |
84,801,013 (GRCm39) |
missense |
probably benign |
|
R2229:Vmn2r67
|
UTSW |
7 |
84,801,250 (GRCm39) |
missense |
probably benign |
0.21 |
R2246:Vmn2r67
|
UTSW |
7 |
84,785,764 (GRCm39) |
missense |
probably damaging |
1.00 |
R2262:Vmn2r67
|
UTSW |
7 |
84,786,182 (GRCm39) |
missense |
probably damaging |
0.96 |
R2398:Vmn2r67
|
UTSW |
7 |
84,785,921 (GRCm39) |
missense |
probably damaging |
1.00 |
R4249:Vmn2r67
|
UTSW |
7 |
84,799,722 (GRCm39) |
splice site |
probably null |
|
R4666:Vmn2r67
|
UTSW |
7 |
84,799,831 (GRCm39) |
missense |
probably benign |
|
R4669:Vmn2r67
|
UTSW |
7 |
84,799,732 (GRCm39) |
missense |
probably benign |
0.11 |
R4966:Vmn2r67
|
UTSW |
7 |
84,785,593 (GRCm39) |
missense |
probably damaging |
1.00 |
R5264:Vmn2r67
|
UTSW |
7 |
84,801,453 (GRCm39) |
missense |
probably damaging |
1.00 |
R5296:Vmn2r67
|
UTSW |
7 |
84,786,230 (GRCm39) |
missense |
probably damaging |
1.00 |
R5327:Vmn2r67
|
UTSW |
7 |
84,785,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R5401:Vmn2r67
|
UTSW |
7 |
84,785,765 (GRCm39) |
missense |
probably damaging |
1.00 |
R5510:Vmn2r67
|
UTSW |
7 |
84,801,023 (GRCm39) |
missense |
probably benign |
0.39 |
R5574:Vmn2r67
|
UTSW |
7 |
84,801,099 (GRCm39) |
missense |
probably benign |
0.00 |
R5643:Vmn2r67
|
UTSW |
7 |
84,799,151 (GRCm39) |
nonsense |
probably null |
|
R5914:Vmn2r67
|
UTSW |
7 |
84,801,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R6248:Vmn2r67
|
UTSW |
7 |
84,799,768 (GRCm39) |
missense |
probably damaging |
0.99 |
R6291:Vmn2r67
|
UTSW |
7 |
84,799,142 (GRCm39) |
missense |
possibly damaging |
0.88 |
R6309:Vmn2r67
|
UTSW |
7 |
84,801,124 (GRCm39) |
missense |
probably benign |
|
R6442:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
possibly damaging |
0.82 |
R6665:Vmn2r67
|
UTSW |
7 |
84,785,900 (GRCm39) |
missense |
probably benign |
0.07 |
R6701:Vmn2r67
|
UTSW |
7 |
84,802,023 (GRCm39) |
missense |
probably damaging |
1.00 |
R6848:Vmn2r67
|
UTSW |
7 |
84,801,840 (GRCm39) |
missense |
probably benign |
0.00 |
R6852:Vmn2r67
|
UTSW |
7 |
84,801,361 (GRCm39) |
missense |
probably damaging |
0.99 |
R6991:Vmn2r67
|
UTSW |
7 |
84,804,953 (GRCm39) |
missense |
possibly damaging |
0.55 |
R7143:Vmn2r67
|
UTSW |
7 |
84,801,846 (GRCm39) |
missense |
probably benign |
|
R7393:Vmn2r67
|
UTSW |
7 |
84,805,086 (GRCm39) |
missense |
probably null |
0.87 |
R7420:Vmn2r67
|
UTSW |
7 |
84,785,944 (GRCm39) |
missense |
possibly damaging |
0.52 |
R7622:Vmn2r67
|
UTSW |
7 |
84,785,662 (GRCm39) |
missense |
probably damaging |
1.00 |
R7664:Vmn2r67
|
UTSW |
7 |
84,805,019 (GRCm39) |
missense |
probably benign |
0.21 |
R7665:Vmn2r67
|
UTSW |
7 |
84,801,196 (GRCm39) |
nonsense |
probably null |
|
R7896:Vmn2r67
|
UTSW |
7 |
84,785,920 (GRCm39) |
missense |
probably damaging |
1.00 |
R7913:Vmn2r67
|
UTSW |
7 |
84,801,036 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8026:Vmn2r67
|
UTSW |
7 |
84,785,924 (GRCm39) |
missense |
probably damaging |
1.00 |
R8114:Vmn2r67
|
UTSW |
7 |
84,805,097 (GRCm39) |
missense |
probably benign |
0.01 |
R8317:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
R8363:Vmn2r67
|
UTSW |
7 |
84,804,969 (GRCm39) |
missense |
probably benign |
0.00 |
R8421:Vmn2r67
|
UTSW |
7 |
84,785,893 (GRCm39) |
missense |
probably damaging |
0.98 |
R8444:Vmn2r67
|
UTSW |
7 |
84,785,854 (GRCm39) |
missense |
probably benign |
0.01 |
R8751:Vmn2r67
|
UTSW |
7 |
84,801,450 (GRCm39) |
missense |
probably benign |
0.01 |
R8810:Vmn2r67
|
UTSW |
7 |
84,786,346 (GRCm39) |
missense |
probably damaging |
1.00 |
R8811:Vmn2r67
|
UTSW |
7 |
84,799,895 (GRCm39) |
missense |
probably damaging |
0.98 |
R9215:Vmn2r67
|
UTSW |
7 |
84,802,008 (GRCm39) |
missense |
probably benign |
0.00 |
R9342:Vmn2r67
|
UTSW |
7 |
84,785,788 (GRCm39) |
missense |
probably benign |
0.00 |
R9433:Vmn2r67
|
UTSW |
7 |
84,804,917 (GRCm39) |
missense |
possibly damaging |
0.60 |
R9453:Vmn2r67
|
UTSW |
7 |
84,800,697 (GRCm39) |
missense |
probably benign |
0.32 |
R9471:Vmn2r67
|
UTSW |
7 |
84,799,723 (GRCm39) |
critical splice donor site |
probably null |
|
R9526:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
R9538:Vmn2r67
|
UTSW |
7 |
84,801,327 (GRCm39) |
missense |
|
|
R9544:Vmn2r67
|
UTSW |
7 |
84,786,317 (GRCm39) |
missense |
possibly damaging |
0.53 |
R9574:Vmn2r67
|
UTSW |
7 |
84,786,017 (GRCm39) |
missense |
probably benign |
0.00 |
R9599:Vmn2r67
|
UTSW |
7 |
84,804,941 (GRCm39) |
missense |
probably damaging |
0.96 |
R9768:Vmn2r67
|
UTSW |
7 |
84,802,037 (GRCm39) |
missense |
probably benign |
0.23 |
|
Predicted Primers |
PCR Primer
(F):5'- AACCATAGTCTTGCCTTTGGTG -3'
(R):5'- TGCCATTGCTTTCACTGTGG -3'
Sequencing Primer
(F):5'- CCTTTGGTGCTATGGTAGACAG -3'
(R):5'- AAGAATGAGGTGGCTGCTTC -3'
|
Posted On |
2019-06-26 |