Mutagenetix > Incidental Mutations

Incidental Mutation 'R7197:Olfr713'

560018

Institutional Source

Beutler Lab

Gene Symbol

Olfr713

Ensembl Gene

ENSMUSG00000073898

Gene Name

olfactory receptor 713

Synonyms

GA_x6K02T2PBJ9-9415724-9416677, MOR263-1, P3

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R7197 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

107031174-107040994 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 107036157 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 8 (M8V)

Ref Sequence

ENSEMBL: ENSMUSP00000095743 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098139] [ENSMUST00000213623]

Predicted Effect

probably benign
Transcript: ENSMUST00000098139
AA Change: M8V

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000095743
Gene: ENSMUSG00000073898
AA Change: M8V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	39	316	4.4e-57	PFAM
Pfam:7tm_1	49	298	2e-23	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000213623
AA Change: M1V

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

97% (77/79)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter allele exhibit abnormal olfactory sensory neuron projections. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	AGCTTCCCTGCTT	AGCTT	9: 57,258,222		probably null	Het
Aars2	T	C	17: 45,508,959	Y221H	probably damaging	Het
Abca8b	G	A	11: 109,945,822	R1216*	probably null	Het
Acad8	A	T	9: 26,977,671		probably null	Het
Acer2	A	G	4: 86,887,050	T84A	probably null	Het
Adgrb2	A	G	4: 130,009,522	N613S	probably damaging	Het
Arap2	T	C	5: 62,641,386	D1300G	possibly damaging	Het
Ccl11	A	T	11: 82,057,839		probably benign	Het
Cfh	A	T	1: 140,088,767	Y1151*	probably null	Het
Cobll1	A	G	2: 65,098,538	S815P	probably benign	Het
Cryz	T	C	3: 154,621,568	S240P	probably damaging	Het
Csmd2	A	G	4: 128,511,033	Y2404C		Het
F13a1	T	C	13: 36,916,886	D428G	probably damaging	Het
Fbxo42	A	G	4: 141,200,085	S559G	probably benign	Het
Fry	A	G	5: 150,469,767	S263G		Het
Fshr	C	T	17: 88,985,469	A594T	probably damaging	Het
Gatsl3	T	C	11: 4,218,949	C39R	probably damaging	Het
Gm1527	A	G	3: 28,926,541	M597V	probably null	Het
Gpr158	A	T	2: 21,810,601	T602S	probably damaging	Het
Hmgxb4	C	A	8: 75,029,996	T583K	probably damaging	Het
Igkv8-30	C	T	6: 70,117,085	C114Y	probably damaging	Het
Igsf5	T	A	16: 96,403,346	N366K	probably damaging	Het
Kif15	T	C	9: 123,009,926		probably null	Het
Klk1b26	T	A	7: 44,016,397		probably null	Het
Lama1	G	T	17: 67,737,705	E200*	probably null	Het
Lpar5	C	T	6: 125,082,384	T356I	probably benign	Het
Lrch3	A	T	16: 32,990,295	T538S	probably damaging	Het
Mansc4	A	G	6: 147,075,705	S138P	probably damaging	Het
Mief1	T	C	15: 80,249,860	S373P	possibly damaging	Het
Nbas	G	T	12: 13,520,750	V2053F	possibly damaging	Het
Nek11	T	C	9: 105,244,415	E435G	probably damaging	Het
Nynrin	A	T	14: 55,871,923	I1496F	probably benign	Het
Odf1	A	T	15: 38,219,550	M41L	probably benign	Het
Olfr1209	A	T	2: 88,910,364	F10I	probably benign	Het
Olfr1220	A	G	2: 89,097,282	V215A	probably benign	Het
Olfr871	T	G	9: 20,212,555	S69A	probably benign	Het
Oxnad1	T	C	14: 32,096,516	V106A	possibly damaging	Het
Padi4	C	A	4: 140,761,658	E157*	probably null	Het
Parp10	A	T	15: 76,242,416	F217L	probably damaging	Het
Pcdhb18	T	A	18: 37,490,383	S255R	probably benign	Het
Pde4c	G	T	8: 70,745,329	G102W	probably damaging	Het
Pde6a	T	C	18: 61,258,224	Y547H	probably damaging	Het
Phf11b	A	T	14: 59,326,058	L137I	probably benign	Het
Pigh	A	C	12: 79,083,689	I134S	probably damaging	Het
Pigt	G	A	2: 164,502,516	V362M	probably damaging	Het
Pld1	A	G	3: 28,024,252	D20G	probably damaging	Het
Pou3f2	T	C	4: 22,487,288	R282G	probably damaging	Het
Ppp2r5d	A	G	17: 46,685,601	V382A	probably damaging	Het
Prdm16	T	C	4: 154,341,510	E606G	probably damaging	Het
Psg28	A	G	7: 18,430,584	Y68H	probably damaging	Het
Qpctl	C	A	7: 19,149,019	W56L	probably damaging	Het
Rab11fip5	G	A	6: 85,342,155	P584L	probably damaging	Het
Sde2	C	T	1: 180,851,278	H36Y	probably benign	Het
Sema4d	T	C	13: 51,702,836	S787G	probably benign	Het
Sgca	C	T	11: 94,973,188		probably null	Het
Shroom3	A	G	5: 92,942,604	E1071G	probably damaging	Het
Skint5	A	G	4: 113,580,482		probably null	Het
Slc44a3	T	A	3: 121,525,762	D110V	probably benign	Het
Slc4a4	A	C	5: 88,934,574		probably benign	Het
Slc4a8	A	G	15: 100,790,976	D389G	probably damaging	Het
Sp3	C	G	2: 72,979,609	E11Q	probably benign	Het
Srrm2	A	G	17: 23,818,224	S1281G	unknown	Het
Tat	A	T	8: 109,996,827	I316F	probably benign	Het
Thoc5	A	G	11: 4,915,563	T381A	probably benign	Het
Tiam1	T	C	16: 89,884,938	Y384C	probably damaging	Het
Tmem45a	A	T	16: 56,811,663	F197L	probably damaging	Het
Trav8d-1	A	G	14: 52,778,978	Y107C	probably damaging	Het
Trim10	T	A	17: 36,876,954	V354D	probably damaging	Het
Unc45b	A	T	11: 82,940,187		probably null	Het
Unc79	A	G	12: 103,112,506	I1643M	probably benign	Het
Unc80	G	T	1: 66,521,566	G818*	probably null	Het
Usp15	A	T	10: 123,131,005	M470K	possibly damaging	Het
Vldlr	T	C	19: 27,234,841	V85A	probably benign	Het
Vma21-ps	A	G	4: 52,496,994	V84A	probably benign	Het
Vmn2r67	C	T	7: 85,136,566	V744I	possibly damaging	Het
Wdr73	A	G	7: 80,893,198	C221R	probably benign	Het
Zxdc	C	T	6: 90,378,837	H443Y	probably damaging	Het

Other mutations in Olfr713

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01324:Olfr713	APN	7	107036847	missense	probably damaging	0.99
IGL01630:Olfr713	APN	7	107037111	utr 3 prime	probably benign
IGL02539:Olfr713	APN	7	107036434	missense	probably damaging	1.00
IGL02727:Olfr713	APN	7	107036695	missense	probably damaging	1.00
IGL03336:Olfr713	APN	7	107036335	missense	probably damaging	1.00
R0501:Olfr713	UTSW	7	107036232	missense	probably benign
R0684:Olfr713	UTSW	7	107036682	missense	probably damaging	1.00
R0909:Olfr713	UTSW	7	107036194	missense	probably benign	0.19
R1481:Olfr713	UTSW	7	107036149	missense	probably benign	0.05
R1958:Olfr713	UTSW	7	107036271	missense	possibly damaging	0.77
R1965:Olfr713	UTSW	7	107036358	missense	probably damaging	1.00
R2119:Olfr713	UTSW	7	107036731	missense	probably damaging	1.00
R2149:Olfr713	UTSW	7	107036338	missense	possibly damaging	0.68
R3012:Olfr713	UTSW	7	107036362	missense	possibly damaging	0.79
R3428:Olfr713	UTSW	7	107036716	missense	probably benign
R4425:Olfr713	UTSW	7	107036491	missense	probably damaging	1.00
R4795:Olfr713	UTSW	7	107036914	missense	probably benign	0.00
R4796:Olfr713	UTSW	7	107036914	missense	probably benign	0.00
R4908:Olfr713	UTSW	7	107036157	start codon destroyed	probably benign	0.02
R4945:Olfr713	UTSW	7	107036319	missense	probably benign	0.00
R5122:Olfr713	UTSW	7	107036848	nonsense	probably null
R5721:Olfr713	UTSW	7	107036358	missense	probably damaging	1.00
R5979:Olfr713	UTSW	7	107036336	missense	probably damaging	1.00
R6739:Olfr713	UTSW	7	107036811	missense	probably damaging	1.00
R6981:Olfr713	UTSW	7	107036749	missense	possibly damaging	0.77
R7228:Olfr713	UTSW	7	107037100	missense	probably benign
R7444:Olfr713	UTSW	7	107036347	missense	probably damaging	1.00
R8830:Olfr713	UTSW	7	107036682	missense	probably benign	0.28

Predicted Primers

PCR Primer
(F):5'- CGCTGGCTTTATGACTTCGC -3'
(R):5'- GAAATACATGGGGCTTTGCAGC -3'

Sequencing Primer
(F):5'- CCATTAGATATGACCGTGCCGTTAG -3'
(R):5'- CTTTGCAGCATGGGGTCAGC -3'

Posted On

2019-06-26