Incidental Mutation 'R7198:Zscan4-ps1'
ID 560076
Institutional Source Beutler Lab
Gene Symbol Zscan4-ps1
Ensembl Gene ENSMUSG00000110103
Gene Name zinc finger and SCAN domain containing 4, pseudogene 1
Synonyms EG545912
MMRRC Submission 045337-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.271) question?
Stock # R7198 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 10799066-10803618 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 10799626 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Methionine at position 421 (K421M)
Ref Sequence ENSEMBL: ENSMUSP00000131258 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165848]
AlphaFold A0A1C7CYV3
Predicted Effect probably damaging
Transcript: ENSMUST00000165848
AA Change: K421M

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000131258
Gene: ENSMUSG00000110103
AA Change: K421M

DomainStartEndE-ValueType
Pfam:SCAN 43 122 1.3e-17 PFAM
low complexity region 181 197 N/A INTRINSIC
ZnF_C2H2 395 417 5.14e-3 SMART
ZnF_C2H2 424 446 7.68e0 SMART
ZnF_C2H2 452 474 4.17e-3 SMART
ZnF_C2H2 480 503 3.83e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a C T 11: 109,969,481 (GRCm39) S365N probably damaging Het
Baiap3 G A 17: 25,462,814 (GRCm39) R1075C probably benign Het
Baz2b A G 2: 59,792,550 (GRCm39) L526P probably benign Het
Bbs1 A T 19: 4,945,043 (GRCm39) L376Q probably damaging Het
Bcl9 T A 3: 97,112,511 (GRCm39) M1315L possibly damaging Het
Bcl9 T C 3: 97,116,183 (GRCm39) Q837R probably damaging Het
Cct2 A G 10: 116,889,029 (GRCm39) V490A probably benign Het
Cdh23 T C 10: 60,148,378 (GRCm39) Y2663C possibly damaging Het
Chit1 A G 1: 134,078,229 (GRCm39) K346E possibly damaging Het
Chl1 A G 6: 103,683,517 (GRCm39) Y781C probably damaging Het
Col12a1 A C 9: 79,557,314 (GRCm39) L1938R possibly damaging Het
Cpxm2 T A 7: 131,681,813 (GRCm39) N239Y probably damaging Het
Cyp3a41b A G 5: 145,519,330 (GRCm39) Y54H probably benign Het
Dclk1 A C 3: 55,385,296 (GRCm39) D369A possibly damaging Het
Dnai4 A G 4: 102,919,610 (GRCm39) V498A probably damaging Het
Dpy19l3 T C 7: 35,449,190 (GRCm39) N71S possibly damaging Het
Efcab3 T A 11: 104,642,711 (GRCm39) N1111K probably benign Het
Fer T A 17: 64,228,683 (GRCm39) V186E possibly damaging Het
Gm11042 T A 12: 74,361,888 (GRCm39) H39L unknown Het
Gm14325 A G 2: 177,473,798 (GRCm39) I428T probably benign Het
Gm47995 A G 1: 151,074,404 (GRCm39) E69G possibly damaging Het
Gm6176 T A 7: 21,750,596 (GRCm39) I112F probably damaging Het
Hivep2 T A 10: 14,005,710 (GRCm39) D769E probably benign Het
Hsdl1 C T 8: 120,294,607 (GRCm39) V40I probably benign Het
Ipmk A G 10: 71,183,882 (GRCm39) H34R probably damaging Het
Kcnd3 T C 3: 105,366,856 (GRCm39) L242P probably damaging Het
Kdm4d T C 9: 14,375,316 (GRCm39) M181V probably damaging Het
Lats2 A T 14: 57,934,582 (GRCm39) I716N probably damaging Het
Liph T C 16: 21,784,772 (GRCm39) Y305C probably damaging Het
Ltbp1 T C 17: 75,533,962 (GRCm39) V150A possibly damaging Het
Ly6d A T 15: 74,634,384 (GRCm39) S69T probably benign Het
Meltf A G 16: 31,702,617 (GRCm39) R115G possibly damaging Het
Msgn1 G T 12: 11,258,902 (GRCm39) D16E probably benign Het
Mthfd2l T A 5: 91,094,705 (GRCm39) I58K probably damaging Het
Mup18 G C 4: 61,591,573 (GRCm39) probably null Het
Nek10 T A 14: 14,850,947 (GRCm38) W331R probably damaging Het
Nphp3 A G 9: 103,881,974 (GRCm39) Y148C probably damaging Het
Or4a47 T C 2: 89,666,076 (GRCm39) Y71C probably damaging Het
Or5h19 C T 16: 58,856,456 (GRCm39) V215I probably benign Het
Or6c33 T A 10: 129,853,760 (GRCm39) C177S probably damaging Het
Oscp1 A G 4: 125,980,459 (GRCm39) T325A possibly damaging Het
Pcdha4 T A 18: 37,086,613 (GRCm39) N265K probably damaging Het
Pigq C T 17: 26,153,199 (GRCm39) V331I probably benign Het
Plekhg4 A G 8: 106,105,329 (GRCm39) E598G probably damaging Het
Pou6f2 G A 13: 18,303,748 (GRCm39) T120M probably damaging Het
Psg27 T A 7: 18,295,726 (GRCm39) T240S probably damaging Het
Samd12 T A 15: 53,723,649 (GRCm39) I15F probably damaging Het
Scaf4 A T 16: 90,049,318 (GRCm39) D256E unknown Het
Scaf8 T A 17: 3,213,373 (GRCm39) M154K unknown Het
Slc27a1 T C 8: 72,032,071 (GRCm39) V64A possibly damaging Het
Smc5 G A 19: 23,237,064 (GRCm39) R256* probably null Het
Snx31 A G 15: 36,555,455 (GRCm39) F31L probably benign Het
Spag17 T C 3: 100,002,888 (GRCm39) S1871P probably benign Het
Tdpoz4 T G 3: 93,704,662 (GRCm39) S320A probably benign Het
Tmprss11c A T 5: 86,379,691 (GRCm39) C406S probably damaging Het
Tnip1 G A 11: 54,808,630 (GRCm39) A519V probably benign Het
Tssc4 T A 7: 142,624,724 (GRCm39) probably null Het
Uba3 A T 6: 97,182,512 (GRCm39) M1K probably null Het
Usp32 GAACAAGTCCACAACAA GAACAA 11: 84,913,681 (GRCm39) probably null Het
Wnt11 T C 7: 98,496,588 (GRCm39) M176T possibly damaging Het
Wrn C T 8: 33,814,346 (GRCm39) G366D probably benign Het
Xylt1 T A 7: 117,255,807 (GRCm39) I793N probably damaging Het
Zfp677 T G 17: 21,618,679 (GRCm39) C579G probably damaging Het
Other mutations in Zscan4-ps1
AlleleSourceChrCoordTypePredicted EffectPPH Score
G1patch:Zscan4-ps1 UTSW 7 10,799,906 (GRCm39) missense probably benign 0.13
R6135:Zscan4-ps1 UTSW 7 10,799,913 (GRCm39) missense probably benign
R6258:Zscan4-ps1 UTSW 7 10,799,829 (GRCm39) missense probably benign 0.00
R6377:Zscan4-ps1 UTSW 7 10,802,418 (GRCm39) splice site probably null
R6601:Zscan4-ps1 UTSW 7 10,802,761 (GRCm39) missense probably benign 0.03
R6725:Zscan4-ps1 UTSW 7 10,799,906 (GRCm39) missense probably benign 0.13
R7850:Zscan4-ps1 UTSW 7 10,799,735 (GRCm39) missense probably benign
R8427:Zscan4-ps1 UTSW 7 10,802,447 (GRCm39) missense possibly damaging 0.93
R8966:Zscan4-ps1 UTSW 7 10,800,250 (GRCm39) missense probably benign 0.00
R9098:Zscan4-ps1 UTSW 7 10,799,495 (GRCm39) missense probably damaging 0.99
R9281:Zscan4-ps1 UTSW 7 10,799,589 (GRCm39) missense possibly damaging 0.77
R9378:Zscan4-ps1 UTSW 7 10,800,192 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GGGAACAGACATAAGGCATTTCTC -3'
(R):5'- AAAGACCCTAGGGAGGTACC -3'

Sequencing Primer
(F):5'- CAGACATAAGGCATTTCTCCTGTGTG -3'
(R):5'- CAAGAGGAGCCTATCTCTGATCCTG -3'
Posted On 2019-06-26