Incidental Mutation 'R7198:Smc5'
ID 560118
Institutional Source Beutler Lab
Gene Symbol Smc5
Ensembl Gene ENSMUSG00000024943
Gene Name structural maintenance of chromosomes 5
Synonyms Smc5l1
MMRRC Submission 045337-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7198 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 23183815-23251261 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 23237064 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 256 (R256*)
Ref Sequence ENSEMBL: ENSMUSP00000084837 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087556] [ENSMUST00000223934] [ENSMUST00000226111]
AlphaFold Q8CG46
Predicted Effect probably null
Transcript: ENSMUST00000087556
AA Change: R256*
SMART Domains Protein: ENSMUSP00000084837
Gene: ENSMUSG00000024943
AA Change: R256*

DomainStartEndE-ValueType
Pfam:SMC_N 52 1057 9.2e-19 PFAM
Pfam:AAA_23 55 456 1.2e-9 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000223934
AA Change: R256*
Predicted Effect probably null
Transcript: ENSMUST00000226111
AA Change: R180*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 98% (62/63)
MGI Phenotype PHENOTYPE: Homozygous knockout in embryonic stem cells causes abnormal mitosis, increased apoptosis and a shift from pluripotency to differentiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a C T 11: 109,969,481 (GRCm39) S365N probably damaging Het
Baiap3 G A 17: 25,462,814 (GRCm39) R1075C probably benign Het
Baz2b A G 2: 59,792,550 (GRCm39) L526P probably benign Het
Bbs1 A T 19: 4,945,043 (GRCm39) L376Q probably damaging Het
Bcl9 T A 3: 97,112,511 (GRCm39) M1315L possibly damaging Het
Bcl9 T C 3: 97,116,183 (GRCm39) Q837R probably damaging Het
Cct2 A G 10: 116,889,029 (GRCm39) V490A probably benign Het
Cdh23 T C 10: 60,148,378 (GRCm39) Y2663C possibly damaging Het
Chit1 A G 1: 134,078,229 (GRCm39) K346E possibly damaging Het
Chl1 A G 6: 103,683,517 (GRCm39) Y781C probably damaging Het
Col12a1 A C 9: 79,557,314 (GRCm39) L1938R possibly damaging Het
Cpxm2 T A 7: 131,681,813 (GRCm39) N239Y probably damaging Het
Cyp3a41b A G 5: 145,519,330 (GRCm39) Y54H probably benign Het
Dclk1 A C 3: 55,385,296 (GRCm39) D369A possibly damaging Het
Dnai4 A G 4: 102,919,610 (GRCm39) V498A probably damaging Het
Dpy19l3 T C 7: 35,449,190 (GRCm39) N71S possibly damaging Het
Efcab3 T A 11: 104,642,711 (GRCm39) N1111K probably benign Het
Fer T A 17: 64,228,683 (GRCm39) V186E possibly damaging Het
Gm11042 T A 12: 74,361,888 (GRCm39) H39L unknown Het
Gm14325 A G 2: 177,473,798 (GRCm39) I428T probably benign Het
Gm47995 A G 1: 151,074,404 (GRCm39) E69G possibly damaging Het
Gm6176 T A 7: 21,750,596 (GRCm39) I112F probably damaging Het
Hivep2 T A 10: 14,005,710 (GRCm39) D769E probably benign Het
Hsdl1 C T 8: 120,294,607 (GRCm39) V40I probably benign Het
Ipmk A G 10: 71,183,882 (GRCm39) H34R probably damaging Het
Kcnd3 T C 3: 105,366,856 (GRCm39) L242P probably damaging Het
Kdm4d T C 9: 14,375,316 (GRCm39) M181V probably damaging Het
Lats2 A T 14: 57,934,582 (GRCm39) I716N probably damaging Het
Liph T C 16: 21,784,772 (GRCm39) Y305C probably damaging Het
Ltbp1 T C 17: 75,533,962 (GRCm39) V150A possibly damaging Het
Ly6d A T 15: 74,634,384 (GRCm39) S69T probably benign Het
Meltf A G 16: 31,702,617 (GRCm39) R115G possibly damaging Het
Msgn1 G T 12: 11,258,902 (GRCm39) D16E probably benign Het
Mthfd2l T A 5: 91,094,705 (GRCm39) I58K probably damaging Het
Mup18 G C 4: 61,591,573 (GRCm39) probably null Het
Nek10 T A 14: 14,850,947 (GRCm38) W331R probably damaging Het
Nphp3 A G 9: 103,881,974 (GRCm39) Y148C probably damaging Het
Or4a47 T C 2: 89,666,076 (GRCm39) Y71C probably damaging Het
Or5h19 C T 16: 58,856,456 (GRCm39) V215I probably benign Het
Or6c33 T A 10: 129,853,760 (GRCm39) C177S probably damaging Het
Oscp1 A G 4: 125,980,459 (GRCm39) T325A possibly damaging Het
Pcdha4 T A 18: 37,086,613 (GRCm39) N265K probably damaging Het
Pigq C T 17: 26,153,199 (GRCm39) V331I probably benign Het
Plekhg4 A G 8: 106,105,329 (GRCm39) E598G probably damaging Het
Pou6f2 G A 13: 18,303,748 (GRCm39) T120M probably damaging Het
Psg27 T A 7: 18,295,726 (GRCm39) T240S probably damaging Het
Samd12 T A 15: 53,723,649 (GRCm39) I15F probably damaging Het
Scaf4 A T 16: 90,049,318 (GRCm39) D256E unknown Het
Scaf8 T A 17: 3,213,373 (GRCm39) M154K unknown Het
Slc27a1 T C 8: 72,032,071 (GRCm39) V64A possibly damaging Het
Snx31 A G 15: 36,555,455 (GRCm39) F31L probably benign Het
Spag17 T C 3: 100,002,888 (GRCm39) S1871P probably benign Het
Tdpoz4 T G 3: 93,704,662 (GRCm39) S320A probably benign Het
Tmprss11c A T 5: 86,379,691 (GRCm39) C406S probably damaging Het
Tnip1 G A 11: 54,808,630 (GRCm39) A519V probably benign Het
Tssc4 T A 7: 142,624,724 (GRCm39) probably null Het
Uba3 A T 6: 97,182,512 (GRCm39) M1K probably null Het
Usp32 GAACAAGTCCACAACAA GAACAA 11: 84,913,681 (GRCm39) probably null Het
Wnt11 T C 7: 98,496,588 (GRCm39) M176T possibly damaging Het
Wrn C T 8: 33,814,346 (GRCm39) G366D probably benign Het
Xylt1 T A 7: 117,255,807 (GRCm39) I793N probably damaging Het
Zfp677 T G 17: 21,618,679 (GRCm39) C579G probably damaging Het
Zscan4-ps1 T A 7: 10,799,626 (GRCm39) K421M probably damaging Het
Other mutations in Smc5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00569:Smc5 APN 19 23,213,329 (GRCm39) missense probably damaging 1.00
IGL01070:Smc5 APN 19 23,208,965 (GRCm39) missense possibly damaging 0.86
IGL01315:Smc5 APN 19 23,208,968 (GRCm39) missense probably benign
IGL01879:Smc5 APN 19 23,205,548 (GRCm39) missense probably damaging 0.97
IGL01902:Smc5 APN 19 23,237,132 (GRCm39) missense possibly damaging 0.85
IGL02016:Smc5 APN 19 23,251,076 (GRCm39) missense probably benign 0.00
IGL02186:Smc5 APN 19 23,209,223 (GRCm39) missense probably damaging 1.00
IGL02383:Smc5 APN 19 23,191,996 (GRCm39) splice site probably benign
IGL02447:Smc5 APN 19 23,234,856 (GRCm39) missense probably benign 0.01
IGL02534:Smc5 APN 19 23,205,536 (GRCm39) critical splice donor site probably null
IGL02834:Smc5 APN 19 23,234,968 (GRCm39) missense probably benign 0.30
IGL03290:Smc5 APN 19 23,251,022 (GRCm39) missense probably benign 0.19
R0722:Smc5 UTSW 19 23,186,291 (GRCm39) missense probably damaging 0.99
R0893:Smc5 UTSW 19 23,241,017 (GRCm39) missense possibly damaging 0.67
R0970:Smc5 UTSW 19 23,216,362 (GRCm39) missense probably damaging 1.00
R1281:Smc5 UTSW 19 23,213,247 (GRCm39) missense probably benign
R1368:Smc5 UTSW 19 23,187,807 (GRCm39) missense probably damaging 1.00
R2092:Smc5 UTSW 19 23,216,263 (GRCm39) missense probably benign
R3721:Smc5 UTSW 19 23,187,856 (GRCm39) missense probably benign 0.21
R4382:Smc5 UTSW 19 23,246,210 (GRCm39) missense probably benign 0.39
R4735:Smc5 UTSW 19 23,220,069 (GRCm39) missense probably benign
R4936:Smc5 UTSW 19 23,211,367 (GRCm39) missense probably damaging 1.00
R5306:Smc5 UTSW 19 23,237,009 (GRCm39) critical splice donor site probably null
R5754:Smc5 UTSW 19 23,221,467 (GRCm39) missense possibly damaging 0.92
R6175:Smc5 UTSW 19 23,191,534 (GRCm39) missense possibly damaging 0.60
R6313:Smc5 UTSW 19 23,186,312 (GRCm39) nonsense probably null
R6527:Smc5 UTSW 19 23,205,554 (GRCm39) missense probably benign 0.00
R6611:Smc5 UTSW 19 23,206,283 (GRCm39) missense probably benign 0.13
R6750:Smc5 UTSW 19 23,220,004 (GRCm39) missense probably damaging 1.00
R6801:Smc5 UTSW 19 23,192,010 (GRCm39) missense probably benign 0.34
R6821:Smc5 UTSW 19 23,220,151 (GRCm39) missense probably benign 0.20
R7002:Smc5 UTSW 19 23,209,247 (GRCm39) missense probably benign 0.00
R7386:Smc5 UTSW 19 23,192,539 (GRCm39) missense possibly damaging 0.59
R7439:Smc5 UTSW 19 23,220,064 (GRCm39) missense probably damaging 0.97
R7596:Smc5 UTSW 19 23,191,533 (GRCm39) missense probably damaging 0.99
R7666:Smc5 UTSW 19 23,206,381 (GRCm39) missense probably benign 0.15
R7760:Smc5 UTSW 19 23,213,254 (GRCm39) missense probably benign 0.01
R7990:Smc5 UTSW 19 23,213,246 (GRCm39) missense probably benign 0.01
R8255:Smc5 UTSW 19 23,186,290 (GRCm39) missense
R8359:Smc5 UTSW 19 23,211,443 (GRCm39) missense possibly damaging 0.49
R8473:Smc5 UTSW 19 23,221,446 (GRCm39) missense probably benign 0.02
R8711:Smc5 UTSW 19 23,243,058 (GRCm39) missense probably damaging 0.98
R8815:Smc5 UTSW 19 23,221,422 (GRCm39) missense probably damaging 1.00
R8885:Smc5 UTSW 19 23,191,234 (GRCm39) missense probably damaging 0.99
R8940:Smc5 UTSW 19 23,237,126 (GRCm39) missense probably benign 0.00
R9642:Smc5 UTSW 19 23,238,752 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGACATACTTTGTAGGTACTCAGTC -3'
(R):5'- AGAACCCTGACAGAGTTCTTGTG -3'

Sequencing Primer
(F):5'- GAGAAAATGCCTCCTTTAGACTGGC -3'
(R):5'- CTGACAGAGTTCTTGTGAAATTTTGC -3'
Posted On 2019-06-26