Incidental Mutation 'R7202:Adgrf3'
ID 560361
Institutional Source Beutler Lab
Gene Symbol Adgrf3
Ensembl Gene ENSMUSG00000067642
Gene Name adhesion G protein-coupled receptor F3
Synonyms PGR23, LOC381628, Gpr113
MMRRC Submission 045280-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7202 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 30398429-30410720 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 30409378 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 38 (K38*)
Ref Sequence ENSEMBL: ENSMUSP00000085440 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088117]
AlphaFold Q58Y75
Predicted Effect probably null
Transcript: ENSMUST00000088117
AA Change: K38*
SMART Domains Protein: ENSMUSP00000085440
Gene: ENSMUSG00000067642
AA Change: K38*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 85 97 N/A INTRINSIC
Blast:IG 163 252 2e-20 BLAST
Blast:CCP 341 399 1e-6 BLAST
low complexity region 403 415 N/A INTRINSIC
low complexity region 471 483 N/A INTRINSIC
GPS 632 684 2.68e-17 SMART
Pfam:7tm_2 687 935 1e-30 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 99% (74/75)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 T C 7: 119,917,236 (GRCm39) I1467T probably damaging Het
Abtb3 A G 10: 85,223,629 (GRCm39) E146G unknown Het
Ahdc1 T A 4: 132,789,198 (GRCm39) C146* probably null Het
Ahnak A T 19: 8,995,163 (GRCm39) K5482N probably damaging Het
Arhgap23 C T 11: 97,342,819 (GRCm39) A367V possibly damaging Het
Arvcf T C 16: 18,223,948 (GRCm39) S960P probably damaging Het
Asb14 C A 14: 26,622,394 (GRCm39) P74Q probably benign Het
Atad5 T C 11: 79,980,601 (GRCm39) V2A probably damaging Het
Baz2a A G 10: 127,954,428 (GRCm39) I691M possibly damaging Het
Brca2 A G 5: 150,455,819 (GRCm39) T187A probably benign Het
Calr4 T A 4: 109,101,254 (GRCm39) N152K possibly damaging Het
Ccnb2 C T 9: 70,318,128 (GRCm39) A215T probably damaging Het
Cdh16 C T 8: 105,340,780 (GRCm39) D140N unknown Het
Ces1g T C 8: 94,029,595 (GRCm39) T546A probably benign Het
Cfap74 G T 4: 155,510,654 (GRCm39) probably null Het
Cfap91 T C 16: 38,155,959 (GRCm39) Y88C probably benign Het
Col5a1 G T 2: 27,842,390 (GRCm39) D422Y unknown Het
Cyp2c66 A T 19: 39,130,348 (GRCm39) Y61F probably damaging Het
Dnah12 G A 14: 26,500,869 (GRCm39) probably null Het
Dnah6 A G 6: 73,158,688 (GRCm39) probably null Het
Dop1a T G 9: 86,386,220 (GRCm39) probably null Het
Fam163a A G 1: 155,954,834 (GRCm39) F106L probably damaging Het
Gfy T C 7: 44,827,596 (GRCm39) T167A probably benign Het
Gm6525 A T 3: 84,082,341 (GRCm39) R87S probably benign Het
Gramd1c C A 16: 43,879,584 (GRCm39) A19S possibly damaging Het
Herc2 T C 7: 55,781,034 (GRCm39) V1233A probably damaging Het
Hibch G A 1: 52,892,874 (GRCm39) probably null Het
Ibsp A T 5: 104,450,027 (GRCm39) S9C probably benign Het
Il17ra A G 6: 120,452,572 (GRCm39) I252V probably benign Het
Ino80 A T 2: 119,204,918 (GRCm39) M1536K probably benign Het
Ipo11 A T 13: 107,012,078 (GRCm39) L568Q probably damaging Het
Kcnu1 T G 8: 26,409,609 (GRCm39) probably null Het
Kdm5b T G 1: 134,552,497 (GRCm39) S1158A probably benign Het
Kmt2a T C 9: 44,759,012 (GRCm39) T946A probably benign Het
Kmt2e A T 5: 23,697,292 (GRCm39) probably benign Het
Krba1 G A 6: 48,389,261 (GRCm39) V594M probably damaging Het
Lamb1 T C 12: 31,374,314 (GRCm39) L1559P probably damaging Het
Lig1 C T 7: 13,025,175 (GRCm39) P227S probably benign Het
Lims2 T A 18: 32,090,017 (GRCm39) D255E probably benign Het
Marchf3 C T 18: 56,909,161 (GRCm39) C208Y probably benign Het
Mei1 A G 15: 81,976,843 (GRCm39) E142G Het
Melk G T 4: 44,351,106 (GRCm39) R549L probably benign Het
Muc6 AGGCGCAGAAACCCTGGC AGGC 7: 141,214,363 (GRCm39) probably null Het
Myorg T C 4: 41,498,268 (GRCm39) Y454C probably damaging Het
Nae1 T C 8: 105,250,215 (GRCm39) Y226C possibly damaging Het
Nap1l1 T C 10: 111,326,964 (GRCm39) F175S probably damaging Het
Ndn T C 7: 61,998,709 (GRCm39) L185P probably damaging Het
Ndst3 T A 3: 123,465,388 (GRCm39) I195F possibly damaging Het
Ndufaf1 A T 2: 119,488,907 (GRCm39) S206T probably benign Het
Nek10 C A 14: 14,836,171 (GRCm38) H131N probably benign Het
Obsl1 T A 1: 75,466,360 (GRCm39) D1456V possibly damaging Het
Or10a2 A G 7: 106,673,448 (GRCm39) N138D probably benign Het
Or10ak7 C T 4: 118,791,215 (GRCm39) V277I probably benign Het
Or52s6 T A 7: 103,092,292 (GRCm39) T13S probably benign Het
Otog C T 7: 45,937,474 (GRCm39) L1728F probably damaging Het
Pcx A T 19: 4,652,361 (GRCm39) M150L possibly damaging Het
Pole A G 5: 110,444,973 (GRCm39) D443G possibly damaging Het
Prr14 G T 7: 127,075,648 (GRCm39) R552L probably damaging Het
Rasgrf1 T G 9: 89,899,125 (GRCm39) S1156A possibly damaging Het
Rfc4 T A 16: 22,946,359 (GRCm39) probably benign Het
Rfx5 G T 3: 94,866,272 (GRCm39) A524S unknown Het
Ryr3 G A 2: 112,596,664 (GRCm39) P2497S probably damaging Het
Scg3 T C 9: 75,590,992 (GRCm39) T6A probably benign Het
Slc26a9 A T 1: 131,690,526 (GRCm39) D510V possibly damaging Het
Stpg3 A G 2: 25,104,586 (GRCm39) F10L probably damaging Het
Tmc5 T A 7: 118,239,179 (GRCm39) H357Q possibly damaging Het
Tmem40 A T 6: 115,707,420 (GRCm39) L253H probably damaging Het
Tmie A G 9: 110,696,632 (GRCm39) V83A probably damaging Het
Uck2 A T 1: 167,054,084 (GRCm39) I218N probably damaging Het
Vtn A G 11: 78,391,626 (GRCm39) D310G possibly damaging Het
Wdr49 A T 3: 75,240,580 (GRCm39) S430T probably benign Het
Wtip A G 7: 33,832,087 (GRCm39) V133A probably benign Het
Zbtb9 T A 17: 27,193,666 (GRCm39) V357E probably damaging Het
Zfp953 G A 13: 67,491,706 (GRCm39) T82M probably benign Het
Other mutations in Adgrf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03080:Adgrf3 APN 5 30,401,827 (GRCm39) missense probably benign 0.02
IGL03171:Adgrf3 APN 5 30,401,292 (GRCm39) missense probably damaging 1.00
R0010:Adgrf3 UTSW 5 30,410,607 (GRCm39) splice site probably benign
R0042:Adgrf3 UTSW 5 30,402,426 (GRCm39) missense probably damaging 1.00
R0140:Adgrf3 UTSW 5 30,401,379 (GRCm39) missense probably benign 0.19
R0617:Adgrf3 UTSW 5 30,400,078 (GRCm39) missense probably benign 0.25
R0748:Adgrf3 UTSW 5 30,401,874 (GRCm39) missense probably damaging 1.00
R1291:Adgrf3 UTSW 5 30,404,532 (GRCm39) missense probably damaging 0.99
R1330:Adgrf3 UTSW 5 30,400,093 (GRCm39) missense probably benign 0.24
R1468:Adgrf3 UTSW 5 30,407,227 (GRCm39) splice site probably benign
R1695:Adgrf3 UTSW 5 30,408,553 (GRCm39) missense probably benign 0.05
R1716:Adgrf3 UTSW 5 30,402,549 (GRCm39) missense probably benign 0.03
R1844:Adgrf3 UTSW 5 30,404,211 (GRCm39) missense probably damaging 0.96
R1935:Adgrf3 UTSW 5 30,407,304 (GRCm39) missense probably benign 0.00
R1936:Adgrf3 UTSW 5 30,407,304 (GRCm39) missense probably benign 0.00
R2059:Adgrf3 UTSW 5 30,404,489 (GRCm39) missense possibly damaging 0.91
R2656:Adgrf3 UTSW 5 30,401,436 (GRCm39) missense possibly damaging 0.96
R2913:Adgrf3 UTSW 5 30,401,992 (GRCm39) missense probably damaging 1.00
R2914:Adgrf3 UTSW 5 30,401,992 (GRCm39) missense probably damaging 1.00
R2987:Adgrf3 UTSW 5 30,402,358 (GRCm39) missense probably damaging 1.00
R3797:Adgrf3 UTSW 5 30,401,821 (GRCm39) missense possibly damaging 0.49
R3798:Adgrf3 UTSW 5 30,401,821 (GRCm39) missense possibly damaging 0.49
R3799:Adgrf3 UTSW 5 30,401,821 (GRCm39) missense possibly damaging 0.49
R3934:Adgrf3 UTSW 5 30,405,432 (GRCm39) unclassified probably benign
R4043:Adgrf3 UTSW 5 30,409,360 (GRCm39) missense probably benign 0.00
R4080:Adgrf3 UTSW 5 30,402,367 (GRCm39) nonsense probably null
R4575:Adgrf3 UTSW 5 30,407,255 (GRCm39) missense probably benign 0.00
R4754:Adgrf3 UTSW 5 30,402,615 (GRCm39) critical splice acceptor site probably null
R4819:Adgrf3 UTSW 5 30,403,442 (GRCm39) missense possibly damaging 0.66
R4893:Adgrf3 UTSW 5 30,405,476 (GRCm39) missense probably benign 0.00
R4991:Adgrf3 UTSW 5 30,404,146 (GRCm39) missense probably benign 0.26
R5686:Adgrf3 UTSW 5 30,402,304 (GRCm39) missense probably damaging 1.00
R5965:Adgrf3 UTSW 5 30,410,637 (GRCm39) missense probably benign 0.00
R5997:Adgrf3 UTSW 5 30,403,360 (GRCm39) critical splice donor site probably null
R6103:Adgrf3 UTSW 5 30,401,265 (GRCm39) missense probably damaging 1.00
R6244:Adgrf3 UTSW 5 30,402,531 (GRCm39) missense probably benign 0.17
R6409:Adgrf3 UTSW 5 30,402,312 (GRCm39) missense probably damaging 0.96
R6575:Adgrf3 UTSW 5 30,401,522 (GRCm39) missense possibly damaging 0.72
R6745:Adgrf3 UTSW 5 30,408,601 (GRCm39) missense probably benign 0.31
R6790:Adgrf3 UTSW 5 30,401,385 (GRCm39) missense probably benign 0.00
R6813:Adgrf3 UTSW 5 30,402,519 (GRCm39) missense probably damaging 0.96
R7250:Adgrf3 UTSW 5 30,400,680 (GRCm39) missense probably damaging 1.00
R7353:Adgrf3 UTSW 5 30,403,495 (GRCm39) missense probably damaging 0.98
R7634:Adgrf3 UTSW 5 30,407,245 (GRCm39) missense probably benign 0.01
R7658:Adgrf3 UTSW 5 30,402,204 (GRCm39) missense probably benign 0.41
R8037:Adgrf3 UTSW 5 30,404,510 (GRCm39) missense probably damaging 1.00
R8281:Adgrf3 UTSW 5 30,402,301 (GRCm39) missense possibly damaging 0.46
R8717:Adgrf3 UTSW 5 30,403,579 (GRCm39) unclassified probably benign
R8857:Adgrf3 UTSW 5 30,402,065 (GRCm39) nonsense probably null
R8926:Adgrf3 UTSW 5 30,405,446 (GRCm39) missense possibly damaging 0.46
R9391:Adgrf3 UTSW 5 30,400,071 (GRCm39) missense possibly damaging 0.94
R9446:Adgrf3 UTSW 5 30,401,957 (GRCm39) missense probably benign 0.01
R9522:Adgrf3 UTSW 5 30,404,482 (GRCm39) missense possibly damaging 0.90
Z1088:Adgrf3 UTSW 5 30,404,118 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- GTCTTTCTAGGCCTCACAGC -3'
(R):5'- CCTGGAATTGTGCCCCTGTC -3'

Sequencing Primer
(F):5'- CCTGGAGCTCAGTTTATAGACCAG -3'
(R):5'- GAACATCCTTTTCTCCCTCCAGATAC -3'
Posted On 2019-06-26