Mutagenetix > Incidental Mutations

Incidental Mutation 'R7204:Vmn1r13'

560439

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r13

Ensembl Gene

ENSMUSG00000064259

Gene Name

vomeronasal 1 receptor 13

Synonyms

V1rc5

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R7204 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

57203290-57214799 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 57210156 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 100 (I100N)

Ref Sequence

ENSEMBL: ENSMUSP00000077924 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078885] [ENSMUST00000226892] [ENSMUST00000227298] [ENSMUST00000227421]

Predicted Effect

probably benign
Transcript: ENSMUST00000078885
AA Change: I100N

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000077924
Gene: ENSMUSG00000064259
AA Change: I100N

Domain	Start	End	E-Value	Type
Pfam:V1R	28	294	3.3e-58	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226892
AA Change: I100N

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)

Predicted Effect

probably benign
Transcript: ENSMUST00000227298
AA Change: I100N

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)

Predicted Effect

probably benign
Transcript: ENSMUST00000227421
AA Change: I100N

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

99% (75/76)

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700067K01Rik	T	C	8: 84,004,007	S227P	probably damaging	Het
4930444G20Rik	A	G	10: 22,067,886	L65P	probably damaging	Het
9130019O22Rik	A	T	7: 127,384,346	I528K	possibly damaging	Het
Acot6	A	G	12: 84,106,527	H181R	probably benign	Het
Adam15	A	T	3: 89,346,937	H184Q	probably benign	Het
Agl	A	G	3: 116,793,820	F29L	probably benign	Het
Ak7	A	G	12: 105,742,243	Y319C	probably benign	Het
Ano8	C	A	8: 71,479,025	V813L	probably benign	Het
Apbb2	T	G	5: 66,451,603	K234Q	probably damaging	Het
Arfgef3	A	T	10: 18,646,462	D605E	probably damaging	Het
Bfsp2	C	A	9: 103,432,666	R340L	probably damaging	Het
Birc6	C	A	17: 74,640,108	P2956T	probably damaging	Het
C1rb	T	C	6: 124,577,427	I389T	probably benign	Het
Ccdc146	A	G	5: 21,308,626	F498S	probably benign	Het
Cdc14b	A	C	13: 64,210,198	V361G	possibly damaging	Het
Cdc25b	A	T	2: 131,191,632	I164F	probably damaging	Het
Col18a1	A	G	10: 77,085,276	S297P	unknown	Het
Col3a1	A	T	1: 45,322,418	I117F	unknown	Het
Cox4i2	AG	A	2: 152,760,698		probably null	Het
Crybg3	C	A	16: 59,558,890	G667V	probably benign	Het
Ctc1	A	G	11: 69,029,741	D623G	probably damaging	Het
Dennd1a	A	T	2: 38,039,203	H152Q	probably damaging	Het
Dgke	G	A	11: 89,041,480	P495S	probably damaging	Het
Dll3	A	T	7: 28,298,905	C212S	possibly damaging	Het
Dll4	A	T	2: 119,328,573	S235C	probably damaging	Het
Dnah12	G	A	14: 26,778,912		probably null	Het
Dnah12	A	T	14: 26,781,485	T1599S	probably damaging	Het
Elavl1	G	A	8: 4,311,712	T20M	probably damaging	Het
Epha3	T	C	16: 63,652,332	T397A	probably benign	Het
Fanca	A	T	8: 123,286,477	I859N	probably damaging	Het
Fzd1	A	T	5: 4,755,980	V534D	probably damaging	Het
Glmp	A	G	3: 88,326,610	Y258C	probably damaging	Het
Gm9195	G	A	14: 72,474,186	P329S	probably damaging	Het
Gm9573	AGCTGGATGCAGTGGTGGTCAGGGTGGGTGTAGAGCCTGAGCCAGTGCTGGATACAGTGGTGGTC	AGCTGGATACAGTGGTGGTC	17: 35,621,213		probably benign	Het
Gpt	A	G	15: 76,698,999	R379G	probably benign	Het
Gsdmc2	T	C	15: 63,825,054	T423A	probably damaging	Het
Hemgn	T	C	4: 46,397,054	K61E	possibly damaging	Het
Ikzf4	A	T	10: 128,643,890	S56T	possibly damaging	Het
Jak1	T	C	4: 101,175,135	T425A	probably benign	Het
Jsrp1	T	C	10: 80,810,485	T80A	probably benign	Het
Klra9	T	A	6: 130,188,680	D124V	possibly damaging	Het
Lama5	A	T	2: 180,202,177	V397D	probably damaging	Het
Lrp2	A	G	2: 69,472,533	S2951P	probably benign	Het
Map7d1	A	G	4: 126,256,015		probably null	Het
Mcm6	A	T	1: 128,338,127	C636S	probably damaging	Het
Mia	T	C	7: 27,180,933	E39G	possibly damaging	Het
Mpeg1	T	A	19: 12,462,894	I572N	probably damaging	Het
Muc6	AGGCGCAGAAACCCTGGC	AGGC	7: 141,634,450		probably null	Het
Mup5	A	G	4: 61,833,755	Y86H	probably damaging	Het
Nckap5	A	T	1: 126,026,367	V816D	probably benign	Het
Nfib	T	C	4: 82,296,815		probably null	Het
Nlrc5	T	A	8: 94,491,525	V1056D	possibly damaging	Het
Nynrin	G	C	14: 55,872,733	E1766Q	probably damaging	Het
Olfr39	A	T	9: 20,285,804	Y43F	probably benign	Het
Oxct1	T	A	15: 4,094,042	L328Q	probably damaging	Het
Pax5	T	A	4: 44,679,485	I187F	possibly damaging	Het
Pcdhb4	A	T	18: 37,309,239	D534V	probably damaging	Het
Pebp4	C	T	14: 69,847,597	P35S	probably benign	Het
Pkhd1l1	T	A	15: 44,523,553	V1274E	possibly damaging	Het
Plcz1	A	T	6: 140,010,424	V373D	probably benign	Het
Plxnb1	C	T	9: 109,100,175	T33I	probably damaging	Het
Prag1	T	C	8: 36,146,761	C1156R	probably benign	Het
Ptprc	T	A	1: 138,117,862	I87F	probably benign	Het
Rbp4	G	A	19: 38,124,103	T138I	possibly damaging	Het
Slc12a1	A	T	2: 125,200,622	N733Y	possibly damaging	Het
Slc27a3	A	G	3: 90,389,726	V22A	probably benign	Het
Tcaf1	T	C	6: 42,675,039		probably null	Het
Tnc	T	C	4: 63,971,155		probably null	Het
Tspan31	A	T	10: 127,068,118	*211R	probably null	Het
Ttc17	A	T	2: 94,362,428	V86D	possibly damaging	Het
Ubr1	T	A	2: 120,904,077	N1114I	possibly damaging	Het
Ulk2	C	T	11: 61,783,631	G850R	probably benign	Het
Zan	T	C	5: 137,427,978	D2512G	unknown	Het
Zc3h14	A	T	12: 98,771,356	N34I	probably damaging	Het
Zcwpw1	T	G	5: 137,812,084	L374R	probably damaging	Het

Other mutations in Vmn1r13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00870:Vmn1r13	APN	6	57210113	missense	probably benign	0.10
IGL01511:Vmn1r13	APN	6	57210329	missense	probably benign	0.00
IGL02412:Vmn1r13	APN	6	57210489	missense	possibly damaging	0.46
IGL02455:Vmn1r13	APN	6	57210472	missense	probably damaging	1.00
IGL03046:Vmn1r13	APN	6	57210732	missense	probably benign
R0285:Vmn1r13	UTSW	6	57209994	missense	probably benign	0.06
R0304:Vmn1r13	UTSW	6	57210626	missense	probably benign	0.01
R0385:Vmn1r13	UTSW	6	57210705	missense	probably benign	0.06
R0402:Vmn1r13	UTSW	6	57210098	missense	possibly damaging	0.96
R0544:Vmn1r13	UTSW	6	57210263	missense	probably benign
R0960:Vmn1r13	UTSW	6	57210011	missense	probably benign	0.06
R1297:Vmn1r13	UTSW	6	57210407	missense	probably damaging	0.99
R4056:Vmn1r13	UTSW	6	57209985	missense	probably benign	0.03
R5108:Vmn1r13	UTSW	6	57209916	missense	probably benign	0.33
R6388:Vmn1r13	UTSW	6	57209918	missense	probably benign	0.01
R7136:Vmn1r13	UTSW	6	57210254	missense	possibly damaging	0.93
R7239:Vmn1r13	UTSW	6	57210626	missense	probably benign	0.01
R7303:Vmn1r13	UTSW	6	57210602	missense	probably damaging	1.00
X0066:Vmn1r13	UTSW	6	57210597	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- AGCTCATTGACCTGATCTCCTG -3'
(R):5'- TCATTGGCAAGATTGAGCAGG -3'

Sequencing Primer
(F):5'- GACCTGATCTCCTGTCAACTGAC -3'
(R):5'- AGCAGGACTTAGTGATCTTCATCTGC -3'

Posted On

2019-06-26