Incidental Mutation 'R7203:Dapk1'
| ID |
560816 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, 2310039H24Rik, D13Ucla1, 2810425C21Rik |
| MMRRC Submission |
045281-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7203 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
60601947-60763191 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 60696335 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 56
(V56E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076666
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000044083
AA Change: V56E
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
AA Change: V56E
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000077453
AA Change: V56E
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
AA Change: V56E
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224789
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226059
AA Change: V56E
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| Meta Mutation Damage Score |
0.3368 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (108/108) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930544G11Rik |
T |
C |
6: 65,953,333 (GRCm38) |
V184A |
probably benign |
Het |
| Aars2 |
A |
G |
17: 45,516,571 (GRCm38) |
Y513C |
probably damaging |
Het |
| Ackr2 |
G |
A |
9: 121,908,967 (GRCm38) |
C136Y |
probably damaging |
Het |
| Aldh1l1 |
A |
G |
6: 90,570,800 (GRCm38) |
K414R |
probably benign |
Het |
| Arl9 |
A |
G |
5: 77,007,271 (GRCm38) |
Y83C |
possibly damaging |
Het |
| Atp10a |
G |
T |
7: 58,786,473 (GRCm38) |
R337L |
probably benign |
Het |
| Atp6v1g3 |
A |
T |
1: 138,287,800 (GRCm38) |
Q66L |
probably damaging |
Het |
| Atp7b |
A |
T |
8: 21,997,335 (GRCm38) |
N1321K |
probably damaging |
Het |
| Axdnd1 |
A |
T |
1: 156,382,389 (GRCm38) |
M437K |
probably damaging |
Het |
| Bap1 |
C |
A |
14: 31,254,169 (GRCm38) |
P147Q |
probably damaging |
Het |
| Bicd1 |
C |
T |
6: 149,512,905 (GRCm38) |
T372I |
possibly damaging |
Het |
| Brix1 |
T |
C |
15: 10,483,292 (GRCm38) |
|
probably null |
Het |
| Btrc |
A |
G |
19: 45,513,528 (GRCm38) |
|
probably null |
Het |
| C130050O18Rik |
A |
C |
5: 139,414,374 (GRCm38) |
I61L |
probably benign |
Het |
| Cfap161 |
A |
G |
7: 83,776,050 (GRCm38) |
S278P |
probably damaging |
Het |
| Cgnl1 |
T |
C |
9: 71,724,533 (GRCm38) |
D512G |
possibly damaging |
Het |
| Chat |
T |
C |
14: 32,419,057 (GRCm38) |
D461G |
probably damaging |
Het |
| Chl1 |
T |
A |
6: 103,691,674 (GRCm38) |
V456D |
probably benign |
Het |
| Cib1 |
T |
C |
7: 80,232,372 (GRCm38) |
T20A |
possibly damaging |
Het |
| Cubn |
T |
G |
2: 13,351,003 (GRCm38) |
H1806P |
probably benign |
Het |
| Dennd4a |
A |
G |
9: 64,896,474 (GRCm38) |
N1032D |
probably benign |
Het |
| Dlg5 |
T |
A |
14: 24,138,655 (GRCm38) |
E1756V |
probably damaging |
Het |
| Dnah1 |
T |
C |
14: 31,274,382 (GRCm38) |
T2666A |
probably benign |
Het |
| Dnah11 |
A |
T |
12: 118,045,522 (GRCm38) |
I2135N |
possibly damaging |
Het |
| Dnah6 |
T |
A |
6: 73,173,545 (GRCm38) |
E745V |
probably benign |
Het |
| Dock8 |
A |
T |
19: 25,181,563 (GRCm38) |
N1695I |
probably damaging |
Het |
| Esf1 |
C |
T |
2: 140,164,219 (GRCm38) |
R336Q |
possibly damaging |
Het |
| Fam161a |
A |
G |
11: 23,021,664 (GRCm38) |
|
probably null |
Het |
| Fam89a |
T |
C |
8: 124,751,679 (GRCm38) |
E44G |
possibly damaging |
Het |
| Fndc3b |
A |
T |
3: 27,456,485 (GRCm38) |
D829E |
probably benign |
Het |
| Fxr1 |
C |
T |
3: 34,046,540 (GRCm38) |
T125I |
possibly damaging |
Het |
| Gfer |
T |
C |
17: 24,695,862 (GRCm38) |
D69G |
probably damaging |
Het |
| Gpatch2l |
T |
A |
12: 86,288,937 (GRCm38) |
S471T |
probably benign |
Het |
| Grm7 |
T |
G |
6: 111,358,569 (GRCm38) |
I647S |
possibly damaging |
Het |
| Gsn |
A |
G |
2: 35,298,795 (GRCm38) |
I447V |
probably benign |
Het |
| H2al2c |
C |
T |
Y: 2,599,234 (GRCm38) |
L46F |
possibly damaging |
Het |
| Hao2 |
A |
C |
3: 98,877,282 (GRCm38) |
|
probably null |
Het |
| Ifitm10 |
T |
C |
7: 142,328,568 (GRCm38) |
E155G |
probably benign |
Het |
| Igkv8-16 |
C |
A |
6: 70,386,810 (GRCm38) |
W76L |
probably benign |
Het |
| Igsf21 |
A |
T |
4: 140,107,337 (GRCm38) |
F75I |
possibly damaging |
Het |
| Ints14 |
T |
A |
9: 64,964,419 (GRCm38) |
M13K |
probably damaging |
Het |
| Ipmk |
A |
T |
10: 71,363,468 (GRCm38) |
D53V |
possibly damaging |
Het |
| Iqcn |
A |
T |
8: 70,716,948 (GRCm38) |
E1229V |
probably benign |
Het |
| Itga8 |
A |
G |
2: 12,230,095 (GRCm38) |
F451L |
possibly damaging |
Het |
| Jup |
A |
G |
11: 100,381,734 (GRCm38) |
F284S |
probably damaging |
Het |
| Kctd5 |
T |
C |
17: 24,073,235 (GRCm38) |
D65G |
probably benign |
Het |
| Klrc1 |
A |
T |
6: 129,677,221 (GRCm38) |
S148T |
probably benign |
Het |
| Kmt5b |
A |
G |
19: 3,814,147 (GRCm38) |
K404E |
probably damaging |
Het |
| Krt9 |
A |
C |
11: 100,190,791 (GRCm38) |
M304R |
probably damaging |
Het |
| Krtap5-1 |
A |
T |
7: 142,296,562 (GRCm38) |
S143T |
unknown |
Het |
| Kyat3 |
A |
G |
3: 142,720,401 (GRCm38) |
N68D |
probably damaging |
Het |
| Kynu |
A |
G |
2: 43,681,353 (GRCm38) |
D427G |
probably damaging |
Het |
| Leo1 |
A |
G |
9: 75,445,996 (GRCm38) |
|
probably null |
Het |
| Loxhd1 |
A |
G |
18: 77,414,196 (GRCm38) |
D1737G |
probably damaging |
Het |
| Lpo |
C |
A |
11: 87,809,251 (GRCm38) |
L521F |
possibly damaging |
Het |
| Lrrk1 |
A |
G |
7: 66,270,825 (GRCm38) |
S1477P |
probably damaging |
Het |
| Lrrtm1 |
C |
A |
6: 77,243,601 (GRCm38) |
L14M |
probably damaging |
Het |
| Ly75 |
G |
A |
2: 60,323,852 (GRCm38) |
R1084* |
probably null |
Het |
| Mcf2l |
A |
G |
8: 13,010,456 (GRCm38) |
D764G |
probably benign |
Het |
| Mmut |
A |
T |
17: 40,938,673 (GRCm38) |
M180L |
probably benign |
Het |
| Mrgprd |
A |
T |
7: 145,322,349 (GRCm38) |
D319V |
probably benign |
Het |
| Myom3 |
T |
C |
4: 135,795,179 (GRCm38) |
L897P |
possibly damaging |
Het |
| Ncapd2 |
A |
T |
6: 125,184,328 (GRCm38) |
M247K |
possibly damaging |
Het |
| Nlrp2 |
T |
C |
7: 5,317,534 (GRCm38) |
D868G |
probably damaging |
Het |
| Npy6r |
A |
G |
18: 44,275,932 (GRCm38) |
N140S |
probably damaging |
Het |
| Nsmce4a |
T |
C |
7: 130,539,872 (GRCm38) |
K196E |
probably benign |
Het |
| Nup88 |
T |
C |
11: 70,945,254 (GRCm38) |
K532R |
probably benign |
Het |
| Or6k4 |
T |
A |
1: 174,137,114 (GRCm38) |
Y123* |
probably null |
Het |
| Or8d6 |
T |
A |
9: 39,942,509 (GRCm38) |
V83E |
probably benign |
Het |
| Or8g29-ps1 |
A |
T |
9: 39,289,293 (GRCm38) |
I199N |
unknown |
Het |
| Pbxip1 |
A |
T |
3: 89,447,428 (GRCm38) |
D418V |
possibly damaging |
Het |
| Pde2a |
C |
A |
7: 101,509,944 (GRCm38) |
R761S |
possibly damaging |
Het |
| Phf10 |
A |
T |
17: 14,946,313 (GRCm38) |
C432S |
probably damaging |
Het |
| Pitpnm2 |
T |
C |
5: 124,121,459 (GRCm38) |
D1271G |
probably damaging |
Het |
| Plin1 |
A |
T |
7: 79,723,444 (GRCm38) |
L259Q |
probably damaging |
Het |
| Pmpca |
G |
C |
2: 26,395,034 (GRCm38) |
E424Q |
possibly damaging |
Het |
| Pou6f2 |
T |
A |
13: 18,239,794 (GRCm38) |
Q132L |
unknown |
Het |
| Ppa2 |
A |
T |
3: 133,330,438 (GRCm38) |
N118Y |
possibly damaging |
Het |
| Prickle2 |
T |
C |
6: 92,410,978 (GRCm38) |
E537G |
possibly damaging |
Het |
| Prl3d1 |
A |
G |
13: 27,098,701 (GRCm38) |
I141V |
possibly damaging |
Het |
| Prl8a1 |
A |
T |
13: 27,574,189 (GRCm38) |
V179D |
probably damaging |
Het |
| Prr14l |
A |
G |
5: 32,827,145 (GRCm38) |
F1669L |
probably benign |
Het |
| Prrg4 |
T |
A |
2: 104,839,442 (GRCm38) |
E110V |
possibly damaging |
Het |
| Rfx5 |
C |
A |
3: 94,958,876 (GRCm38) |
H495Q |
unknown |
Het |
| Rgl2 |
C |
T |
17: 33,933,429 (GRCm38) |
R367W |
probably damaging |
Het |
| Rpe65 |
A |
G |
3: 159,622,854 (GRCm38) |
Y433C |
probably damaging |
Het |
| Rpl35rt |
A |
T |
1: 156,366,087 (GRCm38) |
I4F |
probably damaging |
Het |
| Rtn4rl1 |
C |
T |
11: 75,265,750 (GRCm38) |
S336F |
possibly damaging |
Het |
| Scn2a |
A |
G |
2: 65,748,319 (GRCm38) |
D1446G |
probably benign |
Het |
| Sdk1 |
C |
A |
5: 142,046,176 (GRCm38) |
T1002K |
probably benign |
Het |
| Slc9b2 |
T |
C |
3: 135,330,661 (GRCm38) |
S409P |
probably benign |
Het |
| Sowahc |
A |
G |
10: 59,222,278 (GRCm38) |
T79A |
probably benign |
Het |
| Spata31h1 |
G |
A |
10: 82,293,414 (GRCm38) |
T1254I |
probably benign |
Het |
| Stk35 |
T |
A |
2: 129,801,593 (GRCm38) |
C166S |
probably benign |
Het |
| Tarbp2 |
A |
G |
15: 102,522,487 (GRCm38) |
H225R |
probably benign |
Het |
| Tdrd12 |
T |
A |
7: 35,489,223 (GRCm38) |
K530* |
probably null |
Het |
| Terf2ip |
A |
G |
8: 112,017,986 (GRCm38) |
I312V |
probably benign |
Het |
| Tgfb1 |
T |
C |
7: 25,692,539 (GRCm38) |
|
probably null |
Het |
| Thbs2 |
T |
C |
17: 14,671,458 (GRCm38) |
D939G |
probably damaging |
Het |
| Ube4b |
A |
T |
4: 149,398,610 (GRCm38) |
I67K |
probably benign |
Het |
| Ubn1 |
G |
T |
16: 5,077,216 (GRCm38) |
V709F |
possibly damaging |
Het |
| Ugt2b5 |
T |
C |
5: 87,128,399 (GRCm38) |
K339E |
possibly damaging |
Het |
| Vax2 |
T |
C |
6: 83,737,900 (GRCm38) |
S266P |
probably damaging |
Het |
| Vmn2r108 |
A |
G |
17: 20,462,776 (GRCm38) |
I722T |
probably benign |
Het |
| Vmn2r95 |
A |
G |
17: 18,441,315 (GRCm38) |
K441R |
probably benign |
Het |
| Wapl |
C |
A |
14: 34,736,691 (GRCm38) |
D903E |
probably benign |
Het |
| Wee1 |
T |
A |
7: 110,134,794 (GRCm38) |
V442D |
probably benign |
Het |
| Zan |
T |
C |
5: 137,434,096 (GRCm38) |
N2313S |
unknown |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,761,040 (GRCm38) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,760,804 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,761,248 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,761,397 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,760,798 (GRCm38) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,731,031 (GRCm38) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,761,176 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,761,175 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,726,610 (GRCm38) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,736,260 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,730,882 (GRCm38) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,696,394 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,719,770 (GRCm38) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,749,334 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,761,807 (GRCm38) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,696,347 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,751,217 (GRCm38) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,748,320 (GRCm38) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,716,773 (GRCm38) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,761,312 (GRCm38) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,718,149 (GRCm38) |
splice site |
probably benign |
|
|
R0116:Dapk1
|
UTSW |
13 |
60,761,100 (GRCm38) |
missense |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,761,593 (GRCm38) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,729,558 (GRCm38) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,725,287 (GRCm38) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,730,848 (GRCm38) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,730,848 (GRCm38) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,761,384 (GRCm38) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,718,132 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,696,298 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,757,448 (GRCm38) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,730,985 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,721,865 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,716,785 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,696,298 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,754,143 (GRCm38) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,729,531 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,718,464 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,719,654 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2012:Dapk1
|
UTSW |
13 |
60,721,857 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,751,208 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,761,667 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,729,531 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,729,503 (GRCm38) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,761,749 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,757,353 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,730,931 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,752,216 (GRCm38) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,716,817 (GRCm38) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,719,750 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,748,200 (GRCm38) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,760,689 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,719,684 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,761,589 (GRCm38) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,719,684 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,718,128 (GRCm38) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,721,822 (GRCm38) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,718,047 (GRCm38) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,751,147 (GRCm38) |
missense |
probably benign |
0.41 |
|
R4717:Dapk1
|
UTSW |
13 |
60,726,662 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4775:Dapk1
|
UTSW |
13 |
60,749,342 (GRCm38) |
missense |
probably benign |
0.02 |
|
R4790:Dapk1
|
UTSW |
13 |
60,723,105 (GRCm38) |
frame shift |
probably null |
|
|
R4897:Dapk1
|
UTSW |
13 |
60,761,786 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,760,960 (GRCm38) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,721,778 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,725,312 (GRCm38) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,729,395 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,761,662 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,761,199 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R6035:Dapk1
|
UTSW |
13 |
60,761,199 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,761,766 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,761,326 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,729,442 (GRCm38) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,761,161 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,761,347 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,749,204 (GRCm38) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,716,814 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,760,894 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,725,340 (GRCm38) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,752,235 (GRCm38) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,751,289 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,696,442 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,736,324 (GRCm38) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,748,281 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,696,395 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,761,785 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7199:Dapk1
|
UTSW |
13 |
60,754,210 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7404:Dapk1
|
UTSW |
13 |
60,719,641 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7448:Dapk1
|
UTSW |
13 |
60,751,176 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,757,497 (GRCm38) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,730,886 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7574:Dapk1
|
UTSW |
13 |
60,761,173 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,761,551 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,751,193 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,725,339 (GRCm38) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,725,901 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,761,563 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,749,195 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,761,398 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,730,896 (GRCm38) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,723,090 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,740,097 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,760,920 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,718,450 (GRCm38) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,761,394 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,718,448 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,718,311 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,751,177 (GRCm38) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,729,555 (GRCm38) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,762,389 (GRCm38) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,748,123 (GRCm38) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,751,134 (GRCm38) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,761,268 (GRCm38) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,760,804 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCGTGTGTCCCCATGTTATG -3'
(R):5'- CAGTGCTTCTCTCAAGGATGGC -3'
Sequencing Primer
(F):5'- GTGTGTCCCCATGTTATGTCCTTG -3'
(R):5'- CTCTCAAGGATGGCTCAATTGG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation