Incidental Mutation 'R7210:Oxct2b'
ID 560986
Institutional Source Beutler Lab
Gene Symbol Oxct2b
Ensembl Gene ENSMUSG00000076438
Gene Name 3-oxoacid CoA transferase 2B
Synonyms Scot-t2
MMRRC Submission 045239-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R7210 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 123010059-123011793 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) A to C at 123010069 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000099708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002457] [ENSMUST00000102648]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000002457
SMART Domains Protein: ENSMUSP00000002457
Gene: ENSMUSG00000002384

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:TGFb_propeptide 26 248 2.7e-62 PFAM
TGFB 298 399 2.83e-59 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102648
SMART Domains Protein: ENSMUSP00000099708
Gene: ENSMUSG00000076438

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
CoA_trans 43 272 2.02e-79 SMART
CoA_trans 301 499 5.07e-71 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (60/60)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 G A 11: 94,264,767 (GRCm39) P194S probably benign Het
Ackr2 C T 9: 121,737,943 (GRCm39) A106V possibly damaging Het
Alg3 G A 16: 20,424,644 (GRCm39) P112L unknown Het
Areg T A 5: 91,288,764 (GRCm39) Y23* probably null Het
Aspn A G 13: 49,719,967 (GRCm39) T328A probably benign Het
B020011L13Rik A T 1: 117,729,241 (GRCm39) E249D possibly damaging Het
Bptf G A 11: 106,945,290 (GRCm39) Q2650* probably null Het
Btbd3 A T 2: 138,125,664 (GRCm39) R283W probably damaging Het
Cep131 T C 11: 119,955,615 (GRCm39) H1035R probably damaging Het
Cfap57 A T 4: 118,433,900 (GRCm39) Y959* probably null Het
Cnot1 T C 8: 96,515,286 (GRCm39) Y25C probably damaging Het
Crebbp G A 16: 3,902,121 (GRCm39) H2373Y possibly damaging Het
Ctnna3 T C 10: 64,086,547 (GRCm39) L373P probably damaging Het
Cyp8b1 T A 9: 121,744,246 (GRCm39) D362V probably damaging Het
D630003M21Rik T A 2: 158,057,932 (GRCm39) probably null Het
Dpp6 T C 5: 27,803,801 (GRCm39) I249T probably damaging Het
Fam149b T G 14: 20,428,540 (GRCm39) I475M probably damaging Het
Fat1 A G 8: 45,476,540 (GRCm39) Y1862C probably damaging Het
Fcrl5 A T 3: 87,353,719 (GRCm39) N355Y possibly damaging Het
Fgd6 C T 10: 93,969,954 (GRCm39) T1201I probably damaging Het
Fndc8 A T 11: 82,788,692 (GRCm39) D174V probably damaging Het
Gatb A G 3: 85,481,527 (GRCm39) H26R probably benign Het
Gm37240 T A 3: 84,405,114 (GRCm39) T230S probably benign Het
Gria4 T C 9: 4,464,135 (GRCm39) Q609R probably damaging Het
Gse1 C A 8: 120,957,441 (GRCm39) T644K unknown Het
Ifit1bl1 T G 19: 34,571,564 (GRCm39) I298L probably benign Het
Il31ra T C 13: 112,686,034 (GRCm39) D85G possibly damaging Het
Katnip T C 7: 125,471,411 (GRCm39) V1504A probably damaging Het
Lyst T C 13: 13,831,568 (GRCm39) L1664P probably damaging Het
Mrpl35 A G 6: 71,794,722 (GRCm39) L82S possibly damaging Het
Myo7b G A 18: 32,140,155 (GRCm39) R212C probably damaging Het
Myom2 T C 8: 15,154,114 (GRCm39) V684A probably damaging Het
Nbeal1 G C 1: 60,276,310 (GRCm39) V684L probably benign Het
Nop58 G T 1: 59,749,539 (GRCm39) probably null Het
Nudt13 T A 14: 20,359,852 (GRCm39) I193N possibly damaging Het
Nyap1 C A 5: 137,736,244 (GRCm39) R81L probably damaging Het
Or1e28-ps1 T C 11: 73,615,699 (GRCm39) I50M possibly damaging Het
Pcf11 C T 7: 92,312,684 (GRCm39) A230T probably benign Het
Phactr4 A T 4: 132,085,582 (GRCm39) *695R probably null Het
Pkd1 T C 17: 24,794,840 (GRCm39) S2176P probably damaging Het
Plch2 C A 4: 155,093,543 (GRCm39) R133L probably damaging Het
Ptprq G T 10: 107,521,032 (GRCm39) N713K probably damaging Het
Ptrh2 A T 11: 86,580,793 (GRCm39) T137S probably benign Het
R3hdm1 A G 1: 128,138,945 (GRCm39) Y718C possibly damaging Het
Rftn1 T A 17: 50,301,335 (GRCm39) R505* probably null Het
Rps15a A G 7: 117,708,334 (GRCm39) F128L probably benign Het
Slc25a25 A T 2: 32,310,408 (GRCm39) M177K possibly damaging Het
Smgc C A 15: 91,744,492 (GRCm39) P631Q probably damaging Het
Sox2 T C 3: 34,705,306 (GRCm39) S248P probably damaging Het
Sycp1 T C 3: 102,760,808 (GRCm39) K702E probably damaging Het
Tes G T 6: 17,104,761 (GRCm39) C414F probably damaging Het
Tet1 A T 10: 62,650,280 (GRCm39) C14S probably null Het
Tle3 C T 9: 61,319,587 (GRCm39) P452S probably damaging Het
Tmc6 A C 11: 117,666,670 (GRCm39) L131R possibly damaging Het
Tnip3 C T 6: 65,570,495 (GRCm39) R30* probably null Het
Tnrc6b G T 15: 80,813,486 (GRCm39) G1748W probably damaging Het
Ugt2b38 T G 5: 87,558,284 (GRCm39) D459A probably damaging Het
Zdhhc2 A T 8: 40,920,480 (GRCm39) R246S probably damaging Het
Zscan22 T A 7: 12,640,748 (GRCm39) C331S probably damaging Het
Other mutations in Oxct2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00552:Oxct2b APN 4 123,011,301 (GRCm39) missense probably damaging 1.00
R0504:Oxct2b UTSW 4 123,010,705 (GRCm39) small deletion probably benign
R0504:Oxct2b UTSW 4 123,010,633 (GRCm39) missense possibly damaging 0.92
R0543:Oxct2b UTSW 4 123,010,782 (GRCm39) missense possibly damaging 0.93
R1167:Oxct2b UTSW 4 123,011,378 (GRCm39) missense probably damaging 0.99
R1365:Oxct2b UTSW 4 123,011,162 (GRCm39) missense probably benign
R1891:Oxct2b UTSW 4 123,010,938 (GRCm39) missense probably benign 0.01
R2311:Oxct2b UTSW 4 123,011,211 (GRCm39) missense probably damaging 1.00
R2906:Oxct2b UTSW 4 123,010,823 (GRCm39) missense probably benign 0.12
R4168:Oxct2b UTSW 4 123,011,478 (GRCm39) missense probably damaging 0.96
R4657:Oxct2b UTSW 4 123,010,926 (GRCm39) missense probably damaging 1.00
R6159:Oxct2b UTSW 4 123,011,244 (GRCm39) missense probably damaging 1.00
R6221:Oxct2b UTSW 4 123,010,601 (GRCm39) missense probably damaging 1.00
R6271:Oxct2b UTSW 4 123,011,508 (GRCm39) missense probably damaging 1.00
R6357:Oxct2b UTSW 4 123,010,709 (GRCm39) missense probably benign 0.00
R6389:Oxct2b UTSW 4 123,010,367 (GRCm39) missense probably benign 0.21
R6996:Oxct2b UTSW 4 123,011,480 (GRCm39) missense probably benign 0.05
R7655:Oxct2b UTSW 4 123,011,550 (GRCm39) missense probably benign 0.16
R7656:Oxct2b UTSW 4 123,011,550 (GRCm39) missense probably benign 0.16
R7849:Oxct2b UTSW 4 123,010,680 (GRCm39) missense probably damaging 1.00
R7934:Oxct2b UTSW 4 123,010,447 (GRCm39) nonsense probably null
R8094:Oxct2b UTSW 4 123,010,301 (GRCm39) missense possibly damaging 0.66
R8936:Oxct2b UTSW 4 123,010,838 (GRCm39) missense probably benign 0.00
R8979:Oxct2b UTSW 4 123,011,169 (GRCm39) missense probably benign 0.23
R9365:Oxct2b UTSW 4 123,010,589 (GRCm39) missense probably benign 0.03
R9523:Oxct2b UTSW 4 123,011,483 (GRCm39) missense probably damaging 1.00
R9598:Oxct2b UTSW 4 123,010,413 (GRCm39) missense possibly damaging 0.88
R9612:Oxct2b UTSW 4 123,011,019 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTGTCCAAGGCTCTTGAGAG -3'
(R):5'- TGACGATCTTCAGGTCCTTCAC -3'

Sequencing Primer
(F):5'- GCTCTTGAGAGACAGGCTG -3'
(R):5'- ATGACGGTCGACCCATCCTTG -3'
Posted On 2019-06-26