Incidental Mutation 'R7210:Ackr2'
ID 561007
Institutional Source Beutler Lab
Gene Symbol Ackr2
Ensembl Gene ENSMUSG00000044534
Gene Name atypical chemokine receptor 2
Synonyms chemokine decoy receptor D6, D6, Ccbp2
MMRRC Submission 045239-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7210 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 121727421-121740140 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 121737943 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 106 (A106V)
Ref Sequence ENSEMBL: ENSMUSP00000050119 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050327] [ENSMUST00000214340] [ENSMUST00000215664] [ENSMUST00000216326]
AlphaFold O08707
Predicted Effect possibly damaging
Transcript: ENSMUST00000050327
AA Change: A106V

PolyPhen 2 Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000050119
Gene: ENSMUSG00000044534
AA Change: A106V

DomainStartEndE-ValueType
low complexity region 18 29 N/A INTRINSIC
Pfam:7tm_1 62 311 1e-40 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214340
AA Change: A106V

PolyPhen 2 Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect probably benign
Transcript: ENSMUST00000215664
Predicted Effect probably benign
Transcript: ENSMUST00000216326
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display increased inflammatory responses but are viable and fertile without any other gross abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 G A 11: 94,264,767 (GRCm39) P194S probably benign Het
Alg3 G A 16: 20,424,644 (GRCm39) P112L unknown Het
Areg T A 5: 91,288,764 (GRCm39) Y23* probably null Het
Aspn A G 13: 49,719,967 (GRCm39) T328A probably benign Het
B020011L13Rik A T 1: 117,729,241 (GRCm39) E249D possibly damaging Het
Bptf G A 11: 106,945,290 (GRCm39) Q2650* probably null Het
Btbd3 A T 2: 138,125,664 (GRCm39) R283W probably damaging Het
Cep131 T C 11: 119,955,615 (GRCm39) H1035R probably damaging Het
Cfap57 A T 4: 118,433,900 (GRCm39) Y959* probably null Het
Cnot1 T C 8: 96,515,286 (GRCm39) Y25C probably damaging Het
Crebbp G A 16: 3,902,121 (GRCm39) H2373Y possibly damaging Het
Ctnna3 T C 10: 64,086,547 (GRCm39) L373P probably damaging Het
Cyp8b1 T A 9: 121,744,246 (GRCm39) D362V probably damaging Het
D630003M21Rik T A 2: 158,057,932 (GRCm39) probably null Het
Dpp6 T C 5: 27,803,801 (GRCm39) I249T probably damaging Het
Fam149b T G 14: 20,428,540 (GRCm39) I475M probably damaging Het
Fat1 A G 8: 45,476,540 (GRCm39) Y1862C probably damaging Het
Fcrl5 A T 3: 87,353,719 (GRCm39) N355Y possibly damaging Het
Fgd6 C T 10: 93,969,954 (GRCm39) T1201I probably damaging Het
Fndc8 A T 11: 82,788,692 (GRCm39) D174V probably damaging Het
Gatb A G 3: 85,481,527 (GRCm39) H26R probably benign Het
Gm37240 T A 3: 84,405,114 (GRCm39) T230S probably benign Het
Gria4 T C 9: 4,464,135 (GRCm39) Q609R probably damaging Het
Gse1 C A 8: 120,957,441 (GRCm39) T644K unknown Het
Ifit1bl1 T G 19: 34,571,564 (GRCm39) I298L probably benign Het
Il31ra T C 13: 112,686,034 (GRCm39) D85G possibly damaging Het
Katnip T C 7: 125,471,411 (GRCm39) V1504A probably damaging Het
Lyst T C 13: 13,831,568 (GRCm39) L1664P probably damaging Het
Mrpl35 A G 6: 71,794,722 (GRCm39) L82S possibly damaging Het
Myo7b G A 18: 32,140,155 (GRCm39) R212C probably damaging Het
Myom2 T C 8: 15,154,114 (GRCm39) V684A probably damaging Het
Nbeal1 G C 1: 60,276,310 (GRCm39) V684L probably benign Het
Nop58 G T 1: 59,749,539 (GRCm39) probably null Het
Nudt13 T A 14: 20,359,852 (GRCm39) I193N possibly damaging Het
Nyap1 C A 5: 137,736,244 (GRCm39) R81L probably damaging Het
Or1e28-ps1 T C 11: 73,615,699 (GRCm39) I50M possibly damaging Het
Oxct2b A C 4: 123,010,069 (GRCm39) probably benign Het
Pcf11 C T 7: 92,312,684 (GRCm39) A230T probably benign Het
Phactr4 A T 4: 132,085,582 (GRCm39) *695R probably null Het
Pkd1 T C 17: 24,794,840 (GRCm39) S2176P probably damaging Het
Plch2 C A 4: 155,093,543 (GRCm39) R133L probably damaging Het
Ptprq G T 10: 107,521,032 (GRCm39) N713K probably damaging Het
Ptrh2 A T 11: 86,580,793 (GRCm39) T137S probably benign Het
R3hdm1 A G 1: 128,138,945 (GRCm39) Y718C possibly damaging Het
Rftn1 T A 17: 50,301,335 (GRCm39) R505* probably null Het
Rps15a A G 7: 117,708,334 (GRCm39) F128L probably benign Het
Slc25a25 A T 2: 32,310,408 (GRCm39) M177K possibly damaging Het
Smgc C A 15: 91,744,492 (GRCm39) P631Q probably damaging Het
Sox2 T C 3: 34,705,306 (GRCm39) S248P probably damaging Het
Sycp1 T C 3: 102,760,808 (GRCm39) K702E probably damaging Het
Tes G T 6: 17,104,761 (GRCm39) C414F probably damaging Het
Tet1 A T 10: 62,650,280 (GRCm39) C14S probably null Het
Tle3 C T 9: 61,319,587 (GRCm39) P452S probably damaging Het
Tmc6 A C 11: 117,666,670 (GRCm39) L131R possibly damaging Het
Tnip3 C T 6: 65,570,495 (GRCm39) R30* probably null Het
Tnrc6b G T 15: 80,813,486 (GRCm39) G1748W probably damaging Het
Ugt2b38 T G 5: 87,558,284 (GRCm39) D459A probably damaging Het
Zdhhc2 A T 8: 40,920,480 (GRCm39) R246S probably damaging Het
Zscan22 T A 7: 12,640,748 (GRCm39) C331S probably damaging Het
Other mutations in Ackr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Ackr2 APN 9 121,738,566 (GRCm39) missense probably benign 0.02
IGL01744:Ackr2 APN 9 121,738,185 (GRCm39) missense probably benign 0.06
IGL03019:Ackr2 APN 9 121,738,248 (GRCm39) missense probably benign 0.43
IGL03143:Ackr2 APN 9 121,738,333 (GRCm39) missense probably damaging 1.00
IGL03398:Ackr2 APN 9 121,737,654 (GRCm39) missense probably damaging 1.00
R0180:Ackr2 UTSW 9 121,737,982 (GRCm39) missense probably benign 0.44
R0366:Ackr2 UTSW 9 121,738,426 (GRCm39) missense probably damaging 1.00
R1295:Ackr2 UTSW 9 121,737,783 (GRCm39) missense possibly damaging 0.94
R1596:Ackr2 UTSW 9 121,738,278 (GRCm39) missense probably damaging 1.00
R1827:Ackr2 UTSW 9 121,738,581 (GRCm39) missense probably benign 0.36
R2109:Ackr2 UTSW 9 121,738,026 (GRCm39) missense probably damaging 0.98
R2125:Ackr2 UTSW 9 121,737,852 (GRCm39) nonsense probably null
R2414:Ackr2 UTSW 9 121,738,040 (GRCm39) missense probably damaging 1.00
R4161:Ackr2 UTSW 9 121,738,588 (GRCm39) missense probably benign 0.05
R4524:Ackr2 UTSW 9 121,738,609 (GRCm39) missense probably benign
R4732:Ackr2 UTSW 9 121,738,249 (GRCm39) missense probably damaging 0.98
R4733:Ackr2 UTSW 9 121,738,249 (GRCm39) missense probably damaging 0.98
R5809:Ackr2 UTSW 9 121,738,540 (GRCm39) missense probably damaging 1.00
R7203:Ackr2 UTSW 9 121,738,033 (GRCm39) missense probably damaging 1.00
R7267:Ackr2 UTSW 9 121,737,874 (GRCm39) missense probably damaging 1.00
R7665:Ackr2 UTSW 9 121,738,374 (GRCm39) missense probably benign
R8090:Ackr2 UTSW 9 121,738,045 (GRCm39) missense possibly damaging 0.53
R9074:Ackr2 UTSW 9 121,737,729 (GRCm39) missense probably damaging 1.00
R9598:Ackr2 UTSW 9 121,737,657 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- CATCTTGGTTTGCAGGAAGGAC -3'
(R):5'- CAATGAGAAGCAGGTTCCTGAAC -3'

Sequencing Primer
(F):5'- AAGAGTCTTTCTGCCGGTC -3'
(R):5'- AGGTTCCTGAACTGGGCCTTC -3'
Posted On 2019-06-26