Incidental Mutation 'R7211:Brd10'
| ID |
561113 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Brd10
|
| Ensembl Gene |
ENSMUSG00000046138 |
| Gene Name |
bromodomain containing 10 |
| Synonyms |
9930021J03Rik, Gm9832 |
| MMRRC Submission |
045339-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.137)
|
| Stock # |
R7211 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
19 |
| Chromosomal Location |
29691802-29783389 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 29763712 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 121
(F121S)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000177155]
|
| AlphaFold |
H3BKP8 |
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177155
|
| SMART Domains |
Protein: ENSMUSP00000135473
Gene: ENSMUSG00000046138
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
66 |
N/A |
INTRINSIC |
|
BROMO
|
75 |
198 |
1.22e-3 |
SMART |
|
low complexity region
|
205 |
219 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
298 |
N/A |
INTRINSIC |
|
low complexity region
|
428 |
441 |
N/A |
INTRINSIC |
|
coiled coil region
|
606 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
655 |
689 |
N/A |
INTRINSIC |
|
coiled coil region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
1079 |
1093 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1097 |
1226 |
1.32e-7 |
PROSPERO |
|
low complexity region
|
1228 |
1237 |
N/A |
INTRINSIC |
|
low complexity region
|
1319 |
1348 |
N/A |
INTRINSIC |
|
low complexity region
|
1401 |
1416 |
N/A |
INTRINSIC |
|
low complexity region
|
1535 |
1557 |
N/A |
INTRINSIC |
|
low complexity region
|
1580 |
1596 |
N/A |
INTRINSIC |
|
low complexity region
|
1665 |
1678 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1699 |
1843 |
1.32e-7 |
PROSPERO |
|
low complexity region
|
1920 |
1926 |
N/A |
INTRINSIC |
|
low complexity region
|
1946 |
1960 |
N/A |
INTRINSIC |
|
low complexity region
|
1986 |
2004 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.2542 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
99% (84/85) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| a |
T |
A |
2: 154,887,699 (GRCm39) |
V53E |
probably damaging |
Het |
| A1cf |
A |
G |
19: 31,904,541 (GRCm39) |
Y268C |
probably benign |
Het |
| Adam34l |
T |
A |
8: 44,078,914 (GRCm39) |
S437C |
probably damaging |
Het |
| Adamts13 |
C |
T |
2: 26,879,310 (GRCm39) |
T621I |
probably benign |
Het |
| Akr1b7 |
A |
T |
6: 34,398,049 (GRCm39) |
N293Y |
probably benign |
Het |
| Angpt2 |
T |
A |
8: 18,791,147 (GRCm39) |
T50S |
probably benign |
Het |
| Anks1b |
C |
A |
10: 90,346,932 (GRCm39) |
A744D |
possibly damaging |
Het |
| Aqr |
A |
G |
2: 113,965,204 (GRCm39) |
V587A |
probably benign |
Het |
| Atm |
A |
G |
9: 53,399,860 (GRCm39) |
V1540A |
probably benign |
Het |
| C4b |
A |
G |
17: 34,954,508 (GRCm39) |
V887A |
possibly damaging |
Het |
| Cd200r1 |
A |
G |
16: 44,609,120 (GRCm39) |
T26A |
probably benign |
Het |
| Ciao1 |
A |
G |
2: 127,088,928 (GRCm39) |
|
probably null |
Het |
| Clba1 |
T |
A |
12: 112,774,632 (GRCm39) |
|
probably null |
Het |
| Clca3a2 |
A |
G |
3: 144,519,775 (GRCm39) |
C200R |
probably benign |
Het |
| Col6a5 |
T |
A |
9: 105,805,363 (GRCm39) |
Q1181L |
unknown |
Het |
| Copb2 |
T |
A |
9: 98,456,198 (GRCm39) |
I244N |
probably damaging |
Het |
| Cpb2 |
A |
G |
14: 75,512,430 (GRCm39) |
Y281C |
probably damaging |
Het |
| Disp3 |
C |
A |
4: 148,325,979 (GRCm39) |
V1260F |
probably damaging |
Het |
| Dnajc2 |
C |
T |
5: 21,981,777 (GRCm39) |
R123Q |
probably damaging |
Het |
| Dpysl2 |
T |
C |
14: 67,067,425 (GRCm39) |
N162S |
probably damaging |
Het |
| Dsp |
T |
A |
13: 38,372,511 (GRCm39) |
|
probably null |
Het |
| Edc4 |
T |
A |
8: 106,612,941 (GRCm39) |
|
probably null |
Het |
| Efcab3 |
C |
A |
11: 104,601,539 (GRCm39) |
A284D |
probably benign |
Het |
| Efcab3 |
G |
T |
11: 104,615,435 (GRCm39) |
|
probably null |
Het |
| Epm2a |
T |
C |
10: 11,219,419 (GRCm39) |
Y69H |
probably benign |
Het |
| Frzb |
C |
A |
2: 80,248,669 (GRCm39) |
E262* |
probably null |
Het |
| Gaa |
T |
C |
11: 119,175,030 (GRCm39) |
V877A |
possibly damaging |
Het |
| Gpnmb |
T |
C |
6: 49,028,949 (GRCm39) |
I489T |
possibly damaging |
Het |
| Gpr31b |
T |
C |
17: 13,271,104 (GRCm39) |
T22A |
probably benign |
Het |
| Gys1 |
T |
A |
7: 45,097,684 (GRCm39) |
F477Y |
possibly damaging |
Het |
| Hoxc11 |
A |
C |
15: 102,863,487 (GRCm39) |
E176A |
possibly damaging |
Het |
| Kcnk13 |
T |
A |
12: 100,028,076 (GRCm39) |
F384I |
probably damaging |
Het |
| Ky |
A |
G |
9: 102,386,349 (GRCm39) |
E59G |
probably benign |
Het |
| Lama4 |
T |
A |
10: 38,881,491 (GRCm39) |
D93E |
probably damaging |
Het |
| Lrrc23 |
A |
T |
6: 124,755,152 (GRCm39) |
N128K |
probably benign |
Het |
| Lrrc71 |
G |
T |
3: 87,650,633 (GRCm39) |
Q210K |
possibly damaging |
Het |
| Map1a |
G |
A |
2: 121,135,124 (GRCm39) |
R1980H |
probably benign |
Het |
| Med15 |
T |
C |
16: 17,515,977 (GRCm39) |
D15G |
unknown |
Het |
| Mfng |
A |
T |
15: 78,657,268 (GRCm39) |
S69T |
probably benign |
Het |
| Muc16 |
T |
G |
9: 18,409,866 (GRCm39) |
S181R |
probably damaging |
Het |
| Mug1 |
A |
T |
6: 121,857,498 (GRCm39) |
Q1074L |
possibly damaging |
Het |
| Myorg |
A |
G |
4: 41,498,028 (GRCm39) |
I534T |
probably damaging |
Het |
| Nbea |
T |
A |
3: 55,912,322 (GRCm39) |
N1155I |
probably benign |
Het |
| Nbeal1 |
T |
G |
1: 60,240,110 (GRCm39) |
L159V |
probably damaging |
Het |
| Nudt1 |
C |
A |
5: 140,323,402 (GRCm39) |
P118Q |
possibly damaging |
Het |
| Or2q1 |
A |
T |
6: 42,794,950 (GRCm39) |
T182S |
probably benign |
Het |
| Or8g37 |
A |
C |
9: 39,731,154 (GRCm39) |
Q73P |
possibly damaging |
Het |
| Pcdhga6 |
T |
A |
18: 37,842,173 (GRCm39) |
V631D |
probably benign |
Het |
| Pcna |
A |
C |
2: 132,091,792 (GRCm39) |
V203G |
probably damaging |
Het |
| Pgf |
G |
T |
12: 85,222,549 (GRCm39) |
N33K |
probably benign |
Het |
| Pgm2 |
T |
C |
5: 64,263,193 (GRCm39) |
L280P |
probably damaging |
Het |
| Plcg1 |
G |
A |
2: 160,573,794 (GRCm39) |
A20T |
probably benign |
Het |
| Pou2af2 |
G |
T |
9: 51,201,733 (GRCm39) |
Q108K |
probably damaging |
Het |
| Prdx5 |
G |
T |
19: 6,884,958 (GRCm39) |
D126E |
probably damaging |
Het |
| Prkag2 |
T |
C |
5: 25,200,296 (GRCm39) |
T20A |
probably benign |
Het |
| Prr14l |
T |
A |
5: 32,987,431 (GRCm39) |
Q688L |
probably damaging |
Het |
| Pxdn |
T |
G |
12: 30,034,903 (GRCm39) |
D253E |
possibly damaging |
Het |
| Rbm18 |
A |
T |
2: 36,012,905 (GRCm39) |
C53* |
probably null |
Het |
| Rprm |
A |
T |
2: 53,975,270 (GRCm39) |
L16Q |
probably benign |
Het |
| Saysd1 |
A |
G |
14: 20,127,576 (GRCm39) |
F116S |
probably damaging |
Het |
| Scg3 |
A |
G |
9: 75,589,366 (GRCm39) |
S96P |
probably benign |
Het |
| Scgb1b3 |
C |
T |
7: 31,075,078 (GRCm39) |
L16F |
unknown |
Het |
| Sh3tc2 |
A |
G |
18: 62,122,474 (GRCm39) |
T412A |
probably benign |
Het |
| Skint6 |
T |
C |
4: 113,095,566 (GRCm39) |
N31S |
probably benign |
Het |
| Slc22a2 |
T |
C |
17: 12,805,770 (GRCm39) |
|
probably null |
Het |
| Slc8a2 |
C |
T |
7: 15,874,538 (GRCm39) |
T262I |
possibly damaging |
Het |
| Smarcc1 |
A |
T |
9: 109,979,082 (GRCm39) |
K188N |
probably damaging |
Het |
| Taf6 |
T |
C |
5: 138,177,088 (GRCm39) |
T660A |
possibly damaging |
Het |
| Tbx2 |
C |
T |
11: 85,725,540 (GRCm39) |
R164C |
probably damaging |
Het |
| Tec |
T |
C |
5: 72,939,355 (GRCm39) |
D220G |
probably null |
Het |
| Tfec |
A |
T |
6: 16,867,464 (GRCm39) |
W59R |
probably damaging |
Het |
| Tmtc2 |
G |
T |
10: 105,409,587 (GRCm39) |
S8R |
probably benign |
Het |
| Tmtc3 |
A |
T |
10: 100,283,467 (GRCm39) |
M696K |
probably benign |
Het |
| Trpc3 |
A |
T |
3: 36,694,882 (GRCm39) |
S691T |
possibly damaging |
Het |
| Ttf2 |
A |
T |
3: 100,866,623 (GRCm39) |
M503K |
probably benign |
Het |
| Ttll7 |
A |
G |
3: 146,619,031 (GRCm39) |
H312R |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,598,032 (GRCm39) |
Y19627C |
probably damaging |
Het |
| Ugt2b35 |
T |
C |
5: 87,149,177 (GRCm39) |
S143P |
probably benign |
Het |
| Usp53 |
A |
G |
3: 122,751,299 (GRCm39) |
S253P |
probably damaging |
Het |
| Utp18 |
A |
G |
11: 93,776,206 (GRCm39) |
V93A |
probably benign |
Het |
| Utrn |
T |
C |
10: 12,277,079 (GRCm39) |
N3413D |
possibly damaging |
Het |
| Zhx1 |
T |
C |
15: 57,916,647 (GRCm39) |
D533G |
possibly damaging |
Het |
|
| Other mutations in Brd10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01311:Brd10
|
APN |
19 |
29,731,420 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL01535:Brd10
|
APN |
19 |
29,731,212 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02019:Brd10
|
APN |
19 |
29,694,463 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02034:Brd10
|
APN |
19 |
29,694,259 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03114:Brd10
|
APN |
19 |
29,694,532 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03382:Brd10
|
APN |
19 |
29,694,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0020:Brd10
|
UTSW |
19 |
29,693,597 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0020:Brd10
|
UTSW |
19 |
29,693,597 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0142:Brd10
|
UTSW |
19 |
29,695,654 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0178:Brd10
|
UTSW |
19 |
29,732,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0453:Brd10
|
UTSW |
19 |
29,731,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0730:Brd10
|
UTSW |
19 |
29,695,381 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0735:Brd10
|
UTSW |
19 |
29,695,038 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0891:Brd10
|
UTSW |
19 |
29,695,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0894:Brd10
|
UTSW |
19 |
29,697,974 (GRCm39) |
splice site |
probably benign |
|
|
R1289:Brd10
|
UTSW |
19 |
29,700,852 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1368:Brd10
|
UTSW |
19 |
29,693,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1387:Brd10
|
UTSW |
19 |
29,700,853 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1483:Brd10
|
UTSW |
19 |
29,696,745 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1526:Brd10
|
UTSW |
19 |
29,712,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1612:Brd10
|
UTSW |
19 |
29,695,245 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1721:Brd10
|
UTSW |
19 |
29,720,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1764:Brd10
|
UTSW |
19 |
29,696,560 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1822:Brd10
|
UTSW |
19 |
29,693,814 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1824:Brd10
|
UTSW |
19 |
29,693,814 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1859:Brd10
|
UTSW |
19 |
29,732,323 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1868:Brd10
|
UTSW |
19 |
29,720,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1880:Brd10
|
UTSW |
19 |
29,695,523 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1898:Brd10
|
UTSW |
19 |
29,712,532 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1936:Brd10
|
UTSW |
19 |
29,731,077 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1939:Brd10
|
UTSW |
19 |
29,731,077 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1969:Brd10
|
UTSW |
19 |
29,694,075 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2153:Brd10
|
UTSW |
19 |
29,694,229 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2366:Brd10
|
UTSW |
19 |
29,731,035 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2379:Brd10
|
UTSW |
19 |
29,696,275 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3107:Brd10
|
UTSW |
19 |
29,700,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Brd10
|
UTSW |
19 |
29,720,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Brd10
|
UTSW |
19 |
29,696,149 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4328:Brd10
|
UTSW |
19 |
29,720,961 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4329:Brd10
|
UTSW |
19 |
29,720,961 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4387:Brd10
|
UTSW |
19 |
29,782,715 (GRCm39) |
unclassified |
probably benign |
|
|
R4688:Brd10
|
UTSW |
19 |
29,694,501 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4796:Brd10
|
UTSW |
19 |
29,731,018 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4820:Brd10
|
UTSW |
19 |
29,695,809 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4832:Brd10
|
UTSW |
19 |
29,694,616 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5056:Brd10
|
UTSW |
19 |
29,694,759 (GRCm39) |
missense |
probably benign |
|
|
R5150:Brd10
|
UTSW |
19 |
29,782,950 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5224:Brd10
|
UTSW |
19 |
29,696,450 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5306:Brd10
|
UTSW |
19 |
29,707,230 (GRCm39) |
intron |
probably benign |
|
|
R5460:Brd10
|
UTSW |
19 |
29,732,250 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5477:Brd10
|
UTSW |
19 |
29,731,518 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5531:Brd10
|
UTSW |
19 |
29,731,072 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5559:Brd10
|
UTSW |
19 |
29,694,363 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5647:Brd10
|
UTSW |
19 |
29,731,210 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5886:Brd10
|
UTSW |
19 |
29,696,677 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6029:Brd10
|
UTSW |
19 |
29,732,367 (GRCm39) |
unclassified |
probably benign |
|
|
R6240:Brd10
|
UTSW |
19 |
29,694,640 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6331:Brd10
|
UTSW |
19 |
29,695,147 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6456:Brd10
|
UTSW |
19 |
29,693,914 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6584:Brd10
|
UTSW |
19 |
29,696,128 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6661:Brd10
|
UTSW |
19 |
29,700,864 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6991:Brd10
|
UTSW |
19 |
29,696,508 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7059:Brd10
|
UTSW |
19 |
29,696,945 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7128:Brd10
|
UTSW |
19 |
29,693,881 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7471:Brd10
|
UTSW |
19 |
29,707,139 (GRCm39) |
splice site |
probably null |
|
|
R7686:Brd10
|
UTSW |
19 |
29,694,870 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8012:Brd10
|
UTSW |
19 |
29,695,534 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8203:Brd10
|
UTSW |
19 |
29,693,443 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8353:Brd10
|
UTSW |
19 |
29,731,242 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8672:Brd10
|
UTSW |
19 |
29,731,564 (GRCm39) |
missense |
probably benign |
|
|
R8755:Brd10
|
UTSW |
19 |
29,693,890 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8918:Brd10
|
UTSW |
19 |
29,696,841 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8954:Brd10
|
UTSW |
19 |
29,696,126 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9038:Brd10
|
UTSW |
19 |
29,731,900 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9195:Brd10
|
UTSW |
19 |
29,763,703 (GRCm39) |
missense |
|
|
|
R9204:Brd10
|
UTSW |
19 |
29,696,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9518:Brd10
|
UTSW |
19 |
29,731,541 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9743:Brd10
|
UTSW |
19 |
29,694,261 (GRCm39) |
missense |
probably benign |
|
|
R9747:Brd10
|
UTSW |
19 |
29,731,911 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
RF011:Brd10
|
UTSW |
19 |
29,721,009 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
X0027:Brd10
|
UTSW |
19 |
29,712,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGGAATCCTGTTAAAATGGGACC -3'
(R):5'- ACAGCAAAAGAAGTTCTACTGAGGTAC -3'
Sequencing Primer
(F):5'- GACCAAAACTGTGCTATTGGC -3'
(R):5'- GCCTATCCAGAAGGTTTGACC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation