Mutagenetix > Incidental Mutation

Incidental Mutation 'R7214:Dock10'

561263

Institutional Source

Beutler Lab

Gene Symbol

Dock10

Ensembl Gene

ENSMUSG00000038608

Gene Name

dedicator of cytokinesis 10

Synonyms

Zizimin3, A630054M16Rik, Jr5, ZIZ3, Jr4, 9330153B10Rik

MMRRC Submission

045286-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.487) question?

Stock #

R7214 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

80478790-80736244 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 80546246 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 785 (H785L)

Ref Sequence

ENSEMBL: ENSMUSP00000140085 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077946] [ENSMUST00000187774] [ENSMUST00000190595] [ENSMUST00000190983]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000077946
AA Change: H797L

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000077099
Gene: ENSMUSG00000038608
AA Change: H797L

Domain	Start	End	E-Value	Type
low complexity region	25	42	N/A	INTRINSIC
Pfam:DUF3398	61	153	1.7e-36	PFAM
PH	182	292	8.5e-17	SMART
Blast:PH	350	458	7e-18	BLAST
Pfam:DOCK-C2	668	859	1e-50	PFAM
low complexity region	1269	1279	N/A	INTRINSIC
low complexity region	1284	1295	N/A	INTRINSIC
Pfam:DHR-2	1592	2143	1.3e-216	PFAM
low complexity region	2174	2187	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000187774
AA Change: H785L

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000140085
Gene: ENSMUSG00000038608
AA Change: H785L

Domain	Start	End	E-Value	Type
Pfam:DUF3398	46	141	9e-29	PFAM
PH	170	280	3.9e-19	SMART
Blast:PH	338	446	7e-18	BLAST
Pfam:DOCK-C2	655	848	1.5e-54	PFAM
low complexity region	1257	1267	N/A	INTRINSIC
low complexity region	1272	1283	N/A	INTRINSIC
low complexity region	1870	1890	N/A	INTRINSIC
Pfam:Ded_cyto	1954	2131	3.4e-65	PFAM
low complexity region	2162	2175	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190595
AA Change: H450L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000139567
Gene: ENSMUSG00000038608
AA Change: H450L

Domain	Start	End	E-Value	Type
Blast:PH	3	111	5e-18	BLAST
Pfam:DOCK-C2	320	513	1.2e-54	PFAM
low complexity region	922	932	N/A	INTRINSIC
low complexity region	937	948	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
Pfam:Ded_cyto	1588	1765	2.7e-65	PFAM
low complexity region	1783	1795	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190983
AA Change: H784L

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000140719
Gene: ENSMUSG00000038608
AA Change: H784L

Domain	Start	End	E-Value	Type
Pfam:DUF3398	45	140	8.9e-29	PFAM
PH	169	279	3.9e-19	SMART
Blast:PH	337	445	7e-18	BLAST
Pfam:DOCK-C2	654	847	1.5e-54	PFAM
low complexity region	1256	1266	N/A	INTRINSIC
low complexity region	1271	1282	N/A	INTRINSIC
low complexity region	1869	1889	N/A	INTRINSIC
Pfam:Ded_cyto	1953	2130	3.4e-65	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg5	C	T	8: 95,660,646 (GRCm39)	T95I		Het
Arap2	C	T	5: 62,906,681 (GRCm39)	V113I	probably benign	Het
Atraid	C	T	5: 31,209,590 (GRCm39)	Q85*	probably null	Het
Bcdin3d	T	C	15: 99,368,344 (GRCm39)	D285G	probably benign	Het
Bmal1	T	A	7: 112,898,610 (GRCm39)	I346K	probably benign	Het
Carmil3	T	C	14: 55,736,069 (GRCm39)	W604R	probably damaging	Het
Ccl6	C	T	11: 83,480,582 (GRCm39)		probably null	Het
Cct4	C	T	11: 22,940,616 (GRCm39)		probably benign	Het
Cd2ap	C	T	17: 43,156,285 (GRCm39)	R84Q	possibly damaging	Het
Cdt1	T	A	8: 123,295,012 (GRCm39)		probably null	Het
Cln3	C	T	7: 126,181,942 (GRCm39)	G40D	probably damaging	Het
Crlf3	T	C	11: 79,955,216 (GRCm39)	S47G	possibly damaging	Het
Csrp3	T	C	7: 48,480,385 (GRCm39)	K193R	probably benign	Het
Cxcl3	A	C	5: 90,934,219 (GRCm39)	E33A	probably damaging	Het
Cyp11b1	T	C	15: 74,708,708 (GRCm39)	D362G	probably benign	Het
Dnah2	T	C	11: 69,321,935 (GRCm39)	D3795G	probably damaging	Het
Dnah3	G	A	7: 119,521,965 (GRCm39)	A4076V	probably damaging	Het
Dnaja3	T	A	16: 4,519,046 (GRCm39)	I380N	possibly damaging	Het
Dop1b	T	G	16: 93,607,023 (GRCm39)	F2226V	possibly damaging	Het
Dscaml1	A	T	9: 45,581,437 (GRCm39)	I419F	probably benign	Het
Dyrk4	T	A	6: 126,862,200 (GRCm39)	I431F	probably benign	Het
Endog	C	T	2: 30,062,902 (GRCm39)	R181C	probably damaging	Het
Fam90a1a	A	T	8: 22,453,641 (GRCm39)	Y332F	probably benign	Het
Fastkd3	T	C	13: 68,737,499 (GRCm39)	I588T	probably benign	Het
Galnt9	G	A	5: 110,737,694 (GRCm39)	V217I	probably benign	Het
Gm973	A	T	1: 59,601,888 (GRCm39)	R501*	probably null	Het
Gnptab	C	T	10: 88,215,019 (GRCm39)		probably benign	Het
Gpn1	T	C	5: 31,660,761 (GRCm39)	F184S	probably damaging	Het
Imp3	G	T	9: 56,845,007 (GRCm39)	V73L	probably benign	Het
Ipo11	T	C	13: 107,032,365 (GRCm39)	D259G	probably null	Het
Jag1	T	C	2: 136,948,802 (GRCm39)	S142G	probably benign	Het
Klhl5	A	T	5: 65,289,098 (GRCm39)	E120V	probably benign	Het
Lct	C	A	1: 128,228,197 (GRCm39)	V1099L	probably benign	Het
Lrba	G	C	3: 86,235,633 (GRCm39)	W912C	probably damaging	Het
Lss	C	T	10: 76,383,305 (GRCm39)	T535I	probably damaging	Het
Mcts2	T	C	2: 152,529,297 (GRCm39)	I36T	probably benign	Het
Meikin	T	A	11: 54,302,738 (GRCm39)	N383K	probably benign	Het
Myo1g	T	C	11: 6,461,055 (GRCm39)	Y663C	probably damaging	Het
Nadk2	T	A	15: 9,108,342 (GRCm39)	M419K	probably damaging	Het
Nbeal1	G	C	1: 60,276,310 (GRCm39)	V684L	probably benign	Het
Nfat5	T	C	8: 108,020,515 (GRCm39)	S20P	probably damaging	Het
Nlrp1a	C	T	11: 71,014,119 (GRCm39)	C377Y	probably damaging	Het
Nlrp9a	T	C	7: 26,250,463 (GRCm39)	V76A	probably damaging	Het
Nrap	C	A	19: 56,366,567 (GRCm39)	A341S	probably benign	Het
Ntng2	T	C	2: 29,117,732 (GRCm39)	S239G	probably damaging	Het
Nup188	T	A	2: 30,197,566 (GRCm39)	C207S	possibly damaging	Het
Or10a4	T	C	7: 106,697,619 (GRCm39)	*316R	probably null	Het
Or10ak7	T	A	4: 118,791,146 (GRCm39)	I300F	possibly damaging	Het
Or1j17	T	C	2: 36,578,107 (GRCm39)	I31T	probably benign	Het
Or2ag1	T	C	7: 106,473,474 (GRCm39)		probably benign	Het
Or5b118	T	A	19: 13,448,337 (GRCm39)	M1K	probably null	Het
Or8c13	A	C	9: 38,091,318 (GRCm39)	V267G	probably damaging	Het
Or8k31-ps1	C	T	2: 86,356,150 (GRCm39)	V124I	probably damaging	Het
Pcdhgb2	C	A	18: 37,823,159 (GRCm39)	A50E	probably damaging	Het
Pgap1	A	T	1: 54,582,220 (GRCm39)	M209K	possibly damaging	Het
Plbd1	T	A	6: 136,589,829 (GRCm39)	D463V	probably damaging	Het
Plcg2	T	A	8: 118,310,288 (GRCm39)	I380N	probably damaging	Het
Pnpt1	T	C	11: 29,087,285 (GRCm39)	W184R	probably damaging	Het
Pptc7	G	A	5: 122,451,840 (GRCm39)	V202I	probably benign	Het
Prpf6	C	T	2: 181,282,389 (GRCm39)	A510V	probably damaging	Het
Prr5l	T	C	2: 101,559,777 (GRCm39)	Y235C	probably benign	Het
Ptprk	T	C	10: 28,450,905 (GRCm39)	V1022A	probably benign	Het
Rbl2	T	C	8: 91,810,057 (GRCm39)		probably null	Het
Rmnd1	T	C	10: 4,360,753 (GRCm39)	K348E	probably benign	Het
Rsf1	CGGCGGC	CGGCGGCGGGGGCGGC	7: 97,229,136 (GRCm39)		probably benign	Het
Sacs	T	A	14: 61,429,241 (GRCm39)	N433K	probably benign	Het
Scyl1	T	C	19: 5,810,057 (GRCm39)	T590A	probably benign	Het
Sdhd	A	G	9: 50,508,533 (GRCm39)	V111A	possibly damaging	Het
Sec24b	G	T	3: 129,827,509 (GRCm39)	P330Q	probably benign	Het
Serpinb6d	C	T	13: 33,848,128 (GRCm39)	P31S	probably damaging	Het
Slc26a9	A	T	1: 131,687,211 (GRCm39)	R457W	probably damaging	Het
Slc5a8	G	A	10: 88,755,364 (GRCm39)	M490I	probably benign	Het
Slx4	A	G	16: 3,806,844 (GRCm39)	I533T	probably benign	Het
Slx4ip	T	A	2: 136,888,650 (GRCm39)	F110L	probably benign	Het
Smchd1	T	C	17: 71,652,359 (GRCm39)	R2000G	probably benign	Het
Snx8	T	C	5: 140,346,008 (GRCm39)	E75G	possibly damaging	Het
Stab2	C	A	10: 86,735,705 (GRCm39)	C1292F	probably damaging	Het
Swt1	A	T	1: 151,270,364 (GRCm39)	M617K	possibly damaging	Het
Thoc2l	A	G	5: 104,670,229 (GRCm39)	T1584A	probably benign	Het
Tiam2	T	A	17: 3,568,687 (GRCm39)	I1611N	possibly damaging	Het
Tmem63b	T	G	17: 45,972,748 (GRCm39)	N682T	probably benign	Het
Trio	C	T	15: 27,871,273 (GRCm39)	V674M	probably damaging	Het
Trpc3	G	A	3: 36,704,286 (GRCm39)	T557M	possibly damaging	Het
Vac14	T	G	8: 111,397,674 (GRCm39)	L463R	probably damaging	Het
Vmn2r43	C	T	7: 8,256,379 (GRCm39)		probably null	Het
Wdr49	A	T	3: 75,265,751 (GRCm39)	Y232N	possibly damaging	Het
Wdr90	T	C	17: 26,064,367 (GRCm39)	M1835V	probably benign	Het
Xpc	T	C	6: 91,469,320 (GRCm39)	E809G	probably damaging	Het
Zfhx3	A	T	8: 109,675,493 (GRCm39)	Q2181L	probably damaging	Het
Zfp442	T	C	2: 150,251,201 (GRCm39)	T234A	probably benign	Het
Zfp764	A	T	7: 127,004,450 (GRCm39)	M227K	probably benign	Het
Zfp764l1	A	G	7: 126,990,695 (GRCm39)	S431P	probably benign	Het
Zfp957	A	G	14: 79,450,750 (GRCm39)	S350P	unknown	Het
Zscan29	T	A	2: 120,999,761 (GRCm39)	K147*	probably null	Het

Other mutations in Dock10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00569:Dock10	APN	1	80,562,729 (GRCm39)	missense	probably damaging	1.00
IGL00783:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00784:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00858:Dock10	APN	1	80,545,720 (GRCm39)	missense	possibly damaging	0.48
IGL01298:Dock10	APN	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
IGL01351:Dock10	APN	1	80,570,876 (GRCm39)	missense	probably damaging	1.00
IGL01356:Dock10	APN	1	80,501,459 (GRCm39)	missense	probably damaging	1.00
IGL01584:Dock10	APN	1	80,511,567 (GRCm39)	missense	probably damaging	0.99
IGL01619:Dock10	APN	1	80,612,015 (GRCm39)	splice site	probably benign
IGL01678:Dock10	APN	1	80,521,069 (GRCm39)	missense	probably damaging	1.00
IGL01759:Dock10	APN	1	80,503,990 (GRCm39)	missense	probably damaging	1.00
IGL02238:Dock10	APN	1	80,511,510 (GRCm39)	missense	probably damaging	0.99
IGL02352:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02359:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02377:Dock10	APN	1	80,562,711 (GRCm39)	critical splice donor site	probably null
IGL02433:Dock10	APN	1	80,507,905 (GRCm39)	missense	probably damaging	1.00
IGL02471:Dock10	APN	1	80,493,339 (GRCm39)	missense	probably damaging	0.99
IGL02645:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02646:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02648:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02649:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02650:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02652:Dock10	APN	1	80,570,561 (GRCm39)	splice site	probably null
IGL02718:Dock10	APN	1	80,501,535 (GRCm39)	missense	probably benign	0.00
IGL02998:Dock10	APN	1	80,551,259 (GRCm39)	missense	probably damaging	1.00
IGL03057:Dock10	APN	1	80,545,088 (GRCm39)	missense	probably damaging	1.00
IGL03066:Dock10	APN	1	80,562,758 (GRCm39)	missense	probably benign	0.00
IGL03106:Dock10	APN	1	80,546,551 (GRCm39)	missense	probably damaging	0.98
IGL03148:Dock10	APN	1	80,518,075 (GRCm39)	missense	probably benign	0.01
IGL03271:Dock10	APN	1	80,483,126 (GRCm39)	missense	probably damaging	1.00
IGL03352:Dock10	APN	1	80,584,013 (GRCm39)	splice site	probably benign
LCD18:Dock10	UTSW	1	80,716,623 (GRCm38)	intron	probably benign
PIT4366001:Dock10	UTSW	1	80,573,438 (GRCm39)	missense	probably benign	0.30
PIT4581001:Dock10	UTSW	1	80,483,163 (GRCm39)	missense	probably damaging	1.00
R0019:Dock10	UTSW	1	80,583,642 (GRCm39)	missense	probably damaging	1.00
R0081:Dock10	UTSW	1	80,584,295 (GRCm39)	missense	probably damaging	0.99
R0095:Dock10	UTSW	1	80,501,788 (GRCm39)	missense	probably benign	0.00
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0255:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R0267:Dock10	UTSW	1	80,490,171 (GRCm39)	missense	probably damaging	1.00
R0299:Dock10	UTSW	1	80,514,646 (GRCm39)	missense	probably damaging	0.99
R0365:Dock10	UTSW	1	80,573,400 (GRCm39)	missense	probably damaging	1.00
R0387:Dock10	UTSW	1	80,517,993 (GRCm39)	missense	probably damaging	1.00
R0403:Dock10	UTSW	1	80,501,787 (GRCm39)	missense	possibly damaging	0.94
R0408:Dock10	UTSW	1	80,518,193 (GRCm39)	missense	probably benign	0.03
R0414:Dock10	UTSW	1	80,513,650 (GRCm39)	missense	possibly damaging	0.93
R0591:Dock10	UTSW	1	80,518,936 (GRCm39)	splice site	probably benign
R0698:Dock10	UTSW	1	80,507,895 (GRCm39)	missense	probably damaging	1.00
R0711:Dock10	UTSW	1	80,501,692 (GRCm39)	missense	probably damaging	1.00
R0925:Dock10	UTSW	1	80,514,657 (GRCm39)	missense	probably benign	0.20
R1162:Dock10	UTSW	1	80,546,559 (GRCm39)	missense	possibly damaging	0.58
R1370:Dock10	UTSW	1	80,518,060 (GRCm39)	missense	probably damaging	1.00
R1440:Dock10	UTSW	1	80,526,853 (GRCm39)	missense	probably benign	0.03
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1525:Dock10	UTSW	1	80,583,881 (GRCm39)	critical splice donor site	probably null
R1544:Dock10	UTSW	1	80,570,352 (GRCm39)	missense	probably benign	0.00
R1601:Dock10	UTSW	1	80,527,519 (GRCm39)	missense	probably benign	0.00
R1757:Dock10	UTSW	1	80,511,586 (GRCm39)	missense	probably damaging	1.00
R1765:Dock10	UTSW	1	80,583,540 (GRCm39)	missense	probably damaging	1.00
R1783:Dock10	UTSW	1	80,551,897 (GRCm39)	missense	probably benign	0.17
R1823:Dock10	UTSW	1	80,520,814 (GRCm39)	splice site	probably null
R1827:Dock10	UTSW	1	80,508,009 (GRCm39)	missense	probably benign	0.07
R1844:Dock10	UTSW	1	80,520,918 (GRCm39)	missense	probably damaging	0.99
R1856:Dock10	UTSW	1	80,584,285 (GRCm39)	missense	possibly damaging	0.46
R1974:Dock10	UTSW	1	80,488,143 (GRCm39)	missense	possibly damaging	0.50
R2006:Dock10	UTSW	1	80,527,506 (GRCm39)	missense	possibly damaging	0.95
R2112:Dock10	UTSW	1	80,483,360 (GRCm39)	missense	probably damaging	0.99
R2112:Dock10	UTSW	1	80,483,359 (GRCm39)	missense	probably damaging	1.00
R2113:Dock10	UTSW	1	80,584,280 (GRCm39)	missense	probably damaging	1.00
R2439:Dock10	UTSW	1	80,510,149 (GRCm39)	missense	probably damaging	1.00
R2566:Dock10	UTSW	1	80,517,970 (GRCm39)	missense	possibly damaging	0.88
R3086:Dock10	UTSW	1	80,510,074 (GRCm39)	missense	possibly damaging	0.91
R3766:Dock10	UTSW	1	80,514,643 (GRCm39)	missense	probably damaging	0.99
R3768:Dock10	UTSW	1	80,510,085 (GRCm39)	missense	probably damaging	1.00
R4009:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R4016:Dock10	UTSW	1	80,584,286 (GRCm39)	missense	probably damaging	1.00
R4179:Dock10	UTSW	1	80,488,134 (GRCm39)	missense	probably benign	0.00
R4243:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4244:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4245:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4674:Dock10	UTSW	1	80,584,337 (GRCm39)	missense	possibly damaging	0.79
R4696:Dock10	UTSW	1	80,493,330 (GRCm39)	missense	possibly damaging	0.95
R4789:Dock10	UTSW	1	80,518,998 (GRCm39)	missense	probably damaging	1.00
R4851:Dock10	UTSW	1	80,526,874 (GRCm39)	missense	probably benign	0.33
R4911:Dock10	UTSW	1	80,583,953 (GRCm39)	missense	probably damaging	1.00
R4976:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5086:Dock10	UTSW	1	80,529,189 (GRCm39)	missense	possibly damaging	0.89
R5119:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5301:Dock10	UTSW	1	80,625,973 (GRCm39)	missense	probably benign	0.41
R5404:Dock10	UTSW	1	80,481,630 (GRCm39)	intron	probably benign
R5457:Dock10	UTSW	1	80,501,781 (GRCm39)	missense	probably damaging	1.00
R5790:Dock10	UTSW	1	80,482,887 (GRCm39)	missense	probably benign	0.00
R5845:Dock10	UTSW	1	80,483,459 (GRCm39)	intron	probably benign
R5871:Dock10	UTSW	1	80,519,057 (GRCm39)	critical splice acceptor site	probably null
R5873:Dock10	UTSW	1	80,551,855 (GRCm39)	missense	probably damaging	1.00
R5881:Dock10	UTSW	1	80,538,640 (GRCm39)	missense	probably benign	0.19
R5895:Dock10	UTSW	1	80,514,676 (GRCm39)	missense	probably benign
R5935:Dock10	UTSW	1	80,483,304 (GRCm39)	intron	probably benign
R5965:Dock10	UTSW	1	80,546,461 (GRCm39)	splice site	probably null
R5966:Dock10	UTSW	1	80,546,225 (GRCm39)	missense	possibly damaging	0.84
R6008:Dock10	UTSW	1	80,583,890 (GRCm39)	missense	probably damaging	0.98
R6029:Dock10	UTSW	1	80,514,663 (GRCm39)	missense	possibly damaging	0.68
R6083:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R6145:Dock10	UTSW	1	80,553,621 (GRCm39)	nonsense	probably null
R6257:Dock10	UTSW	1	80,481,413 (GRCm39)	intron	probably benign
R6274:Dock10	UTSW	1	80,516,540 (GRCm39)	missense	probably damaging	1.00
R6324:Dock10	UTSW	1	80,482,893 (GRCm39)	missense	probably benign	0.03
R6346:Dock10	UTSW	1	80,553,573 (GRCm39)	splice site	probably null
R6476:Dock10	UTSW	1	80,518,959 (GRCm39)	nonsense	probably null
R6516:Dock10	UTSW	1	80,518,178 (GRCm39)	missense	probably damaging	1.00
R6526:Dock10	UTSW	1	80,564,068 (GRCm39)	missense	probably damaging	0.97
R6534:Dock10	UTSW	1	80,481,388 (GRCm39)	missense	probably benign	0.01
R6620:Dock10	UTSW	1	80,570,355 (GRCm39)	missense	probably benign	0.01
R6640:Dock10	UTSW	1	80,511,555 (GRCm39)	nonsense	probably null
R6669:Dock10	UTSW	1	80,570,572 (GRCm39)	missense	probably damaging	1.00
R6672:Dock10	UTSW	1	80,490,248 (GRCm39)	missense	probably benign	0.00
R6679:Dock10	UTSW	1	80,544,514 (GRCm39)	missense	probably benign	0.11
R6682:Dock10	UTSW	1	80,490,338 (GRCm39)	missense	probably damaging	1.00
R6712:Dock10	UTSW	1	80,514,583 (GRCm39)	missense	probably benign	0.00
R6726:Dock10	UTSW	1	80,490,147 (GRCm39)	missense	probably damaging	1.00
R6788:Dock10	UTSW	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
R6805:Dock10	UTSW	1	80,564,407 (GRCm39)	missense	probably benign
R6815:Dock10	UTSW	1	80,516,576 (GRCm39)	missense	possibly damaging	0.94
R6818:Dock10	UTSW	1	80,593,082 (GRCm39)	missense	possibly damaging	0.95
R6867:Dock10	UTSW	1	80,508,976 (GRCm39)	missense	probably damaging	1.00
R6964:Dock10	UTSW	1	80,481,365 (GRCm39)	intron	probably benign
R7026:Dock10	UTSW	1	80,479,504 (GRCm39)	missense	probably benign	0.40
R7084:Dock10	UTSW	1	80,481,573 (GRCm39)	missense
R7087:Dock10	UTSW	1	80,570,543 (GRCm39)	missense	probably benign
R7158:Dock10	UTSW	1	80,564,589 (GRCm39)	critical splice acceptor site	probably null
R7191:Dock10	UTSW	1	80,518,048 (GRCm39)	missense	possibly damaging	0.93
R7255:Dock10	UTSW	1	80,520,816 (GRCm39)	critical splice donor site	probably null
R7320:Dock10	UTSW	1	80,527,421 (GRCm39)	critical splice donor site	probably null
R7359:Dock10	UTSW	1	80,687,065 (GRCm39)	missense	probably benign	0.01
R7423:Dock10	UTSW	1	80,501,497 (GRCm39)	missense	possibly damaging	0.67
R7464:Dock10	UTSW	1	80,518,032 (GRCm39)	missense	probably damaging	0.99
R7483:Dock10	UTSW	1	80,493,283 (GRCm39)	missense	probably benign	0.01
R7487:Dock10	UTSW	1	80,562,765 (GRCm39)	missense	probably benign	0.00
R7789:Dock10	UTSW	1	80,536,930 (GRCm39)	missense	possibly damaging	0.82
R7943:Dock10	UTSW	1	80,626,006 (GRCm39)	missense	probably damaging	0.98
R7962:Dock10	UTSW	1	80,564,085 (GRCm39)	missense	possibly damaging	0.88
R8079:Dock10	UTSW	1	80,556,421 (GRCm39)	missense	probably benign	0.00
R8086:Dock10	UTSW	1	80,481,707 (GRCm39)	missense	probably benign	0.17
R8184:Dock10	UTSW	1	80,530,469 (GRCm39)	missense	probably damaging	1.00
R8220:Dock10	UTSW	1	80,506,366 (GRCm39)	missense	probably null	1.00
R8225:Dock10	UTSW	1	80,481,447 (GRCm39)	nonsense	probably null
R8267:Dock10	UTSW	1	80,518,045 (GRCm39)	missense	probably benign	0.00
R8276:Dock10	UTSW	1	80,505,998 (GRCm39)	missense	probably benign
R8294:Dock10	UTSW	1	80,488,079 (GRCm39)	missense	possibly damaging	0.88
R8298:Dock10	UTSW	1	80,514,654 (GRCm39)	missense	probably benign	0.00
R8326:Dock10	UTSW	1	80,583,892 (GRCm39)	missense	possibly damaging	0.77
R8724:Dock10	UTSW	1	80,570,344 (GRCm39)	missense	probably benign	0.00
R8828:Dock10	UTSW	1	80,521,134 (GRCm39)	missense	probably damaging	1.00
R8846:Dock10	UTSW	1	80,545,786 (GRCm39)	missense	possibly damaging	0.93
R8919:Dock10	UTSW	1	80,483,147 (GRCm39)	missense	probably benign	0.00
R8950:Dock10	UTSW	1	80,519,016 (GRCm39)	missense	probably benign
R8993:Dock10	UTSW	1	80,551,888 (GRCm39)	missense	probably benign	0.21
R9028:Dock10	UTSW	1	80,584,012 (GRCm39)	splice site	probably benign
R9115:Dock10	UTSW	1	80,490,156 (GRCm39)	missense	probably damaging	1.00
R9327:Dock10	UTSW	1	80,510,184 (GRCm39)	missense	probably damaging	1.00
R9342:Dock10	UTSW	1	80,570,360 (GRCm39)	missense	probably benign
R9421:Dock10	UTSW	1	80,501,509 (GRCm39)	missense	probably damaging	1.00
R9431:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R9486:Dock10	UTSW	1	80,479,452 (GRCm39)	missense	unknown
R9521:Dock10	UTSW	1	80,501,763 (GRCm39)	missense	probably damaging	1.00
R9598:Dock10	UTSW	1	80,625,939 (GRCm39)	missense	probably benign	0.15
R9629:Dock10	UTSW	1	80,481,389 (GRCm39)	missense
R9703:Dock10	UTSW	1	80,517,540 (GRCm39)	missense	probably damaging	0.98
RF021:Dock10	UTSW	1	80,542,290 (GRCm39)	critical splice acceptor site	probably null
X0025:Dock10	UTSW	1	80,514,637 (GRCm39)	missense	probably damaging	0.98
X0065:Dock10	UTSW	1	80,518,977 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock10	UTSW	1	80,510,064 (GRCm39)	missense	probably damaging	1.00
Z1176:Dock10	UTSW	1	80,538,671 (GRCm39)	missense	probably benign
Z1177:Dock10	UTSW	1	80,536,917 (GRCm39)	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- AGCATGATATACTTCCATGGAGTCC -3'
(R):5'- GTGTTTAACTTCAGTTGGAGACC -3'

Sequencing Primer
(F):5'- CACTTCATAAGTACAATGGACATGC -3'
(R):5'- GGAGACCATTTTTAAAAGATGCAGTG -3'

Posted On

2019-06-26