Incidental Mutation 'R7217:Fcrl5'
ID 561524
Institutional Source Beutler Lab
Gene Symbol Fcrl5
Ensembl Gene ENSMUSG00000048031
Gene Name Fc receptor-like 5
Synonyms Fcrh3, BXMAS1-like protein 2, mBXMH2
MMRRC Submission 045289-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R7217 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 87343084-87407985 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 87351081 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 197 (T197M)
Ref Sequence ENSEMBL: ENSMUSP00000142210 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049926] [ENSMUST00000166297] [ENSMUST00000178261] [ENSMUST00000193229] [ENSMUST00000194102]
AlphaFold Q68SN8
Predicted Effect probably damaging
Transcript: ENSMUST00000049926
AA Change: T197M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000050151
Gene: ENSMUSG00000048031
AA Change: T197M

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000166297
AA Change: T109M

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000131176
Gene: ENSMUSG00000048031
AA Change: T109M

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000178261
AA Change: T197M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000136046
Gene: ENSMUSG00000048031
AA Change: T197M

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000193229
AA Change: T109M

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000141311
Gene: ENSMUSG00000048031
AA Change: T109M

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IGc2 40 100 6.16e-4 SMART
IG_like 125 208 4.41e1 SMART
IGc2 228 292 3.97e-7 SMART
IG_like 322 385 2.94e-1 SMART
transmembrane domain 407 429 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000194102
AA Change: T197M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000142210
Gene: ENSMUSG00000048031
AA Change: T197M

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG 40 113 2.08e-1 SMART
IGc2 128 188 6.16e-4 SMART
IG_like 213 296 4.41e1 SMART
IGc2 316 380 3.97e-7 SMART
IG_like 410 473 2.94e-1 SMART
transmembrane domain 495 517 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 91% (40/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik C A 5: 138,645,188 (GRCm39) H358N probably benign Het
Abcg3 A G 5: 105,087,094 (GRCm39) F543L possibly damaging Het
Asnsd1 T C 1: 53,387,352 (GRCm39) T92A probably damaging Het
Atg2a G T 19: 6,303,471 (GRCm39) probably null Het
Aven T A 2: 112,461,191 (GRCm39) N327K possibly damaging Het
Brd9 T C 13: 74,087,063 (GRCm39) V116A probably damaging Het
Car14 A G 3: 95,806,629 (GRCm39) S250P probably damaging Het
Ccdc138 T C 10: 58,345,422 (GRCm39) I138T probably benign Het
Cmya5 A G 13: 93,226,938 (GRCm39) Y2717H probably damaging Het
Eno1b C A 18: 48,180,746 (GRCm39) T308K probably damaging Het
Epha3 T C 16: 63,372,857 (GRCm39) T949A probably benign Het
Foxp2 A T 6: 15,416,023 (GRCm39) Q664L unknown Het
Fsip2 A T 2: 82,819,412 (GRCm39) K5048N possibly damaging Het
Gcnt4 T C 13: 97,082,818 (GRCm39) L38P probably damaging Het
Gpr68 A G 12: 100,845,058 (GRCm39) V162A possibly damaging Het
Grin3a A T 4: 49,770,741 (GRCm39) M677K possibly damaging Het
Grm7 A G 6: 111,335,785 (GRCm39) Y732C probably damaging Het
H2-T15 A C 17: 36,367,235 (GRCm39) M329R probably benign Het
Hoxb4 A G 11: 96,209,906 (GRCm39) E104G probably benign Het
Kat7 A G 11: 95,182,390 (GRCm39) S237P possibly damaging Het
Kif13b T C 14: 65,010,517 (GRCm39) V1272A probably damaging Het
Kif20a T A 18: 34,762,613 (GRCm39) H495Q probably benign Het
Lama1 A T 17: 68,071,668 (GRCm39) T852S Het
Mep1b T A 18: 21,226,600 (GRCm39) D487E probably benign Het
Mki67 T C 7: 135,305,911 (GRCm39) T656A probably damaging Het
Mlh3 A G 12: 85,313,481 (GRCm39) W902R probably benign Het
Muc16 A T 9: 18,555,372 (GRCm39) Y3640* probably null Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Pkd1l2 A G 8: 117,722,536 (GRCm39) I2424T probably benign Het
Prl8a2 A G 13: 27,534,998 (GRCm39) E91G possibly damaging Het
Prpf18 A G 2: 4,650,435 (GRCm39) V65A probably benign Het
Pxmp2 A G 5: 110,433,771 (GRCm39) V34A probably damaging Het
Ranbp2 T G 10: 58,287,839 (GRCm39) Y36D probably damaging Het
Rbm25 G A 12: 83,710,991 (GRCm39) R368Q unknown Het
Rims2 C A 15: 39,339,885 (GRCm39) L860M probably damaging Het
Rsf1 CGGC CGGCGGCGGGGGC 7: 97,229,139 (GRCm39) probably benign Het
Scn8a A T 15: 100,868,108 (GRCm39) M318L probably benign Het
Slc35b2 A G 17: 45,875,955 (GRCm39) T55A probably benign Het
Trnp1 T C 4: 133,225,416 (GRCm39) E118G possibly damaging Het
Ttll13 A C 7: 79,903,911 (GRCm39) K280Q probably damaging Het
Wdfy3 A T 5: 102,049,785 (GRCm39) H1680Q probably damaging Het
Zfp131 A G 13: 120,237,377 (GRCm39) I327T probably damaging Het
Zfp729b A G 13: 67,743,367 (GRCm39) V66A probably damaging Het
Other mutations in Fcrl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Fcrl5 APN 3 87,351,598 (GRCm39) missense probably damaging 0.96
IGL01868:Fcrl5 APN 3 87,351,014 (GRCm39) missense possibly damaging 0.58
IGL01939:Fcrl5 APN 3 87,353,606 (GRCm39) missense probably damaging 0.99
IGL02817:Fcrl5 APN 3 87,343,220 (GRCm39) missense probably benign 0.35
IGL03106:Fcrl5 APN 3 87,343,190 (GRCm39) splice site probably null
R0381:Fcrl5 UTSW 3 87,353,767 (GRCm39) missense probably damaging 1.00
R0523:Fcrl5 UTSW 3 87,365,099 (GRCm39) missense possibly damaging 0.72
R0646:Fcrl5 UTSW 3 87,349,320 (GRCm39) missense probably benign 0.00
R1231:Fcrl5 UTSW 3 87,349,486 (GRCm39) missense probably benign 0.13
R1353:Fcrl5 UTSW 3 87,355,669 (GRCm39) missense probably damaging 1.00
R1711:Fcrl5 UTSW 3 87,364,721 (GRCm39) missense possibly damaging 0.61
R1714:Fcrl5 UTSW 3 87,353,713 (GRCm39) missense probably damaging 1.00
R1719:Fcrl5 UTSW 3 87,364,704 (GRCm39) missense probably damaging 0.98
R2084:Fcrl5 UTSW 3 87,351,537 (GRCm39) missense probably benign 0.24
R2358:Fcrl5 UTSW 3 87,353,726 (GRCm39) missense probably damaging 0.99
R2884:Fcrl5 UTSW 3 87,364,698 (GRCm39) missense probably damaging 1.00
R2885:Fcrl5 UTSW 3 87,364,698 (GRCm39) missense probably damaging 1.00
R3085:Fcrl5 UTSW 3 87,353,771 (GRCm39) missense probably damaging 1.00
R3153:Fcrl5 UTSW 3 87,350,987 (GRCm39) missense probably benign 0.09
R4288:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4289:Fcrl5 UTSW 3 87,349,531 (GRCm39) missense probably benign 0.09
R4614:Fcrl5 UTSW 3 87,355,733 (GRCm39) missense probably damaging 1.00
R4719:Fcrl5 UTSW 3 87,351,496 (GRCm39) missense probably damaging 1.00
R4788:Fcrl5 UTSW 3 87,364,495 (GRCm39) missense probably damaging 1.00
R4920:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R4972:Fcrl5 UTSW 3 87,361,957 (GRCm39) missense probably benign 0.00
R5373:Fcrl5 UTSW 3 87,353,698 (GRCm39) missense probably benign 0.01
R5374:Fcrl5 UTSW 3 87,353,698 (GRCm39) missense probably benign 0.01
R5963:Fcrl5 UTSW 3 87,351,480 (GRCm39) missense probably damaging 1.00
R5975:Fcrl5 UTSW 3 87,349,410 (GRCm39) missense probably benign 0.00
R6022:Fcrl5 UTSW 3 87,363,070 (GRCm39) missense probably benign 0.42
R6267:Fcrl5 UTSW 3 87,355,631 (GRCm39) missense probably damaging 1.00
R6372:Fcrl5 UTSW 3 87,351,501 (GRCm39) nonsense probably null
R6393:Fcrl5 UTSW 3 87,355,634 (GRCm39) missense probably damaging 1.00
R7088:Fcrl5 UTSW 3 87,365,141 (GRCm39) makesense probably null
R7175:Fcrl5 UTSW 3 87,353,645 (GRCm39) missense probably benign 0.37
R7210:Fcrl5 UTSW 3 87,353,719 (GRCm39) missense possibly damaging 0.85
R7243:Fcrl5 UTSW 3 87,349,552 (GRCm39) missense probably benign
R7776:Fcrl5 UTSW 3 87,351,502 (GRCm39) missense possibly damaging 0.84
R7813:Fcrl5 UTSW 3 87,350,930 (GRCm39) missense probably benign 0.09
R8357:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R8457:Fcrl5 UTSW 3 87,351,567 (GRCm39) missense probably damaging 0.99
R9257:Fcrl5 UTSW 3 87,343,195 (GRCm39) missense probably benign 0.11
R9276:Fcrl5 UTSW 3 87,343,138 (GRCm39) start gained probably benign
R9748:Fcrl5 UTSW 3 87,364,469 (GRCm39) missense possibly damaging 0.93
X0054:Fcrl5 UTSW 3 87,353,606 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTTCTGGTGCTGCAAGCTC -3'
(R):5'- GGTGCTGCTTTTGATTACCCAC -3'

Sequencing Primer
(F):5'- TTCTGAGGTGCTACGCAAAG -3'
(R):5'- TGATTACCCACATCCTCCCAC -3'
Posted On 2019-06-26