Incidental Mutation 'R7220:Or10j2'
ID 561711
Institutional Source Beutler Lab
Gene Symbol Or10j2
Ensembl Gene ENSMUSG00000049605
Gene Name olfactory receptor family 10 subfamily J member 2
Synonyms MOR267-8, Olfr418, Olfr1403, GA_x6K02T2P20D-20826777-20827719, Olfr418-ps1, MOR267-12P, GA_x6K02T2R7CC-581296-580364
MMRRC Submission 045292-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R7220 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 173097714-173098704 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 173097811 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 23 (Y23C)
Ref Sequence ENSEMBL: ENSMUSP00000150427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059754] [ENSMUST00000111224] [ENSMUST00000213420]
AlphaFold A0A140T8J6
Predicted Effect possibly damaging
Transcript: ENSMUST00000059754
AA Change: Y23C

PolyPhen 2 Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000052418
Gene: ENSMUSG00000049605
AA Change: Y23C

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.6e-55 PFAM
Pfam:7tm_1 41 289 5.7e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111224
SMART Domains Protein: ENSMUSP00000106855
Gene: ENSMUSG00000079180

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
PTX 20 219 1.93e-94 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000213420
AA Change: Y23C

PolyPhen 2 Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik A T 15: 84,837,337 (GRCm39) H325Q probably damaging Het
Aasdh T C 5: 77,049,772 (GRCm39) I75V probably benign Het
Abca14 G A 7: 119,826,667 (GRCm39) D438N possibly damaging Het
Abca8a T A 11: 109,980,793 (GRCm39) I82F probably benign Het
Abca8b G T 11: 109,872,543 (GRCm39) N19K probably damaging Het
Acan A G 7: 78,757,896 (GRCm39) N506S Het
Alox12e C A 11: 70,206,731 (GRCm39) R652L probably benign Het
Atad3a A G 4: 155,838,498 (GRCm39) V173A probably benign Het
Atl3 A G 19: 7,506,433 (GRCm39) K326R probably null Het
Atm G T 9: 53,423,217 (GRCm39) C636* probably null Het
Atp2c2 G A 8: 120,472,300 (GRCm39) M451I probably benign Het
Best1 A T 19: 9,969,479 (GRCm39) M193K probably benign Het
Bmper G T 9: 23,310,651 (GRCm39) G362C probably damaging Het
Brd4 T A 17: 32,444,557 (GRCm39) Y139F unknown Het
Bzw2 A T 12: 36,173,950 (GRCm39) I108N possibly damaging Het
Cbs C A 17: 31,838,191 (GRCm39) V353L probably benign Het
Ceacam20 A G 7: 19,701,678 (GRCm39) T22A probably damaging Het
Ckap2l C T 2: 129,117,436 (GRCm39) E580K probably damaging Het
Ckmt1 T C 2: 121,189,374 (GRCm39) L15P possibly damaging Het
Clec18a G T 8: 111,808,204 (GRCm39) P66H probably benign Het
Cma1 G T 14: 56,180,120 (GRCm39) T95K probably benign Het
Csmd3 A G 15: 48,320,994 (GRCm39) V272A probably damaging Het
Ctnna3 A T 10: 64,670,368 (GRCm39) E632D probably benign Het
Ctsc T C 7: 87,946,361 (GRCm39) L130P probably damaging Het
Frmpd2 A T 14: 33,229,432 (GRCm39) R339S probably damaging Het
Frrs1 C A 3: 116,674,425 (GRCm39) S69* probably null Het
Gcc2 A T 10: 58,116,416 (GRCm39) E1108D probably benign Het
Gkn1 A T 6: 87,326,135 (GRCm39) probably null Het
Gtf2a1 A T 12: 91,534,498 (GRCm39) M252K probably benign Het
H2-Ob T C 17: 34,460,234 (GRCm39) F115S probably damaging Het
Ighv1-53 T C 12: 115,122,135 (GRCm39) N80S probably benign Het
Ighv1-67 T C 12: 115,567,666 (GRCm39) K82R probably benign Het
Ints1 A T 5: 139,747,828 (GRCm39) I1193N possibly damaging Het
Kmt2c A G 5: 25,549,923 (GRCm39) F1353L probably damaging Het
Luc7l C T 17: 26,472,219 (GRCm39) probably benign Het
Man1a A C 10: 53,796,331 (GRCm39) S454A possibly damaging Het
Mars2 C A 1: 55,277,222 (GRCm39) A275D probably damaging Het
Nrde2 A G 12: 100,097,178 (GRCm39) V874A probably benign Het
Ociad1 A G 5: 73,470,809 (GRCm39) T244A probably benign Het
Or3a10 A T 11: 73,935,589 (GRCm39) D170E possibly damaging Het
Or8c9 A T 9: 38,241,046 (GRCm39) L51F probably damaging Het
Ovca2 A G 11: 75,069,501 (GRCm39) C41R possibly damaging Het
Pacsin2 A T 15: 83,269,260 (GRCm39) D11E probably damaging Het
Pcdh15 G A 10: 74,178,441 (GRCm39) S566N possibly damaging Het
Pde3b A G 7: 114,135,297 (GRCm39) I1038M probably damaging Het
Pi16 C A 17: 29,538,208 (GRCm39) P7Q possibly damaging Het
Pkhd1 T A 1: 20,593,350 (GRCm39) T1588S possibly damaging Het
Ppig A G 2: 69,580,320 (GRCm39) D618G unknown Het
Pramel17 A G 4: 101,694,565 (GRCm39) F106S probably benign Het
Prorp G A 12: 55,351,200 (GRCm39) V170M possibly damaging Het
Prss51 A T 14: 64,333,444 (GRCm39) K18* probably null Het
Ptpra T A 2: 130,386,417 (GRCm39) D622E probably damaging Het
Ptprs A T 17: 56,725,988 (GRCm39) F1431L probably benign Het
Pxdn A G 12: 30,044,479 (GRCm39) I486V probably benign Het
Rnpc3 G A 3: 113,422,004 (GRCm39) A77V probably benign Het
Rtl10 T A 16: 18,320,026 (GRCm39) C85* probably null Het
Skint10 A G 4: 112,586,170 (GRCm39) S149P probably benign Het
Slc17a8 A C 10: 89,412,275 (GRCm39) V570G probably benign Het
Slc25a42 A T 8: 70,642,148 (GRCm39) V98E probably damaging Het
Smco2 A G 6: 146,760,363 (GRCm39) E73G probably benign Het
Ss18 T C 18: 14,812,477 (GRCm39) Y38C probably damaging Het
Sspo T A 6: 48,453,540 (GRCm39) C2909* probably null Het
Tbccd1 A G 16: 22,652,747 (GRCm39) Y125H probably benign Het
Tdrd9 A G 12: 111,980,888 (GRCm39) T446A probably damaging Het
Tecta G T 9: 42,255,183 (GRCm39) Q1672K probably benign Het
Tek G C 4: 94,692,541 (GRCm39) W216C probably damaging Het
Timm17a C T 1: 135,241,313 (GRCm39) probably null Het
Tlr4 A T 4: 66,758,188 (GRCm39) H327L probably benign Het
Trim33 T C 3: 103,234,109 (GRCm39) I449T possibly damaging Het
Vmn1r57 A G 7: 5,223,559 (GRCm39) N28S probably null Het
Vmn2r117 T A 17: 23,696,177 (GRCm39) H410L probably damaging Het
Vmn2r16 A G 5: 109,508,772 (GRCm39) E500G probably damaging Het
Wif1 A G 10: 120,926,019 (GRCm39) N245S possibly damaging Het
Other mutations in Or10j2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01413:Or10j2 APN 1 173,098,275 (GRCm39) missense probably damaging 1.00
IGL01418:Or10j2 APN 1 173,098,275 (GRCm39) missense probably damaging 1.00
IGL01930:Or10j2 APN 1 173,098,177 (GRCm39) missense probably benign
IGL01963:Or10j2 APN 1 173,097,919 (GRCm39) missense probably damaging 0.99
IGL02104:Or10j2 APN 1 173,098,603 (GRCm39) missense probably damaging 0.96
IGL02192:Or10j2 APN 1 173,098,417 (GRCm39) missense probably damaging 1.00
IGL02256:Or10j2 APN 1 173,098,194 (GRCm39) missense probably benign 0.04
IGL02340:Or10j2 APN 1 173,097,972 (GRCm39) missense probably benign 0.10
IGL02454:Or10j2 APN 1 173,098,507 (GRCm39) missense probably damaging 0.99
IGL02638:Or10j2 APN 1 173,097,898 (GRCm39) missense probably benign 0.07
FR4737:Or10j2 UTSW 1 173,098,197 (GRCm39) frame shift probably null
FR4976:Or10j2 UTSW 1 173,098,197 (GRCm39) frame shift probably null
R0552:Or10j2 UTSW 1 173,098,372 (GRCm39) missense probably benign 0.05
R0621:Or10j2 UTSW 1 173,098,242 (GRCm39) missense possibly damaging 0.48
R0735:Or10j2 UTSW 1 173,098,569 (GRCm39) missense probably benign 0.05
R1506:Or10j2 UTSW 1 173,098,336 (GRCm39) missense probably benign 0.04
R1670:Or10j2 UTSW 1 173,098,467 (GRCm39) missense probably damaging 1.00
R2111:Or10j2 UTSW 1 173,097,879 (GRCm39) missense probably benign
R2204:Or10j2 UTSW 1 173,097,703 (GRCm39) splice site probably null
R4475:Or10j2 UTSW 1 173,098,480 (GRCm39) missense probably damaging 0.99
R4909:Or10j2 UTSW 1 173,098,546 (GRCm39) missense probably damaging 0.97
R5457:Or10j2 UTSW 1 173,098,141 (GRCm39) missense probably benign 0.00
R6124:Or10j2 UTSW 1 173,097,846 (GRCm39) missense probably damaging 1.00
R6456:Or10j2 UTSW 1 173,098,105 (GRCm39) missense probably damaging 1.00
R7240:Or10j2 UTSW 1 173,098,561 (GRCm39) missense probably benign 0.27
R7672:Or10j2 UTSW 1 173,098,440 (GRCm39) missense probably benign 0.18
R8073:Or10j2 UTSW 1 173,098,552 (GRCm39) missense probably benign 0.42
R8116:Or10j2 UTSW 1 173,098,047 (GRCm39) missense possibly damaging 0.88
R8982:Or10j2 UTSW 1 173,098,306 (GRCm39) missense probably damaging 1.00
R9038:Or10j2 UTSW 1 173,098,147 (GRCm39) missense possibly damaging 0.63
R9668:Or10j2 UTSW 1 173,098,183 (GRCm39) missense possibly damaging 0.94
RF032:Or10j2 UTSW 1 173,098,276 (GRCm39) frame shift probably null
RF036:Or10j2 UTSW 1 173,098,276 (GRCm39) frame shift probably null
RF040:Or10j2 UTSW 1 173,098,276 (GRCm39) frame shift probably null
X0019:Or10j2 UTSW 1 173,098,124 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTACTAGATGGACAGCTGGC -3'
(R):5'- TTGGCTTGAACCCACAAGG -3'

Sequencing Primer
(F):5'- CTTGCTGACTCGATGTCTACACAAAG -3'
(R):5'- TGGCGAGCATCCTTGGTAC -3'
Posted On 2019-06-26