Mutagenetix > Incidental Mutations

Incidental Mutation 'R7221:Olfr26'

561821

Institutional Source

Beutler Lab

Gene Symbol

Olfr26

Ensembl Gene

ENSMUSG00000047667

Gene Name

olfactory receptor 26

Synonyms

MTPCR09, MOR171-9, GA_x6K02T2PVTD-32550930-32551856

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R7221 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

38855060-38855990 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 38855242 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 60 (Y60C)

Ref Sequence

ENSEMBL: ENSMUSP00000100467 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000104874] [ENSMUST00000217350]

Predicted Effect

probably damaging
Transcript: ENSMUST00000104874
AA Change: Y60C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000100467
Gene: ENSMUSG00000047667
AA Change: Y60C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	3.8e-49	PFAM
Pfam:7tm_1	41	290	2.4e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000217350

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

100% (77/77)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5330417C22Rik	T	G	3: 108,475,001	D232A	possibly damaging	Het
Abr	A	C	11: 76,423,161	M720R	probably benign	Het
Acad10	G	A	5: 121,630,210	T761M	probably damaging	Het
Agxt	G	T	1: 93,137,901	G164V	possibly damaging	Het
Ankar	C	T	1: 72,650,231	G1247D	probably damaging	Het
Bptf	A	C	11: 107,054,832	L2527R	probably damaging	Het
Brinp2	T	C	1: 158,266,547	H195R	possibly damaging	Het
C130079G13Rik	A	G	3: 59,928,933		probably benign	Het
Cacna2d4	G	T	6: 119,236,663	R14S	probably benign	Het
Cep126	A	T	9: 8,100,987	C515*	probably null	Het
Chia1	A	T	3: 106,131,920	N442I	probably damaging	Het
Clasp2	A	G	9: 113,852,757	D327G	probably damaging	Het
Cnbd2	T	C	2: 156,373,661	F519L	probably benign	Het
Cntrl	T	A	2: 35,151,857	F1214I	possibly damaging	Het
Cul9	A	T	17: 46,528,565	M829K	probably damaging	Het
Cyp4b1	T	C	4: 115,635,978	Q223R	possibly damaging	Het
Defb37	A	T	8: 18,990,972	M1K	probably null	Het
Dnah7c	A	T	1: 46,455,777	Q55L	possibly damaging	Het
Eif2b4	A	T	5: 31,187,787	D463E	possibly damaging	Het
Elovl1	C	T	4: 118,431,614	H167Y	probably damaging	Het
Emb	T	A	13: 117,267,477	L255Q	probably damaging	Het
Eogt	T	C	6: 97,112,724	Y465C	probably damaging	Het
Erc2	A	G	14: 27,653,158	H111R	probably damaging	Het
Fam234b	T	C	6: 135,228,531	F498S	probably damaging	Het
Fgfr3	GAGGCTGGCAGCGTGTACGCAGGC	GAGGC	5: 33,732,748		probably null	Het
Flrt3	T	A	2: 140,661,170	E179D	probably damaging	Het
Fndc3a	T	C	14: 72,556,157	R993G	probably benign	Het
Gm11639	A	G	11: 104,900,606	N2882S	probably benign	Het
Gm13762	A	G	2: 88,973,153	V246A	probably damaging	Het
Gm14325	T	C	2: 177,834,610	T14A	probably damaging	Het
Gm5464	T	A	14: 66,869,232	V106D	unknown	Het
Gm7697	T	G	8: 69,522,664	D50A	probably benign	Het
Gpatch11	T	A	17: 78,842,117	I182N	possibly damaging	Het
Grm6	A	G	11: 50,863,043	R725G	probably damaging	Het
Hap1	A	T	11: 100,348,829	M588K	probably benign	Het
Icam2	A	G	11: 106,382,442	F15L	probably benign	Het
Ints8	A	G	4: 11,225,613	M648T	probably benign	Het
Ipo11	A	T	13: 106,892,557	L296Q	probably damaging	Het
Kirrel	G	A	3: 87,086,397	Q518*	probably null	Het
Krt18	G	T	15: 102,029,532	D155Y	possibly damaging	Het
Lctl	A	T	9: 64,118,935	K91*	probably null	Het
Marf1	C	A	16: 14,142,485	R565L	probably damaging	Het
Med13	A	T	11: 86,288,095	D1458E	probably benign	Het
Mroh8	T	A	2: 157,229,917	Y556F	probably benign	Het
Muc16	C	T	9: 18,642,199	G4266D	probably benign	Het
Nsrp1	A	T	11: 77,048,423	F182I	probably damaging	Het
Obox3	A	T	7: 15,626,058	Y229N	probably benign	Het
Olfr1184	T	A	2: 88,487,629	V299D	probably damaging	Het
Olfr124	A	G	17: 37,805,561	K139E	probably benign	Het
Olfr1247	T	C	2: 89,609,928	Y58C	probably damaging	Het
Olfr1359	T	C	13: 21,703,102	S34P	probably damaging	Het
Olfr746	A	T	14: 50,654,071	Y278F	probably damaging	Het
Pabpc2	T	A	18: 39,773,910	V76D	possibly damaging	Het
Parp9	T	C	16: 35,953,701	W348R	probably benign	Het
Pdp1	T	C	4: 11,961,004	T455A	probably damaging	Het
Phactr2	A	C	10: 13,247,039	D446E	possibly damaging	Het
Pi4kb	T	C	3: 94,994,189	L389P	probably damaging	Het
Pla2g4f	C	T	2: 120,300,995	R749H	probably benign	Het
Plec	A	G	15: 76,175,774	V3321A	probably damaging	Het
Plod2	T	C	9: 92,584,527	V180A	probably damaging	Het
Plppr5	A	G	3: 117,620,969	I80V	probably damaging	Het
Rubcn	T	C	16: 32,866,923		probably null	Het
Sacs	T	C	14: 61,208,806	V2767A	probably damaging	Het
Selenbp2	C	G	3: 94,703,826	Y414*	probably null	Het
Slc45a4	A	T	15: 73,586,410	M430K	probably benign	Het
Smg1	A	G	7: 118,182,797	L1145P	possibly damaging	Het
Spns2	A	G	11: 72,456,916	V316A	probably benign	Het
Srl	T	A	16: 4,482,947	E753D	probably damaging	Het
Thada	T	C	17: 84,464,366	T23A	possibly damaging	Het
Tmem231	T	C	8: 111,933,676	T31A	probably benign	Het
Tpr	C	T	1: 150,446,178	T2321M	possibly damaging	Het
Ttn	T	A	2: 76,941,851	N2615I	unknown	Het
Vmn1r41	A	G	6: 89,747,052	I192V	probably benign	Het
Vmn2r83	A	T	10: 79,480,167	T466S	probably benign	Het
Vnn1	A	G	10: 23,895,054	D60G	probably benign	Het
Wiz	G	A	17: 32,359,165	P449S	probably benign	Het
Zic1	A	G	9: 91,364,732	S96P	probably damaging	Het
Zw10	T	A	9: 49,069,712	S471T	probably benign	Het

Other mutations in Olfr26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01518:Olfr26	APN	9	38855799	missense	probably benign	0.00
IGL01909:Olfr26	APN	9	38855717	nonsense	probably null
IGL02146:Olfr26	APN	9	38855358	missense	probably benign	0.01
IGL02229:Olfr26	APN	9	38855416	missense	possibly damaging	0.62
IGL02382:Olfr26	APN	9	38855068	missense	probably benign
IGL03007:Olfr26	APN	9	38855296	missense	probably damaging	1.00
IGL03118:Olfr26	APN	9	38855230	missense	probably damaging	1.00
PIT4403001:Olfr26	UTSW	9	38855380	missense	probably benign	0.39
R0590:Olfr26	UTSW	9	38855470	missense	probably damaging	0.99
R0862:Olfr26	UTSW	9	38855182	missense	possibly damaging	0.89
R1779:Olfr26	UTSW	9	38855550	missense	possibly damaging	0.55
R1796:Olfr26	UTSW	9	38855524	missense	probably benign	0.01
R2083:Olfr26	UTSW	9	38855341	missense	probably benign	0.10
R3420:Olfr26	UTSW	9	38855325	missense	possibly damaging	0.92
R3421:Olfr26	UTSW	9	38855325	missense	possibly damaging	0.92
R4328:Olfr26	UTSW	9	38855836	missense	possibly damaging	0.62
R4470:Olfr26	UTSW	9	38855631	missense	probably damaging	1.00
R4471:Olfr26	UTSW	9	38855631	missense	probably damaging	1.00
R5047:Olfr26	UTSW	9	38855289	missense	probably benign	0.36
R5267:Olfr26	UTSW	9	38855805	missense	probably damaging	1.00
R5318:Olfr26	UTSW	9	38855448	missense	probably damaging	1.00
R6502:Olfr26	UTSW	9	38855637	missense	probably damaging	0.99
R7297:Olfr26	UTSW	9	38855949	missense	probably damaging	1.00
R7448:Olfr26	UTSW	9	38855116	missense	probably damaging	1.00
R7525:Olfr26	UTSW	9	38855238	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- TTATCAAAGAATGGGCACTGGG -3'
(R):5'- GCAATGGTCTACAGATGGCCAC -3'

Sequencing Primer
(F):5'- ACTGGGAATCATTCTGCAGC -3'
(R):5'- TGGTCTACAGATGGCCACATAGC -3'

Posted On

2019-06-26