Incidental Mutation 'R7221:Zw10'
ID 561822
Institutional Source Beutler Lab
Gene Symbol Zw10
Ensembl Gene ENSMUSG00000032264
Gene Name zw10 kinetochore protein
Synonyms MmZw10, 6330566F14Rik
MMRRC Submission 045293-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.968) question?
Stock # R7221 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 48966913-48990075 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 48981012 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 471 (S471T)
Ref Sequence ENSEMBL: ENSMUSP00000034803 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034803]
AlphaFold O54692
Predicted Effect probably benign
Transcript: ENSMUST00000034803
AA Change: S471T

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000034803
Gene: ENSMUSG00000032264
AA Change: S471T

DomainStartEndE-ValueType
Pfam:Zw10 9 621 2.1e-249 PFAM
Predicted Effect
Meta Mutation Damage Score 0.0713 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (77/77)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 A G 3: 59,836,354 (GRCm39) probably benign Het
Abr A C 11: 76,313,987 (GRCm39) M720R probably benign Het
Acad10 G A 5: 121,768,273 (GRCm39) T761M probably damaging Het
Agxt G T 1: 93,065,623 (GRCm39) G164V possibly damaging Het
Ankar C T 1: 72,689,390 (GRCm39) G1247D probably damaging Het
Bptf A C 11: 106,945,658 (GRCm39) L2527R probably damaging Het
Brinp2 T C 1: 158,094,117 (GRCm39) H195R possibly damaging Het
Cacna2d4 G T 6: 119,213,624 (GRCm39) R14S probably benign Het
Cep126 A T 9: 8,100,988 (GRCm39) C515* probably null Het
Chia1 A T 3: 106,039,236 (GRCm39) N442I probably damaging Het
Clasp2 A G 9: 113,681,825 (GRCm39) D327G probably damaging Het
Cnbd2 T C 2: 156,215,581 (GRCm39) F519L probably benign Het
Cntrl T A 2: 35,041,869 (GRCm39) F1214I possibly damaging Het
Cul9 A T 17: 46,839,491 (GRCm39) M829K probably damaging Het
Cyp4b1 T C 4: 115,493,175 (GRCm39) Q223R possibly damaging Het
Defb37 A T 8: 19,040,988 (GRCm39) M1K probably null Het
Dnah7c A T 1: 46,494,937 (GRCm39) Q55L possibly damaging Het
Efcab3 A G 11: 104,791,432 (GRCm39) N2882S probably benign Het
Eif2b4 A T 5: 31,345,131 (GRCm39) D463E possibly damaging Het
Elapor1 T G 3: 108,382,317 (GRCm39) D232A possibly damaging Het
Elovl1 C T 4: 118,288,811 (GRCm39) H167Y probably damaging Het
Emb T A 13: 117,404,013 (GRCm39) L255Q probably damaging Het
Eogt T C 6: 97,089,685 (GRCm39) Y465C probably damaging Het
Erc2 A G 14: 27,375,115 (GRCm39) H111R probably damaging Het
Fam234b T C 6: 135,205,529 (GRCm39) F498S probably damaging Het
Fgfr3 GAGGCTGGCAGCGTGTACGCAGGC GAGGC 5: 33,890,092 (GRCm39) probably null Het
Flrt3 T A 2: 140,503,090 (GRCm39) E179D probably damaging Het
Fndc3a T C 14: 72,793,597 (GRCm39) R993G probably benign Het
Gm14325 T C 2: 177,476,403 (GRCm39) T14A probably damaging Het
Gm5464 T A 14: 67,106,681 (GRCm39) V106D unknown Het
Gpatch11 T A 17: 79,149,546 (GRCm39) I182N possibly damaging Het
Grm6 A G 11: 50,753,870 (GRCm39) R725G probably damaging Het
Hap1 A T 11: 100,239,655 (GRCm39) M588K probably benign Het
Icam2 A G 11: 106,273,268 (GRCm39) F15L probably benign Het
Ints8 A G 4: 11,225,613 (GRCm39) M648T probably benign Het
Ipo11 A T 13: 107,029,065 (GRCm39) L296Q probably damaging Het
Kirrel1 G A 3: 86,993,704 (GRCm39) Q518* probably null Het
Krt18 G T 15: 101,937,967 (GRCm39) D155Y possibly damaging Het
Lctl A T 9: 64,026,217 (GRCm39) K91* probably null Het
Marf1 C A 16: 13,960,349 (GRCm39) R565L probably damaging Het
Med13 A T 11: 86,178,921 (GRCm39) D1458E probably benign Het
Mroh8 T A 2: 157,071,837 (GRCm39) Y556F probably benign Het
Muc16 C T 9: 18,553,495 (GRCm39) G4266D probably benign Het
Nsrp1 A T 11: 76,939,249 (GRCm39) F182I probably damaging Het
Obox3 A T 7: 15,359,983 (GRCm39) Y229N probably benign Het
Or11h7 A T 14: 50,891,528 (GRCm39) Y278F probably damaging Het
Or2b2 T C 13: 21,887,272 (GRCm39) S34P probably damaging Het
Or2b4 A G 17: 38,116,452 (GRCm39) K139E probably benign Het
Or4a74 T C 2: 89,440,272 (GRCm39) Y58C probably damaging Het
Or4c108 A G 2: 88,803,497 (GRCm39) V246A probably damaging Het
Or4p22 T A 2: 88,317,973 (GRCm39) V299D probably damaging Het
Or8d1 A G 9: 38,766,538 (GRCm39) Y60C probably damaging Het
Pabpc2 T A 18: 39,906,963 (GRCm39) V76D possibly damaging Het
Parp9 T C 16: 35,774,071 (GRCm39) W348R probably benign Het
Pdp1 T C 4: 11,961,004 (GRCm39) T455A probably damaging Het
Phactr2 A C 10: 13,122,783 (GRCm39) D446E possibly damaging Het
Pi4kb T C 3: 94,901,500 (GRCm39) L389P probably damaging Het
Pla2g4f C T 2: 120,131,476 (GRCm39) R749H probably benign Het
Plec A G 15: 76,059,974 (GRCm39) V3321A probably damaging Het
Plod2 T C 9: 92,466,580 (GRCm39) V180A probably damaging Het
Plppr5 A G 3: 117,414,618 (GRCm39) I80V probably damaging Het
Potefam3d T G 8: 69,975,316 (GRCm39) D50A probably benign Het
Rubcn T C 16: 32,687,293 (GRCm39) probably null Het
Sacs T C 14: 61,446,255 (GRCm39) V2767A probably damaging Het
Selenbp2 C G 3: 94,611,133 (GRCm39) Y414* probably null Het
Slc45a4 A T 15: 73,458,259 (GRCm39) M430K probably benign Het
Smg1 A G 7: 117,782,020 (GRCm39) L1145P possibly damaging Het
Spns2 A G 11: 72,347,742 (GRCm39) V316A probably benign Het
Srl T A 16: 4,300,811 (GRCm39) E753D probably damaging Het
Thada T C 17: 84,771,794 (GRCm39) T23A possibly damaging Het
Tmem231 T C 8: 112,660,308 (GRCm39) T31A probably benign Het
Tpr C T 1: 150,321,929 (GRCm39) T2321M possibly damaging Het
Ttn T A 2: 76,772,195 (GRCm39) N2615I unknown Het
Vmn1r41 A G 6: 89,724,034 (GRCm39) I192V probably benign Het
Vmn2r83 A T 10: 79,316,001 (GRCm39) T466S probably benign Het
Vnn1 A G 10: 23,770,952 (GRCm39) D60G probably benign Het
Wiz G A 17: 32,578,139 (GRCm39) P449S probably benign Het
Zic1 A G 9: 91,246,785 (GRCm39) S96P probably damaging Het
Other mutations in Zw10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01778:Zw10 APN 9 48,980,915 (GRCm39) missense probably benign
IGL02111:Zw10 APN 9 48,980,054 (GRCm39) missense probably damaging 0.98
IGL02673:Zw10 APN 9 48,988,893 (GRCm39) splice site probably null
PIT4382001:Zw10 UTSW 9 48,982,944 (GRCm39) missense probably benign 0.15
R0402:Zw10 UTSW 9 48,980,023 (GRCm39) missense probably benign 0.00
R0736:Zw10 UTSW 9 48,975,432 (GRCm39) missense probably benign 0.00
R1830:Zw10 UTSW 9 48,981,041 (GRCm39) missense probably damaging 1.00
R1966:Zw10 UTSW 9 48,980,133 (GRCm39) missense probably damaging 1.00
R2231:Zw10 UTSW 9 48,975,421 (GRCm39) missense possibly damaging 0.79
R2474:Zw10 UTSW 9 48,978,105 (GRCm39) missense probably damaging 1.00
R2849:Zw10 UTSW 9 48,968,941 (GRCm39) critical splice acceptor site probably null
R3162:Zw10 UTSW 9 48,988,860 (GRCm39) missense probably damaging 0.98
R3162:Zw10 UTSW 9 48,988,860 (GRCm39) missense probably damaging 0.98
R4893:Zw10 UTSW 9 48,985,325 (GRCm39) missense possibly damaging 0.58
R4927:Zw10 UTSW 9 48,979,983 (GRCm39) missense probably damaging 1.00
R5070:Zw10 UTSW 9 48,988,759 (GRCm39) nonsense probably null
R5214:Zw10 UTSW 9 48,975,463 (GRCm39) missense possibly damaging 0.91
R5637:Zw10 UTSW 9 48,968,950 (GRCm39) missense probably damaging 1.00
R5983:Zw10 UTSW 9 48,988,745 (GRCm39) splice site probably null
R6368:Zw10 UTSW 9 48,984,535 (GRCm39) missense probably damaging 1.00
R6605:Zw10 UTSW 9 48,980,926 (GRCm39) missense probably benign 0.00
R7292:Zw10 UTSW 9 48,972,491 (GRCm39) missense probably benign 0.00
R7938:Zw10 UTSW 9 48,982,933 (GRCm39) missense probably benign 0.04
R8120:Zw10 UTSW 9 48,985,413 (GRCm39) missense probably benign 0.26
R8376:Zw10 UTSW 9 48,988,783 (GRCm39) missense possibly damaging 0.85
R8471:Zw10 UTSW 9 48,982,914 (GRCm39) missense probably damaging 0.99
R8480:Zw10 UTSW 9 48,986,299 (GRCm39) missense probably benign 0.01
R8735:Zw10 UTSW 9 48,988,861 (GRCm39) missense probably damaging 0.99
R9699:Zw10 UTSW 9 48,966,942 (GRCm39) start gained probably benign
RF007:Zw10 UTSW 9 48,972,220 (GRCm39) missense possibly damaging 0.81
Z1177:Zw10 UTSW 9 48,985,396 (GRCm39) missense probably benign 0.12
Predicted Primers PCR Primer
(F):5'- AACAGTCTTTTCTGCTGCTGTG -3'
(R):5'- CGGCATAGCAATCTACACCTGC -3'

Sequencing Primer
(F):5'- CTGTGTTTGAATTTTAGATTGGTCCC -3'
(R):5'- AGTTACCTTAGTAGGCCTAGACC -3'
Posted On 2019-06-26