Incidental Mutation 'R7222:Or5p72'
ID 561881
Institutional Source Beutler Lab
Gene Symbol Or5p72
Ensembl Gene ENSMUSG00000095239
Gene Name olfactory receptor family 5 subfamily P member 72
Synonyms MOR204-9, GA_x6K02T2PBJ9-10752603-10753547, Olfr497
MMRRC Submission 045294-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R7222 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 108021780-108022724 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108021844 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 22 (D22G)
Ref Sequence ENSEMBL: ENSMUSP00000150439 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076406] [ENSMUST00000213521]
AlphaFold Q8VG08
Predicted Effect probably benign
Transcript: ENSMUST00000076406
AA Change: D22G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000075741
Gene: ENSMUSG00000095239
AA Change: D22G

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.5e-55 PFAM
Pfam:7tm_1 44 293 1.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213521
AA Change: D22G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (49/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,082,519 (GRCm39) N1151K probably benign Het
Add3 T C 19: 53,205,277 (GRCm39) V9A unknown Het
Ankar A G 1: 72,705,514 (GRCm39) I832T probably damaging Het
Arhgef10l C A 4: 140,248,580 (GRCm39) W785L probably damaging Het
Atp7b G A 8: 22,512,394 (GRCm39) Q490* probably null Het
Chrna5 A G 9: 54,905,347 (GRCm39) D53G probably benign Het
Clip1 T A 5: 123,749,904 (GRCm39) N993I probably damaging Het
Cyp3a59 A T 5: 146,033,385 (GRCm39) probably null Het
Dnah3 T A 7: 119,670,746 (GRCm39) N651Y probably benign Het
Dop1a T C 9: 86,404,929 (GRCm39) probably null Het
Eva1c AGGGTGTCCTGTACGAAGGACTTCCGGG AGGG 16: 90,701,072 (GRCm39) probably benign Het
Flg T A 3: 93,195,621 (GRCm39) S74T unknown Het
Fras1 T C 5: 96,784,045 (GRCm39) Y850H probably damaging Het
Fras1 A T 5: 96,784,668 (GRCm39) T884S probably benign Het
Fsip2 A G 2: 82,814,015 (GRCm39) T3445A probably benign Het
Herc1 C A 9: 66,374,781 (GRCm39) P3237H probably damaging Het
Ifi35 A G 11: 101,348,341 (GRCm39) N123S probably benign Het
Igkv1-117 A T 6: 68,098,733 (GRCm39) D94V probably damaging Het
Kif1b T C 4: 149,309,614 (GRCm39) D764G probably damaging Het
Lztr1 A G 16: 17,341,996 (GRCm39) E657G possibly damaging Het
Mmd2 G T 5: 142,553,682 (GRCm39) L160I probably benign Het
Muc2 A T 7: 141,290,758 (GRCm39) T15S Het
Muc6 T A 7: 141,214,428 (GRCm39) H2835L unknown Het
Myo1h G A 5: 114,493,322 (GRCm39) probably null Het
Or10v5 C A 19: 11,806,021 (GRCm39) R123L probably damaging Het
Or51ag1 A G 7: 103,155,664 (GRCm39) V163A possibly damaging Het
Or52n4 T C 7: 104,293,937 (GRCm39) D214G probably damaging Het
Or5d43 T A 2: 88,104,809 (GRCm39) M195L probably benign Het
Or6c219 A G 10: 129,781,758 (GRCm39) Y58H probably damaging Het
Or7g32 A T 9: 19,388,763 (GRCm39) V261E probably damaging Het
Osbpl7 A G 11: 96,951,364 (GRCm39) T684A probably damaging Het
P2ry14 T C 3: 59,022,803 (GRCm39) K219R probably benign Het
Pde4d A T 13: 109,894,113 (GRCm39) H156L probably damaging Het
Polq G T 16: 36,906,995 (GRCm39) E2319* probably null Het
Ranbp3 T G 17: 57,017,211 (GRCm39) V409G probably damaging Het
Sart3 T C 5: 113,884,717 (GRCm39) D629G probably benign Het
Selenon T A 4: 134,275,288 (GRCm39) T137S possibly damaging Het
Setd2 T A 9: 110,380,530 (GRCm39) D55E Het
Slamf8 G A 1: 172,411,775 (GRCm39) T240I possibly damaging Het
Slc39a10 A G 1: 46,858,452 (GRCm39) L615P possibly damaging Het
Speer1e T A 5: 11,233,080 (GRCm39) N14K probably damaging Het
Tbce T C 13: 14,172,735 (GRCm39) D505G probably damaging Het
Tenm3 C T 8: 48,754,004 (GRCm39) G800R probably damaging Het
Terf2ip T C 8: 112,738,547 (GRCm39) V145A possibly damaging Het
Tmprss7 T C 16: 45,511,256 (GRCm39) I41V probably benign Het
Traj49 A T 14: 54,406,160 (GRCm39) N6I Het
Trim30a T C 7: 104,070,639 (GRCm39) probably null Het
Ubr4 T A 4: 139,190,684 (GRCm39) S905T unknown Het
Unc93a2 A G 17: 7,643,866 (GRCm39) S148P probably damaging Het
Zfp948 T A 17: 21,808,102 (GRCm39) H431Q probably damaging Het
Zfyve1 A G 12: 83,601,779 (GRCm39) F525L probably benign Het
Other mutations in Or5p72
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Or5p72 APN 7 108,022,235 (GRCm39) nonsense probably null
IGL03145:Or5p72 APN 7 108,021,806 (GRCm39) missense probably benign 0.00
R0732:Or5p72 UTSW 7 108,021,784 (GRCm39) missense probably benign 0.00
R1892:Or5p72 UTSW 7 108,022,147 (GRCm39) missense possibly damaging 0.61
R2008:Or5p72 UTSW 7 108,022,389 (GRCm39) missense probably benign 0.01
R3721:Or5p72 UTSW 7 108,022,326 (GRCm39) missense probably damaging 1.00
R4497:Or5p72 UTSW 7 108,022,122 (GRCm39) missense probably benign 0.37
R4674:Or5p72 UTSW 7 108,022,309 (GRCm39) missense possibly damaging 0.65
R4675:Or5p72 UTSW 7 108,022,309 (GRCm39) missense possibly damaging 0.65
R4695:Or5p72 UTSW 7 108,022,196 (GRCm39) missense probably benign 0.18
R5265:Or5p72 UTSW 7 108,022,609 (GRCm39) missense possibly damaging 0.94
R5656:Or5p72 UTSW 7 108,021,825 (GRCm39) missense probably benign 0.03
R5758:Or5p72 UTSW 7 108,022,369 (GRCm39) missense probably benign 0.02
R6124:Or5p72 UTSW 7 108,022,725 (GRCm39) splice site probably null
R6787:Or5p72 UTSW 7 108,021,889 (GRCm39) missense possibly damaging 0.52
R7174:Or5p72 UTSW 7 108,022,367 (GRCm39) missense probably benign 0.01
R7240:Or5p72 UTSW 7 108,022,140 (GRCm39) missense probably damaging 1.00
R8752:Or5p72 UTSW 7 108,022,480 (GRCm39) missense probably benign
R9548:Or5p72 UTSW 7 108,022,416 (GRCm39) missense possibly damaging 0.75
R9786:Or5p72 UTSW 7 108,021,924 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- GGAACCCTGAGTAAAACATGAATTG -3'
(R):5'- TGATGAAAGGCCCATGTCAAC -3'

Sequencing Primer
(F):5'- CCATCACAGCCTTAATCTAGT -3'
(R):5'- CATGTCAACAGAAGCCAAGTGACTG -3'
Posted On 2019-06-26