Incidental Mutation 'R7222:Ifi35'
ID 561895
Institutional Source Beutler Lab
Gene Symbol Ifi35
Ensembl Gene ENSMUSG00000010358
Gene Name interferon-induced protein 35
Synonyms IFP35, 2010008K16Rik
MMRRC Submission 045294-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # R7222 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 101339238-101349527 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 101348341 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 123 (N123S)
Ref Sequence ENSEMBL: ENSMUSP00000010502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010502] [ENSMUST00000040430] [ENSMUST00000131024]
AlphaFold Q9D8C4
Predicted Effect probably benign
Transcript: ENSMUST00000010502
AA Change: N123S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000010502
Gene: ENSMUSG00000010358
AA Change: N123S

DomainStartEndE-ValueType
Pfam:IFP_35_N 8 80 9.1e-21 PFAM
Pfam:NID 81 170 1.5e-31 PFAM
Pfam:NID 179 266 1.6e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000040430
SMART Domains Protein: ENSMUSP00000048350
Gene: ENSMUSG00000034993

DomainStartEndE-ValueType
low complexity region 3 31 N/A INTRINSIC
low complexity region 41 60 N/A INTRINSIC
Pfam:ADH_N 89 157 8.8e-11 PFAM
Pfam:ADH_zinc_N 213 355 2.1e-21 PFAM
Pfam:ADH_zinc_N_2 245 398 6.9e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131024
SMART Domains Protein: ENSMUSP00000117189
Gene: ENSMUSG00000010358

DomainStartEndE-ValueType
Pfam:IFP_35_N 8 45 2.7e-13 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (49/50)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,082,519 (GRCm39) N1151K probably benign Het
Add3 T C 19: 53,205,277 (GRCm39) V9A unknown Het
Ankar A G 1: 72,705,514 (GRCm39) I832T probably damaging Het
Arhgef10l C A 4: 140,248,580 (GRCm39) W785L probably damaging Het
Atp7b G A 8: 22,512,394 (GRCm39) Q490* probably null Het
Chrna5 A G 9: 54,905,347 (GRCm39) D53G probably benign Het
Clip1 T A 5: 123,749,904 (GRCm39) N993I probably damaging Het
Cyp3a59 A T 5: 146,033,385 (GRCm39) probably null Het
Dnah3 T A 7: 119,670,746 (GRCm39) N651Y probably benign Het
Dop1a T C 9: 86,404,929 (GRCm39) probably null Het
Eva1c AGGGTGTCCTGTACGAAGGACTTCCGGG AGGG 16: 90,701,072 (GRCm39) probably benign Het
Flg T A 3: 93,195,621 (GRCm39) S74T unknown Het
Fras1 T C 5: 96,784,045 (GRCm39) Y850H probably damaging Het
Fras1 A T 5: 96,784,668 (GRCm39) T884S probably benign Het
Fsip2 A G 2: 82,814,015 (GRCm39) T3445A probably benign Het
Herc1 C A 9: 66,374,781 (GRCm39) P3237H probably damaging Het
Igkv1-117 A T 6: 68,098,733 (GRCm39) D94V probably damaging Het
Kif1b T C 4: 149,309,614 (GRCm39) D764G probably damaging Het
Lztr1 A G 16: 17,341,996 (GRCm39) E657G possibly damaging Het
Mmd2 G T 5: 142,553,682 (GRCm39) L160I probably benign Het
Muc2 A T 7: 141,290,758 (GRCm39) T15S Het
Muc6 T A 7: 141,214,428 (GRCm39) H2835L unknown Het
Myo1h G A 5: 114,493,322 (GRCm39) probably null Het
Or10v5 C A 19: 11,806,021 (GRCm39) R123L probably damaging Het
Or51ag1 A G 7: 103,155,664 (GRCm39) V163A possibly damaging Het
Or52n4 T C 7: 104,293,937 (GRCm39) D214G probably damaging Het
Or5d43 T A 2: 88,104,809 (GRCm39) M195L probably benign Het
Or5p72 A G 7: 108,021,844 (GRCm39) D22G probably benign Het
Or6c219 A G 10: 129,781,758 (GRCm39) Y58H probably damaging Het
Or7g32 A T 9: 19,388,763 (GRCm39) V261E probably damaging Het
Osbpl7 A G 11: 96,951,364 (GRCm39) T684A probably damaging Het
P2ry14 T C 3: 59,022,803 (GRCm39) K219R probably benign Het
Pde4d A T 13: 109,894,113 (GRCm39) H156L probably damaging Het
Polq G T 16: 36,906,995 (GRCm39) E2319* probably null Het
Ranbp3 T G 17: 57,017,211 (GRCm39) V409G probably damaging Het
Sart3 T C 5: 113,884,717 (GRCm39) D629G probably benign Het
Selenon T A 4: 134,275,288 (GRCm39) T137S possibly damaging Het
Setd2 T A 9: 110,380,530 (GRCm39) D55E Het
Slamf8 G A 1: 172,411,775 (GRCm39) T240I possibly damaging Het
Slc39a10 A G 1: 46,858,452 (GRCm39) L615P possibly damaging Het
Speer1e T A 5: 11,233,080 (GRCm39) N14K probably damaging Het
Tbce T C 13: 14,172,735 (GRCm39) D505G probably damaging Het
Tenm3 C T 8: 48,754,004 (GRCm39) G800R probably damaging Het
Terf2ip T C 8: 112,738,547 (GRCm39) V145A possibly damaging Het
Tmprss7 T C 16: 45,511,256 (GRCm39) I41V probably benign Het
Traj49 A T 14: 54,406,160 (GRCm39) N6I Het
Trim30a T C 7: 104,070,639 (GRCm39) probably null Het
Ubr4 T A 4: 139,190,684 (GRCm39) S905T unknown Het
Unc93a2 A G 17: 7,643,866 (GRCm39) S148P probably damaging Het
Zfp948 T A 17: 21,808,102 (GRCm39) H431Q probably damaging Het
Zfyve1 A G 12: 83,601,779 (GRCm39) F525L probably benign Het
Other mutations in Ifi35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00553:Ifi35 APN 11 101,348,152 (GRCm39) missense probably damaging 0.99
R0362:Ifi35 UTSW 11 101,348,038 (GRCm39) missense probably benign 0.02
R1753:Ifi35 UTSW 11 101,347,461 (GRCm39) missense probably damaging 1.00
R1982:Ifi35 UTSW 11 101,349,112 (GRCm39) missense probably damaging 0.99
R3522:Ifi35 UTSW 11 101,348,511 (GRCm39) missense probably benign 0.25
R3704:Ifi35 UTSW 11 101,339,430 (GRCm39) start codon destroyed probably null 0.08
R4553:Ifi35 UTSW 11 101,348,717 (GRCm39) missense probably damaging 1.00
R5864:Ifi35 UTSW 11 101,349,069 (GRCm39) missense probably damaging 1.00
R7992:Ifi35 UTSW 11 101,348,307 (GRCm39) nonsense probably null
R8255:Ifi35 UTSW 11 101,348,608 (GRCm39) missense probably benign 0.08
R9183:Ifi35 UTSW 11 101,348,091 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCACCTTTGAGGACCCCAAAG -3'
(R):5'- AGATCTCCAGCTTGTCCAACAG -3'

Sequencing Primer
(F):5'- AGGTTAGCCTTGGTGTGTG -3'
(R):5'- AACAGTTCCTCTTCACTCAGCCTAAG -3'
Posted On 2019-06-26