Incidental Mutation 'R0575:Anapc11'
ID56193
Institutional Source Beutler Lab
Gene Symbol Anapc11
Ensembl Gene ENSMUSG00000025135
Gene Nameanaphase promoting complex subunit 11
Synonyms
MMRRC Submission 038765-MU
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.871) question?
Stock #R0575 (G1)
Quality Score181
Status Validated
Chromosome11
Chromosomal Location120598421-120608198 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 120599366 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 36 (D36G)
Ref Sequence ENSEMBL: ENSMUSP00000097714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026125] [ENSMUST00000026128] [ENSMUST00000093140]
Predicted Effect probably benign
Transcript: ENSMUST00000026125
SMART Domains Protein: ENSMUSP00000026125
Gene: ENSMUSG00000025134

DomainStartEndE-ValueType
low complexity region 16 53 N/A INTRINSIC
low complexity region 56 75 N/A INTRINSIC
low complexity region 94 105 N/A INTRINSIC
RRM 106 178 7.64e-20 SMART
FoP_duplication 187 255 1.33e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000026128
AA Change: D36G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000026128
Gene: ENSMUSG00000025135
AA Change: D36G

DomainStartEndE-ValueType
RING 23 76 4.48e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000093140
AA Change: D36G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000097714
Gene: ENSMUSG00000025135
AA Change: D36G

DomainStartEndE-ValueType
RING 23 76 4.48e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129263
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148114
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155325
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156685
Meta Mutation Damage Score 0.3930 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.0%
Validation Efficiency 100% (30/30)
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik C T 14: 54,591,252 S264N possibly damaging Het
Acsm1 G A 7: 119,659,201 probably null Het
Adsl C T 15: 80,963,685 A93V probably damaging Het
Agbl5 A T 5: 30,894,454 S539C probably damaging Het
Aggf1 T A 13: 95,368,397 T285S probably benign Het
Ankrd44 G A 1: 54,762,310 A286V probably damaging Het
Atf7ip2 G T 16: 10,237,211 G281C probably damaging Het
Birc6 A G 17: 74,689,237 K4475E probably damaging Het
Ccbe1 T A 18: 66,093,995 probably benign Het
Cyp26b1 A G 6: 84,575,306 probably benign Het
Dcun1d1 T C 3: 35,897,785 probably benign Het
Dtwd2 C A 18: 49,698,472 C156F probably damaging Het
Efcab6 T G 15: 83,967,700 I326L probably benign Het
Extl1 TGCGTTGCACCGATACCGGG TG 4: 134,357,677 probably benign Het
F5 C A 1: 164,176,244 Q203K probably damaging Het
Frs3 A G 17: 47,703,723 H447R possibly damaging Het
Gmds T G 13: 31,940,583 Q264P probably damaging Het
Golgb1 T A 16: 36,918,809 D2503E probably benign Het
Lgi4 G A 7: 31,060,093 G25R probably benign Het
Olfr10 G A 11: 49,318,053 C169Y probably damaging Het
Olfr1461 T A 19: 13,165,387 Y124* probably null Het
Pcdh20 A G 14: 88,467,612 S751P probably damaging Het
Pcnx4 A G 12: 72,567,236 T652A probably benign Het
Pom121l2 T G 13: 21,984,168 F870V probably damaging Het
Prob1 T C 18: 35,654,721 D160G possibly damaging Het
Spa17 T C 9: 37,603,393 K133E probably damaging Het
Strbp T A 2: 37,640,873 D123V possibly damaging Het
Tnxb A G 17: 34,717,206 T3586A possibly damaging Het
Zfp518a T A 19: 40,912,315 H229Q probably damaging Het
Other mutations in Anapc11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01656:Anapc11 APN 11 120599347 missense possibly damaging 0.95
IGL02689:Anapc11 APN 11 120599342 missense probably benign 0.06
IGL02738:Anapc11 APN 11 120599276 missense probably benign 0.07
R0373:Anapc11 UTSW 11 120605377 missense probably benign
R8167:Anapc11 UTSW 11 120599286 missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TTCCGTACTAACTCCAGGTCATCCTC -3'
(R):5'- GCAACCAATGTCTGAACTTCAATTTGCT -3'

Sequencing Primer
(F):5'- CTTCCCTCAGGTCACAGGC -3'
(R):5'- ttcacttgcctctgcctc -3'
Posted On2013-07-11