|Institutional Source||Beutler Lab|
|Gene Name||glycoprotein 2 (zymogen granule membrane)|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7223 (G1)|
|Chromosomal Location||119442537-119459285 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 119451498 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000146487 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000033255] [ENSMUST00000207887]|
|Meta Mutation Damage Score||0.9493|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
PHENOTYPE: Homozygous null mice display no obvious abnormalities in pancreas morphology and function, development, growth, weight, behavior, life span, or fertility. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gp2||
(F):5'- TCACCAGTGCCTTGATCATAC -3'
(R):5'- TGGGAACACTGACCATAGAAC -3'
(F):5'- CACCAGTGCCTTGATCATACTGAATG -3'
(R):5'- TCTGAGTTCAAGATATACCTACACAC -3'