Incidental Mutation 'R7224:Lrrk1'
| ID |
562027 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
|
| MMRRC Submission |
045296-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7224 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
66226912-66388350 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 66332386 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 169
(V169A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000015277
AA Change: V169A
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: V169A
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.4%
|
| Validation Efficiency |
99% (79/80) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432K21Rik |
A |
G |
8: 84,172,213 (GRCm38) |
T577A |
probably benign |
Het |
| Aadac |
C |
T |
3: 60,035,854 (GRCm38) |
T60M |
probably benign |
Het |
| Actn4 |
C |
T |
7: 28,962,084 (GRCm38) |
A34T |
probably benign |
Het |
| Acvrl1 |
A |
G |
15: 101,143,364 (GRCm38) |
M466V |
probably benign |
Het |
| Adamts7 |
T |
C |
9: 90,185,815 (GRCm38) |
Y453H |
probably damaging |
Het |
| Amfr |
G |
A |
8: 93,984,856 (GRCm38) |
P351S |
probably damaging |
Het |
| Ankrd26 |
G |
A |
6: 118,539,727 (GRCm38) |
T492M |
probably benign |
Het |
| Anxa6 |
A |
G |
11: 54,986,167 (GRCm38) |
F547L |
probably damaging |
Het |
| Ap5m1 |
T |
G |
14: 49,080,927 (GRCm38) |
Y394D |
unknown |
Het |
| Atic |
G |
A |
1: 71,570,855 (GRCm38) |
V342I |
probably benign |
Het |
| Atl1 |
C |
A |
12: 69,955,353 (GRCm38) |
T362N |
probably benign |
Het |
| Atp10a |
A |
T |
7: 58,797,471 (GRCm38) |
M654L |
probably benign |
Het |
| B3gnt5 |
A |
T |
16: 19,769,753 (GRCm38) |
M241L |
probably benign |
Het |
| Bbs7 |
A |
G |
3: 36,605,728 (GRCm38) |
V186A |
possibly damaging |
Het |
| C8b |
T |
C |
4: 104,780,598 (GRCm38) |
L89P |
probably damaging |
Het |
| Capn7 |
G |
T |
14: 31,370,721 (GRCm38) |
E742* |
probably null |
Het |
| Ccdc162 |
G |
A |
10: 41,561,191 (GRCm38) |
R1741C |
probably damaging |
Het |
| Chsy3 |
T |
A |
18: 59,408,975 (GRCm38) |
L395H |
probably damaging |
Het |
| Cnot9 |
A |
G |
1: 74,517,229 (GRCm38) |
T62A |
probably benign |
Het |
| Cyfip1 |
AGTGT |
AGT |
7: 55,928,189 (GRCm38) |
|
probably null |
Het |
| Cyp2d12 |
T |
A |
15: 82,557,648 (GRCm38) |
|
probably null |
Het |
| Dnah7a |
A |
G |
1: 53,397,261 (GRCm38) |
V3974A |
probably benign |
Het |
| Dync1h1 |
G |
A |
12: 110,617,762 (GRCm38) |
G533D |
possibly damaging |
Het |
| Elfn1 |
A |
G |
5: 139,972,473 (GRCm38) |
S411G |
probably benign |
Het |
| Enpp3 |
T |
C |
10: 24,776,884 (GRCm38) |
D725G |
possibly damaging |
Het |
| Epp13 |
T |
G |
7: 6,268,802 (GRCm38) |
M77R |
probably benign |
Het |
| Fmnl1 |
T |
C |
11: 103,182,769 (GRCm38) |
|
probably null |
Het |
| Fndc8 |
T |
C |
11: 82,892,325 (GRCm38) |
M44T |
probably benign |
Het |
| Gcgr |
A |
T |
11: 120,534,712 (GRCm38) |
|
probably benign |
Het |
| Ggt1 |
T |
A |
10: 75,574,276 (GRCm38) |
V14D |
possibly damaging |
Het |
| Gigyf2 |
A |
G |
1: 87,403,725 (GRCm38) |
I198M |
unknown |
Het |
| Gm28710 |
T |
C |
5: 16,836,594 (GRCm38) |
V615A |
possibly damaging |
Het |
| Gm40460 |
GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG |
GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG |
7: 142,240,434 (GRCm38) |
|
probably benign |
Het |
| Gm6034 |
T |
A |
17: 36,056,439 (GRCm38) |
S59T |
unknown |
Het |
| Gm6408 |
G |
A |
5: 146,484,370 (GRCm38) |
V270I |
probably benign |
Het |
| Gm853 |
C |
G |
4: 130,219,199 (GRCm38) |
A135P |
probably damaging |
Het |
| Gpr20 |
A |
T |
15: 73,696,132 (GRCm38) |
I136N |
probably damaging |
Het |
| Ide |
T |
C |
19: 37,290,761 (GRCm38) |
E565G |
|
Het |
| Igsf9 |
T |
C |
1: 172,494,782 (GRCm38) |
S515P |
probably damaging |
Het |
| Kbtbd12 |
G |
A |
6: 88,613,983 (GRCm38) |
R416* |
probably null |
Het |
| Kcnd3 |
A |
T |
3: 105,669,084 (GRCm38) |
I615F |
probably damaging |
Het |
| Kcnk7 |
A |
T |
19: 5,706,777 (GRCm38) |
M265L |
probably benign |
Het |
| Klhdc1 |
G |
A |
12: 69,263,149 (GRCm38) |
S275N |
probably damaging |
Het |
| Lrba |
A |
C |
3: 86,395,246 (GRCm38) |
N1871T |
probably damaging |
Het |
| Magi1 |
A |
G |
6: 93,683,089 (GRCm38) |
I1175T |
probably benign |
Het |
| Man1a2 |
T |
C |
3: 100,582,053 (GRCm38) |
T537A |
possibly damaging |
Het |
| Mrpl17 |
T |
C |
7: 105,810,002 (GRCm38) |
N129S |
probably damaging |
Het |
| Mup5 |
G |
A |
4: 61,832,385 (GRCm38) |
R174C |
probably damaging |
Het |
| Ndufaf1 |
G |
A |
2: 119,658,396 (GRCm38) |
R216C |
probably damaging |
Het |
| Neb |
T |
C |
2: 52,334,659 (GRCm38) |
|
probably null |
Het |
| Olfml3 |
T |
C |
3: 103,735,860 (GRCm38) |
K402E |
probably damaging |
Het |
| Olfr553 |
A |
T |
7: 102,614,767 (GRCm38) |
M74K |
probably damaging |
Het |
| Olfr76 |
T |
C |
19: 12,120,548 (GRCm38) |
T55A |
probably benign |
Het |
| Olfr875 |
G |
A |
9: 37,773,415 (GRCm38) |
G252D |
possibly damaging |
Het |
| Osbpl8 |
C |
T |
10: 111,275,011 (GRCm38) |
P458L |
possibly damaging |
Het |
| Pcdh20 |
T |
C |
14: 88,469,075 (GRCm38) |
E263G |
possibly damaging |
Het |
| Pkd1l1 |
A |
G |
11: 8,945,241 (GRCm38) |
L623P |
|
Het |
| Plxdc1 |
T |
C |
11: 97,932,327 (GRCm38) |
T363A |
possibly damaging |
Het |
| Pole3 |
T |
C |
4: 62,524,050 (GRCm38) |
D111G |
unknown |
Het |
| R3hdm2 |
T |
A |
10: 127,458,153 (GRCm38) |
L172Q |
probably damaging |
Het |
| Rbm33 |
T |
C |
5: 28,394,324 (GRCm38) |
V90A |
|
Het |
| Rcbtb1 |
C |
G |
14: 59,228,379 (GRCm38) |
I390M |
probably damaging |
Het |
| Romo1 |
G |
A |
2: 156,144,375 (GRCm38) |
|
probably benign |
Het |
| Sars |
A |
G |
3: 108,428,203 (GRCm38) |
Y410H |
probably damaging |
Het |
| Sesn2 |
T |
C |
4: 132,497,413 (GRCm38) |
T327A |
probably benign |
Het |
| Slc30a5 |
A |
G |
13: 100,809,254 (GRCm38) |
V530A |
probably damaging |
Het |
| Slc30a9 |
G |
A |
5: 67,315,701 (GRCm38) |
E43K |
probably benign |
Het |
| Slc38a2 |
A |
C |
15: 96,691,359 (GRCm38) |
L418W |
probably damaging |
Het |
| Snx14 |
T |
C |
9: 88,394,561 (GRCm38) |
E557G |
possibly damaging |
Het |
| Spata33 |
T |
A |
8: 123,221,998 (GRCm38) |
I123K |
probably damaging |
Het |
| Tdrd3 |
A |
T |
14: 87,477,403 (GRCm38) |
H170L |
probably damaging |
Het |
| Trpm1 |
A |
G |
7: 64,219,106 (GRCm38) |
|
probably null |
Het |
| Tsr3 |
A |
T |
17: 25,242,595 (GRCm38) |
E302D |
probably benign |
Het |
| Ttll11 |
A |
G |
2: 35,902,673 (GRCm38) |
I386T |
probably damaging |
Het |
| Usp2 |
C |
T |
9: 44,075,969 (GRCm38) |
T188M |
possibly damaging |
Het |
| Usp44 |
A |
G |
10: 93,845,993 (GRCm38) |
I102V |
probably benign |
Het |
| Wasf1 |
A |
G |
10: 40,926,550 (GRCm38) |
N67S |
probably benign |
Het |
| Zfp445 |
T |
C |
9: 122,852,143 (GRCm38) |
N911S |
probably benign |
Het |
| Zfp467 |
A |
G |
6: 48,444,969 (GRCm38) |
|
probably null |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
66,287,701 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
66,265,450 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
66,279,416 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
66,308,659 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
66,274,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
66,330,767 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
66,308,691 (GRCm38) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
66,262,563 (GRCm38) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
66,262,890 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
66,259,959 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
66,306,894 (GRCm38) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
66,262,665 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
66,302,710 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
66,265,474 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
66,262,733 (GRCm38) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
66,294,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
66,281,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
66,279,372 (GRCm38) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
66,278,520 (GRCm38) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
66,262,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
66,273,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
66,292,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
66,292,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
66,296,263 (GRCm38) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
66,290,908 (GRCm38) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
66,266,615 (GRCm38) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
66,292,336 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
66,294,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
66,262,283 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
66,273,028 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
66,259,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
66,259,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
66,302,671 (GRCm38) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,381,538 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
66,262,437 (GRCm38) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
66,279,300 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
66,281,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
66,279,282 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
66,330,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
66,296,163 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
66,285,411 (GRCm38) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
66,305,521 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
66,305,521 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
66,292,364 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
66,278,520 (GRCm38) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
66,294,903 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
66,330,764 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
66,273,053 (GRCm38) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
66,273,053 (GRCm38) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
66,279,372 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
66,262,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
66,262,293 (GRCm38) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
66,306,873 (GRCm38) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
66,262,665 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
66,295,454 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
66,332,363 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
66,307,107 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
66,270,797 (GRCm38) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
66,330,670 (GRCm38) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
66,307,215 (GRCm38) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
66,287,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
66,262,133 (GRCm38) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
66,302,710 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
66,307,103 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
66,306,839 (GRCm38) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
66,302,728 (GRCm38) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
66,262,733 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
66,281,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
66,273,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
66,342,779 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
66,292,342 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
66,287,443 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
66,285,279 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
66,270,825 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7239:Lrrk1
|
UTSW |
7 |
66,262,155 (GRCm38) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
66,290,854 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
66,262,562 (GRCm38) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
66,308,691 (GRCm38) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
66,262,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
66,300,729 (GRCm38) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
66,262,454 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
66,265,474 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
66,285,341 (GRCm38) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
66,342,782 (GRCm38) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
66,262,623 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
66,292,315 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
66,278,684 (GRCm38) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
66,282,327 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
66,262,596 (GRCm38) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
66,302,729 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
66,269,825 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
66,278,609 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
66,278,583 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
66,259,918 (GRCm38) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
66,274,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,381,502 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTAGCGGTAAGGGTGAAGCC -3'
(R):5'- AACACGAGTTACTTGGCAGAAG -3'
Sequencing Primer
(F):5'- CAGAGTCCCACACTGGAAAGTG -3'
(R):5'- GCAGAGCTTTCATTCAGACCTAG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation