Incidental Mutation 'R7225:Spag9'
| ID |
562108 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Spag9
|
| Ensembl Gene |
ENSMUSG00000020859 |
| Gene Name |
sperm associated antigen 9 |
| Synonyms |
syd1, JIP4, Mapk8ip4, 4733401I23Rik, JLP, 3110018C07Rik, 4831406C20Rik |
| MMRRC Submission |
045297-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.784)
|
| Stock # |
R7225 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
93996091-94126085 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 94097358 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 833
(C833R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000042271
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000024979]
[ENSMUST00000041956]
[ENSMUST00000075695]
[ENSMUST00000092777]
[ENSMUST00000103168]
[ENSMUST00000132079]
[ENSMUST00000153076]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000024979
AA Change: C695R
PolyPhen 2
Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000024979
Gene: ENSMUSG00000020859
AA Change: C695R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
253 |
305 |
1e-25 |
PDB |
|
low complexity region
|
306 |
339 |
N/A |
INTRINSIC |
|
coiled coil region
|
572 |
606 |
N/A |
INTRINSIC |
|
low complexity region
|
735 |
751 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
823 |
969 |
3e-5 |
SMART |
|
Blast:WD40
|
924 |
964 |
8e-18 |
BLAST |
|
low complexity region
|
1132 |
1150 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000041956
AA Change: C833R
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000042271
Gene: ENSMUSG00000020859
AA Change: C833R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Jnk-SapK_ap_N
|
24 |
179 |
2e-61 |
PFAM |
|
Pfam:JIP_LZII
|
390 |
460 |
5.3e-32 |
PFAM |
|
coiled coil region
|
710 |
744 |
N/A |
INTRINSIC |
|
low complexity region
|
873 |
889 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
961 |
1107 |
1e-5 |
SMART |
|
Blast:WD40
|
1062 |
1102 |
1e-17 |
BLAST |
|
low complexity region
|
1270 |
1288 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000075695
AA Change: C694R
PolyPhen 2
Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000075115
Gene: ENSMUSG00000020859
AA Change: C694R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
253 |
305 |
1e-25 |
PDB |
|
low complexity region
|
306 |
339 |
N/A |
INTRINSIC |
|
coiled coil region
|
571 |
605 |
N/A |
INTRINSIC |
|
low complexity region
|
734 |
750 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
822 |
968 |
3e-5 |
SMART |
|
Blast:WD40
|
923 |
963 |
7e-18 |
BLAST |
|
low complexity region
|
1131 |
1149 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000092777
AA Change: C695R
PolyPhen 2
Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000090452
Gene: ENSMUSG00000020859
AA Change: C695R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
254 |
306 |
1e-25 |
PDB |
|
low complexity region
|
307 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
572 |
606 |
N/A |
INTRINSIC |
|
low complexity region
|
735 |
751 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
823 |
969 |
3e-5 |
SMART |
|
Blast:WD40
|
924 |
964 |
7e-18 |
BLAST |
|
low complexity region
|
1132 |
1150 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000103168
AA Change: C690R
PolyPhen 2
Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000099457
Gene: ENSMUSG00000020859
AA Change: C690R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
249 |
301 |
1e-25 |
PDB |
|
low complexity region
|
302 |
335 |
N/A |
INTRINSIC |
|
coiled coil region
|
567 |
601 |
N/A |
INTRINSIC |
|
low complexity region
|
730 |
746 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
818 |
964 |
3e-5 |
SMART |
|
Blast:WD40
|
919 |
959 |
8e-18 |
BLAST |
|
low complexity region
|
1127 |
1145 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000132079
AA Change: C483R
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000118850
Gene: ENSMUSG00000020859
AA Change: C483R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
394 |
N/A |
INTRINSIC |
|
low complexity region
|
523 |
539 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000153076
AA Change: C414R
PolyPhen 2
Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000117502
Gene: ENSMUSG00000020859
AA Change: C414R
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:2W83|D
|
1 |
25 |
4e-8 |
PDB |
|
low complexity region
|
26 |
59 |
N/A |
INTRINSIC |
|
coiled coil region
|
291 |
325 |
N/A |
INTRINSIC |
|
low complexity region
|
454 |
470 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
542 |
688 |
3e-5 |
SMART |
|
Blast:WD40
|
643 |
683 |
1e-17 |
BLAST |
|
low complexity region
|
864 |
882 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000115864
Gene: ENSMUSG00000020859
AA Change: C682R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:JIP_LZII
|
240 |
310 |
1.1e-32 |
PFAM |
|
coiled coil region
|
559 |
593 |
N/A |
INTRINSIC |
|
low complexity region
|
723 |
739 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.7482 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
98% (62/63) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Male mice homozygous for a null mutation display reduced fertility with oligoasthenozoospermia. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(5) : Targeted, knock-out(1) Gene trapped(4) |
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001K19Rik |
T |
C |
12: 110,670,865 (GRCm38) |
|
probably benign |
Het |
| 5730480H06Rik |
T |
A |
5: 48,380,233 (GRCm38) |
|
probably null |
Het |
| Actn4 |
A |
T |
7: 28,898,699 (GRCm38) |
V492D |
probably damaging |
Het |
| Alpk2 |
T |
C |
18: 65,305,199 (GRCm38) |
E1041G |
probably benign |
Het |
| Asap1 |
G |
A |
15: 64,130,250 (GRCm38) |
T404M |
probably damaging |
Het |
| Cd22 |
C |
T |
7: 30,877,634 (GRCm38) |
A83T |
not run |
Het |
| Cdan1 |
T |
C |
2: 120,724,912 (GRCm38) |
T783A |
probably benign |
Het |
| Cdh9 |
C |
T |
15: 16,856,073 (GRCm38) |
S733F |
probably damaging |
Het |
| Cfap54 |
A |
G |
10: 92,904,374 (GRCm38) |
F2282S |
unknown |
Het |
| Chst9 |
T |
C |
18: 15,452,661 (GRCm38) |
K282E |
probably damaging |
Het |
| Clcn1 |
G |
A |
6: 42,293,462 (GRCm38) |
D232N |
probably damaging |
Het |
| Clpb |
T |
A |
7: 101,711,465 (GRCm38) |
L234Q |
probably damaging |
Het |
| Cluh |
T |
G |
11: 74,666,406 (GRCm38) |
|
probably null |
Het |
| Cnp |
C |
T |
11: 100,580,587 (GRCm38) |
Q352* |
probably null |
Het |
| Cyfip1 |
AGTGT |
AGT |
7: 55,928,189 (GRCm38) |
|
probably null |
Het |
| Dtx3 |
C |
T |
10: 127,191,489 (GRCm38) |
C272Y |
probably damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,142,756 (GRCm38) |
I1156T |
probably benign |
Het |
| Epg5 |
T |
A |
18: 78,012,702 (GRCm38) |
V1697E |
probably benign |
Het |
| Exoc3l4 |
A |
G |
12: 111,423,624 (GRCm38) |
D211G |
probably benign |
Het |
| Fank1 |
A |
G |
7: 133,853,259 (GRCm38) |
K36R |
probably benign |
Het |
| Fat4 |
T |
C |
3: 38,980,176 (GRCm38) |
I2659T |
possibly damaging |
Het |
| Fer1l5 |
T |
C |
1: 36,420,952 (GRCm38) |
W1893R |
possibly damaging |
Het |
| Gorasp2 |
T |
A |
2: 70,684,047 (GRCm38) |
L256Q |
probably damaging |
Het |
| Gpc5 |
T |
G |
14: 115,552,298 (GRCm38) |
V528G |
probably damaging |
Het |
| Gria2 |
T |
A |
3: 80,802,631 (GRCm38) |
|
probably benign |
Het |
| Htatip2 |
A |
G |
7: 49,770,856 (GRCm38) |
E150G |
possibly damaging |
Het |
| Jak3 |
C |
A |
8: 71,685,511 (GRCm38) |
Q869K |
probably benign |
Het |
| Jmjd1c |
T |
C |
10: 67,226,065 (GRCm38) |
V1218A |
probably benign |
Het |
| Kcnf1 |
A |
G |
12: 17,175,693 (GRCm38) |
C176R |
possibly damaging |
Het |
| Kcnq4 |
A |
G |
4: 120,746,914 (GRCm38) |
V88A |
probably benign |
Het |
| Lmod3 |
T |
A |
6: 97,247,384 (GRCm38) |
D492V |
probably benign |
Het |
| Lurap1l |
A |
C |
4: 80,911,481 (GRCm38) |
S43R |
probably benign |
Het |
| Mamdc4 |
T |
C |
2: 25,565,546 (GRCm38) |
H890R |
possibly damaging |
Het |
| Mertk |
T |
G |
2: 128,801,562 (GRCm38) |
N960K |
possibly damaging |
Het |
| Nudt9 |
C |
A |
5: 104,065,100 (GRCm38) |
D346E |
probably benign |
Het |
| Opa1 |
A |
G |
16: 29,614,039 (GRCm38) |
|
probably null |
Het |
| Or5an1 |
A |
T |
19: 12,283,467 (GRCm38) |
T140S |
probably benign |
Het |
| Oxr1 |
C |
T |
15: 41,813,608 (GRCm38) |
P187L |
not run |
Het |
| Paxbp1 |
T |
C |
16: 91,027,068 (GRCm38) |
E564G |
probably damaging |
Het |
| Pcdhb13 |
C |
T |
18: 37,444,437 (GRCm38) |
R623C |
possibly damaging |
Het |
| Pkhd1l1 |
G |
T |
15: 44,546,941 (GRCm38) |
V2615F |
probably damaging |
Het |
| Plin3 |
T |
C |
17: 56,286,541 (GRCm38) |
T58A |
possibly damaging |
Het |
| Por |
A |
G |
5: 135,732,587 (GRCm38) |
D309G |
probably benign |
Het |
| Ppp2r5e |
T |
C |
12: 75,468,579 (GRCm38) |
K261R |
probably damaging |
Het |
| Ptpn18 |
C |
T |
1: 34,472,846 (GRCm38) |
T366I |
possibly damaging |
Het |
| Ptprz1 |
G |
A |
6: 23,000,929 (GRCm38) |
G1006E |
possibly damaging |
Het |
| Rnf219 |
T |
C |
14: 104,479,858 (GRCm38) |
T360A |
probably benign |
Het |
| Rpl12 |
C |
T |
2: 32,961,897 (GRCm38) |
|
probably benign |
Het |
| Rpsa |
T |
G |
9: 120,131,156 (GRCm38) |
F262V |
probably benign |
Het |
| Sh3pxd2a |
G |
T |
19: 47,267,389 (GRCm38) |
N991K |
probably damaging |
Het |
| Shank2 |
T |
A |
7: 144,285,025 (GRCm38) |
N19K |
probably benign |
Het |
| Sik1 |
T |
C |
17: 31,854,300 (GRCm38) |
T61A |
probably benign |
Het |
| Sipa1l3 |
A |
C |
7: 29,399,428 (GRCm38) |
V472G |
probably damaging |
Het |
| Sirt6 |
A |
G |
10: 81,622,481 (GRCm38) |
S313P |
probably benign |
Het |
| Slc12a7 |
A |
G |
13: 73,763,962 (GRCm38) |
|
probably benign |
Het |
| Sox13 |
A |
T |
1: 133,387,124 (GRCm38) |
V266E |
probably benign |
Het |
| Tcof1 |
T |
C |
18: 60,828,448 (GRCm38) |
T812A |
unknown |
Het |
| Tnfsf4 |
A |
G |
1: 161,417,250 (GRCm38) |
D170G |
possibly damaging |
Het |
| Tshz3 |
A |
G |
7: 36,769,657 (GRCm38) |
N357S |
probably damaging |
Het |
| Txk |
C |
T |
5: 72,700,714 (GRCm38) |
D418N |
probably damaging |
Het |
| Ube2j2 |
A |
G |
4: 155,949,316 (GRCm38) |
|
probably null |
Het |
| Vmn2r84 |
G |
A |
10: 130,386,683 (GRCm38) |
P556L |
probably damaging |
Het |
| Zfp1007 |
T |
C |
5: 109,677,149 (GRCm38) |
H145R |
possibly damaging |
Het |
| Zfp442 |
T |
C |
2: 150,409,005 (GRCm38) |
N326D |
probably benign |
Het |
|
| Other mutations in Spag9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00422:Spag9
|
APN |
11 |
94,097,866 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL01776:Spag9
|
APN |
11 |
94,116,727 (GRCm38) |
splice site |
probably benign |
|
|
IGL02095:Spag9
|
APN |
11 |
94,108,582 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02307:Spag9
|
APN |
11 |
94,102,160 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02417:Spag9
|
APN |
11 |
94,116,741 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL02480:Spag9
|
APN |
11 |
94,108,587 (GRCm38) |
nonsense |
probably null |
|
|
IGL02864:Spag9
|
APN |
11 |
94,106,661 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02976:Spag9
|
APN |
11 |
94,083,953 (GRCm38) |
missense |
probably benign |
0.30 |
|
IGL02979:Spag9
|
APN |
11 |
94,097,364 (GRCm38) |
missense |
probably benign |
|
|
IGL03349:Spag9
|
APN |
11 |
94,093,509 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
dazzle
|
UTSW |
11 |
94,093,624 (GRCm38) |
nonsense |
probably null |
|
|
R0128:Spag9
|
UTSW |
11 |
94,093,539 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0418:Spag9
|
UTSW |
11 |
94,091,753 (GRCm38) |
splice site |
probably benign |
|
|
R1463:Spag9
|
UTSW |
11 |
94,116,837 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1593:Spag9
|
UTSW |
11 |
94,097,233 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1605:Spag9
|
UTSW |
11 |
94,048,539 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1649:Spag9
|
UTSW |
11 |
94,108,452 (GRCm38) |
splice site |
probably null |
|
|
R1697:Spag9
|
UTSW |
11 |
93,996,565 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1952:Spag9
|
UTSW |
11 |
94,097,358 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R2011:Spag9
|
UTSW |
11 |
94,092,375 (GRCm38) |
nonsense |
probably null |
|
|
R2012:Spag9
|
UTSW |
11 |
94,092,375 (GRCm38) |
nonsense |
probably null |
|
|
R2351:Spag9
|
UTSW |
11 |
94,092,900 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2367:Spag9
|
UTSW |
11 |
94,116,757 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3027:Spag9
|
UTSW |
11 |
94,086,377 (GRCm38) |
missense |
probably null |
1.00 |
|
R3766:Spag9
|
UTSW |
11 |
94,060,283 (GRCm38) |
intron |
probably benign |
|
|
R3777:Spag9
|
UTSW |
11 |
94,099,026 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R3937:Spag9
|
UTSW |
11 |
94,044,479 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R3937:Spag9
|
UTSW |
11 |
94,044,417 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4417:Spag9
|
UTSW |
11 |
94,060,346 (GRCm38) |
intron |
probably benign |
|
|
R4445:Spag9
|
UTSW |
11 |
94,097,253 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R4711:Spag9
|
UTSW |
11 |
94,114,351 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4799:Spag9
|
UTSW |
11 |
94,048,517 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4799:Spag9
|
UTSW |
11 |
94,048,516 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R4816:Spag9
|
UTSW |
11 |
94,048,599 (GRCm38) |
intron |
probably benign |
|
|
R4843:Spag9
|
UTSW |
11 |
94,097,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5020:Spag9
|
UTSW |
11 |
94,097,786 (GRCm38) |
missense |
probably benign |
0.08 |
|
R5119:Spag9
|
UTSW |
11 |
94,122,722 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5298:Spag9
|
UTSW |
11 |
94,100,135 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5304:Spag9
|
UTSW |
11 |
94,069,012 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5305:Spag9
|
UTSW |
11 |
94,069,012 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5395:Spag9
|
UTSW |
11 |
94,091,751 (GRCm38) |
splice site |
probably null |
|
|
R5636:Spag9
|
UTSW |
11 |
94,069,012 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5638:Spag9
|
UTSW |
11 |
94,069,012 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5654:Spag9
|
UTSW |
11 |
94,090,712 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5779:Spag9
|
UTSW |
11 |
94,114,253 (GRCm38) |
missense |
probably benign |
0.20 |
|
R5814:Spag9
|
UTSW |
11 |
94,082,828 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5912:Spag9
|
UTSW |
11 |
94,044,425 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6038:Spag9
|
UTSW |
11 |
94,112,092 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6038:Spag9
|
UTSW |
11 |
94,112,092 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6269:Spag9
|
UTSW |
11 |
94,044,507 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6294:Spag9
|
UTSW |
11 |
94,093,485 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R6389:Spag9
|
UTSW |
11 |
94,086,311 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6420:Spag9
|
UTSW |
11 |
94,086,302 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6460:Spag9
|
UTSW |
11 |
94,068,975 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6482:Spag9
|
UTSW |
11 |
94,093,502 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6860:Spag9
|
UTSW |
11 |
94,081,370 (GRCm38) |
missense |
probably benign |
0.25 |
|
R7086:Spag9
|
UTSW |
11 |
94,097,864 (GRCm38) |
missense |
probably benign |
|
|
R7179:Spag9
|
UTSW |
11 |
94,089,432 (GRCm38) |
splice site |
probably null |
|
|
R7351:Spag9
|
UTSW |
11 |
94,092,976 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7366:Spag9
|
UTSW |
11 |
94,108,521 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R7378:Spag9
|
UTSW |
11 |
94,114,351 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7401:Spag9
|
UTSW |
11 |
94,097,689 (GRCm38) |
missense |
probably benign |
|
|
R7506:Spag9
|
UTSW |
11 |
94,108,464 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7507:Spag9
|
UTSW |
11 |
94,068,080 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7513:Spag9
|
UTSW |
11 |
94,112,083 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7655:Spag9
|
UTSW |
11 |
93,996,563 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R7656:Spag9
|
UTSW |
11 |
93,996,563 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R7664:Spag9
|
UTSW |
11 |
94,102,160 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7665:Spag9
|
UTSW |
11 |
94,013,654 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7862:Spag9
|
UTSW |
11 |
94,112,066 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R8074:Spag9
|
UTSW |
11 |
94,112,051 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8085:Spag9
|
UTSW |
11 |
94,099,044 (GRCm38) |
missense |
probably benign |
|
|
R8469:Spag9
|
UTSW |
11 |
94,091,801 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8547:Spag9
|
UTSW |
11 |
94,122,821 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R8709:Spag9
|
UTSW |
11 |
94,068,090 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8732:Spag9
|
UTSW |
11 |
94,071,688 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8899:Spag9
|
UTSW |
11 |
94,092,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8983:Spag9
|
UTSW |
11 |
94,067,989 (GRCm38) |
missense |
probably benign |
|
|
R9043:Spag9
|
UTSW |
11 |
94,060,259 (GRCm38) |
missense |
|
|
|
R9050:Spag9
|
UTSW |
11 |
94,044,468 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9502:Spag9
|
UTSW |
11 |
94,068,966 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9575:Spag9
|
UTSW |
11 |
94,071,583 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9667:Spag9
|
UTSW |
11 |
93,996,293 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R9683:Spag9
|
UTSW |
11 |
94,097,742 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9774:Spag9
|
UTSW |
11 |
94,114,236 (GRCm38) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTTGTTTACTGGGTATTCCAAC -3'
(R):5'- TAACATGGGCACTACAGCATC -3'
Sequencing Primer
(F):5'- GTTTACTGGGTATTCCAACAAAGTTG -3'
(R):5'- ATGGGCACTACAGCATCTTCTTC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation