Incidental Mutation 'R7232:Arhgef10'
| ID |
562561 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef10
|
| Ensembl Gene |
ENSMUSG00000071176 |
| Gene Name |
Rho guanine nucleotide exchange factor 10 |
| Synonyms |
6430549H08Rik |
| MMRRC Submission |
045303-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7232 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
14961663-15051085 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 14990323 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 266
(G266D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000081225
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084207]
[ENSMUST00000110800]
[ENSMUST00000161162]
[ENSMUST00000163062]
|
| AlphaFold |
Q8C033 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084207
AA Change: G266D
PolyPhen 2
Score 0.100 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000081225
Gene: ENSMUSG00000071176
AA Change: G266D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
73 |
82 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
165 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
247 |
265 |
N/A |
INTRINSIC |
|
coiled coil region
|
308 |
335 |
N/A |
INTRINSIC |
|
RhoGEF
|
401 |
583 |
9.79e-58 |
SMART |
|
Blast:PH
|
617 |
829 |
6e-47 |
BLAST |
|
low complexity region
|
1256 |
1272 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110800
AA Change: G266D
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000106424
Gene: ENSMUSG00000071176
AA Change: G266D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
73 |
82 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
165 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
247 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
291 |
N/A |
INTRINSIC |
|
RhoGEF
|
362 |
544 |
9.79e-58 |
SMART |
|
Blast:PH
|
578 |
790 |
8e-47 |
BLAST |
|
low complexity region
|
1217 |
1233 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161162
AA Change: G265D
PolyPhen 2
Score 0.109 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000125606
Gene: ENSMUSG00000071176
AA Change: G265D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
73 |
82 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
165 |
N/A |
INTRINSIC |
|
low complexity region
|
235 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
246 |
264 |
N/A |
INTRINSIC |
|
coiled coil region
|
307 |
334 |
N/A |
INTRINSIC |
|
RhoGEF
|
400 |
579 |
2.2e-51 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163062
|
| SMART Domains |
Protein: ENSMUSP00000125526
Gene: ENSMUSG00000071176
| Domain | Start | End | E-Value | Type |
|---|
|
RhoGEF
|
73 |
255 |
9.79e-58 |
SMART |
|
Blast:PH
|
289 |
501 |
2e-47 |
BLAST |
|
low complexity region
|
899 |
915 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
99% (80/81) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
G |
A |
7: 40,642,603 (GRCm39) |
G91S |
probably damaging |
Het |
| Adam21 |
T |
G |
12: 81,607,330 (GRCm39) |
N144T |
probably damaging |
Het |
| Adgrg7 |
T |
C |
16: 56,597,515 (GRCm39) |
|
probably null |
Het |
| Angpt4 |
T |
C |
2: 151,771,460 (GRCm39) |
S259P |
possibly damaging |
Het |
| Aqr |
A |
C |
2: 113,936,363 (GRCm39) |
L1320R |
probably damaging |
Het |
| Bop1 |
A |
G |
15: 76,337,546 (GRCm39) |
V693A |
probably damaging |
Het |
| Cd86 |
CA |
CAA |
16: 36,426,917 (GRCm39) |
|
probably null |
Het |
| Cdc5l |
A |
G |
17: 45,738,863 (GRCm39) |
|
probably null |
Het |
| Cfap46 |
C |
A |
7: 139,197,493 (GRCm39) |
R2126L |
unknown |
Het |
| Chek2 |
T |
C |
5: 111,008,781 (GRCm39) |
V304A |
probably damaging |
Het |
| Cntnap4 |
T |
A |
8: 113,391,731 (GRCm39) |
|
probably null |
Het |
| Ctps1 |
C |
A |
4: 120,405,321 (GRCm39) |
G374C |
probably damaging |
Het |
| Defa27 |
A |
T |
8: 21,805,625 (GRCm39) |
I22F |
probably damaging |
Het |
| Dnah14 |
T |
C |
1: 181,584,928 (GRCm39) |
S3220P |
probably damaging |
Het |
| Dop1b |
T |
G |
16: 93,557,373 (GRCm39) |
|
probably null |
Het |
| Dpysl5 |
G |
A |
5: 30,949,642 (GRCm39) |
V471I |
probably benign |
Het |
| Duoxa1 |
T |
A |
2: 122,135,728 (GRCm39) |
I124F |
probably damaging |
Het |
| Eif4enif1 |
A |
G |
11: 3,165,678 (GRCm39) |
E85G |
possibly damaging |
Het |
| Eogt |
T |
A |
6: 97,096,944 (GRCm39) |
I355F |
probably damaging |
Het |
| Epha7 |
T |
A |
4: 28,951,279 (GRCm39) |
V800E |
probably damaging |
Het |
| Evi5l |
A |
G |
8: 4,255,906 (GRCm39) |
Q633R |
possibly damaging |
Het |
| Fam170a |
T |
C |
18: 50,414,728 (GRCm39) |
Y125H |
probably damaging |
Het |
| Fbxo15 |
T |
C |
18: 84,980,747 (GRCm39) |
Y241H |
probably damaging |
Het |
| Gbe1 |
T |
C |
16: 70,233,828 (GRCm39) |
I235T |
possibly damaging |
Het |
| Gfra3 |
C |
T |
18: 34,844,234 (GRCm39) |
R102Q |
probably damaging |
Het |
| Gjd4 |
C |
T |
18: 9,280,380 (GRCm39) |
G233S |
probably damaging |
Het |
| Gm29106 |
C |
T |
1: 118,127,291 (GRCm39) |
P328S |
probably damaging |
Het |
| Hgfac |
G |
T |
5: 35,204,258 (GRCm39) |
R507L |
probably damaging |
Het |
| Jakmip3 |
A |
G |
7: 138,609,355 (GRCm39) |
K153R |
probably benign |
Het |
| Kcnc1 |
T |
A |
7: 46,077,383 (GRCm39) |
V395E |
probably damaging |
Het |
| Krt6b |
T |
C |
15: 101,586,577 (GRCm39) |
D304G |
probably damaging |
Het |
| Ldha |
T |
C |
7: 46,500,323 (GRCm39) |
Y174H |
probably benign |
Het |
| Lgi4 |
G |
A |
7: 30,766,776 (GRCm39) |
V268M |
possibly damaging |
Het |
| Lpar3 |
T |
G |
3: 145,947,061 (GRCm39) |
|
probably null |
Het |
| Lrp3 |
T |
C |
7: 34,905,477 (GRCm39) |
D103G |
probably damaging |
Het |
| Marchf5 |
G |
A |
19: 37,194,713 (GRCm39) |
|
probably null |
Het |
| Muc5b |
A |
T |
7: 141,419,866 (GRCm39) |
H4115L |
possibly damaging |
Het |
| Myh13 |
G |
A |
11: 67,239,672 (GRCm39) |
D741N |
probably damaging |
Het |
| Naglu |
A |
T |
11: 100,967,252 (GRCm39) |
I401F |
probably damaging |
Het |
| Ncam2 |
T |
A |
16: 81,309,759 (GRCm39) |
N416K |
probably damaging |
Het |
| Ncan |
A |
G |
8: 70,564,738 (GRCm39) |
L292S |
probably damaging |
Het |
| Nkiras1 |
T |
C |
14: 18,276,732 (GRCm38) |
V7A |
probably damaging |
Het |
| Nlrp4c |
T |
A |
7: 6,068,708 (GRCm39) |
L203* |
probably null |
Het |
| Nscme3l |
A |
T |
19: 5,553,659 (GRCm39) |
S41T |
possibly damaging |
Het |
| Onecut2 |
T |
A |
18: 64,474,633 (GRCm39) |
W395R |
probably damaging |
Het |
| Or10a2 |
T |
A |
7: 106,673,062 (GRCm39) |
I9K |
probably benign |
Het |
| Pak6 |
T |
A |
2: 118,524,003 (GRCm39) |
V386E |
probably damaging |
Het |
| Pias2 |
A |
G |
18: 77,220,931 (GRCm39) |
S396G |
probably benign |
Het |
| Plxna2 |
T |
A |
1: 194,394,568 (GRCm39) |
L483H |
probably damaging |
Het |
| Prss36 |
G |
T |
7: 127,534,763 (GRCm39) |
R484S |
probably benign |
Het |
| Ptpn21 |
A |
T |
12: 98,654,996 (GRCm39) |
V657E |
probably benign |
Het |
| Rassf2 |
T |
C |
2: 131,838,332 (GRCm39) |
E318G |
probably damaging |
Het |
| Rp1 |
A |
C |
1: 4,298,824 (GRCm39) |
S623A |
unknown |
Het |
| Runx2 |
G |
A |
17: 45,125,079 (GRCm39) |
P80L |
probably damaging |
Het |
| Scn11a |
T |
A |
9: 119,588,982 (GRCm39) |
E1308V |
probably damaging |
Het |
| Serpina3c |
A |
T |
12: 104,115,771 (GRCm39) |
S258T |
possibly damaging |
Het |
| Slit3 |
A |
G |
11: 35,501,516 (GRCm39) |
T417A |
possibly damaging |
Het |
| Sostdc1 |
C |
A |
12: 36,367,310 (GRCm39) |
A162E |
possibly damaging |
Het |
| Sox13 |
A |
T |
1: 133,312,129 (GRCm39) |
|
probably null |
Het |
| Sox8 |
G |
T |
17: 25,786,514 (GRCm39) |
S396R |
probably benign |
Het |
| Sult2a3 |
A |
T |
7: 13,816,685 (GRCm39) |
F164L |
possibly damaging |
Het |
| Susd2 |
T |
C |
10: 75,475,685 (GRCm39) |
Y438C |
probably damaging |
Het |
| Tas2r106 |
T |
G |
6: 131,655,810 (GRCm39) |
T14P |
probably damaging |
Het |
| Tcf25 |
T |
A |
8: 124,127,800 (GRCm39) |
|
probably null |
Het |
| Tenm3 |
G |
A |
8: 48,688,970 (GRCm39) |
R2206W |
probably damaging |
Het |
| Tep1 |
A |
G |
14: 51,081,789 (GRCm39) |
L471P |
unknown |
Het |
| Ticrr |
A |
T |
7: 79,343,490 (GRCm39) |
K1118N |
probably damaging |
Het |
| Tlr5 |
G |
A |
1: 182,801,064 (GRCm39) |
E123K |
probably benign |
Het |
| Ttn |
ATATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTG |
ATATCTCTCCAGAGCCTCCCCTGGAGGAGTGGAGTATCTCTCCAGAGCCTCCCCTG |
2: 76,746,150 (GRCm39) |
|
probably benign |
Het |
| U2surp |
A |
G |
9: 95,375,770 (GRCm39) |
V141A |
probably benign |
Het |
| Unc79 |
T |
A |
12: 103,100,734 (GRCm39) |
S2050T |
possibly damaging |
Het |
| Usp13 |
A |
G |
3: 32,920,020 (GRCm39) |
D235G |
probably benign |
Het |
| Vcam1 |
T |
C |
3: 115,919,628 (GRCm39) |
T213A |
possibly damaging |
Het |
| Vmn2r60 |
T |
A |
7: 41,786,166 (GRCm39) |
I323N |
possibly damaging |
Het |
| Vps13b |
A |
G |
15: 35,877,703 (GRCm39) |
I2892M |
probably damaging |
Het |
| Wnt5a |
T |
A |
14: 28,240,329 (GRCm39) |
S160T |
probably benign |
Het |
| Zar1 |
G |
A |
5: 72,738,294 (GRCm39) |
P36L |
possibly damaging |
Het |
| Zfp773 |
A |
T |
7: 7,135,984 (GRCm39) |
M204K |
probably benign |
Het |
| Zhx1 |
T |
C |
15: 57,916,465 (GRCm39) |
T594A |
probably benign |
Het |
|
| Other mutations in Arhgef10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00766:Arhgef10
|
APN |
8 |
15,025,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00823:Arhgef10
|
APN |
8 |
14,990,378 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01012:Arhgef10
|
APN |
8 |
15,029,977 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01311:Arhgef10
|
APN |
8 |
15,041,054 (GRCm39) |
splice site |
probably null |
|
|
IGL01596:Arhgef10
|
APN |
8 |
15,049,468 (GRCm39) |
nonsense |
probably null |
|
|
IGL01888:Arhgef10
|
APN |
8 |
15,012,577 (GRCm39) |
nonsense |
probably null |
|
|
IGL01938:Arhgef10
|
APN |
8 |
15,041,062 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02151:Arhgef10
|
APN |
8 |
14,978,889 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02274:Arhgef10
|
APN |
8 |
14,997,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02369:Arhgef10
|
APN |
8 |
15,047,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02411:Arhgef10
|
APN |
8 |
15,004,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02500:Arhgef10
|
APN |
8 |
15,011,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02597:Arhgef10
|
APN |
8 |
14,980,198 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL02602:Arhgef10
|
APN |
8 |
14,980,198 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL02743:Arhgef10
|
APN |
8 |
14,980,198 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL02744:Arhgef10
|
APN |
8 |
14,980,198 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL03113:Arhgef10
|
APN |
8 |
15,004,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03248:Arhgef10
|
APN |
8 |
14,978,847 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0028:Arhgef10
|
UTSW |
8 |
14,978,925 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
P4748:Arhgef10
|
UTSW |
8 |
14,978,925 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0049:Arhgef10
|
UTSW |
8 |
15,004,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0197:Arhgef10
|
UTSW |
8 |
15,012,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0479:Arhgef10
|
UTSW |
8 |
15,041,070 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0701:Arhgef10
|
UTSW |
8 |
15,012,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0966:Arhgef10
|
UTSW |
8 |
14,990,343 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1367:Arhgef10
|
UTSW |
8 |
14,990,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1572:Arhgef10
|
UTSW |
8 |
15,041,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1631:Arhgef10
|
UTSW |
8 |
14,997,157 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1766:Arhgef10
|
UTSW |
8 |
15,029,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1920:Arhgef10
|
UTSW |
8 |
15,006,987 (GRCm39) |
splice site |
probably benign |
|
|
R2051:Arhgef10
|
UTSW |
8 |
14,995,320 (GRCm39) |
missense |
probably null |
1.00 |
|
R2088:Arhgef10
|
UTSW |
8 |
15,033,898 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2118:Arhgef10
|
UTSW |
8 |
14,984,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2120:Arhgef10
|
UTSW |
8 |
14,984,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2121:Arhgef10
|
UTSW |
8 |
14,984,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2122:Arhgef10
|
UTSW |
8 |
14,984,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2124:Arhgef10
|
UTSW |
8 |
14,984,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2318:Arhgef10
|
UTSW |
8 |
14,978,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Arhgef10
|
UTSW |
8 |
15,025,666 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2870:Arhgef10
|
UTSW |
8 |
15,025,666 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2870:Arhgef10
|
UTSW |
8 |
15,025,093 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2870:Arhgef10
|
UTSW |
8 |
15,025,093 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2872:Arhgef10
|
UTSW |
8 |
15,025,666 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2872:Arhgef10
|
UTSW |
8 |
15,025,666 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2872:Arhgef10
|
UTSW |
8 |
15,025,093 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2872:Arhgef10
|
UTSW |
8 |
15,025,093 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2874:Arhgef10
|
UTSW |
8 |
15,025,666 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2874:Arhgef10
|
UTSW |
8 |
15,025,093 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3522:Arhgef10
|
UTSW |
8 |
15,004,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4049:Arhgef10
|
UTSW |
8 |
15,029,998 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4324:Arhgef10
|
UTSW |
8 |
14,990,335 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R4351:Arhgef10
|
UTSW |
8 |
15,041,145 (GRCm39) |
nonsense |
probably null |
|
|
R4384:Arhgef10
|
UTSW |
8 |
14,980,157 (GRCm39) |
nonsense |
probably null |
|
|
R4385:Arhgef10
|
UTSW |
8 |
14,980,157 (GRCm39) |
nonsense |
probably null |
|
|
R4685:Arhgef10
|
UTSW |
8 |
15,006,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5111:Arhgef10
|
UTSW |
8 |
14,982,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5169:Arhgef10
|
UTSW |
8 |
14,980,051 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5670:Arhgef10
|
UTSW |
8 |
15,004,774 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5945:Arhgef10
|
UTSW |
8 |
15,030,028 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6593:Arhgef10
|
UTSW |
8 |
15,012,564 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6593:Arhgef10
|
UTSW |
8 |
15,012,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6734:Arhgef10
|
UTSW |
8 |
15,025,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6859:Arhgef10
|
UTSW |
8 |
15,025,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6890:Arhgef10
|
UTSW |
8 |
14,978,786 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7068:Arhgef10
|
UTSW |
8 |
15,008,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7081:Arhgef10
|
UTSW |
8 |
15,047,547 (GRCm39) |
nonsense |
probably null |
|
|
R7157:Arhgef10
|
UTSW |
8 |
14,980,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7514:Arhgef10
|
UTSW |
8 |
15,025,956 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7544:Arhgef10
|
UTSW |
8 |
15,029,854 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7657:Arhgef10
|
UTSW |
8 |
15,029,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7736:Arhgef10
|
UTSW |
8 |
15,030,583 (GRCm39) |
nonsense |
probably null |
|
|
R7777:Arhgef10
|
UTSW |
8 |
14,995,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8000:Arhgef10
|
UTSW |
8 |
14,980,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8060:Arhgef10
|
UTSW |
8 |
15,004,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8441:Arhgef10
|
UTSW |
8 |
15,041,237 (GRCm39) |
splice site |
probably benign |
|
|
R8545:Arhgef10
|
UTSW |
8 |
15,025,931 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8545:Arhgef10
|
UTSW |
8 |
14,978,868 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8702:Arhgef10
|
UTSW |
8 |
14,992,638 (GRCm39) |
missense |
probably benign |
|
|
R8846:Arhgef10
|
UTSW |
8 |
15,025,956 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8854:Arhgef10
|
UTSW |
8 |
15,029,798 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9076:Arhgef10
|
UTSW |
8 |
15,024,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9384:Arhgef10
|
UTSW |
8 |
15,041,067 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9479:Arhgef10
|
UTSW |
8 |
15,047,632 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9799:Arhgef10
|
UTSW |
8 |
14,990,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0024:Arhgef10
|
UTSW |
8 |
15,028,486 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0027:Arhgef10
|
UTSW |
8 |
15,047,631 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Z1088:Arhgef10
|
UTSW |
8 |
15,014,191 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGCCTCTGTCTGGTAACTCAG -3'
(R):5'- TTACACATAGGAGACCACTTCGC -3'
Sequencing Primer
(F):5'- TGGTAACTCAGCAGGCTCATG -3'
(R):5'- ATAGGAGACCACTTCGCTGGTAC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation