Mutagenetix > Incidental Mutations

Incidental Mutation 'R7233:Olfr373'

562636

Institutional Source

Beutler Lab

Gene Symbol

Olfr373

Ensembl Gene

ENSMUSG00000061561

Gene Name

olfactory receptor 373

Synonyms

MOR282-2, GA_x6K02T2NUPS-231686-232630, MOR282-1

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.154) question?

Stock #

R7233 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

72083177-72103084 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 72100056 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 99 (T99A)

Ref Sequence

ENSEMBL: ENSMUSP00000149853 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074540] [ENSMUST00000213940] [ENSMUST00000215198]

Predicted Effect

probably benign
Transcript: ENSMUST00000074540
AA Change: T99A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000074128
Gene: ENSMUSG00000061561
AA Change: T99A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	6.1e-57	PFAM
Pfam:7TM_GPCR_Srsx	35	253	6.5e-8	PFAM
Pfam:7tm_1	41	290	4.9e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213940
AA Change: T99A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000215198
AA Change: T99A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (75/75)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402H24Rik	C	A	2: 130,806,788	R258L	unknown	Het
8030462N17Rik	C	A	18: 77,635,186	V385F	probably damaging	Het
Acox3	A	G	5: 35,605,297	K505R	probably benign	Het
Arhgap24	A	G	5: 102,878,501	K263E	probably benign	Het
Armc2	A	T	10: 41,923,804	V686D	probably damaging	Het
Bhmt	T	A	13: 93,621,517	K229*	probably null	Het
Birc2	A	T	9: 7,827,008	C326S	probably damaging	Het
Blzf1	A	T	1: 164,295,943		probably null	Het
Camsap3	T	A	8: 3,600,371	F223Y	probably damaging	Het
Ccdc126	C	T	6: 49,339,841	T85M	probably damaging	Het
Ccng2	C	G	5: 93,273,343	S237R	probably benign	Het
Ces2h	T	A	8: 105,017,456	C279S	probably damaging	Het
Cfap44	T	A	16: 44,422,408	L725Q	probably damaging	Het
Clip1	T	C	5: 123,611,859	E987G	probably damaging	Het
Cog1	G	T	11: 113,649,730	R57L	probably damaging	Het
Ctdspl	T	C	9: 119,020,046		probably null	Het
Dnttip2	T	C	3: 122,276,390	V418A	probably benign	Het
Dopey1	G	A	9: 86,521,696	A186T	probably benign	Het
Engase	T	A	11: 118,483,001	V323E	probably damaging	Het
Fam92b	A	G	8: 120,171,922	L131P	probably damaging	Het
Farsb	A	G	1: 78,471,081		probably null	Het
Fpr2	G	T	17: 17,893,504	W254L	probably damaging	Het
Frmd3	A	C	4: 74,013,786	H6P	probably benign	Het
Fscn1	C	T	5: 142,970,274	S366L	possibly damaging	Het
Galt	T	A	4: 41,758,267	I344N	probably benign	Het
Gfra4	A	T	2: 131,041,117	V194E	probably damaging	Het
Gm11639	T	C	11: 104,839,843	S1966P	possibly damaging	Het
Gm11756	G	T	4: 73,917,571	L219M	probably benign	Het
Gm3139	A	T	5: 94,537,665	M395L	probably benign	Het
Golgb1	T	C	16: 36,914,758	S1497P	possibly damaging	Het
Igfn1	A	C	1: 135,970,135	S898A	probably benign	Het
Igkv1-135	T	C	6: 67,610,348	S68P	probably benign	Het
Lama2	A	T	10: 27,231,663	C784S	probably damaging	Het
Lars2	G	T	9: 123,411,954	G229*	probably null	Het
Lats2	A	T	14: 57,722,694		probably null	Het
Lgr6	A	C	1: 135,000,476		probably null	Het
Lrp1	A	T	10: 127,595,061	I373N	probably damaging	Het
Maml2	A	T	9: 13,620,771	H427L		Het
Mansc1	A	G	6: 134,621,843	V37A	probably damaging	Het
Map4k3	A	G	17: 80,597,648	V738A	possibly damaging	Het
Mastl	A	G	2: 23,133,658	I351T	probably benign	Het
Mcmdc2	T	G	1: 9,932,183		probably null	Het
Mrgprd	A	G	7: 145,321,935	D181G	possibly damaging	Het
Msra	T	C	14: 64,123,265	Y209C	probably damaging	Het
Musk	A	G	4: 58,373,307	E759G	possibly damaging	Het
Nab1	T	C	1: 52,459,219	*487W	probably null	Het
Olfr490	T	A	7: 108,286,716	T137S	probably benign	Het
Pkdrej	A	G	15: 85,821,148	S196P	probably damaging	Het
Pln	A	G	10: 53,343,912	T17A	probably damaging	Het
Polrmt	A	T	10: 79,745,785		probably null	Het
Ppp1r14a	T	A	7: 29,289,524	Y64N	probably damaging	Het
Ppp1r9a	A	T	6: 5,134,804	H959L	probably benign	Het
Prmt7	A	G	8: 106,220,010	T75A	probably damaging	Het
Prom1	T	C	5: 44,037,474	S319G	possibly damaging	Het
Prtg	G	A	9: 72,911,991	G1089S	probably benign	Het
Ptprd	T	C	4: 76,059,783	D596G	probably benign	Het
Rbm12	C	T	2: 156,095,974	G793S	unknown	Het
Rora	A	T	9: 69,197,522	R43*	probably null	Het
Sez6	T	C	11: 77,973,137	Y482H	probably damaging	Het
Skint2	A	T	4: 112,625,925	N176Y	probably damaging	Het
Slc44a2	G	T	9: 21,348,149		probably null	Het
Sox6	A	G	7: 115,489,809	V606A	possibly damaging	Het
Spa17	T	C	9: 37,603,291		probably null	Het
Syne1	A	C	10: 5,302,160	L2498R	probably damaging	Het
Synpo2	T	G	3: 123,117,684	H104P	probably benign	Het
Tapbp	G	T	17: 33,919,969	A46S	probably damaging	Het
Tbc1d30	C	A	10: 121,272,057	R480L	probably benign	Het
Tshz1	T	C	18: 84,014,819	D488G	possibly damaging	Het
Ulk1	A	G	5: 110,809,042	L70P	probably damaging	Het
Zcchc17	T	A	4: 130,327,323	D145V	probably damaging	Het
Zfp318	T	A	17: 46,406,052	L1037M	probably damaging	Het
Zfp324	C	T	7: 12,970,597	Q238*	probably null	Het
Zfp874a	A	G	13: 67,442,657	Y303H	possibly damaging	Het
Zfp975	T	C	7: 42,662,494	K232E	probably benign	Het
Zfp982	T	A	4: 147,513,261	N358K	probably benign	Het
Zmiz1	C	T	14: 25,649,668	P417S	possibly damaging	Het

Other mutations in Olfr373

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01592:Olfr373	APN	8	72100512	missense	probably damaging	1.00
IGL02440:Olfr373	APN	8	72100530	missense	probably damaging	1.00
IGL03403:Olfr373	APN	8	72100497	missense	probably benign	0.00
R1099:Olfr373	UTSW	8	72100659	missense	probably benign	0.00
R1418:Olfr373	UTSW	8	72100387	missense	probably damaging	1.00
R1452:Olfr373	UTSW	8	72100176	nonsense	probably null
R1621:Olfr373	UTSW	8	72100129	missense	probably damaging	1.00
R2021:Olfr373	UTSW	8	72100086	missense	possibly damaging	0.90
R4230:Olfr373	UTSW	8	72100344	missense	probably damaging	1.00
R4290:Olfr373	UTSW	8	72099768	missense	probably benign
R5035:Olfr373	UTSW	8	72100078	missense	probably damaging	1.00
R6884:Olfr373	UTSW	8	72100501	missense	probably benign	0.26
R6909:Olfr373	UTSW	8	72100528	missense	possibly damaging	0.95
R7304:Olfr373	UTSW	8	72100346	nonsense	probably null
R7312:Olfr373	UTSW	8	72099949	missense	probably damaging	1.00
R7701:Olfr373	UTSW	8	72100186	missense	probably damaging	1.00
Z1088:Olfr373	UTSW	8	72100517	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CCACCGTGTTCATCATTGGC -3'
(R):5'- AAGAAGTGGTCCACGGTGTG -3'

Sequencing Primer
(F):5'- TTCATCATTGGCCTGCTAGG -3'
(R):5'- TCAGGATGGAGGCCACC -3'

Posted On

2019-06-26