Incidental Mutation 'R7234:Vmn2r69'
ID 562699
Institutional Source Beutler Lab
Gene Symbol Vmn2r69
Ensembl Gene ENSMUSG00000091006
Gene Name vomeronasal 2, receptor 69
Synonyms
MMRRC Submission 045304-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R7234 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 85055584-85064884 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85056315 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 608 (T608A)
Ref Sequence ENSEMBL: ENSMUSP00000132726 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171213]
AlphaFold G3XA45
Predicted Effect probably benign
Transcript: ENSMUST00000171213
AA Change: T608A

PolyPhen 2 Score 0.217 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000132726
Gene: ENSMUSG00000091006
AA Change: T608A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 465 1.3e-28 PFAM
Pfam:NCD3G 507 559 1.8e-20 PFAM
Pfam:7tm_3 592 827 3.2e-54 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (66/66)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acy3 T A 19: 4,037,758 (GRCm39) Y88* probably null Het
AI606181 T A 19: 41,582,076 (GRCm39) I82N unknown Het
Akap1 T C 11: 88,729,808 (GRCm39) Y638C probably damaging Het
Angpt1 T C 15: 42,323,121 (GRCm39) N383D probably benign Het
Ank T C 15: 27,571,742 (GRCm39) probably null Het
Aoc1 C T 6: 48,882,750 (GRCm39) Q209* probably null Het
Apol7c A T 15: 77,409,875 (GRCm39) L357* probably null Het
Atxn2l A G 7: 126,092,373 (GRCm39) L958P probably damaging Het
Cab39l T A 14: 59,734,395 (GRCm39) probably null Het
Cdk5rap2 A G 4: 70,295,024 (GRCm39) probably null Het
Cdkn3 T C 14: 47,008,918 (GRCm39) S204P unknown Het
Cds2 T C 2: 132,146,400 (GRCm39) probably null Het
Cideb C T 14: 55,992,017 (GRCm39) R179H probably benign Het
Cped1 A G 6: 22,254,625 (GRCm39) Q1006R probably damaging Het
Csmd2 A G 4: 128,350,572 (GRCm39) Y1547C Het
Dicer1 A G 12: 104,675,108 (GRCm39) L718S probably damaging Het
Dnaaf9 C A 2: 130,648,708 (GRCm39) R258L unknown Het
Dyrk2 T C 10: 118,696,136 (GRCm39) H374R possibly damaging Het
Edem2 A T 2: 155,552,886 (GRCm39) Y283N probably benign Het
Ero1b A T 13: 12,615,203 (GRCm39) S345C possibly damaging Het
Fam83g T C 11: 61,593,342 (GRCm39) V292A possibly damaging Het
Farp2 A G 1: 93,507,841 (GRCm39) D513G possibly damaging Het
Fbxl5 A G 5: 43,915,562 (GRCm39) W617R probably benign Het
Fzd7 G A 1: 59,522,443 (GRCm39) V109M probably damaging Het
Gbp5 A T 3: 142,226,898 (GRCm39) H583L probably benign Het
Gm10306 T A 4: 94,445,032 (GRCm39) L84M unknown Het
Gsap A G 5: 21,391,433 (GRCm39) T25A probably benign Het
Hectd4 G T 5: 121,467,136 (GRCm39) R2466L possibly damaging Het
Ide C A 19: 37,268,184 (GRCm39) C557F Het
Ift70a2 A T 2: 75,806,540 (GRCm39) Y657* probably null Het
Igdcc4 T A 9: 65,042,750 (GRCm39) C1234* probably null Het
Ints4 A G 7: 97,179,507 (GRCm39) I701V probably benign Het
Kalrn T A 16: 33,996,792 (GRCm39) I1467F possibly damaging Het
Kcnip3 C A 2: 127,363,256 (GRCm39) R2M unknown Het
Kcnrg A T 14: 61,845,531 (GRCm39) E190D unknown Het
Klk13 T C 7: 43,370,841 (GRCm39) L131P probably damaging Het
Lhcgr A T 17: 89,099,359 (GRCm39) L14Q possibly damaging Het
Mdm4 A T 1: 132,938,853 (GRCm39) D80E probably damaging Het
Mib2 G T 4: 155,742,350 (GRCm39) Q311K probably damaging Het
Msantd5f9 G T 4: 73,835,808 (GRCm39) L219M probably benign Het
Mycbp2 A T 14: 103,452,773 (GRCm39) S1703T probably damaging Het
Naip6 A T 13: 100,452,011 (GRCm39) C200* probably null Het
Ncapd3 T A 9: 26,961,655 (GRCm39) I361N probably damaging Het
Nom1 A G 5: 29,640,451 (GRCm39) E259G probably benign Het
Or10j5 T A 1: 172,784,673 (GRCm39) F104I probably damaging Het
Or51v14 A G 7: 103,261,089 (GRCm39) L157P probably damaging Het
Plxna2 A T 1: 194,488,698 (GRCm39) H1658L probably damaging Het
Ranbp6 T C 19: 29,789,462 (GRCm39) T297A possibly damaging Het
Rap1gap T A 4: 137,455,851 (GRCm39) C722* probably null Het
Ribc2 A G 15: 85,019,733 (GRCm39) K172E probably benign Het
Scamp5 C A 9: 57,354,423 (GRCm39) W77L probably damaging Het
Scin T A 12: 40,130,957 (GRCm39) K319* probably null Het
Sec16a G T 2: 26,329,780 (GRCm39) T745K probably damaging Het
Slc15a2 G A 16: 36,578,173 (GRCm39) A403V probably benign Het
Slco6c1 A G 1: 97,053,466 (GRCm39) V145A probably benign Het
Sncaip C T 18: 53,048,416 (GRCm39) H951Y probably benign Het
Spem1 A G 11: 69,712,630 (GRCm39) probably null Het
Spen C T 4: 141,206,446 (GRCm39) R727Q unknown Het
Thra T C 11: 98,654,544 (GRCm39) S305P probably damaging Het
Tlr1 A G 5: 65,084,067 (GRCm39) V170A probably damaging Het
Tmem260 T A 14: 48,742,786 (GRCm39) C388* probably null Het
Tmem60 T A 5: 21,091,619 (GRCm39) V128D possibly damaging Het
Tpo G A 12: 30,142,685 (GRCm39) P680S probably benign Het
Umodl1 A G 17: 31,205,595 (GRCm39) E730G possibly damaging Het
Xrra1 G A 7: 99,563,456 (GRCm39) S481N possibly damaging Het
Zc3h4 G A 7: 16,162,961 (GRCm39) V446I unknown Het
Other mutations in Vmn2r69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Vmn2r69 APN 7 85,055,739 (GRCm39) missense probably benign
IGL01457:Vmn2r69 APN 7 85,055,836 (GRCm39) missense possibly damaging 0.87
IGL01760:Vmn2r69 APN 7 85,056,072 (GRCm39) missense possibly damaging 0.90
IGL01834:Vmn2r69 APN 7 85,061,576 (GRCm39) missense probably damaging 1.00
IGL02001:Vmn2r69 APN 7 85,056,434 (GRCm39) missense probably benign 0.05
IGL02057:Vmn2r69 APN 7 85,060,990 (GRCm39) missense possibly damaging 0.93
IGL02289:Vmn2r69 APN 7 85,056,054 (GRCm39) missense probably damaging 1.00
IGL02472:Vmn2r69 APN 7 85,058,960 (GRCm39) missense probably benign 0.01
IGL02478:Vmn2r69 APN 7 85,055,889 (GRCm39) missense probably damaging 1.00
IGL02554:Vmn2r69 APN 7 85,059,014 (GRCm39) missense probably damaging 1.00
IGL02723:Vmn2r69 APN 7 85,059,416 (GRCm39) missense probably damaging 1.00
R0526:Vmn2r69 UTSW 7 85,060,711 (GRCm39) missense probably damaging 1.00
R0560:Vmn2r69 UTSW 7 85,058,922 (GRCm39) critical splice donor site probably null
R0909:Vmn2r69 UTSW 7 85,055,873 (GRCm39) missense probably benign 0.00
R0976:Vmn2r69 UTSW 7 85,056,108 (GRCm39) missense probably damaging 1.00
R1158:Vmn2r69 UTSW 7 85,059,058 (GRCm39) splice site probably benign
R1459:Vmn2r69 UTSW 7 85,055,908 (GRCm39) nonsense probably null
R1482:Vmn2r69 UTSW 7 85,056,082 (GRCm39) missense probably damaging 1.00
R1917:Vmn2r69 UTSW 7 85,060,891 (GRCm39) missense probably damaging 1.00
R2016:Vmn2r69 UTSW 7 85,056,493 (GRCm39) missense probably damaging 0.98
R2108:Vmn2r69 UTSW 7 85,059,404 (GRCm39) missense probably benign
R2571:Vmn2r69 UTSW 7 85,064,764 (GRCm39) missense probably benign
R2910:Vmn2r69 UTSW 7 85,055,918 (GRCm39) missense probably damaging 1.00
R2920:Vmn2r69 UTSW 7 85,060,973 (GRCm39) missense probably benign 0.08
R3708:Vmn2r69 UTSW 7 85,061,029 (GRCm39) missense probably damaging 0.98
R3710:Vmn2r69 UTSW 7 85,055,601 (GRCm39) missense probably benign
R4757:Vmn2r69 UTSW 7 85,061,575 (GRCm39) missense probably damaging 0.99
R4823:Vmn2r69 UTSW 7 85,060,508 (GRCm39) missense probably benign 0.21
R4870:Vmn2r69 UTSW 7 85,060,793 (GRCm39) missense possibly damaging 0.93
R4918:Vmn2r69 UTSW 7 85,055,967 (GRCm39) missense probably benign 0.06
R5022:Vmn2r69 UTSW 7 85,060,367 (GRCm39) missense possibly damaging 0.72
R5174:Vmn2r69 UTSW 7 85,064,739 (GRCm39) missense possibly damaging 0.92
R5200:Vmn2r69 UTSW 7 85,055,717 (GRCm39) missense probably damaging 1.00
R5278:Vmn2r69 UTSW 7 85,060,991 (GRCm39) missense probably benign 0.02
R5643:Vmn2r69 UTSW 7 85,056,404 (GRCm39) missense probably damaging 0.98
R5996:Vmn2r69 UTSW 7 85,061,117 (GRCm39) splice site probably null
R6083:Vmn2r69 UTSW 7 85,055,711 (GRCm39) missense probably damaging 1.00
R6140:Vmn2r69 UTSW 7 85,060,657 (GRCm39) missense probably damaging 0.99
R6306:Vmn2r69 UTSW 7 85,064,799 (GRCm39) missense probably benign 0.04
R6330:Vmn2r69 UTSW 7 85,060,835 (GRCm39) missense probably benign
R6380:Vmn2r69 UTSW 7 85,061,067 (GRCm39) missense probably benign
R6466:Vmn2r69 UTSW 7 85,056,378 (GRCm39) missense probably benign 0.01
R6542:Vmn2r69 UTSW 7 85,060,413 (GRCm39) nonsense probably null
R6583:Vmn2r69 UTSW 7 85,059,017 (GRCm39) missense probably benign
R6623:Vmn2r69 UTSW 7 85,056,309 (GRCm39) missense possibly damaging 0.84
R6709:Vmn2r69 UTSW 7 85,061,069 (GRCm39) missense probably benign 0.03
R6732:Vmn2r69 UTSW 7 85,060,351 (GRCm39) missense probably benign 0.00
R6741:Vmn2r69 UTSW 7 85,061,724 (GRCm39) missense probably benign 0.01
R7070:Vmn2r69 UTSW 7 85,060,688 (GRCm39) missense probably damaging 0.98
R7323:Vmn2r69 UTSW 7 85,060,972 (GRCm39) missense possibly damaging 0.95
R7427:Vmn2r69 UTSW 7 85,060,467 (GRCm39) missense probably benign 0.28
R7428:Vmn2r69 UTSW 7 85,060,467 (GRCm39) missense probably benign 0.28
R7453:Vmn2r69 UTSW 7 85,060,768 (GRCm39) frame shift probably null
R7532:Vmn2r69 UTSW 7 85,059,622 (GRCm39) missense probably benign 0.36
R7556:Vmn2r69 UTSW 7 85,060,768 (GRCm39) frame shift probably null
R7562:Vmn2r69 UTSW 7 85,056,420 (GRCm39) missense probably benign
R7592:Vmn2r69 UTSW 7 85,060,768 (GRCm39) frame shift probably null
R7708:Vmn2r69 UTSW 7 85,061,755 (GRCm39) missense possibly damaging 0.87
R7803:Vmn2r69 UTSW 7 85,056,324 (GRCm39) missense probably benign 0.00
R7960:Vmn2r69 UTSW 7 85,055,973 (GRCm39) missense probably benign
R7966:Vmn2r69 UTSW 7 85,060,762 (GRCm39) missense possibly damaging 0.81
R8071:Vmn2r69 UTSW 7 85,055,713 (GRCm39) nonsense probably null
R8237:Vmn2r69 UTSW 7 85,060,340 (GRCm39) missense probably benign 0.02
R8347:Vmn2r69 UTSW 7 85,064,838 (GRCm39) missense probably benign 0.00
R8737:Vmn2r69 UTSW 7 85,055,783 (GRCm39) missense probably damaging 1.00
R8795:Vmn2r69 UTSW 7 85,064,883 (GRCm39) start codon destroyed probably null 0.94
R8831:Vmn2r69 UTSW 7 85,059,018 (GRCm39) nonsense probably null
R8856:Vmn2r69 UTSW 7 85,061,663 (GRCm39) missense probably benign 0.00
R8998:Vmn2r69 UTSW 7 85,060,307 (GRCm39) missense probably benign 0.33
R8999:Vmn2r69 UTSW 7 85,060,307 (GRCm39) missense probably benign 0.33
R9161:Vmn2r69 UTSW 7 85,056,177 (GRCm39) missense possibly damaging 0.88
R9228:Vmn2r69 UTSW 7 85,064,697 (GRCm39) missense probably benign 0.01
R9494:Vmn2r69 UTSW 7 85,060,768 (GRCm39) missense probably damaging 1.00
R9494:Vmn2r69 UTSW 7 85,056,084 (GRCm39) missense probably benign 0.08
R9541:Vmn2r69 UTSW 7 85,056,209 (GRCm39) missense probably benign
R9620:Vmn2r69 UTSW 7 85,061,504 (GRCm39) missense probably benign 0.10
Z1176:Vmn2r69 UTSW 7 85,055,696 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTATTTGGGTGCCCCTGAC -3'
(R):5'- GATCAATGTGTAAAGTGTCTGGAAG -3'

Sequencing Primer
(F):5'- TATTTGGGTGCCCCTGACACAAG -3'
(R):5'- AGTGTCTGGAAGATCAATATGCC -3'
Posted On 2019-06-26