Incidental Mutation 'R7234:Ncapd3'
ID 562704
Institutional Source Beutler Lab
Gene Symbol Ncapd3
Ensembl Gene ENSMUSG00000035024
Gene Name non-SMC condensin II complex, subunit D3
Synonyms 4632407J06Rik, 2810487N22Rik, B130055D15Rik
MMRRC Submission 045304-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.962) question?
Stock # R7234 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 26941471-27006611 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 26961655 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 361 (I361N)
Ref Sequence ENSEMBL: ENSMUSP00000083374 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073127] [ENSMUST00000086198] [ENSMUST00000216677]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000073127
AA Change: I361N

PolyPhen 2 Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000072871
Gene: ENSMUSG00000035024
AA Change: I361N

DomainStartEndE-ValueType
low complexity region 159 170 N/A INTRINSIC
low complexity region 173 184 N/A INTRINSIC
Pfam:Cnd1 949 1148 1.7e-46 PFAM
low complexity region 1192 1200 N/A INTRINSIC
coiled coil region 1213 1270 N/A INTRINSIC
low complexity region 1290 1315 N/A INTRINSIC
low complexity region 1393 1410 N/A INTRINSIC
low complexity region 1485 1498 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000086198
AA Change: I361N

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000083374
Gene: ENSMUSG00000035024
AA Change: I361N

DomainStartEndE-ValueType
low complexity region 159 170 N/A INTRINSIC
low complexity region 173 184 N/A INTRINSIC
Pfam:Cohesin_HEAT 536 560 4.6e-5 PFAM
Pfam:Cnd1 949 1148 6.6e-59 PFAM
low complexity region 1192 1200 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000216677
AA Change: I361N

PolyPhen 2 Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acy3 T A 19: 4,037,758 (GRCm39) Y88* probably null Het
AI606181 T A 19: 41,582,076 (GRCm39) I82N unknown Het
Akap1 T C 11: 88,729,808 (GRCm39) Y638C probably damaging Het
Angpt1 T C 15: 42,323,121 (GRCm39) N383D probably benign Het
Ank T C 15: 27,571,742 (GRCm39) probably null Het
Aoc1 C T 6: 48,882,750 (GRCm39) Q209* probably null Het
Apol7c A T 15: 77,409,875 (GRCm39) L357* probably null Het
Atxn2l A G 7: 126,092,373 (GRCm39) L958P probably damaging Het
Cab39l T A 14: 59,734,395 (GRCm39) probably null Het
Cdk5rap2 A G 4: 70,295,024 (GRCm39) probably null Het
Cdkn3 T C 14: 47,008,918 (GRCm39) S204P unknown Het
Cds2 T C 2: 132,146,400 (GRCm39) probably null Het
Cideb C T 14: 55,992,017 (GRCm39) R179H probably benign Het
Cped1 A G 6: 22,254,625 (GRCm39) Q1006R probably damaging Het
Csmd2 A G 4: 128,350,572 (GRCm39) Y1547C Het
Dicer1 A G 12: 104,675,108 (GRCm39) L718S probably damaging Het
Dnaaf9 C A 2: 130,648,708 (GRCm39) R258L unknown Het
Dyrk2 T C 10: 118,696,136 (GRCm39) H374R possibly damaging Het
Edem2 A T 2: 155,552,886 (GRCm39) Y283N probably benign Het
Ero1b A T 13: 12,615,203 (GRCm39) S345C possibly damaging Het
Fam83g T C 11: 61,593,342 (GRCm39) V292A possibly damaging Het
Farp2 A G 1: 93,507,841 (GRCm39) D513G possibly damaging Het
Fbxl5 A G 5: 43,915,562 (GRCm39) W617R probably benign Het
Fzd7 G A 1: 59,522,443 (GRCm39) V109M probably damaging Het
Gbp5 A T 3: 142,226,898 (GRCm39) H583L probably benign Het
Gm10306 T A 4: 94,445,032 (GRCm39) L84M unknown Het
Gsap A G 5: 21,391,433 (GRCm39) T25A probably benign Het
Hectd4 G T 5: 121,467,136 (GRCm39) R2466L possibly damaging Het
Ide C A 19: 37,268,184 (GRCm39) C557F Het
Ift70a2 A T 2: 75,806,540 (GRCm39) Y657* probably null Het
Igdcc4 T A 9: 65,042,750 (GRCm39) C1234* probably null Het
Ints4 A G 7: 97,179,507 (GRCm39) I701V probably benign Het
Kalrn T A 16: 33,996,792 (GRCm39) I1467F possibly damaging Het
Kcnip3 C A 2: 127,363,256 (GRCm39) R2M unknown Het
Kcnrg A T 14: 61,845,531 (GRCm39) E190D unknown Het
Klk13 T C 7: 43,370,841 (GRCm39) L131P probably damaging Het
Lhcgr A T 17: 89,099,359 (GRCm39) L14Q possibly damaging Het
Mdm4 A T 1: 132,938,853 (GRCm39) D80E probably damaging Het
Mib2 G T 4: 155,742,350 (GRCm39) Q311K probably damaging Het
Msantd5f9 G T 4: 73,835,808 (GRCm39) L219M probably benign Het
Mycbp2 A T 14: 103,452,773 (GRCm39) S1703T probably damaging Het
Naip6 A T 13: 100,452,011 (GRCm39) C200* probably null Het
Nom1 A G 5: 29,640,451 (GRCm39) E259G probably benign Het
Or10j5 T A 1: 172,784,673 (GRCm39) F104I probably damaging Het
Or51v14 A G 7: 103,261,089 (GRCm39) L157P probably damaging Het
Plxna2 A T 1: 194,488,698 (GRCm39) H1658L probably damaging Het
Ranbp6 T C 19: 29,789,462 (GRCm39) T297A possibly damaging Het
Rap1gap T A 4: 137,455,851 (GRCm39) C722* probably null Het
Ribc2 A G 15: 85,019,733 (GRCm39) K172E probably benign Het
Scamp5 C A 9: 57,354,423 (GRCm39) W77L probably damaging Het
Scin T A 12: 40,130,957 (GRCm39) K319* probably null Het
Sec16a G T 2: 26,329,780 (GRCm39) T745K probably damaging Het
Slc15a2 G A 16: 36,578,173 (GRCm39) A403V probably benign Het
Slco6c1 A G 1: 97,053,466 (GRCm39) V145A probably benign Het
Sncaip C T 18: 53,048,416 (GRCm39) H951Y probably benign Het
Spem1 A G 11: 69,712,630 (GRCm39) probably null Het
Spen C T 4: 141,206,446 (GRCm39) R727Q unknown Het
Thra T C 11: 98,654,544 (GRCm39) S305P probably damaging Het
Tlr1 A G 5: 65,084,067 (GRCm39) V170A probably damaging Het
Tmem260 T A 14: 48,742,786 (GRCm39) C388* probably null Het
Tmem60 T A 5: 21,091,619 (GRCm39) V128D possibly damaging Het
Tpo G A 12: 30,142,685 (GRCm39) P680S probably benign Het
Umodl1 A G 17: 31,205,595 (GRCm39) E730G possibly damaging Het
Vmn2r69 T C 7: 85,056,315 (GRCm39) T608A probably benign Het
Xrra1 G A 7: 99,563,456 (GRCm39) S481N possibly damaging Het
Zc3h4 G A 7: 16,162,961 (GRCm39) V446I unknown Het
Other mutations in Ncapd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00339:Ncapd3 APN 9 26,963,649 (GRCm39) missense probably benign
IGL00544:Ncapd3 APN 9 26,974,634 (GRCm39) missense possibly damaging 0.94
IGL01657:Ncapd3 APN 9 26,983,120 (GRCm39) missense possibly damaging 0.81
IGL01979:Ncapd3 APN 9 26,983,261 (GRCm39) critical splice donor site probably null
IGL02073:Ncapd3 APN 9 26,974,612 (GRCm39) missense probably benign 0.03
IGL02083:Ncapd3 APN 9 26,963,117 (GRCm39) missense probably damaging 1.00
IGL02383:Ncapd3 APN 9 26,961,624 (GRCm39) missense probably benign 0.44
IGL02429:Ncapd3 APN 9 27,000,598 (GRCm39) missense probably benign 0.08
IGL02437:Ncapd3 APN 9 26,975,264 (GRCm39) splice site probably benign
IGL02861:Ncapd3 APN 9 26,981,195 (GRCm39) missense probably benign 0.00
IGL03202:Ncapd3 APN 9 26,983,011 (GRCm39) splice site probably benign
IGL03219:Ncapd3 APN 9 26,975,169 (GRCm39) splice site probably benign
IGL03252:Ncapd3 APN 9 26,962,745 (GRCm39) missense probably damaging 1.00
pevensie UTSW 9 26,997,342 (GRCm39) missense probably damaging 1.00
R0015:Ncapd3 UTSW 9 26,963,105 (GRCm39) missense probably damaging 1.00
R0015:Ncapd3 UTSW 9 26,963,105 (GRCm39) missense probably damaging 1.00
R0084:Ncapd3 UTSW 9 26,967,407 (GRCm39) missense probably damaging 0.98
R0491:Ncapd3 UTSW 9 26,969,179 (GRCm39) missense probably damaging 0.97
R0513:Ncapd3 UTSW 9 26,975,401 (GRCm39) splice site probably benign
R0565:Ncapd3 UTSW 9 26,999,294 (GRCm39) missense probably benign 0.00
R0601:Ncapd3 UTSW 9 26,952,803 (GRCm39) missense probably benign 0.05
R0671:Ncapd3 UTSW 9 26,998,773 (GRCm39) missense probably benign 0.00
R0673:Ncapd3 UTSW 9 26,998,773 (GRCm39) missense probably benign 0.00
R0842:Ncapd3 UTSW 9 26,948,380 (GRCm39) missense probably benign 0.01
R1178:Ncapd3 UTSW 9 26,952,717 (GRCm39) missense probably benign
R1366:Ncapd3 UTSW 9 26,969,236 (GRCm39) missense probably damaging 1.00
R1432:Ncapd3 UTSW 9 26,981,168 (GRCm39) splice site probably benign
R1439:Ncapd3 UTSW 9 26,998,862 (GRCm39) critical splice donor site probably null
R1532:Ncapd3 UTSW 9 26,994,656 (GRCm39) nonsense probably null
R2131:Ncapd3 UTSW 9 26,994,642 (GRCm39) missense probably damaging 0.98
R2178:Ncapd3 UTSW 9 26,999,845 (GRCm39) missense probably benign 0.01
R2238:Ncapd3 UTSW 9 26,978,320 (GRCm39) missense probably benign
R2258:Ncapd3 UTSW 9 26,967,368 (GRCm39) missense probably benign 0.16
R2259:Ncapd3 UTSW 9 26,967,368 (GRCm39) missense probably benign 0.16
R2260:Ncapd3 UTSW 9 26,967,368 (GRCm39) missense probably benign 0.16
R2297:Ncapd3 UTSW 9 26,952,797 (GRCm39) nonsense probably null
R2877:Ncapd3 UTSW 9 26,955,783 (GRCm39) splice site probably null
R3612:Ncapd3 UTSW 9 26,961,653 (GRCm39) missense probably damaging 1.00
R3709:Ncapd3 UTSW 9 26,963,645 (GRCm39) missense probably benign 0.00
R3791:Ncapd3 UTSW 9 26,963,931 (GRCm39) missense probably benign 0.27
R4052:Ncapd3 UTSW 9 27,000,679 (GRCm39) splice site probably null
R4297:Ncapd3 UTSW 9 26,963,623 (GRCm39) missense probably benign
R4299:Ncapd3 UTSW 9 26,963,623 (GRCm39) missense probably benign
R4441:Ncapd3 UTSW 9 26,962,941 (GRCm39) missense possibly damaging 0.81
R4572:Ncapd3 UTSW 9 27,005,911 (GRCm39) missense probably damaging 1.00
R4675:Ncapd3 UTSW 9 27,006,038 (GRCm39) unclassified probably benign
R4790:Ncapd3 UTSW 9 26,963,146 (GRCm39) missense probably benign 0.00
R4835:Ncapd3 UTSW 9 26,997,342 (GRCm39) missense probably damaging 1.00
R4919:Ncapd3 UTSW 9 26,963,071 (GRCm39) missense possibly damaging 0.95
R4928:Ncapd3 UTSW 9 26,983,031 (GRCm39) nonsense probably null
R4939:Ncapd3 UTSW 9 26,975,165 (GRCm39) critical splice donor site probably null
R4980:Ncapd3 UTSW 9 26,974,591 (GRCm39) missense probably damaging 0.99
R5030:Ncapd3 UTSW 9 26,983,062 (GRCm39) missense probably damaging 0.98
R5052:Ncapd3 UTSW 9 26,963,015 (GRCm39) missense probably damaging 1.00
R5180:Ncapd3 UTSW 9 26,962,941 (GRCm39) missense possibly damaging 0.81
R5343:Ncapd3 UTSW 9 26,999,349 (GRCm39) small deletion probably benign
R5656:Ncapd3 UTSW 9 26,962,941 (GRCm39) missense possibly damaging 0.81
R5840:Ncapd3 UTSW 9 27,006,054 (GRCm39) missense probably benign 0.00
R5900:Ncapd3 UTSW 9 26,978,265 (GRCm39) missense probably benign 0.26
R6093:Ncapd3 UTSW 9 26,967,454 (GRCm39) missense probably damaging 0.99
R6122:Ncapd3 UTSW 9 26,975,278 (GRCm39) missense probably benign 0.00
R6249:Ncapd3 UTSW 9 26,999,349 (GRCm39) small deletion probably benign
R6428:Ncapd3 UTSW 9 26,963,960 (GRCm39) splice site probably null
R6432:Ncapd3 UTSW 9 26,955,805 (GRCm39) missense probably damaging 0.98
R6441:Ncapd3 UTSW 9 26,974,712 (GRCm39) missense probably benign 0.03
R6459:Ncapd3 UTSW 9 26,963,051 (GRCm39) missense probably benign 0.00
R6567:Ncapd3 UTSW 9 26,978,300 (GRCm39) missense possibly damaging 0.83
R6722:Ncapd3 UTSW 9 26,998,852 (GRCm39) missense probably benign
R6862:Ncapd3 UTSW 9 26,942,105 (GRCm39) missense probably damaging 0.98
R7286:Ncapd3 UTSW 9 26,981,254 (GRCm39) missense probably damaging 1.00
R7404:Ncapd3 UTSW 9 26,978,315 (GRCm39) missense probably benign 0.01
R7541:Ncapd3 UTSW 9 26,978,336 (GRCm39) missense probably damaging 0.99
R7583:Ncapd3 UTSW 9 26,983,144 (GRCm39) missense probably damaging 1.00
R7655:Ncapd3 UTSW 9 26,966,801 (GRCm39) missense possibly damaging 0.47
R7656:Ncapd3 UTSW 9 26,966,801 (GRCm39) missense possibly damaging 0.47
R7815:Ncapd3 UTSW 9 26,974,736 (GRCm39) nonsense probably null
R7876:Ncapd3 UTSW 9 26,956,519 (GRCm39) critical splice donor site probably null
R7913:Ncapd3 UTSW 9 26,959,522 (GRCm39) nonsense probably null
R8068:Ncapd3 UTSW 9 26,974,657 (GRCm39) missense possibly damaging 0.66
R8147:Ncapd3 UTSW 9 26,942,014 (GRCm39) start gained probably benign
R8197:Ncapd3 UTSW 9 26,997,329 (GRCm39) missense probably damaging 0.98
R8264:Ncapd3 UTSW 9 27,006,038 (GRCm39) unclassified probably benign
R8353:Ncapd3 UTSW 9 26,983,100 (GRCm39) missense probably benign 0.03
R8539:Ncapd3 UTSW 9 26,959,520 (GRCm39) missense probably benign
R8839:Ncapd3 UTSW 9 27,005,730 (GRCm39) missense
R8917:Ncapd3 UTSW 9 26,999,297 (GRCm39) missense probably benign
R8997:Ncapd3 UTSW 9 26,959,577 (GRCm39) missense probably damaging 1.00
R9215:Ncapd3 UTSW 9 26,975,386 (GRCm39) missense possibly damaging 0.51
R9393:Ncapd3 UTSW 9 26,962,682 (GRCm39) missense possibly damaging 0.54
R9412:Ncapd3 UTSW 9 26,967,451 (GRCm39) nonsense probably null
R9688:Ncapd3 UTSW 9 26,967,349 (GRCm39) missense probably benign 0.01
R9746:Ncapd3 UTSW 9 26,974,655 (GRCm39) missense probably benign
R9749:Ncapd3 UTSW 9 26,956,873 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- TGGCTAACACCAATGAGTAGG -3'
(R):5'- AAGCTTCTGTGCATGTTTAGC -3'

Sequencing Primer
(F):5'- TGGCTAACACCAATGAGTAGGTTGTC -3'
(R):5'- AGAACACTTTGCTATTAGCTGGG -3'
Posted On 2019-06-26