Incidental Mutation 'R7238:Dennd4a'
| ID |
563001 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4a
|
| Ensembl Gene |
ENSMUSG00000053641 |
| Gene Name |
DENN/MADD domain containing 4A |
| Synonyms |
F730015K02Rik |
| MMRRC Submission |
045345-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.432)
|
| Stock # |
R7238 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
64811340-64919667 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 64861956 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Lysine
at position 408
(T408K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000037915
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038890]
|
| AlphaFold |
E9Q8V6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000038890
AA Change: T408K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000037915
Gene: ENSMUSG00000053641
AA Change: T408K
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
45 |
93 |
3.26e-5 |
PROSPERO |
|
uDENN
|
169 |
276 |
1.71e-28 |
SMART |
|
DENN
|
309 |
493 |
2.4e-73 |
SMART |
|
dDENN
|
559 |
633 |
4.15e-27 |
SMART |
|
low complexity region
|
724 |
735 |
N/A |
INTRINSIC |
|
low complexity region
|
936 |
950 |
N/A |
INTRINSIC |
|
low complexity region
|
1176 |
1191 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1262 |
N/A |
INTRINSIC |
|
low complexity region
|
1402 |
1417 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
97% (104/107) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
T |
3: 138,069,951 (GRCm38) |
T1634S |
probably damaging |
Het |
| 4930402H24Rik |
C |
A |
2: 130,806,788 (GRCm38) |
R258L |
unknown |
Het |
| 4933402N22Rik |
T |
C |
5: 11,920,745 (GRCm38) |
I127T |
|
Het |
| 5830473C10Rik |
A |
T |
5: 90,579,660 (GRCm38) |
Y379F |
probably damaging |
Het |
| Adgrl1 |
T |
A |
8: 83,939,064 (GRCm38) |
M1460K |
probably damaging |
Het |
| Adig |
T |
A |
2: 158,505,853 (GRCm38) |
L29Q |
unknown |
Het |
| Adnp |
T |
G |
2: 168,183,967 (GRCm38) |
K469N |
probably damaging |
Het |
| Akap3 |
A |
G |
6: 126,865,237 (GRCm38) |
D273G |
probably benign |
Het |
| Ankrd34b |
T |
C |
13: 92,438,631 (GRCm38) |
Y124H |
possibly damaging |
Het |
| Ap2b1 |
T |
G |
11: 83,333,122 (GRCm38) |
F221C |
possibly damaging |
Het |
| Atp2c2 |
A |
G |
8: 119,742,421 (GRCm38) |
I358V |
possibly damaging |
Het |
| BC051665 |
G |
A |
13: 60,782,722 (GRCm38) |
T272I |
probably benign |
Het |
| BC117090 |
C |
T |
16: 36,321,831 (GRCm38) |
G61D |
probably benign |
Het |
| Cdan1 |
G |
T |
2: 120,730,302 (GRCm38) |
A262E |
probably benign |
Het |
| Ces1d |
C |
T |
8: 93,178,135 (GRCm38) |
V326I |
probably benign |
Het |
| Chd3 |
T |
C |
11: 69,364,047 (GRCm38) |
R156G |
probably benign |
Het |
| Clip1 |
C |
T |
5: 123,613,265 (GRCm38) |
E818K |
|
Het |
| Col6a4 |
C |
T |
9: 106,000,320 (GRCm38) |
V2153M |
probably damaging |
Het |
| Crlf3 |
T |
C |
11: 80,056,525 (GRCm38) |
N296D |
possibly damaging |
Het |
| D130052B06Rik |
A |
G |
11: 33,623,594 (GRCm38) |
I109V |
probably benign |
Het |
| Dcaf5 |
G |
T |
12: 80,338,709 (GRCm38) |
T881K |
probably benign |
Het |
| Dnah2 |
A |
G |
11: 69,459,146 (GRCm38) |
|
probably null |
Het |
| Eif2ak2 |
C |
T |
17: 78,866,331 (GRCm38) |
V273I |
probably benign |
Het |
| Elac1 |
C |
T |
18: 73,739,288 (GRCm38) |
G212D |
probably damaging |
Het |
| Ercc6l2 |
A |
G |
13: 63,865,984 (GRCm38) |
D623G |
probably damaging |
Het |
| Exo1 |
T |
C |
1: 175,888,847 (GRCm38) |
F177L |
probably damaging |
Het |
| Fat4 |
A |
G |
3: 38,890,413 (GRCm38) |
T1152A |
probably benign |
Het |
| Fbxl12 |
G |
T |
9: 20,618,413 (GRCm38) |
|
probably null |
Het |
| Fbxo43 |
T |
C |
15: 36,151,825 (GRCm38) |
Y582C |
probably damaging |
Het |
| Fsip2 |
T |
A |
2: 82,982,140 (GRCm38) |
N2934K |
possibly damaging |
Het |
| Gm4951 |
A |
G |
18: 60,246,283 (GRCm38) |
S297G |
possibly damaging |
Het |
| Gm8300 |
A |
T |
12: 87,517,236 (GRCm38) |
K114* |
probably null |
Het |
| Gna12 |
A |
G |
5: 140,830,092 (GRCm38) |
S69P |
probably damaging |
Het |
| Gpatch8 |
C |
A |
11: 102,478,528 (GRCm38) |
G1395C |
probably damaging |
Het |
| Gpr137c |
A |
G |
14: 45,278,691 (GRCm38) |
Y294C |
probably damaging |
Het |
| Greb1 |
A |
G |
12: 16,674,672 (GRCm38) |
S1834P |
probably damaging |
Het |
| Grin2b |
T |
C |
6: 135,780,251 (GRCm38) |
D404G |
probably damaging |
Het |
| Hectd2 |
A |
T |
19: 36,597,078 (GRCm38) |
N236I |
probably damaging |
Het |
| Hhip |
C |
T |
8: 79,987,012 (GRCm38) |
V562I |
probably benign |
Het |
| Hipk2 |
G |
T |
6: 38,716,057 (GRCm38) |
T867N |
probably benign |
Het |
| Hmgcl |
T |
C |
4: 135,962,113 (GRCm38) |
V294A |
possibly damaging |
Het |
| Hnrnpl |
T |
A |
7: 28,813,975 (GRCm38) |
F158I |
|
Het |
| Hspa5 |
T |
C |
2: 34,772,371 (GRCm38) |
V17A |
unknown |
Het |
| Hspg2 |
T |
C |
4: 137,508,393 (GRCm38) |
V168A |
probably damaging |
Het |
| Idh1 |
A |
G |
1: 65,166,125 (GRCm38) |
F227S |
probably damaging |
Het |
| Immp2l |
T |
C |
12: 41,110,916 (GRCm38) |
V71A |
possibly damaging |
Het |
| Iqce |
G |
A |
5: 140,689,958 (GRCm38) |
R193* |
probably null |
Het |
| Kcnq5 |
T |
C |
1: 21,402,302 (GRCm38) |
D907G |
probably benign |
Het |
| Krt17 |
T |
A |
11: 100,257,787 (GRCm38) |
T306S |
probably benign |
Het |
| Lhx3 |
T |
C |
2: 26,202,997 (GRCm38) |
D149G |
probably damaging |
Het |
| Lrrc73 |
G |
A |
17: 46,254,562 (GRCm38) |
R73H |
probably damaging |
Het |
| Mgat5b |
T |
C |
11: 116,984,983 (GRCm38) |
S678P |
probably benign |
Het |
| Mink1 |
T |
C |
11: 70,611,479 (GRCm38) |
|
probably null |
Het |
| Mroh5 |
T |
G |
15: 73,791,429 (GRCm38) |
|
probably null |
Het |
| Muc5ac |
G |
C |
7: 141,809,687 (GRCm38) |
|
probably benign |
Het |
| Muc5ac |
T |
A |
7: 141,809,517 (GRCm38) |
H2188Q |
unknown |
Het |
| Musk |
G |
A |
4: 58,344,312 (GRCm38) |
G305D |
probably benign |
Het |
| Mx1 |
A |
G |
16: 97,448,296 (GRCm38) |
I347T |
unknown |
Het |
| Mybbp1a |
G |
T |
11: 72,443,512 (GRCm38) |
V198F |
probably damaging |
Het |
| Mycbp2 |
A |
G |
14: 103,156,297 (GRCm38) |
S2943P |
probably damaging |
Het |
| Myo18a |
G |
A |
11: 77,842,233 (GRCm38) |
R1363K |
probably damaging |
Het |
| Nav3 |
T |
A |
10: 109,853,324 (GRCm38) |
D364V |
possibly damaging |
Het |
| Olfr127 |
T |
C |
17: 37,904,437 (GRCm38) |
L297S |
probably benign |
Het |
| Olfr178 |
T |
A |
16: 58,889,889 (GRCm38) |
E110D |
probably damaging |
Het |
| Olfr309 |
T |
C |
7: 86,306,591 (GRCm38) |
H174R |
probably damaging |
Het |
| Olfr341 |
T |
A |
2: 36,479,714 (GRCm38) |
N139Y |
possibly damaging |
Het |
| Olfr385 |
A |
T |
11: 73,589,735 (GRCm38) |
M1K |
probably null |
Het |
| Pecr |
T |
C |
1: 72,259,433 (GRCm38) |
D276G |
probably damaging |
Het |
| Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 109,624,195 (GRCm38) |
|
probably benign |
Het |
| Ppp1cb |
A |
T |
5: 32,491,032 (GRCm38) |
T320S |
probably benign |
Het |
| Ppp1r9a |
G |
T |
6: 5,159,716 (GRCm38) |
K1084N |
probably damaging |
Het |
| Prdm2 |
A |
G |
4: 143,135,821 (GRCm38) |
S300P |
probably benign |
Het |
| Prkg1 |
C |
T |
19: 30,624,690 (GRCm38) |
V389I |
probably damaging |
Het |
| Psg25 |
C |
T |
7: 18,532,202 (GRCm38) |
|
probably benign |
Het |
| Ptpn6 |
A |
G |
6: 124,721,858 (GRCm38) |
S498P |
possibly damaging |
Het |
| Pus3 |
A |
G |
9: 35,566,669 (GRCm38) |
H399R |
probably benign |
Het |
| Pus7 |
T |
C |
5: 23,778,452 (GRCm38) |
T6A |
probably benign |
Het |
| Rnf169 |
A |
G |
7: 99,925,747 (GRCm38) |
V547A |
probably benign |
Het |
| Rsf1 |
GGCGGCGGC |
GGCGGCGGCCGCGGCGGC |
7: 97,579,921 (GRCm38) |
|
probably benign |
Het |
| Ryr1 |
C |
T |
7: 29,095,382 (GRCm38) |
D1194N |
probably benign |
Het |
| Scn5a |
T |
C |
9: 119,491,544 (GRCm38) |
M1490V |
possibly damaging |
Het |
| Sec23b |
A |
G |
2: 144,590,338 (GRCm38) |
D756G |
possibly damaging |
Het |
| Selenoo |
T |
A |
15: 89,089,224 (GRCm38) |
M39K |
probably benign |
Het |
| Sept8 |
T |
G |
11: 53,536,692 (GRCm38) |
V246G |
possibly damaging |
Het |
| Serpina3k |
T |
A |
12: 104,343,108 (GRCm38) |
N270K |
probably damaging |
Het |
| Setd5 |
G |
A |
6: 113,121,130 (GRCm38) |
R710H |
probably damaging |
Het |
| Sirt4 |
A |
T |
5: 115,482,990 (GRCm38) |
I41N |
possibly damaging |
Het |
| Slc26a9 |
T |
A |
1: 131,758,818 (GRCm38) |
Y425* |
probably null |
Het |
| Slc4a9 |
A |
G |
18: 36,529,720 (GRCm38) |
E176G |
probably benign |
Het |
| Spidr |
A |
T |
16: 15,966,816 (GRCm38) |
W463R |
probably benign |
Het |
| Tenm4 |
G |
A |
7: 96,553,496 (GRCm38) |
R106H |
probably benign |
Het |
| Tmcc1 |
G |
A |
6: 116,134,237 (GRCm38) |
Q28* |
probably null |
Het |
| Tmem52b |
A |
G |
6: 129,516,688 (GRCm38) |
E88G |
probably damaging |
Het |
| Trpc7 |
A |
T |
13: 56,826,897 (GRCm38) |
I402K |
probably benign |
Het |
| Tshz3 |
T |
C |
7: 36,770,097 (GRCm38) |
Y504H |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,881,328 (GRCm38) |
R8290C |
unknown |
Het |
| Ttn |
T |
C |
2: 76,712,205 (GRCm38) |
E33479G |
possibly damaging |
Het |
| Urb1 |
T |
C |
16: 90,752,115 (GRCm38) |
D2235G |
possibly damaging |
Het |
| Usp10 |
T |
C |
8: 119,941,544 (GRCm38) |
F195L |
probably benign |
Het |
| Vmn1r31 |
A |
T |
6: 58,472,873 (GRCm38) |
F2L |
|
Het |
| Vmn2r109 |
C |
T |
17: 20,541,074 (GRCm38) |
V674M |
probably damaging |
Het |
| Vmn2r12 |
G |
A |
5: 109,097,789 (GRCm38) |
P26S |
possibly damaging |
Het |
| Vmn2r61 |
T |
A |
7: 42,267,205 (GRCm38) |
M414K |
possibly damaging |
Het |
| Yipf3 |
T |
C |
17: 46,251,659 (GRCm38) |
V330A |
probably benign |
Het |
| Zic4 |
A |
T |
9: 91,379,397 (GRCm38) |
H235L |
probably benign |
Het |
| Zxdc |
T |
A |
6: 90,369,660 (GRCm38) |
W16R |
unknown |
Het |
|
| Other mutations in Dennd4a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00476:Dennd4a
|
APN |
9 |
64,911,762 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01610:Dennd4a
|
APN |
9 |
64,906,884 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01788:Dennd4a
|
APN |
9 |
64,842,621 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01827:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01828:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01829:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01979:Dennd4a
|
APN |
9 |
64,894,409 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02100:Dennd4a
|
APN |
9 |
64,909,706 (GRCm38) |
splice site |
probably benign |
|
|
IGL02339:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL02341:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL02584:Dennd4a
|
APN |
9 |
64,851,298 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02607:Dennd4a
|
APN |
9 |
64,862,327 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02654:Dennd4a
|
APN |
9 |
64,910,191 (GRCm38) |
splice site |
probably benign |
|
|
IGL02701:Dennd4a
|
APN |
9 |
64,897,353 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
IGL03051:Dennd4a
|
APN |
9 |
64,862,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03257:Dennd4a
|
APN |
9 |
64,871,874 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL03346:Dennd4a
|
APN |
9 |
64,888,526 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
IGL03349:Dennd4a
|
APN |
9 |
64,888,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03398:Dennd4a
|
APN |
9 |
64,871,882 (GRCm38) |
missense |
probably benign |
0.32 |
|
R0010:Dennd4a
|
UTSW |
9 |
64,896,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0010:Dennd4a
|
UTSW |
9 |
64,896,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0129:Dennd4a
|
UTSW |
9 |
64,893,294 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0220:Dennd4a
|
UTSW |
9 |
64,852,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0396:Dennd4a
|
UTSW |
9 |
64,862,391 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0881:Dennd4a
|
UTSW |
9 |
64,851,383 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1225:Dennd4a
|
UTSW |
9 |
64,911,675 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1311:Dennd4a
|
UTSW |
9 |
64,910,004 (GRCm38) |
missense |
probably benign |
0.34 |
|
R1448:Dennd4a
|
UTSW |
9 |
64,906,045 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1450:Dennd4a
|
UTSW |
9 |
64,911,665 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1630:Dennd4a
|
UTSW |
9 |
64,871,882 (GRCm38) |
missense |
probably benign |
0.32 |
|
R1709:Dennd4a
|
UTSW |
9 |
64,889,605 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1824:Dennd4a
|
UTSW |
9 |
64,859,358 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1851:Dennd4a
|
UTSW |
9 |
64,862,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1870:Dennd4a
|
UTSW |
9 |
64,897,234 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1900:Dennd4a
|
UTSW |
9 |
64,897,336 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1911:Dennd4a
|
UTSW |
9 |
64,889,086 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1938:Dennd4a
|
UTSW |
9 |
64,842,490 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1954:Dennd4a
|
UTSW |
9 |
64,852,467 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1955:Dennd4a
|
UTSW |
9 |
64,852,467 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2049:Dennd4a
|
UTSW |
9 |
64,889,605 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2129:Dennd4a
|
UTSW |
9 |
64,905,974 (GRCm38) |
splice site |
probably null |
|
|
R2138:Dennd4a
|
UTSW |
9 |
64,889,337 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2929:Dennd4a
|
UTSW |
9 |
64,852,417 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R3083:Dennd4a
|
UTSW |
9 |
64,906,081 (GRCm38) |
missense |
probably benign |
0.03 |
|
R3108:Dennd4a
|
UTSW |
9 |
64,912,387 (GRCm38) |
missense |
probably benign |
0.23 |
|
R3176:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3177:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3276:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3277:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3890:Dennd4a
|
UTSW |
9 |
64,872,028 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3953:Dennd4a
|
UTSW |
9 |
64,852,575 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3963:Dennd4a
|
UTSW |
9 |
64,862,331 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4059:Dennd4a
|
UTSW |
9 |
64,911,892 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4499:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4500:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4501:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4671:Dennd4a
|
UTSW |
9 |
64,894,407 (GRCm38) |
missense |
probably benign |
|
|
R4701:Dennd4a
|
UTSW |
9 |
64,897,357 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4821:Dennd4a
|
UTSW |
9 |
64,897,249 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4829:Dennd4a
|
UTSW |
9 |
64,889,056 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4876:Dennd4a
|
UTSW |
9 |
64,896,590 (GRCm38) |
missense |
probably benign |
|
|
R4881:Dennd4a
|
UTSW |
9 |
64,838,844 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R4962:Dennd4a
|
UTSW |
9 |
64,906,003 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5225:Dennd4a
|
UTSW |
9 |
64,888,928 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5557:Dennd4a
|
UTSW |
9 |
64,904,227 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5649:Dennd4a
|
UTSW |
9 |
64,851,209 (GRCm38) |
splice site |
probably null |
|
|
R5868:Dennd4a
|
UTSW |
9 |
64,896,729 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5876:Dennd4a
|
UTSW |
9 |
64,911,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6052:Dennd4a
|
UTSW |
9 |
64,886,945 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6411:Dennd4a
|
UTSW |
9 |
64,871,899 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6596:Dennd4a
|
UTSW |
9 |
64,852,420 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6668:Dennd4a
|
UTSW |
9 |
64,886,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6915:Dennd4a
|
UTSW |
9 |
64,852,489 (GRCm38) |
nonsense |
probably null |
|
|
R7056:Dennd4a
|
UTSW |
9 |
64,906,923 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7107:Dennd4a
|
UTSW |
9 |
64,894,399 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R7203:Dennd4a
|
UTSW |
9 |
64,896,474 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7373:Dennd4a
|
UTSW |
9 |
64,897,269 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7454:Dennd4a
|
UTSW |
9 |
64,852,570 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7546:Dennd4a
|
UTSW |
9 |
64,873,044 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7590:Dennd4a
|
UTSW |
9 |
64,888,587 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7662:Dennd4a
|
UTSW |
9 |
64,852,431 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7782:Dennd4a
|
UTSW |
9 |
64,906,920 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7909:Dennd4a
|
UTSW |
9 |
64,872,993 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7976:Dennd4a
|
UTSW |
9 |
64,852,512 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8026:Dennd4a
|
UTSW |
9 |
64,873,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8034:Dennd4a
|
UTSW |
9 |
64,888,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8089:Dennd4a
|
UTSW |
9 |
64,849,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8298:Dennd4a
|
UTSW |
9 |
64,906,875 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8397:Dennd4a
|
UTSW |
9 |
64,889,109 (GRCm38) |
missense |
probably benign |
|
|
R8425:Dennd4a
|
UTSW |
9 |
64,838,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8495:Dennd4a
|
UTSW |
9 |
64,886,879 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8855:Dennd4a
|
UTSW |
9 |
64,912,390 (GRCm38) |
missense |
probably benign |
|
|
R9219:Dennd4a
|
UTSW |
9 |
64,889,094 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9275:Dennd4a
|
UTSW |
9 |
64,842,624 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9376:Dennd4a
|
UTSW |
9 |
64,912,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9485:Dennd4a
|
UTSW |
9 |
64,907,106 (GRCm38) |
nonsense |
probably null |
|
|
R9672:Dennd4a
|
UTSW |
9 |
64,893,358 (GRCm38) |
missense |
probably benign |
|
|
R9746:Dennd4a
|
UTSW |
9 |
64,894,511 (GRCm38) |
missense |
probably benign |
|
|
X0026:Dennd4a
|
UTSW |
9 |
64,897,320 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
Z1088:Dennd4a
|
UTSW |
9 |
64,872,022 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGTCCTGCCCAACAACAG -3'
(R):5'- CGAAGCATAAGTTATCAGCATAGACAC -3'
Sequencing Primer
(F):5'- CAACAGCACTTACGTTTAAAGTTG -3'
(R):5'- AGGAAATTAAAACTGCTTCAACAATG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation