Incidental Mutation 'R7240:Olfr476'
ID 563144
Institutional Source Beutler Lab
Gene Symbol Olfr476
Ensembl Gene ENSMUSG00000095301
Gene Name olfactory receptor 476
Synonyms MOR204-3, GA_x6K02T2PBJ9-10296787-10297719
MMRRC Submission 045347-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R7240 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 107964803-107969514 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107968188 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 264 (S264P)
Ref Sequence ENSEMBL: ENSMUSP00000149760 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077249] [ENSMUST00000217173]
AlphaFold Q8VGI4
Predicted Effect probably benign
Transcript: ENSMUST00000077249
AA Change: S264P

PolyPhen 2 Score 0.417 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000076485
Gene: ENSMUSG00000095301
AA Change: S264P

Pfam:7tm_4 31 308 1.7e-51 PFAM
Pfam:7tm_1 41 290 4.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217173
AA Change: S264P

PolyPhen 2 Score 0.417 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 96% (50/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210017I01Rik A G 3: 92,605,075 (GRCm38) I59T unknown Het
Aspm C T 1: 139,478,651 (GRCm38) Q1759* probably null Het
Atn1 A T 6: 124,747,898 (GRCm38) I124K unknown Het
Ccdc88c C T 12: 100,944,939 (GRCm38) V879M probably benign Het
Cd300c A G 11: 114,959,783 (GRCm38) C65R possibly damaging Het
Cd69 A T 6: 129,270,042 (GRCm38) S112T possibly damaging Het
Cdh19 T C 1: 110,893,407 (GRCm38) T534A probably benign Het
Cdk5rap2 T A 4: 70,291,908 (GRCm38) D701V probably damaging Het
D130052B06Rik A G 11: 33,623,874 (GRCm38) H157R possibly damaging Het
Dpf1 T A 7: 29,311,627 (GRCm38) F150L probably benign Het
Dsg1c T C 18: 20,283,109 (GRCm38) L689P probably damaging Het
Dstyk G A 1: 132,454,123 (GRCm38) M538I probably benign Het
E4f1 T A 17: 24,444,325 (GRCm38) I669F probably damaging Het
Gm7138 T C 10: 77,776,755 (GRCm38) T64A unknown Het
Gnai2 A C 9: 107,615,773 (GRCm38) D310E Het
Iqca A G 1: 90,070,550 (GRCm38) V567A possibly damaging Het
Iqgap1 A T 7: 80,759,839 (GRCm38) N249K probably benign Het
Lamc1 A G 1: 153,234,650 (GRCm38) V1093A possibly damaging Het
Mfap3 A G 11: 57,529,756 (GRCm38) K188E probably damaging Het
N4bp2 T A 5: 65,794,545 (GRCm38) V431D probably damaging Het
Notch4 A G 17: 34,576,471 (GRCm38) T792A probably benign Het
Ntn4 A G 10: 93,745,741 (GRCm38) H592R probably damaging Het
Ofcc1 A G 13: 40,208,841 (GRCm38) C202R probably benign Het
Olfr13 A G 6: 43,174,501 (GRCm38) K172E probably benign Het
Olfr418 T C 1: 173,270,994 (GRCm38) I273T probably benign Het
Olfr497 A G 7: 108,422,933 (GRCm38) M121V probably damaging Het
Olfr922 A G 9: 38,815,713 (GRCm38) D70G probably benign Het
Olfr938 A T 9: 39,078,610 (GRCm38) M45K probably damaging Het
Parpbp G A 10: 88,124,940 (GRCm38) T228I probably damaging Het
Pcdhgb8 G A 18: 37,763,703 (GRCm38) V609M probably damaging Het
Pla2g4d T C 2: 120,270,349 (GRCm38) N543S probably damaging Het
Puf60 A G 15: 76,072,539 (GRCm38) probably benign Het
Rbm6 A T 9: 107,852,896 (GRCm38) D184E probably damaging Het
Rnase9 A C 14: 51,038,979 (GRCm38) S181A probably benign Het
Rnpc3 T A 3: 113,616,831 (GRCm38) R270S probably damaging Het
Rundc1 T C 11: 101,431,548 (GRCm38) probably null Het
Ryr1 T C 7: 29,052,015 (GRCm38) S3715G possibly damaging Het
Scn3a A T 2: 65,469,042 (GRCm38) D1373E possibly damaging Het
Serpina3k T G 12: 104,340,602 (GRCm38) I31S probably benign Het
Sipa1l2 A G 8: 125,469,860 (GRCm38) F712L probably damaging Het
Slc22a29 A G 19: 8,161,511 (GRCm38) V529A probably damaging Het
Tdrd3 A G 14: 87,458,803 (GRCm38) N58S probably benign Het
Tmc2 C T 2: 130,234,804 (GRCm38) T350I possibly damaging Het
Tpst2 T C 5: 112,307,678 (GRCm38) C28R probably benign Het
Trbv21 A T 6: 41,202,958 (GRCm38) K69N probably benign Het
Trpm2 A G 10: 77,935,876 (GRCm38) probably null Het
Ttn A G 2: 76,848,990 (GRCm38) V10796A unknown Het
Ush2a A G 1: 188,911,661 (GRCm38) T4407A possibly damaging Het
Vmn2r95 A G 17: 18,451,963 (GRCm38) H726R probably benign Het
Zfp777 A G 6: 48,044,449 (GRCm38) S80P probably benign Het
Other mutations in Olfr476
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Olfr476 APN 7 107,967,534 (GRCm38) missense probably damaging 1.00
IGL01403:Olfr476 APN 7 107,967,621 (GRCm38) missense possibly damaging 0.64
IGL01564:Olfr476 APN 7 107,967,991 (GRCm38) missense probably benign 0.11
IGL01615:Olfr476 APN 7 107,967,937 (GRCm38) missense probably damaging 1.00
IGL01777:Olfr476 APN 7 107,967,502 (GRCm38) missense probably damaging 1.00
IGL01999:Olfr476 APN 7 107,967,468 (GRCm38) missense probably benign
IGL02239:Olfr476 APN 7 107,968,047 (GRCm38) missense probably damaging 1.00
R0636:Olfr476 UTSW 7 107,967,472 (GRCm38) missense probably benign 0.00
R1986:Olfr476 UTSW 7 107,967,670 (GRCm38) missense probably benign
R5109:Olfr476 UTSW 7 107,967,897 (GRCm38) missense probably benign 0.06
R6363:Olfr476 UTSW 7 107,967,750 (GRCm38) missense possibly damaging 0.57
R6526:Olfr476 UTSW 7 107,967,462 (GRCm38) missense probably benign 0.03
R6907:Olfr476 UTSW 7 107,968,252 (GRCm38) missense probably damaging 1.00
R7063:Olfr476 UTSW 7 107,968,204 (GRCm38) missense probably benign
R7218:Olfr476 UTSW 7 107,967,667 (GRCm38) missense probably benign
R7444:Olfr476 UTSW 7 107,967,604 (GRCm38) missense probably damaging 0.99
R7939:Olfr476 UTSW 7 107,967,779 (GRCm38) nonsense probably null
R8060:Olfr476 UTSW 7 107,967,405 (GRCm38) missense probably benign
R8953:Olfr476 UTSW 7 107,968,044 (GRCm38) missense probably benign 0.00
R9159:Olfr476 UTSW 7 107,968,317 (GRCm38) nonsense probably null
R9438:Olfr476 UTSW 7 107,967,793 (GRCm38) missense probably damaging 1.00
X0025:Olfr476 UTSW 7 107,968,188 (GRCm38) missense possibly damaging 0.75
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-06-26