Mutagenetix > Incidental Mutations

Incidental Mutation 'R7240:Vmn2r95'

563164

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r95

Ensembl Gene

ENSMUSG00000091631

Gene Name

vomeronasal 2, receptor 95

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.320) question?

Stock #

R7240 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

18424078-18460905 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18451963 bp

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 726 (H726R)

Ref Sequence

ENSEMBL: ENSMUSP00000156117 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166327] [ENSMUST00000232090] [ENSMUST00000232464]

Predicted Effect

probably benign
Transcript: ENSMUST00000166327

SMART Domains

Protein: ENSMUSP00000126106
Gene: ENSMUSG00000091631

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	462	1.8e-35	PFAM
Pfam:NCD3G	509	562	3.2e-20	PFAM
Pfam:7tm_3	594	830	3.2e-51	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000232090
AA Change: H726R

PolyPhen 2 Score 0.151 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000232464
AA Change: H654R

PolyPhen 2 Score 0.136 (Sensitivity: 0.92; Specificity: 0.86)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

96% (50/52)

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210017I01Rik	A	G	3: 92,605,075	I59T	unknown	Het
Aspm	C	T	1: 139,478,651	Q1759*	probably null	Het
Atn1	A	T	6: 124,747,898	I124K	unknown	Het
Catsper2	TAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCT	TAGGATGGCTTTTCTCAGGATAGCTTTTCTCAGGATGGCTTTTCTCAGGATAGCTTTTCT	2: 121,397,572		probably benign	Het
Ccdc88c	C	T	12: 100,944,939	V879M	probably benign	Het
Cd300c	A	G	11: 114,959,783	C65R	possibly damaging	Het
Cd69	A	T	6: 129,270,042	S112T	possibly damaging	Het
Cdh19	T	C	1: 110,893,407	T534A	probably benign	Het
Cdk5rap2	T	A	4: 70,291,908	D701V	probably damaging	Het
D130052B06Rik	A	G	11: 33,623,874	H157R	possibly damaging	Het
Dpf1	T	A	7: 29,311,627	F150L	probably benign	Het
Dsg1c	T	C	18: 20,283,109	L689P	probably damaging	Het
Dstyk	G	A	1: 132,454,123	M538I	probably benign	Het
E4f1	T	A	17: 24,444,325	I669F	probably damaging	Het
Gm7138	T	C	10: 77,776,755	T64A	unknown	Het
Gnai2	A	C	9: 107,615,773	D310E		Het
Iqca	A	G	1: 90,070,550	V567A	possibly damaging	Het
Iqgap1	A	T	7: 80,759,839	N249K	probably benign	Het
Lamc1	A	G	1: 153,234,650	V1093A	possibly damaging	Het
Mfap3	A	G	11: 57,529,756	K188E	probably damaging	Het
N4bp2	T	A	5: 65,794,545	V431D	probably damaging	Het
Notch4	A	G	17: 34,576,471	T792A	probably benign	Het
Ntn4	A	G	10: 93,745,741	H592R	probably damaging	Het
Ofcc1	A	G	13: 40,208,841	C202R	probably benign	Het
Olfr13	A	G	6: 43,174,501	K172E	probably benign	Het
Olfr418	T	C	1: 173,270,994	I273T	probably benign	Het
Olfr476	T	C	7: 107,968,188	S264P	probably benign	Het
Olfr497	A	G	7: 108,422,933	M121V	probably damaging	Het
Olfr922	A	G	9: 38,815,713	D70G	probably benign	Het
Olfr938	A	T	9: 39,078,610	M45K	probably damaging	Het
Parpbp	G	A	10: 88,124,940	T228I	probably damaging	Het
Pcdhgb8	G	A	18: 37,763,703	V609M	probably damaging	Het
Pla2g4d	T	C	2: 120,270,349	N543S	probably damaging	Het
Puf60	A	G	15: 76,072,539		probably benign	Het
Rbm6	A	T	9: 107,852,896	D184E	probably damaging	Het
Rnase9	A	C	14: 51,038,979	S181A	probably benign	Het
Rnpc3	T	A	3: 113,616,831	R270S	probably damaging	Het
Rundc1	T	C	11: 101,431,548		probably null	Het
Ryr1	T	C	7: 29,052,015	S3715G	possibly damaging	Het
Scn3a	A	T	2: 65,469,042	D1373E	possibly damaging	Het
Serpina3k	T	G	12: 104,340,602	I31S	probably benign	Het
Sipa1l2	A	G	8: 125,469,860	F712L	probably damaging	Het
Slc22a29	A	G	19: 8,161,511	V529A	probably damaging	Het
Tdrd3	A	G	14: 87,458,803	N58S	probably benign	Het
Tmc2	C	T	2: 130,234,804	T350I	possibly damaging	Het
Tpst2	T	C	5: 112,307,678	C28R	probably benign	Het
Trbv21	A	T	6: 41,202,958	K69N	probably benign	Het
Trpm2	A	G	10: 77,935,876		probably null	Het
Ttn	A	G	2: 76,848,990	V10796A	unknown	Het
Ush2a	A	G	1: 188,911,661	T4407A	possibly damaging	Het
Zfp777	A	G	6: 48,044,449	S80P	probably benign	Het

Other mutations in Vmn2r95

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01024:Vmn2r95	APN	17	18452328	utr 3 prime	probably benign
IGL01479:Vmn2r95	APN	17	18443862	missense	probably damaging	1.00
IGL01890:Vmn2r95	APN	17	18451475	missense	probably damaging	1.00
IGL01986:Vmn2r95	APN	17	18440211	missense	probably benign	0.06
IGL02113:Vmn2r95	APN	17	18439907	missense	possibly damaging	0.47
IGL02154:Vmn2r95	APN	17	18451986	missense	probably benign	0.16
IGL02190:Vmn2r95	APN	17	18451776	missense	probably benign	0.00
IGL02412:Vmn2r95	APN	17	18439956	missense	probably damaging	1.00
IGL02550:Vmn2r95	APN	17	18451732	missense	probably damaging	1.00
IGL02679:Vmn2r95	APN	17	18443854	missense	probably damaging	1.00
IGL02691:Vmn2r95	APN	17	18451858	missense	probably benign	0.07
IGL02990:Vmn2r95	APN	17	18452036	nonsense	probably null
IGL03032:Vmn2r95	APN	17	18452313	missense	probably benign	0.00
R0416:Vmn2r95	UTSW	17	18441402	missense	probably damaging	1.00
R0448:Vmn2r95	UTSW	17	18451743	missense	possibly damaging	0.92
R0514:Vmn2r95	UTSW	17	18451582	missense	probably benign
R0519:Vmn2r95	UTSW	17	18439503	missense	probably damaging	1.00
R0539:Vmn2r95	UTSW	17	18452100	missense	probably damaging	1.00
R1501:Vmn2r95	UTSW	17	18439856	missense	probably damaging	0.99
R1598:Vmn2r95	UTSW	17	18452313	missense	probably benign	0.03
R1613:Vmn2r95	UTSW	17	18440639	splice site	probably benign
R1861:Vmn2r95	UTSW	17	18452268	missense	probably damaging	1.00
R1921:Vmn2r95	UTSW	17	18424313	missense	probably benign	0.11
R1986:Vmn2r95	UTSW	17	18451543	missense	probably benign
R2031:Vmn2r95	UTSW	17	18439455	missense	possibly damaging	0.94
R2040:Vmn2r95	UTSW	17	18441299	missense	probably damaging	1.00
R3608:Vmn2r95	UTSW	17	18439973	missense	possibly damaging	0.47
R3727:Vmn2r95	UTSW	17	18441482	nonsense	probably null
R3953:Vmn2r95	UTSW	17	18440096	missense	possibly damaging	0.79
R3955:Vmn2r95	UTSW	17	18440096	missense	possibly damaging	0.79
R3957:Vmn2r95	UTSW	17	18440096	missense	possibly damaging	0.79
R4474:Vmn2r95	UTSW	17	18452245	missense	probably damaging	1.00
R4672:Vmn2r95	UTSW	17	18452151	missense	probably damaging	1.00
R4850:Vmn2r95	UTSW	17	18451653	missense	probably damaging	1.00
R5054:Vmn2r95	UTSW	17	18451446	missense	possibly damaging	0.63
R5178:Vmn2r95	UTSW	17	18440075	missense	probably benign	0.01
R5980:Vmn2r95	UTSW	17	18441362	missense	probably benign
R6183:Vmn2r95	UTSW	17	18443930	missense	probably damaging	0.99
R6276:Vmn2r95	UTSW	17	18451470	missense	possibly damaging	0.96
R6651:Vmn2r95	UTSW	17	18440360	missense	probably damaging	1.00
R6682:Vmn2r95	UTSW	17	18440227	missense	probably damaging	1.00
R6797:Vmn2r95	UTSW	17	18452289	utr 3 prime	probably benign
R6799:Vmn2r95	UTSW	17	18439293	missense	probably damaging	1.00
R6849:Vmn2r95	UTSW	17	18443919	missense	probably damaging	1.00
R6849:Vmn2r95	UTSW	17	18443920	missense	probably damaging	1.00
R6982:Vmn2r95	UTSW	17	18452061	missense	probably damaging	1.00
R7203:Vmn2r95	UTSW	17	18441315	missense	probably benign	0.01
R7226:Vmn2r95	UTSW	17	18451983	missense	possibly damaging	0.90
R7383:Vmn2r95	UTSW	17	18440472	missense	probably benign	0.06
R7614:Vmn2r95	UTSW	17	18440090	missense	probably benign
R7755:Vmn2r95	UTSW	17	18424105	start codon destroyed	probably null	0.99
Z1088:Vmn2r95	UTSW	17	18440401	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- CCAAAGCCATCACTGTGGTC -3'
(R):5'- TCCCTTTAGTGCTGTGGTAGAC -3'

Sequencing Primer
(F):5'- CACTGTGGTCCTTGCCTTTAAGG -3'
(R):5'- GGTGATCCAGACACAGAAGAACAC -3'

Posted On

2019-06-26