Mutagenetix > Incidental Mutations

Incidental Mutation 'R0579:Ifna9'

56351

Institutional Source

Beutler Lab

Gene Symbol

Ifna9

Ensembl Gene

ENSMUSG00000095270

Gene Name

interferon alpha 9

Synonyms

Ifa9

MMRRC Submission

038769-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R0579 (G1)

Quality Score

195

Status

Validated

Chromosome

Chromosomal Location

88591813-88592385 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 88592271 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 39 (T39S)

Ref Sequence

ENSEMBL: ENSMUSP00000099871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102807]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000102807
AA Change: T39S

PolyPhen 2 Score 0.837 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000099871
Gene: ENSMUSG00000095270
AA Change: T39S

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	1.68e-67	SMART

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.4%
20x: 94.7%

Validation Efficiency

89% (34/38)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921517D22Rik	GCC	GC	13: 59,691,598		probably null	Het
Abcf3	G	A	16: 20,550,648	R260Q	probably benign	Het
Abcg3	A	G	5: 104,974,103	V136A	probably damaging	Het
Acr	C	G	15: 89,569,475	H72Q	probably damaging	Het
Ambra1	A	G	2: 91,824,465	N783S	possibly damaging	Het
Cd300ld2	A	G	11: 115,012,299	F240S	probably benign	Het
Cep83	A	G	10: 94,749,053	D340G	possibly damaging	Het
Crybg2	T	A	4: 134,072,738	I403N	probably damaging	Het
Dnah14	T	A	1: 181,744,747	M2881K	possibly damaging	Het
Erbb4	T	C	1: 68,042,462	M1138V	probably benign	Het
Evi5	A	G	5: 107,821,709	V112A	probably benign	Het
F2r	A	G	13: 95,618,349	V9A	probably benign	Het
Flot1	C	A	17: 35,831,008	S337R	probably benign	Het
Glt28d2	G	A	3: 85,872,133	T11I	probably damaging	Het
Gm19345	A	G	7: 19,854,976		probably benign	Het
Gm6605	C	A	7: 38,448,275		noncoding transcript	Het
Hmgcs2	A	T	3: 98,290,948	I56F	probably damaging	Het
Il21	T	G	3: 37,227,774	K74Q	possibly damaging	Het
Itpripl1	G	T	2: 127,141,091	Y370*	probably null	Het
Kif24	G	A	4: 41,393,706	P1056S	probably damaging	Het
L2hgdh	A	T	12: 69,701,272		probably benign	Het
Lipo2	A	T	19: 33,746,898	L156Q	probably damaging	Het
Nlrp4c	T	A	7: 6,060,845	M84K	probably benign	Het
Npy4r	G	A	14: 34,146,683	T216I	probably benign	Het
Olfr109	T	C	17: 37,466,347	V47A	probably benign	Het
Olfr802	A	T	10: 129,682,237	C167*	probably null	Het
Olfr92	G	C	17: 37,111,455	L176V	probably benign	Het
Pafah1b2	T	C	9: 45,968,713	E222G	probably benign	Het
Pop1	T	A	15: 34,509,969	D406E	possibly damaging	Het
Proser1	A	G	3: 53,467,151	Y32C	probably damaging	Het
Ptprj	C	A	2: 90,436,569		probably null	Het
Slc1a3	T	A	15: 8,688,309	I100F	probably damaging	Het
Slc25a22	T	C	7: 141,431,359	D176G	probably damaging	Het
Stard7	T	C	2: 127,284,553	V99A	probably damaging	Het
Stk33	C	T	7: 109,325,697	V184I	probably damaging	Het
Timmdc1	A	G	16: 38,522,383	L51P	probably benign	Het
Tppp	T	C	13: 74,021,233	S31P	probably benign	Het
Upf2	A	T	2: 5,988,429	R599W	unknown	Het
Vav1	G	T	17: 57,279,271	W25L	probably benign	Het

Other mutations in Ifna9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01788:Ifna9	APN	4	88591860	missense	probably damaging	1.00
IGL02268:Ifna9	APN	4	88592354	nonsense	probably null
R1530:Ifna9	UTSW	4	88592172	missense	possibly damaging	0.83
R1663:Ifna9	UTSW	4	88591983	missense	probably benign	0.00
R1872:Ifna9	UTSW	4	88592255	missense	probably damaging	0.97
R3923:Ifna9	UTSW	4	88592271	missense	possibly damaging	0.84
R4534:Ifna9	UTSW	4	88592048	missense	possibly damaging	0.76
R4882:Ifna9	UTSW	4	88592303	missense	probably benign	0.01
R5440:Ifna9	UTSW	4	88591811	splice site	probably null
R6008:Ifna9	UTSW	4	88592363	missense	probably null	1.00
R6464:Ifna9	UTSW	4	88592250	missense	possibly damaging	0.93
R6584:Ifna9	UTSW	4	88592138	missense	probably damaging	0.99
R6899:Ifna9	UTSW	4	88592063	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CAAGCAGCAGATGAGTCCTTTGATGTG -3'
(R):5'- TACCCAGACCCAAGCAGAGAATGTGG -3'

Sequencing Primer
(F):5'- CAGATGAGTCCTTTGATGTGAAGAG -3'
(R):5'- CTACATAGGATGGTCTTCAGAGAACC -3'

Posted On

2013-07-11