Mutagenetix > Incidental Mutation

Incidental Mutation 'R0580:Scgb2b19'

56390

Institutional Source

Beutler Lab

Gene Symbol

Scgb2b19

Ensembl Gene

ENSMUSG00000096467

Gene Name

secretoglobin, family 2B, member 19

Synonyms

Gm5894, Abpbg19

MMRRC Submission

038770-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.033) question?

Stock #

R0580 (G1)

Quality Score

Status

Not validated

Chromosome

Chromosomal Location

32977795-32979763 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 32977995 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 101 (S101T)

Ref Sequence

ENSEMBL: ENSMUSP00000136155 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179688]

AlphaFold

J3QM75

Predicted Effect

probably benign
Transcript: ENSMUST00000179688
AA Change: S101T

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000136155
Gene: ENSMUSG00000096467
AA Change: S101T

Domain	Start	End	E-Value	Type
low complexity region	3	16	N/A	INTRINSIC
Pfam:Feld-I_B	24	90	2.4e-31	PFAM

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.2%
20x: 93.7%

Validation Efficiency

95% (40/42)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2fm3	T	A	3: 59,784,470 (GRCm39)	D314E	probably damaging	Het
Abcc10	C	T	17: 46,616,882 (GRCm39)		probably null	Het
Adgrg5	T	C	8: 95,663,972 (GRCm39)		probably null	Het
Akap12	A	T	10: 4,304,741 (GRCm39)	D517V	possibly damaging	Het
Arhgap23	AGAGGAGGAGGAGGAGG	AGAGGAGGAGGAGG	11: 97,337,362 (GRCm39)		probably null	Het
Bpi	A	T	2: 158,100,215 (GRCm39)	M1L	probably damaging	Het
Carm1	C	T	9: 21,494,880 (GRCm39)	P339S	probably damaging	Het
Chchd3	A	C	6: 32,870,325 (GRCm39)		probably null	Het
Chd9	T	C	8: 91,721,191 (GRCm39)	V520A	possibly damaging	Het
Chmp7	C	T	14: 69,956,899 (GRCm39)	M336I	probably benign	Het
Col10a1	A	G	10: 34,270,948 (GRCm39)	R307G	probably benign	Het
Cpeb3	T	C	19: 37,151,435 (GRCm39)	T314A	probably benign	Het
Csmd1	A	T	8: 15,960,528 (GRCm39)	Y3296N	probably damaging	Het
Dtx2	A	T	5: 136,061,180 (GRCm39)	T521S	probably damaging	Het
Ext2	A	T	2: 93,626,070 (GRCm39)	V330E	probably benign	Het
Extl3	A	G	14: 65,313,178 (GRCm39)	L668P	probably damaging	Het
Gm6605	C	A	7: 38,147,699 (GRCm39)		noncoding transcript	Het
Grm8	A	G	6: 27,761,370 (GRCm39)		probably benign	Het
Herc2	T	A	7: 55,788,539 (GRCm39)	V1763D	probably damaging	Het
Ino80	G	A	2: 119,213,962 (GRCm39)	P1203S	probably damaging	Het
Iqce	A	G	5: 140,651,156 (GRCm39)	F768L	possibly damaging	Het
Kntc1	G	A	5: 123,941,732 (GRCm39)	V1809I	probably benign	Het
Lyzl1	A	C	18: 4,181,134 (GRCm39)	T58P	probably damaging	Het
Mlxipl	A	G	5: 135,152,829 (GRCm39)	T287A	probably benign	Het
Mroh2a	G	A	1: 88,171,672 (GRCm39)	R770Q	probably damaging	Het
Net1	A	G	13: 3,936,612 (GRCm39)	Y264H	probably damaging	Het
Nnmt	T	C	9: 48,503,600 (GRCm39)	D142G	probably damaging	Het
Nod2	T	A	8: 89,391,034 (GRCm39)	I432N	probably damaging	Het
Or2h2c	G	C	17: 37,422,347 (GRCm39)	L176V	probably benign	Het
Or2y1g	T	A	11: 49,171,449 (GRCm39)	I158N	probably damaging	Het
Or6b6	A	G	7: 106,571,447 (GRCm39)	Y35H	probably damaging	Het
Pign	A	C	1: 105,519,419 (GRCm39)	I501S	probably benign	Het
Slc7a5	A	T	8: 122,611,855 (GRCm39)	M391K	probably benign	Het
Sptan1	A	G	2: 29,897,587 (GRCm39)	R1217G	probably damaging	Het
Srgap2	A	G	1: 131,277,239 (GRCm39)	V336A	possibly damaging	Het
Srsf11	C	T	3: 157,717,704 (GRCm39)		probably benign	Het
Syt10	A	T	15: 89,711,379 (GRCm39)	D51E	probably benign	Het
Vmn2r96	T	C	17: 18,802,900 (GRCm39)	V270A	probably damaging	Het

Other mutations in Scgb2b19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01653:Scgb2b19	APN	7	32,979,153 (GRCm39)	missense	probably damaging	0.99
PIT4515001:Scgb2b19	UTSW	7	32,979,036 (GRCm39)	critical splice donor site	probably null
R1437:Scgb2b19	UTSW	7	32,977,980 (GRCm39)	missense	probably benign	0.08
R1445:Scgb2b19	UTSW	7	32,979,037 (GRCm39)	critical splice donor site	probably null
R5332:Scgb2b19	UTSW	7	32,978,006 (GRCm39)	missense	probably benign	0.07
R6424:Scgb2b19	UTSW	7	32,978,022 (GRCm39)	missense	possibly damaging	0.91
R7102:Scgb2b19	UTSW	7	32,979,711 (GRCm39)	missense	probably null
R7576:Scgb2b19	UTSW	7	32,979,211 (GRCm39)	missense	possibly damaging	0.92
R9551:Scgb2b19	UTSW	7	32,979,198 (GRCm39)	missense	probably damaging	1.00
R9552:Scgb2b19	UTSW	7	32,979,198 (GRCm39)	missense	probably damaging	1.00
R9561:Scgb2b19	UTSW	7	32,978,039 (GRCm39)	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- TCCCCTGAAGACTTTGTTCAGCAC -3'
(R):5'- ACTAGGGACCTGAATCACTGCATGG -3'

Sequencing Primer
(F):5'- GACTTTGTTCAGCACATAGACACAG -3'
(R):5'- CTGAATCACTGCATGGGATTTTC -3'

Posted On

2013-07-11