Incidental Mutation 'R7251:Or14c44'
ID 563927
Institutional Source Beutler Lab
Gene Symbol Or14c44
Ensembl Gene ENSMUSG00000061549
Gene Name olfactory receptor family 14 subfamily C member 44
Synonyms GA_x6K02T2NHDJ-9695951-9695766, Olfr302, Olfr1531-ps1, Olfr301, GA_x6K02T2NHDJ-9693313-9692378, MOR221-4, MOR221-1P, MOR221-1P, MOR211-8P
MMRRC Submission 045313-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R7251 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 86053057-86062507 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86062209 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 213 (V213A)
Ref Sequence ENSEMBL: ENSMUSP00000133780 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000174362]
AlphaFold Q7TS04
Predicted Effect probably benign
Transcript: ENSMUST00000174362
AA Change: V213A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000133780
Gene: ENSMUSG00000061549
AA Change: V213A

DomainStartEndE-ValueType
low complexity region 21 38 N/A INTRINSIC
Pfam:7tm_1 39 289 2e-28 PFAM
Pfam:7tm_4 137 282 1.1e-40 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 97% (66/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930480E11Rik G T X: 77,414,311 (GRCm39) M345I probably benign Het
Adamts19 A T 18: 58,970,974 (GRCm39) D186V probably damaging Het
Agrn T C 4: 156,259,063 (GRCm39) D884G probably damaging Het
Akr1c6 T A 13: 4,497,019 (GRCm39) C154S probably damaging Het
Apob T C 12: 8,057,037 (GRCm39) Y1840H probably damaging Het
Arfgef1 T C 1: 10,269,200 (GRCm39) E399G possibly damaging Het
Arg2 G A 12: 79,197,572 (GRCm39) G197S probably damaging Het
Arhgap32 T C 9: 32,119,481 (GRCm39) V308A probably damaging Het
Atcay A T 10: 81,046,366 (GRCm39) C319* probably null Het
Bend4 C G 5: 67,584,876 (GRCm39) R16P unknown Het
Braf A G 6: 39,654,504 (GRCm39) probably null Het
Camsap1 T C 2: 25,828,898 (GRCm39) E942G probably damaging Het
Cdpf1 C T 15: 85,693,494 (GRCm39) G11D probably damaging Het
Cgn T C 3: 94,683,509 (GRCm39) E382G possibly damaging Het
Cndp1 T A 18: 84,640,322 (GRCm39) E294D probably benign Het
Cnn1 T A 9: 22,019,513 (GRCm39) Y294N unknown Het
Cyp2ab1 A G 16: 20,134,646 (GRCm39) F104S possibly damaging Het
Cyp2t4 G A 7: 26,857,144 (GRCm39) V336M possibly damaging Het
D430041D05Rik T A 2: 104,051,511 (GRCm39) D782V probably damaging Het
Ddx39b A G 17: 35,472,464 (GRCm39) *429W probably null Het
Dgkb T C 12: 38,031,985 (GRCm39) S16P possibly damaging Het
Dll4 T C 2: 119,162,773 (GRCm39) C465R probably damaging Het
Dsp A G 13: 38,377,524 (GRCm39) I1770V probably benign Het
Fbxw11 A G 11: 32,681,370 (GRCm39) N250S probably benign Het
Fsip2 G A 2: 82,809,425 (GRCm39) V1915M possibly damaging Het
Greb1l G A 18: 10,515,319 (GRCm39) V704M probably damaging Het
Hgf T A 5: 16,798,942 (GRCm39) N323K possibly damaging Het
Hhatl A T 9: 121,614,116 (GRCm39) probably null Het
Hip1r T C 5: 124,132,813 (GRCm39) S204P probably damaging Het
Igsf10 T A 3: 59,226,875 (GRCm39) N2266I probably damaging Het
Krtap15-1 A G 16: 88,625,982 (GRCm39) probably null Het
Lrp1 T C 10: 127,408,423 (GRCm39) D1751G probably damaging Het
Madd A T 2: 90,992,521 (GRCm39) D1050E probably benign Het
Man1c1 C T 4: 134,308,147 (GRCm39) G323R probably damaging Het
Mgll A G 6: 88,800,357 (GRCm39) E252G probably benign Het
Muc2 A G 7: 141,278,965 (GRCm39) N145S possibly damaging Het
Ncoa2 C T 1: 13,218,599 (GRCm39) S1410N probably benign Het
Nek10 A G 14: 14,853,965 (GRCm38) T384A probably benign Het
Nexn T C 3: 151,952,832 (GRCm39) E310G probably damaging Het
Nol10 T C 12: 17,452,108 (GRCm39) L354P probably damaging Het
Npy4r T C 14: 33,868,872 (GRCm39) R139G probably damaging Het
Nup160 A G 2: 90,530,518 (GRCm39) E463G probably damaging Het
Or52a33 C T 7: 103,288,909 (GRCm39) G146D probably damaging Het
Or8j3c G A 2: 86,253,940 (GRCm39) L27F probably benign Het
Pdzd8 A T 19: 59,289,077 (GRCm39) N774K possibly damaging Het
Pmpca G C 2: 26,285,046 (GRCm39) E424Q possibly damaging Het
Pot1a T C 6: 25,752,497 (GRCm39) probably null Het
Ppip5k1 T A 2: 121,178,052 (GRCm39) E283D probably benign Het
Ptpn2 A C 18: 67,808,862 (GRCm39) I318R possibly damaging Het
Raph1 A G 1: 60,529,027 (GRCm39) F745L unknown Het
Rgs19 C T 2: 181,331,541 (GRCm39) V88I probably benign Het
Ripk4 A G 16: 97,544,449 (GRCm39) S733P probably benign Het
Rprd1b T A 2: 157,870,899 (GRCm39) W29R probably damaging Het
Rtkn A G 6: 83,112,943 (GRCm39) N5S probably damaging Het
Sh3bp5l A T 11: 58,232,128 (GRCm39) Q131L probably damaging Het
Slain2 T A 5: 73,131,891 (GRCm39) F461I possibly damaging Het
Stk24 A T 14: 121,545,434 (GRCm39) L108Q probably damaging Het
Syne3 TC T 12: 104,927,830 (GRCm39) probably null Het
Tapbpl A T 6: 125,203,558 (GRCm39) V374E probably damaging Het
Tax1bp1 A G 6: 52,698,341 (GRCm39) I18V possibly damaging Het
Tecta T A 9: 42,299,048 (GRCm39) I233F probably damaging Het
Tet3 A G 6: 83,381,038 (GRCm39) S377P probably benign Het
Uty A G Y: 1,154,262 (GRCm39) S721P probably benign Het
Wnk4 C A 11: 101,155,979 (GRCm39) T412K possibly damaging Het
Zdhhc11 G T 13: 74,140,216 (GRCm39) V336L probably benign Het
Zfp605 T A 5: 110,275,826 (GRCm39) S315T probably damaging Het
Zfp746 A G 6: 48,041,811 (GRCm39) L305P probably damaging Het
Other mutations in Or14c44
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01015:Or14c44 APN 7 86,061,998 (GRCm39) missense probably damaging 1.00
IGL01459:Or14c44 APN 7 86,061,759 (GRCm39) missense probably damaging 1.00
IGL01538:Or14c44 APN 7 86,062,167 (GRCm39) missense possibly damaging 0.80
IGL01547:Or14c44 APN 7 86,062,079 (GRCm39) missense possibly damaging 0.94
R0918:Or14c44 UTSW 7 86,062,403 (GRCm39) missense probably benign 0.01
R1559:Or14c44 UTSW 7 86,061,575 (GRCm39) missense probably benign 0.00
R1651:Or14c44 UTSW 7 86,057,078 (GRCm39) utr 5 prime probably benign
R2411:Or14c44 UTSW 7 86,062,290 (GRCm39) missense possibly damaging 0.51
R3732:Or14c44 UTSW 7 86,061,841 (GRCm39) missense probably damaging 0.98
R3832:Or14c44 UTSW 7 86,062,401 (GRCm39) missense probably damaging 1.00
R5175:Or14c44 UTSW 7 86,062,254 (GRCm39) missense probably benign 0.00
R5372:Or14c44 UTSW 7 86,062,176 (GRCm39) missense possibly damaging 0.66
R5413:Or14c44 UTSW 7 86,061,675 (GRCm39) missense probably benign
R5520:Or14c44 UTSW 7 86,062,064 (GRCm39) missense probably benign 0.02
R5579:Or14c44 UTSW 7 86,061,934 (GRCm39) nonsense probably null
R6037:Or14c44 UTSW 7 86,062,478 (GRCm39) missense probably benign 0.02
R6037:Or14c44 UTSW 7 86,062,478 (GRCm39) missense probably benign 0.02
R7340:Or14c44 UTSW 7 86,061,957 (GRCm39) missense possibly damaging 0.92
R7860:Or14c44 UTSW 7 86,057,119 (GRCm39) start gained probably benign
R8305:Or14c44 UTSW 7 86,061,987 (GRCm39) missense probably damaging 1.00
R8338:Or14c44 UTSW 7 86,061,702 (GRCm39) missense probably benign 0.14
R8487:Or14c44 UTSW 7 86,061,647 (GRCm39) missense probably benign 0.34
R8799:Or14c44 UTSW 7 86,061,854 (GRCm39) missense probably damaging 1.00
R9342:Or14c44 UTSW 7 86,062,430 (GRCm39) missense probably benign 0.37
Z1176:Or14c44 UTSW 7 86,061,906 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- GATGACACTGGCTTCCCTAC -3'
(R):5'- ACAGAAAGAGTCATCTCCTTAGCTAC -3'

Sequencing Primer
(F):5'- GATGACACTGGCTTCCCTACTTAGC -3'
(R):5'- GCTACTTCTAATGTTACCACTGGAGG -3'
Posted On 2019-06-26